-
1
-
-
0027310612
-
Naturally occurring antibodies devoid of light chains
-
10.1038/363446a0 8502296
-
Hamers-Casterman C Atarhouch T Muyldermans S Robinson G Hamers C Songa EB Bendahman N Hamers R Naturally occurring antibodies devoid of light chains Nature 1993 363 446-448 10.1038/363446a0 8502296
-
(1993)
Nature
, vol.363
, pp. 446-448
-
-
Hamers-Casterman, C.1
Atarhouch, T.2
Muyldermans, S.3
Robinson, G.4
Hamers, C.5
Songa, E.B.6
Bendahman, N.7
Hamers, R.8
-
2
-
-
0028962371
-
A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
-
10.1038/374168a0 7877689
-
Greenberg AS Avila D Hughes M Hughes A McKinney EC Flajnik MF A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks Nature 1995 374 168-73 10.1038/ 374168a0 7877689
-
(1995)
Nature
, vol.374
, pp. 168-173
-
-
Greenberg, A.S.1
Avila, D.2
Hughes, M.3
Hughes, A.4
McKinney, E.C.5
Flajnik, M.F.6
-
3
-
-
4544250973
-
Crystal structure of a shark single-domain antibody V region in complex with lysozyme
-
10.1126/science.1101148 15319492
-
Stanfield LR Dooley H Flajnik MF Wilson IA Crystal structure of a shark single-domain antibody V region in complex with lysozyme Science 2004 305 1770-1773 10.1126/science.1101148 15319492
-
(2004)
Science
, vol.305
, pp. 1770-1773
-
-
Stanfield, L.R.1
Dooley, H.2
Flajnik, M.F.3
Wilson, I.A.4
-
4
-
-
0032578554
-
Structural analysis of the nurse shark (new) antigen receptor (NAR): Molecular convergence of NAR and unusual mammalian immunoglobulins
-
21721 9751746 10.1073/pnas.95.20.11804
-
Roux KH Greenberg AS Greene L Strelets L Avila D McKinney EC Flajnik MF Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins Proc Natl Acad Sci USA 1998 95 11804-11809 21721 9751746 10.1073/ pnas.95.20.11804
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11804-11809
-
-
Roux, K.H.1
Greenberg, A.S.2
Greene, L.3
Strelets, L.4
Avila, D.5
McKinney, E.C.6
Flajnik, M.F.7
-
5
-
-
0036032290
-
Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): Identification of a new locus preferentially expressed in early development
-
10.1007/s00251-002-0479-z 12389098
-
Diaz M Stanfield RL Greenberg AS Flajnik MF Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development Immunogenetics 2002 54 501-512 10.1007/s00251-002-0479-z 12389098
-
(2002)
Immunogenetics
, vol.54
, pp. 501-512
-
-
Diaz, M.1
Stanfield, R.L.2
Greenberg, A.S.3
Flajnik, M.F.4
-
6
-
-
4344565797
-
Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor
-
515081 15304650 10.1073/pnas.0403509101
-
Streltsov VA Varghese JN Carmichael JA Irving RA Hudson PJ Nuttall SD Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor Proc Natl Acad Sci USA 2004 101 12444-12449 515081 15304650 10.1073/pnas.0403509101
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12444-12449
-
-
Streltsov, V.A.1
Varghese, J.N.2
Carmichael, J.A.3
Irving, R.A.4
Hudson, P.J.5
Nuttall, S.D.6
-
7
-
-
0034329287
-
Immunoglobulin VH domains and beyond: Design and selection of single-domain binding and targeting reagents
-
10.2174/1389201003378906 11469383
-
Nuttall SD Irving RA Hudson PJ Immunoglobulin VH domains and beyond: design and selection of single-domain binding and targeting reagents Curr Pharm Biotechnol 2000 1 3 253-263 10.2174/1389201003378906 11469383
