Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

Molecular and Cellular Biology

Volumn 26, Issue 1, 2006, Pages 28-38

  Solomon, Jonathan M ^a   Pasupuleti, Rao ^a   Xu, Lei ^a   McDonagh, Thomas ^a   Curtis, Rory ^a   DiStefano, Peter S ^a   Huber, L Julie ^a  

^a Elixir Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; ENZYME INHIBITOR; ETOPOSIDE; EX 527; HISTONE DEACETYLASE INHIBITOR; HYDROXYUREA; NICOTINAMIDE; PROTEIN P53; PROTEIN SIRT1; SIRTUIN; TRICHOSTATIN A; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; DNA; HISTONE DEACETYLASE; HYDROXAMIC ACID; SIRT1 PROTEIN, HUMAN;

ACETYLATION; ARTICLE; BREAST EPITHELIUM; CELL DEATH; CELL GROWTH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DEACETYLATION; DNA DAMAGE; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; CATALYSIS; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM;

ACETYLATION; CATALYSIS; CELL LINE; CELL SURVIVAL; DNA; DNA DAMAGE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; SIRTUINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33645221885     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.26.1.28-38.2006     Document Type: Article

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