Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition

Journal of Molecular Biology

Volumn 407, Issue 1, 2011, Pages 138-148

  Oyen, David ^a,b   Srinivasan, Vasundara ^a,b   Steyaert, Jan ^a,b   Barlow, John N ^a,b  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

allosteric effector; antibody; crystal structure; dihydrofolate reductase; transient kinetics

Indexed keywords

ANTIBODY; DIHYDROFOLATE REDUCTASE; EPITOPE; NANOBODY 216; UNCLASSIFIED DRUG;

ALLOSTERISM; ANTIBODY COMBINING SITE; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME INHIBITION; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN FUNCTION;

EID: 79952009210     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.01.017     Document Type: Article

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