-
(2000)
Curr Pharm Biotechnol
, vol.1
, Issue.3
, pp. 253-263
-
-
Nuttall, S.D.1
Irving, R.A.2
Hudson, P.J.3
-
8
-
-
0032564347
-
Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: Possible role in antigen-driven reactions in the absence of germinal centers
-
10.1073/pnas.95.24.14343
-
Diaz M Greenberg AS Flajnik MF Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers Proc Natl Acad Sc 1998 95 14343-14348 10.1073/pnas.95.24.14343
-
(1998)
Proc Natl Acad Sc
, vol.95
, pp. 14343-14348
-
-
Diaz, M.1
Greenberg, A.S.2
Flajnik, M.F.3
-
9
-
-
33847103076
-
Maturation of shark single-domain (IgNAR) antibodies: Evidence for induced-fit binding
-
10.1016/j.jmb.2006.12.045 17258766
-
Stanfield RL Dooley H Verdino P Flajnik MF Wilson IA Maturation of shark single-domain (IgNAR) antibodies: Evidence for induced-fit binding J Mol Biol 2007 367 2 358-372 10.1016/j.jmb.2006.12.045 17258766
-
(2007)
J Mol Biol
, vol.367
, Issue.2
, pp. 358-372
-
-
Stanfield, R.L.1
Dooley, H.2
Verdino, P.3
Flajnik, M.F.4
Wilson, I.A.5
-
10
-
-
0034830063
-
Isolation of the new antigen receptor from wobbegong sharks, and use as a scaffold for the display of protein loop libraries
-
10.1016/S0161-5890(01)00057-8 11566324
-
Nuttall SD Krishnan UV Hattarki M De Gori R Irving RA Hudson PJ Isolation of the new antigen receptor from wobbegong sharks, and use as a scaffold for the display of protein loop libraries Mol Immunol 2001 38 313-326 10.1016/S0161-5890(01)00057-8 11566324
-
(2001)
Mol Immunol
, vol.38
, pp. 313-326
-
-
Nuttall, S.D.1
Krishnan, U.V.2
Hattarki, M.3
De Gori, R.4
Irving, R.A.5
Hudson, P.J.6
-
11
-
-
0042195979
-
Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display
-
10.1016/S0161-5890(03)00084-1 12909128
-
Dooley H Flajnik MF Porter AJ Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display Mol Immunol 2003 40 25-33 10.1016/ S0161-5890(03)00084-1 12909128
-
(2003)
Mol Immunol
, vol.40
, pp. 25-33
-
-
Dooley, H.1
Flajnik, M.F.2
Porter, A.J.3
-
12
-
-
33747858104
-
Rapid isolation of IgNAR variable single-domain antibody fragments from a shark synthetic library
-
10.1016/j.molimm.2006.01.010 16500706
-
Shao CY Secombes CJ Porter AJ Rapid isolation of IgNAR variable single-domain antibody fragments from a shark synthetic library Mol Immunol 2007 44 4 656-665 10.1016/j.molimm.2006.01.010 16500706
-
(2007)
Mol Immunol
, vol.44
, Issue.4
, pp. 656-665
-
-
Shao, C.Y.1
Secombes, C.J.2
Porter, A.J.3
-
13
-
-
0036182644
-
Single-domain antibody fragments with high conformational stability
-
10.1110/ps.34602 11847273
-
Dumoulin M Conrath K Van Meirhaeghe A Meersman F Heremans K Frenken LG Muyldermans S Wyns L Matagne A Single-domain antibody fragments with high conformational stability Protein Sci 2002 11 3 500-515 10.1110/ ps.34602 11847273
-
(2002)
Protein Sci
, vol.11
, Issue.3
, pp. 500-515
-
-
Dumoulin, M.1
Conrath, K.2
Van Meirhaeghe, A.3
Meersman, F.4
Heremans, K.5
Frenken, L.G.6
Muyldermans, S.7
Wyns, L.8
Matagne, A.9
-
14
-
-
0037051895
-
A naturally occurring NAR variable domain binds th eKgp protease from Porphyromonas gingivalis
-
