Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom

Biochemical Journal

Volumn 424, Issue 2, 2009, Pages 263-272

  Abderrazek, Rahma Ben ^a   Hmila, Issam ^a   Vincke, Cécile ^b,c   Benlasfar, Zakaria ^a   Pellis, Mireille ^b,c   Dabbek, Hafedh ^d   Saerens, Dirk ^b,c   El Ayeb, Mohamed ^a   Muyldermans, Serge ^b,c   Bouhaouala Zahar, Balkiss ^a,e  

^a PASTEUR INSTITUTE OF TUNIS   (Tunisia)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d Centre Régional de Production Animalière de Kébili   (Tunisia)

^e UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

Author keywords

Anti venom; Dromedary; Recombinant antibody; Scorpion toxin; Single domain antibody

Indexed keywords

DISSOCIATION; EPITOPES; EQUILIBRIUM CONSTANTS; MEDICAL PROBLEMS; MONOCLONAL ANTIBODIES; RATE CONSTANTS; TOXIC MATERIALS;

ANTI-VENOM; DROMEDARY; RECOMBINANT ANTIBODY; SCORPION TOXIN; SINGLE-DOMAIN ANTIBODIES;

POLYPEPTIDES;

AAHII NANOBODY; ARGININE; EPITOPE; GLUTAMINE; GLYCINE; MONOCLONAL ANTIBODY; NANOBODY; PHENYLALANINE; SCORPION VENOM; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TYROSINE; UNCLASSIFIED DRUG; VARIABLE DOMAIN OF THE HEAVY CHAIN OF A HEAVY CHAIN ANTIBODY;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ARTICLE; EQUILIBRIUM CONSTANT; FEMALE; HUMORAL IMMUNITY; HYDROPHILICITY; LD 50; MOUSE; NANOBODY AFFINITY; NONHUMAN; PRIORITY JOURNAL; SCORPION; SEQUENCE ANALYSIS;

ANDROCTONUS AUSTRALIS HECTOR; CAMELUS DROMEDARIUS; MUS; SCORPIONES;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; CAMELS; EPITOPES; FEMALE; MICE; MOLECULAR SEQUENCE DATA; NEUROTOXICITY SYNDROMES; NEUROTOXINS; PEPTIDES; SCORPION VENOMS; SCORPIONS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 70450178687     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090697     Document Type: Article

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