Neutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell receptor binding domain

Journal of Biological Chemistry

Volumn 286, Issue 11, 2011, Pages 8961-8976

  Hussack, Greg ^a,b   Arbabi Ghahroudi, Mehdi ^a,c   Van Faassen, Henk ^a   Songer, J Glenn ^d   Ng, Kenneth K S ^e   MacKenzie, Roger ^a,f   Tanha, Jamshid ^a,b,f  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c CARLETON UNIVERSITY   (Canada)

^d UNIVERSITY OF ARIZONA   (United States)

^e UNIVERSITY OF CALGARY   (Canada)

^f UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BINDING SITES; CELL CULTURE; CELL MEMBRANES; CLOSTRIDIUM; DISEASE CONTROL; HOSPITALS; PHAGE DISPLAY; TOXIC MATERIALS;

CLOSTRIDIUM DIFFICILE; CONFORMATIONAL EPITOPES; GASTROINTESTINAL TRACT; GRAM-POSITIVE BACTERIUM; HEALTH CARE PROFESSIONALS; PHAGE DISPLAY LIBRARIES; SINGLE-DOMAIN ANTIBODIES; SYNERGISTIC COMBINATIONS;

EPITOPES;

ANTIBODY; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; EPITOPE; UNCLASSIFIED DRUG; VARIABLE HEAVY CHAIN SINGLE DOMAIN ANTIBODY;

ARTICLE; BINDING SITE; CELL RECEPTOR BINDING DOMAIN; CLOSTRIDIUM DIFFICILE; CONFORMATION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; EPITOPE MAPPING; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG FIBROBLAST; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DOMAIN;

CLOSTRIDIUM DIFFICILE; LAMA (MAMMAL); POSIBACTERIA;

EID: 79953206941     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.198754     Document Type: Article

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