10.1016/S0014-5793(02)02506-1 11959108
-
Nutall SD Krishnan UV Doughty L Nathanielsz A Ally N Pike RN Hudson PJ Kortt AA Irving RA A naturally occurring NAR variable domain binds th eKgp protease from Porphyromonas gingivalis FEBS Lett 2002 516 1-3 80-86 10.1016/S0014-5793(02)02506-1 11959108
-
(2002)
FEBS Lett
, vol.516
, Issue.1-3
, pp. 80-86
-
-
Nutall, S.D.1
Krishnan, U.V.2
Doughty, L.3
Nathanielsz, A.4
Ally, N.5
Pike, R.N.6
Hudson, P.J.7
Kortt, A.A.8
Irving, R.A.9
-
15
-
-
10744225632
-
Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1
-
10.1002/prot.20005 14997552
-
Nuttall SD Humberstone KS Krishnan UV Carmichael JA Doughty L Hattarki M Coley AM Casey JL Anders RF Foley M Irving RA Hudson PJ Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1 Proteins 2004 55 1 187-197 10.1002/prot.20005 14997552
-
(2004)
Proteins
, vol.55
, Issue.1
, pp. 187-197
-
-
Nuttall, S.D.1
Humberstone, K.S.2
Krishnan, U.V.3
Carmichael, J.A.4
Doughty, L.5
Hattarki, M.6
Coley, A.M.7
Casey, J.L.8
Anders, R.F.9
Foley, M.10
Irving, R.A.11
Hudson, P.J.12
-
16
-
-
0028110130
-
DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution
-
45099 7938023 10.1073/pnas.91.22.10747
-
Stemmer WP DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution Proc Natl Acad Sci USA 1994 91 10747-10751 45099 7938023 10.1073/pnas.91.22.10747
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10747-10751
-
-
Stemmer, W.P.1
-
17
-
-
0028816556
-
Direct random mutagenesis of gene-sized DNA fragments using polymerase chain reaction
-
10.1006/abio.1995.1050 7710092
-
Fromant M Blanquet S Plateau P Direct random mutagenesis of gene-sized DNA fragments using polymerase chain reaction Anal Biochem 1995 224 347-353 10.1006/abio.1995.1050 7710092
-
(1995)
Anal Biochem
, vol.224
, pp. 347-353
-
-
Fromant, M.1
Blanquet, S.2
Plateau, P.3
-
18
-
-
0029869449
-
An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues
-
10.1006/jmbi.1996.0049 8568899
-
Zaccolo M Williams DM Brow DM Gherardi E An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues J Mol Biol 1996 255 589-603 10.1006/jmbi.1996.0049 8568899
-
(1996)
J Mol Biol
, vol.255
, pp. 589-603
-
-
Zaccolo, M.1
Williams, D.M.2
Brow, D.M.3
Gherardi, E.4
-
19
-
-
33845516882
-
Facile generation of heat-stable antiviral and antitoxin single domain antibodies from a semisynthetic llama library
-
10.1021/ac0610053 17165813
-
Goldman ER Anderson GP Liu JL Delehanty JB Sherwood LJ Osborn LE Cummins LB Hayhurst A Facile generation of heat-stable antiviral and antitoxin single domain antibodies from a semisynthetic llama library Anal Chem 2006 78 24 8245-8255 10.1021/ac0610053 17165813
-
(2006)
Anal Chem
, vol.78
, Issue.24
, pp. 8245-8255
-
-
Goldman, E.R.1
Anderson, G.P.2
Liu, J.L.3
Delehanty, J.B.4
Sherwood, L.J.5
Osborn, L.E.6
Cummins, L.B.7
Hayhurst, A.8
-
20
-
-
39049132442
-
Selection of cholera toxin specific IgNAR single-domain antibodies from a naïve shark library
-
10.1016/j.molimm.2006.07.299 17007931
-
Liu JL Anderson GP Delehanty JB Baumann R Hayhurst A Goldman ER Selection of cholera toxin specific IgNAR single-domain antibodies from a naïve shark library Mol Immunol 2007 44 7 1775-1783 10.1016/ j.molimm.2006.07.299 17007931
