After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 12, 2011, Pages 3616-3624

  Huber, Kilian ^a   Superti Furga, Giulio ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

Alzheimer; Histone deacetylases; Huntington's disease; Neurodegenerative disorders; Parkinson's disease; Resveratrol; Sirtuins

Indexed keywords

3 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE) 1,3 DIHYDRO 5 IODO 2 INDOLONE; AGK 2; AK 1; ALPHA SYNUCLEIN; ENZYME INHIBITOR; EX 527; HUNTINGTIN; NICOTINAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; POLYGLUTAMINE; RESVERATROL; SIRTINOL; SIRTUIN; SIRTUIN 1; SIRTUIN 2; SIRTUIN 2 INHIBITOR; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5; SIRTUIN 6; SIRTUIN 7; SRT 1460; SRT 1720; SRT 2183; SRT 501M; STILBENE DERIVATIVE; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BIOLOGICAL ACTIVITY; COGNITIVE DEFECT; DOPAMINERGIC ACTIVITY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; EPIGENETICS; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GRAPE; HIGH THROUGHPUT SCREENING; HUMAN; HUNTINGTON CHOREA; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PROTEIN DEGRADATION;

ALZHEIMER DISEASE; ENZYME INHIBITORS; EPIGENESIS, GENETIC; HUMANS; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; SIRTUINS; STILBENES; UP-REGULATION;

VITACEAE;

EID: 79958265915     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.018     Document Type: Article

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