Selection and optimization of proteolytically stable llama single-domain antibody fragments for oral immunotherapy

Applied Microbiology and Biotechnology

Volumn 72, Issue 3, 2006, Pages 544-551

  Harmsen, M M ^a   Van Solt, C B ^a   Van Zijderveld Van Bemmel, A M ^a   Niewold, T A ^a   Van Zijderveld, F G ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY FRAGMENTS; FIMBRIAL ADHESION; ORAL IMMUNOTHERAPY; PROTEOLYTIC STABILITY;

DNA; ESCHERICHIA COLI; GENETIC ENGINEERING; IMMUNOLOGY; PROTEINS; STABILITY;

ANTIBODIES;

RECOMBINANT ANTIBODY; RECOMBINANT SINGLE DOMAIN ANTIBODY FRAGMENT K609; RECOMBINANT SINGLE DOMAIN ANTIBODY FRAGMENT K922; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID; ANTIBODY; BODY FLUID; COLIFORM BACTERIUM; DIARRHEAL DISEASE; GENETIC ENGINEERING; PIG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIODACTYLA; BINDING AFFINITY; CONTROLLED STUDY; DIARRHEA; DNA SHUFFLING; DRUG BINDING; DRUG STABILITY; ESCHERICHIA COLI; FIMBRIA; IMMUNOTHERAPY; LLAMA; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN STABILITY; SWINE; SWINE DISEASE;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, BACTERIAL; CAMELIDS, NEW WORLD; DNA SHUFFLING; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FIMBRIAE, BACTERIAL; GASTROINTESTINAL CONTENTS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOTHERAPY; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; PEPTIDE LIBRARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SPECIFIC PATHOGEN-FREE ORGANISMS; SWINE;

ESCHERICHIA COLI; LAMA GLAMA;

EID: 33747738604     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-005-0300-7     Document Type: Article

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