An intrabody based on a llama single-domain antibody targeting the N-terminal α-helical multimerization domain of HIV-1 Rev prevents viral production

Journal of Biological Chemistry

Volumn 285, Issue 28, 2010, Pages 21768-21780

  Vercruysse, Thomas ^a   Pardon, Els ^b   Vanstreels, Els ^a   Steyaert, Jan ^b   Daelemans, Dirk ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-HIV AGENTS; CELLULAR MACHINERY; HUMAN IMMUNODEFICIENCY VIRUS; IN-CELL; MOLECULAR MODELS; MULTIMERIC; MULTIMERIZATION; MULTIMERS; N-TERMINALS; PROTEIN-PROTEIN COMPLEXES; REV RESPONSE ELEMENTS; SINGLE DOMAINS; VIRAL PRODUCTION;

ANTIBODIES; BINDING ENERGY; CYTOLOGY; MACHINERY; RNA; VIRUSES;

STRATEGIC PLANNING;

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; NANOBODY; OLIGOMER; REV PROTEIN; UNCLASSIFIED DRUG; VIRUS RNA;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; ARTIODACTYLA; BINDING SITE; CONTROLLED STUDY; EMBRYO; GENETIC IMMUNIZATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TARGETING; RNA SPLICING; VACCINE PRODUCTION; VIRUS CELL INTERACTION; VIRUS REPLICATION;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; ANTI-HIV AGENTS; ANTIBODIES; CAMELIDS, NEW WORLD; DIMERIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE PRODUCTS, REV; HELA CELLS; HIV INFECTIONS; HIV-1; HUMANS; LYSINE; MOLECULAR SEQUENCE DATA; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; TYROSINE;

HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA (MAMMAL);

EID: 77954356408     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.112490     Document Type: Article

References (56)

