Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer

Cancer Research

Volumn 58, Issue 6, 1998, Pages 1130-1134

  Sparks, Andrew B ^a   Morin, Patrice J ^a   Vogelstein, Bert ^a,b   Kinzler, Kenneth W ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GENE PRODUCT;

ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; COLON POLYPOSIS; COLORECTAL CANCER; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; TRANSACTIVATION; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADENOMA; AMINO ACID SEQUENCE; BETA CATENIN; COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; DESMOPLAKINS; DNA MUTATIONAL ANALYSIS; GAMMA CATENIN; GENES, APC; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE ALIGNMENT; TCF TRANSCRIPTION FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0032521433     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Kinzler, K. W., and Vogelstein, B. Lessons from hereditary colon cancer. Cell, 87: 159-170, 1996.
2. Rubinfeld, B., Souza, B., Albert, I., Muller, O., Chamberlain, S. H., Masiarz, F. R., Munemitsu, S., and Polakis, P. Association of the APC gene product with β-catenin. Science (Washington DC), 262: 1731-1734, 1993.
3. Su, L. K., Vogelstein, B., and Kinzler, K. W. Association of the APC tumor suppressor protein with catenins. Science (Washington DC), 262: 1734-1737, 1993.
4. Hulsken, J., Birchmeier, W., and Behrens, J. E-cadherin and APC compete for the interaction with β-catenin and the cytoskeleton. J. Cell Biol., 127: 2061-2069, 1994.
5. Rubinfeld, B., Souza, B., Albert, I., Munemitsu, S., and Polakis, P. The APC protein and E-cadherin form similar but independent complexes with α-catenin, β-catenin, and plakoglobin. J. Biol. Chem., 270: 5549-5555, 1995.
6. Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C., Munemitsu, S., and Polakis, P. Binding of GSK3-β to the APC-β-catenin complex and regulation of complex assembly. Science (Washington DC), 272: 1023-1025, 1996.
7. Su, L. K., Burrell, M., Hill, D. E., Gyuris, J., Brent, R., Wiltshire, R., Trent, J., Vogelstein, B., and Kinzler, K. W. APC binds to the novel protein EB1. Cancer Res., 55: 2972-2977, 1995.
8. Matsumine, A., Ogai, A., Senda, T., Okumura, N., Satoh, K., Baeg, G-H., Kawahara, T., Kobayashi, S., Okada, M., Toyoshima, K., and Akiyama, T. Binding of APC to the human homolog of the drosophila discs large tumor suppressor protein. Science (Washington DC), 272: 1020-1023, 1996.
9. Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., and Clevers, H. Constitutive transcriptional activation by a β-calenin-Tcf complex in APC -/-colon carcinoma. Science (Washington DC), 275: 1784-1787, 1997.
10. Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science (Washington DC), 275: 1787-1790, 1997.
11. Munemitsu, S., Albert, I., Souza, B., Rubinfeld, B., and Polakis, P. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA, 92: 3046-3050, 1995.
12. Munemitsu, S., Albert, I., Rubinfeld, B., and Polakis, P. Deletion of an ammo-terminal sequence β-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein. Mol. Cell. Biol., 16: 4088-4094, 1996.
13. Rubinfeld, B., Robbins, P., El-Gamil, M., Albert, I., Porfiri, E., and Polakis, P. Stabilization of β-catenin by genetic defects in melanoma cell lines Science (Washington DC), 275: 1790-1792, 1997.
14. Peifer, M. Regulating cell proliferation: as easy as APC. Science (Washington DC) 272: 974-975, 1996.
15. Powell, S. M., Zilz, N., Beazer-Barclay, Y., Bryan, T. M., Hamilton, S. R., Thibodeau, S. N., Vogelstein, B., and Kinzler, K. W. APC mutations occur early during colorectal tumorigenesis. Nature (Lond.), 359: 235-237, 1992.