-
(2007)
Mol Immunol
, vol.44
, Issue.7
, pp. 1775-1783
-
-
Liu, J.L.1
Anderson, G.P.2
Delehanty, J.B.3
Baumann, R.4
Hayhurst, A.5
Goldman, E.R.6
-
21
-
-
38649085390
-
-
http://www.ebi.ac.uk/Tools/clustalw/
-
-
-
-
22
-
-
27644475866
-
Structure of shark IgNAR antibody variable domain and modeling of an early-developmental isotype
-
10.1110/ps.051709505
-
Strelstov VA Carmichael JA Nuttall SD Structure of shark IgNAR antibody variable domain and modeling of an early-developmental isotype Pro Sci 2005 14 11 2901-2909 10.1110/ps.051709505
-
(2005)
Pro Sci
, vol.14
, Issue.11
, pp. 2901-2909
-
-
Strelstov, V.A.1
Carmichael, J.A.2
Nuttall, S.D.3
-
23
-
-
32444436434
-
First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate
-
1413636 16446445 10.1073/pnas.0508341103
-
Dooley H Stanfield RL Brady RA Flajnik MF First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate Proc Natl Acad Sci USA 2006 103 6 1846-1851 1413636 16446445 10.1073/pnas.0508341103
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.6
, pp. 1846-1851
-
-
Dooley, H.1
Stanfield, R.L.2
Brady, R.A.3
Flajnik, M.F.4
-
24
-
-
0035014528
-
Isolation of high-affinity ligand-binding proteins by periplasmic expression with cytometric screening (PECS)
-
10.1038/89281 11385457
-
Chen G Hayhurst A Thomas JG Harvey BR Iverson BL Georgiou G Isolation of high-affinity ligand-binding proteins by periplasmic expression with cytometric screening (PECS) Nat Biotechnol 2001 19 537-542 10.1038/89281 11385457
-
(2001)
Nat Biotechnol
, vol.19
, pp. 537-542
-
-
Chen, G.1
Hayhurst, A.2
Thomas, J.G.3
Harvey, B.R.4
Iverson, B.L.5
Georgiou, G.6
-
25
-
-
0344255688
-
Pentamerization of single-domain antibodies from phage libraries: A novel strategy for the rapid generation of high-avidity antibody reagents
-
10.1016/j.jmb.2003.09.034 14659739
-
Zhang J Tanha J Hirama T Khieu NH To R Tong-Servinv H Stone E Brisson JR Mackenzie CR Pentamerization of single-domain antibodies from phage libraries: A novel strategy for the rapid generation of high-avidity antibody reagents J Mol Biol 2004 335 1 49-56 10.1016/j.jmb.2003.09.034 14659739
-
(2004)
J Mol Biol
, vol.335
, Issue.1
, pp. 49-56
-
-
Zhang, J.1
Tanha, J.2
Hirama, T.3
Khieu, N.H.4
To, R.5
Tong-Servinv, H.6
Stone, E.7
Brisson, J.R.8
Mackenzie, C.R.9
-
26
-
-
33748784077
-
Dimerization strategies for shark IgNAR single domain antibody fragments
-
16962608
-
Simmons DP Abregu FA Krishnan UV Proll DF Streltsov VA Doughty L Hattarki MK Nuttall SD Dimerization strategies for shark IgNAR single domain antibody fragments J Immunol Methods 315 1-2 171-184 16962608
-
J Immunol Methods
, vol.315
, Issue.1-2
, pp. 171-184
-
-
Simmons, D.P.1
Abregu, F.A.2
Krishnan, U.V.3
Proll, D.F.4
Streltsov, V.A.5
Doughty, L.6
Hattarki, M.K.7
Nuttall, S.D.8
-
27
-
-
0014010845
-
The release of enzymes by osmotic shock from Escherichia coli in exponential phase
-
4287907
-
Nossal NG Heppel LA The release of enzymes by osmotic shock from Escherichia coli in exponential phase J Biol Chem 1966 241 3055-3062 4287907
-
(1966)
J Biol Chem
, vol.241
, pp. 3055-3062
-
-
Nossal, N.G.1
Heppel, L.A.2
|