Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6

Journal of Biological Chemistry

Volumn 283, Issue 23, 2008, Pages 16115-16123

  MacDonald, Bryan T ^a   Yokota, Chika ^a   Tamai, Keiko ^a,b   Zeng, Xin ^a   He, Xi ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; AMPLIFICATION; ENZYME ACTIVITY; ORGANIC ACIDS; PHOSPHORYLATION; SIGNAL PROCESSING;

AMINO ACID RESIDUES; BINDING ACTIVITIES; CATENIN; COMPREHENSIVE ANALYSIS; COOPERATIVITY; DOCKING SITES; GLYCOGEN SYNTHASE KINASES; INTRACELLULAR DOMAINS; LOW DENSITY LIPOPROTEIN RECEPTORS; SCAFFOLDING PROTEINS; SIGNAL AMPLIFICATIONS; SIGNALING ACTIVITIES;

CHEMICAL REACTIONS;

AXIN; GLYCOGEN SYNTHASE KINASE 3; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; WNT PROTEIN; AXIN PROTEIN; LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LRP6 PROTEIN, HUMAN; REPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; ANIMAL; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

ANIMALS; HUMANS; LDL-RECEPTOR RELATED PROTEINS; MUTAGENESIS; PHOSPHORYLATION; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; WNT PROTEINS; XENOPUS LAEVIS;

EID: 47049121052     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800327200     Document Type: Article

References (22)

1. Clevers, H. (2006) Cell 127, 469-480
2. Liu, C., Li, Y., Semenov, M., Han, C., Baeg, G. H., Tan, Y., Zhang, Z., Lin, X., and He, X. (2002) Cell 108, 837-847
3. He, X., Semenov, M., Tamai, K., and Zeng, X. (2004) Development (Camb.) 131, 1663-1677
4. Macdonald, B. T., Semenov, M. V., and He, X. (2007) Cell 131, 1204
5. Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., 3rd, Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., and Wu, D. (2001) Mol. Cell 7, 801-809
6. Tamai, K., Zeng, X., Liu, C., Zhang, X., Harada, Y., Chang, Z., and He, X. (2004) Mol. Cell 13, 149-156
7. Zeng, X., Huang, H., Tamai, K., Zhang, X., Harada, Y., Yokota, C., Almeida, K., Wang, J., Doble, B., Woodgett, J., Wynshaw-Boris, A., Hsieh, J. C., and He, X. (2008) Development (Camb.) 135, 367-375
8. Nusse, R. (2005) Cell Res. 15, 28-32
9. Little, R. D., Carulli, J. P., Del Mastro, R. G., Dupuis, J., Osborne, M., Folz, C., Manning, S. P., Swain, P. M., Zhao, S. C., Eustace, B., Lappe, M. M., Spitzer, L., Zweier, S., Braunschweiger, K., Benchekroun, Y., Hu, X., Adair, R., Chee, L., FitzGerald, M. G., Tulig, C., Caruso, A., Tzellas, N., Bawa, A., Franklin, B., McGuire, S., Nogues, X., Gong, G., Allen, K. M., Anisowicz, A., Morales, A. J., Lomedico, P. T., Recker, S. M., Van Eerdewegh, P., Recker, R. R., and Johnson, M. L. (2002) Am. J. Hum. Genet. 70, 11-19
10. Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., and Lifton, R. P. (2002) N. Engl. J. Med. 346, 1513-1521
11. Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., Zacharin, M., Oexle, K., Marcelino, J., Suwairi, W., Heeger, S., Sabatakos, G., Apte, S., Adkins, W. N., Allgrove, J., Arslan-Kirchner, M., Batch, J. A., Beighton, P., Black, G. C., Boles, R. G., Boon, L. M., Borrone, C., Brunner, H. G., Carle, G. F., Dallapiccola, B., De Paepe, A., Floege, B., Halfhide, M. L., Hall, B., Hennekam, R. C., Hirose, T., Jans, A., Juppner, H., Kim, C. A., Keppler-Noreuil, K., Kohlschuetter, A., LaCombe, D., Lambert, M., Lemyre, E., Letteboer, T., Peltonen, L., Ramesar, R. S., Romanengo, M., Somer, H., Steichen-Gersdorf, E., Steinmann, B., Sullivan, B., Superti-Furga, A., Swoboda, W., van den Boogaard, M. J., Van Hul, W., Vikkula, M., Votruba, M., Zabel, B., Garcia, T., Baron, R., Olsen, B. R., and Warman, M. L. (2001) Cell 107, 513-523
12. Mani, A., Radhakrishnan, J., Wang, H., Mani, A., Mani, M. A., Nelson-Williams, C., Carew, K. S., Mane, S., Najmabadi, H., Wu, D., and Lifton, R. P. (2007) Science 315, 1278-1282
13. Tamai, K., Semenov, M., Kato, Y., Spokony, R., Liu, C., Katsuyama, Y., Hess, F., Saint-Jeannet, J. P., and He, X. (2000) Nature 407, 530-535
14. Zeng, X., Tamai, K., Doble, B., Li, S., Huang, H., Habas, R., Okamura, H., Woodgett, J., and He, X. (2005) Nature 438, 873-877
15. Wei, Q., Yokota, C., Semenov, M. V., Doble, B., Woodgett, J., and He, X. (2007) J. Biol. Chem. 282, 15903-15911
16. Kato, Y., Shi, Y., and He, X. (1999) J. Neurosci. 19, 9364-9373
17. Frame, S., and Cohen, P. (2001) Biochem. J. 359, 1-16
18. McGrew, L. L., Lai, C. J., and Moon, R. T. (1995) Dev. Biol. 172, 337-342
19. Niehrs, C. (2004) Nat. Rev. Genet. 5, 425-434
20. Bilic, J., Huang, Y. L., Davidson, G., Zimmermann, T., Cruciat, C. M., Bienz, M., and Niehrs, C. (2007) Science 316, 1619-1622
21. Baig-Lewis, S., Peterson-Nedry, W., and Wehrli, M. (2007) Dev. Biol. 306, 94-111
22. Wolf, J., Palmby, T. R., Gavard, J., Williams, B. O., and Gutkind, J. S. (2008) FEBS Lett. 582, 255-261