16. 2 gene alterations in human colorectal cancer Cancer Res., 55: 5184-5186, 1995.
17. Powell, S. M., Petersen, G. M., Krush, A. J., Booker, S., Jen, J., Giardiello, F. M., Hamilton, S. R., Vogelstein, B., and Kinzler, K. W. Molecular diagnosis of familial adenomatous polyposis. N. Engl. J. Med., 329: 1982-1987, 1993.
18. van der Luijt, R., Khan, P. M., Vasen, H., van Leeuwen, C., Tops, C., Roest, P., den Dunnen, J., and Fodde, R. Rapid detection of translation-terminating mutations at the adenomatous polyposis coli (APC) gene by direct protein truncation test. Genomics 20: 1-4, 1994.
19. Ilyas, M., Tomlinson, I. P., Rowan, A., Pignatelli, M., and Bodmer, W. F. β-Catenin mutations in cell lines established from human colorectal cancers. Proc. Natl. Acad. Sci. USA, 94: 10330-10334, 1997.
20. Kitaeva, M. N., Grogan, L., Williams, J. P., Dimond, E., Nakahara, K., Hausner, P., DeNobile, J. W., Soballe, P. W., and Kirsch, I. R. Mutations in β-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors. Cancer Res., 57: 4478-4481, 1997.
21. Ionov, Y., Peinado, M. A., Malkhosyan, S., Shibata, D., and Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonie carcinogenesis. Nature (Lond.), 363: 558-561, 1993.
22. Thibodeau, S. N., Bren, G., and Schaid, D. Microsatellite instability in cancer of the proximal colon. Science (Washington DC), 260: 816-819, 1993.
23. Aaltonen, L. A., Peltomaki, P., Leach, F. S., Sistonen, P., Pylkkanen, L., Mecklin, J. P., Jarvinen, H., Powell, S. M., Jen, J., Hamilton, S. R., Petersen, G. M., Kinzler, K. W., Vogelstein, B., and de la Chapelle, A. Clues to the pathogenesis of familial colorectal cancer. Science (Washington DC), 260: 812-816, 1993.
24. Huang, J., Papadopoulos, N., McKinley, A. J., Farrington, S. M., Curtis, L. J., Wyllie, A. H., Zheng, S., Willson, J. K. V., Markowitz, S. D., Morin, P., Kanzler, K. W., Vogelstein, B., and Dunlop, M. G. APC mutations in colorectal tumors with mismatch repair deficiency. Proc. Natl. Acad. Sci. USA, 93: 9049-9054, 1996.
25. Yost, C., Torres, M., Miller, J. R., Huang, E., Kimelman, D., and Moon, R. T. The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev., 10: 1443-1454, 1996.
26. Aberle, H., Bauer, A., Stappert, J., Kispert, A., and Kemler, R. β-Catenin is a target for the ubiquitin-proteasome pathway. EMBO J., 16: 3797-3804, 1997.
27. Orford, K., Crockett, C., Jensen, J. P., Weissman, A. M., and Byers, S. W. Serine phosphorylation-regulated ubiquitination and degradation of β-catenin. J. Biol. Chem., 272: 24735-24738, 1997.
28. Sacco, P. A., McGranahan, T. M., Wheelock, M. J., and Johnson, K. R. Identification of plakoglobin domains required for association with N-cadherin and α-catenin. J. Biol. Chem., 270: 20201-20206, 1995.
29. Huber, O., Korn, R., McLaughlin, J., Ohsugi, M., Herrmann, B. G., and Kemler, R. Nuclear localization of β-catenin by interaction with transcription factor LEF-1. Mech. Dev., 59: 3-10, 1996.
30. Karnovsky, A., and Klymkowsky, M. W. Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin. Proc. Natl. Acad. Sci. USA, 92: 4522-4526, 1995.
31. Smith, K. J., Johnson, K. A., Bryan, T. M., Hill, D. E., Markowitz, S., Willson, J. K., Paraskeva, C., Petersen, G. M., Hamilton, S. R., Vogelstein, B., and Kinzler, K. W. The APC gene product in normal and tumor cells. Proc. Natl. Acad Sci. USA, 90: 2846-2850, 1993.
32. Chen, Z., Hagler, J., Palombella, V. J., Melandri, F., Scherer, D., Ballard, D., and Maniatis, T. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes & Dev., 9: 1586-1597, 1995.