1. Pollard, V. W., and Malim, M. H. (1998) Annu. Rev. Microbiol. 52, 491-532
2. Dayton, E. T., Powell, D. M., and Dayton, A. I. (1989) Science 246, 1625-1629
3. Daly, T. J., Cook, K. S., Gray, G. S., Maione, T. E., and Rusche, J. R. (1989) Nature 342, 816-819
4. Malim, M. H., Hauber, J., Le, S. Y., Maizel, J. V., and Cullen, B. R. (1989) Nature 338, 254-257
5. Fornerod, M., Ohno, M., Yoshida, M., and Mattaj, I. W. (1997) Cell 90, 1051-1060
6. Fukuda, M., Asano, S., Nakamura, T., Adachi, M., Yoshida, M., Yanagida, M., and Nishida, E. (1997) Nature 390, 308-311
7. Neville, M., Stutz, F., Lee, L., Davis, L. I., and Rosbash, M. (1997) Curr. Biol. 7, 767-775
8. Cochrane, A. W., Perkins, A., and Rosen, C. A. (1990) J. Virol. 64, 881-885
9. Felber, B. K., Hadzopoulou-Cladaras, M., Cladaras, C., Copeland, T., and Pavlakis, G. N. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 1495-1499
10. Kalland, K. H., Szilvay, A. M., Brokstad, K. A., Saetrevik, W., and Haukenes, G. (1994) Mol. Cell. Biol. 14, 7436-7444
11. Meyer, B. E., and Malim, M. H. (1994) Genes Dev. 8, 1538-1547
12. Auer, M., Gremlich, H. U., Seifert, J. M., Daly, T. J., Parslow, T. G., Casari, G., and Gstach, H. (1994) Biochemistry 33, 2988-2996
13. Blanco, F. J., Hess, S., Pannell, L. K., Rizzo, N. W., and Tycko, R. (2001) J. Mol. Biol. 313, 845-859
14. Tan, R., Chen, L., Buettner, J. A., Hudson, D., and Frankel, A. D. (1993) Cell 73, 1031-1040
15. Fischer, U., Huber, J., Boelens, W. C., Mattaj, I. W., and Lührmann, R. (1995) Cell 82, 475-483
16. Daelemans, D., Costes, S. V., Lockett, S., and Pavlakis, G. N. (2005) Mol. Cell. Biol. 25, 728-739
17. Malim, M. H., Böhnlein, S., Hauber, J., and Cullen, B. R. (1989) Cell 58, 205-214
18. Daelemans, D., Afonina, E., Nilsson, J., Werner, G., Kjems, J., De Clercq, E., Pavlakis, G. N., and Vandamme, A. M. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 14440-14445
19. Van Neck, T., Pannecouque, C., Vanstreels, E., Stevens, M., Dehaen, W., and Daelemans, D. (2008) Bioorg. Med. Chem. 16, 9487-9497
20. Wolff, B., Sanglier, J. J., and Wang, Y. (1997) Chem. Biol. 4, 139-147
21. Malim, M. H., and Cullen, B. R. (1991) Cell 65, 241-248
22. Mann, D. A., Mikaélian, I., Zemmel, R. W., Green, S. M., Lowe, A. D., Kimura, T., Singh, M., Butler, P. J., Gait, M. J., and Karn, J. (1994) J. Mol. Biol. 241, 193-207
23. Daelemans, D., Costes, S. V., Cho, E. H., Erwin-Cohen, R. A., Lockett, S., and Pavlakis, G. N. (2004) J. Biol. Chem. 279, 50167-50175
24. Jain, C., and Belasco, J. G. (2001) Mol. Cell 7, 603-614
25. Thomas, S. L., Oft, M., Jaksche, H., Casari, G., Heger, P., Dobrovnik, M., Bevec, D., and Hauber, J. (1998) J. Virol. 72, 2935-2944
26. Daugherty, M. D., D'Orso, I., and Frankel, A. D. (2008) Mol. Cell 31, 824-834
27. Pond, S. J., Ridgeway, W. K., Robertson, R., Wang, J., and Millar, D. P. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 1404-1408
28. Smith, C. A., Calabro, V., and Frankel, A. D. (2000) Mol. Cell 6, 1067-1076
29. Pomerantz, R. J., Seshamma, T., and Trono, D. (1992) J. Virol. 66, 1809-1813
30. Hamers-Casterman, C., Atarhouch, T., Muyldermans, S., Robinson, G., Hamers, C., Songa, E. B., Bendahman, N., and Hamers, R. (1993) Nature 363, 446-448
31. Muyldermans, S., Cambillau, C., and Wyns, L. (2001) Trends Biochem. Sci. 26, 230-235
32. Arbabi Ghahroudi, M., Desmyter, A., Wyns, L., Hamers, R., and Muyldermans, S. (1997) FEBS Lett. 414, 521-526
33. Conrath, K. E., Lauwereys, M., Galleni, M., Matagne, A., Frère, J. M., Kinne, J., Wyns, L., and Muyldermans, S. (2001) Antimicrob. Agents Chemother. 45, 2807-2812
34. Fisher, A. G., Collalti, E., Ratner, L., Gallo, R. C., and Wong-Staal, F. (1985) Nature 316, 262-265
35. Gibbs, J. S., Regier, D. A., and Desrosiers, R. C. (1994) AIDS Res. Hum. Retroviruses 10, 343-350
36. McNally, J. G. (2008) Methods Cell Biol. 85, 329-351
37. Pasternak, A. O., Adema, K. W., Bakker, M., Jurriaans, S., Berkhout, B., Cornelissen, M., and Lukashov, V. V. (2008) J. Clin. Microbiol. 46, 2206-2211
38. Tiley, L. S., Malim, M. H., Tewary, H. K., Stockley, P. G., and Cullen, B. R. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 758-762
39. Madore, S. J., Tiley, L. S., Malim, M. H., and Cullen, B. R. (1994) Virology 202, 186-194
40. Hope, T. J., McDonald, D., Huang, X. J., Low, J., and Parslow, T. G. (1990) J. Virol. 64, 5360-5366
41. Sonigo, P., Barker, C., Hunter, E., and Wain-Hobson, S. (1986) Cell 45, 375-385
42. Bray, M., Prasad, S., Dubay, J. W., Hunter, E., Jeang, K. T., Rekosh, D., and Hammarskjöld, M. L. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 1256-1260
43. Zolotukhin, A. S., Valentin, A., Pavlakis, G. N., and Felber, B. K. (1994) J. Virol. 68, 7944-7952
44. Hadzopoulou-Cladaras, M., Felber, B. K., Cladaras, C., Athanassopoulos, A., Tse, A., and Pavlakis, G. N. (1989) J. Virol. 63, 1265-1274
45. Kim, S. Y., Byrn, R., Groopman, J., and Baltimore, D. (1989) J. Virol. 63, 3708-3713
46. Duan, L., Bagasra, O., Laughlin, M. A., Oakes, J. W., and Pomerantz, R. J. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 5075-5079
47. Kubota, S., and Pomerantz, R. J. (1998) Oncogene 16, 1851-1861
48. Fang, J., Kubota, S., Yang, B., Zhou, N., Zhang, H., Godbout, R., and Pomerantz, R. J. (2004) Virology 330, 471-480
49. Yedavalli, V. S., Neuveut, C., Chi, Y. H., Kleiman, L., and Jeang, K. T. (2004) Cell 119, 381-392
50. He, M. M., Smith, A. S., Oslob, J. D., Flanagan, W. M., Braisted, A. C., Whitty, A., Cancilla, M. T., Wang, J., Lugovskoy, A. A., Yoburn, J. C., Fung, A. D., Farrington, G., Eldredge, J. K., Day, E. S., Cruz, L. A., Cachero, T. G., Miller, S. K., Friedman, J. E., Choong, I. C., and Cunningham, B. C. (2005) Science 310, 1022-1025
51. Fischer, P. M., and Lane, D. P. (2004) Trends Pharmacol. Sci. 25, 343-346
52. Watts, N. R., Misra, M., Wingfield, P. T., Stahl, S. J., Cheng, N., Trus, B. L., Steven, A. C., and Williams, R. W. (1998) J. Struct. Biol. 121, 41-52
53. Lam, A. Y., Pardon, E., Korotkov, K. V., Hol, W. G., and Steyaert, J. (2008) J. Struct. Biol. 166, 8-15
54. Bayer, T. S., Booth, L. N., Knudsen, S. M., and Ellington, A. D. (2005) RNA 11, 1848-1857
55. Bevec, D., Dobrovnik, M., Hauber, J., and Böhnlein, E. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 9870-9874
56. Costes, S. V., Daelemans, D., Cho, E. H., Dobbin, Z., Pavlakis, G., and Lockett, S. (2004) Biophys. J. 86, 3993-4003