-
1
-
-
0022239908
-
Polymorphism and quantitative variations of toxins in the venom of the scorpion Androctonus australis Hector
-
El Ayeb, M., and Rochat, H. (1985) Polymorphism and quantitative variations of toxins in the venom of the scorpion Androctonus australis Hector. Toxicon 23, 755-760
-
(1985)
Toxicon
, vol.23
, pp. 755-760
-
-
El Ayeb, M.1
Rochat, H.2
-
2
-
-
0023008978
-
Use of antibodies specific to defined regions of scorpion alpha-toxin to study its interaction with its receptor site on the sodium channel
-
El Ayeb, M., Bahraoui, E. M., Granier, C., and Rochat, H. (1986) Use of antibodies specific to defined regions of scorpion alphatoxin to study its interaction with its receptor site on the sodium channel. Biochemistry 25, 6671-6678 (Pubitemid 17217919)
-
(1986)
Biochemistry
, vol.25
, Issue.21
, pp. 6671-6678
-
-
Ayeb, E.M.1
Bahraoui, E.M.2
Granier, C.3
Rochat, H.4
-
3
-
-
11144245555
-
Pharmacokinetic studies of scorpion venom before and after antivenom immunotherapy
-
DOI 10.1016/j.toxicon.2004.10.007, PII S0041010104004374
-
Krifi, M. N., Savin, S., Debray, M., Cassian, B., El Ayeb, M., and Choumet, V. (2005) Pharmacokinetic studies of scorpion venom before and after antivenom immunotherapy. Toxicon 45, 187-198 (Pubitemid 40051148)
-
(2005)
Toxicon
, vol.45
, Issue.2
, pp. 187-198
-
-
Krifi, M.N.1
Savin, S.2
Debray, M.3
Bon, C.4
El Ayeb, M.5
Choumet, V.6
-
4
-
-
0034990816
-
Effects of antivenom on Buthus occitanus tunetanus (Bot) scorpion venom pharmacokinetics: Towards an optimization of antivenom immunotherapy in a rabbit model
-
DOI 10.1016/S0041-0101(01)00083-6, PII S0041010101000836
-
Krifi, M. N., Miled, K., Abderrazak, M., and El Ayeb, M. (2001) Effects of antivenom on Buthus occitanus tunetanus (Bot) scorpion venom pharmacokinetics: towards an optimization of antivenom immunotherapy in a rabbit model. Toxicon 39, 1317-1326 (Pubitemid 32510961)
-
(2001)
Toxicon
, vol.39
, Issue.9
, pp. 1317-1326
-
-
Krifi, M.N.1
Miled, K.2
Abderrazek, M.3
El Ayeb, M.4
-
5
-
-
47649126821
-
Epidemiology of scorpionism: A global appraisal
-
Chippaux, J. P., and Goyffon, M. (2008) Epidemiology of scorpionism: a global appraisal. Acta Trop. 107, 71-79
-
(2008)
Acta Trop.
, vol.107
, pp. 71-79
-
-
Chippaux, J.P.1
Goyffon, M.2
-
6
-
-
0033546905
-
Serotherapy in scorpion envenomation: A randomised controlled trial
-
Abroug, F., Elatrous, S., Nouira, S., Haguiga, H., Touzi, N., and Bouchoucha, S. (1999) Serotherapy in scorpion envenomation: a randomised controlled trial. Lancet 354, 906-909
-
(1999)
Lancet
, vol.354
, pp. 906-909
-
-
Abroug, F.1
Elatrous, S.2
Nouira, S.3
Haguiga, H.4
Touzi, N.5
Bouchoucha, S.6
-
7
-
-
0031593834
-
Pharmacokinetics of 125I-labelled IgG, F(ab′)2 and Fab fractions of scorpion and snake antivenins: Merits and potential for therapeutic use
-
Ismail, M., and Abd-Elsalam, M. A. (1998) Pharmacokinetics of 125I-labelled IgG, F(ab′)2 and Fab fractions of scorpion and snake antivenins: merits and potential for therapeutic use. Toxicon 36, 1523-1528
-
(1998)
Toxicon
, vol.36
, pp. 1523-1528
-
-
Ismail, M.1
Abd-Elsalam, M.A.2
-
8
-
-
0031771071
-
The development and use of immunotherapy in Africa
-
Chippaux, J. P. (1998) The development and use of immunotherapy in Africa. Toxicon 36, 1503-1506
-
(1998)
Toxicon
, vol.36
, pp. 1503-1506
-
-
Chippaux, J.P.1
-
9
-
-
0024044244
-
Monoclonal antibodies to scorpion toxins. Characterization and molecular mechanisms of neutralization
-
Bahraoui, E., Pichon, J., Muller, JM., Darbon, H., El ayeb, M., Granier, C., Marvaldi, J., and Rochat, H., (1988) Monoclonal antibodies to scorpion toxins. Characterization and molecular mechanisms of neutralization. J. Immunol. 141, 214-220
-
(1988)
J. Immunol.
, vol.141
, pp. 214-220
-
-
Bahraoui, E.1
Pichon, J.2
Muller, J.M.3
Darbon, H.4
El Ayeb, M.5
Granier, C.6
Marvaldi, J.7
Rochat, H.8
-
10
-
-
0032831205
-
Monoclonal antibodies against the Androctonus australis hector scorpion neurotoxin I: Characterisation and use for venom neutralization
-
Clot-Faybesse, O., Juin, M., Rochat, H., and Devaux, C. (1999) Monoclonal antibodies against the Androctonus australis hector scorpion neurotoxin I: characterisation and use for venom neutralization. FEBS Lett. 458, 313-318
-
(1999)
FEBS Lett.
, vol.458
, pp. 313-318
-
-
Clot-Faybesse, O.1
Juin, M.2
Rochat, H.3
Devaux, C.4
-
11
-
-
0032910690
-
A recombinant single-chain antibody fragment that neutralizes toxin II from the venom of the scorpion Androctonus australis hector
-
Mousli, M., Devaux, C., Rochat, H., Goyffon, M., and Billiald, P. (1999) A recombinant single-chain antibody fragment that neutralizes toxin II from the venom of the scorpion Androctonus australis hector. FEBS Lett. 442, 183-188
-
(1999)
FEBS Lett.
, vol.442
, pp. 183-188
-
-
Mousli, M.1
Devaux, C.2
Rochat, H.3
Goyffon, M.4
Billiald, P.5
-
12
-
-
0034834559
-
Construction and functional evaluation of a single-chain antibody fragment that neutralizes toxin Aahl from the venom of the scorpion Androctonus australis hector
-
DOI 10.1046/j.1432-1327.2001.01923.x
-
Devaux, C., Moreau, E., Goyffon, M., Rochat, H., and Billiald, P. (2001) Construction and functional evaluation of a single-chain antibody fragment that neutralizes toxin AahI from the venom of the scorpion Androctonus australis hector. Eur. J. Biochem. 268, 694-702 (Pubitemid 32862627)
-
(2001)
European Journal of Biochemistry
, vol.268
, Issue.3
, pp. 694-702
-
-
Devaux, C.1
Moreau, E.2
Goyffon, M.3
Rochat, H.4
Billiald, P.5
-
14
-
-
33747616656
-
Engineering of therapeutic antibodies to minimize immunogenicity and optimize function
-
Presta, L. G. (2006) Engineering of therapeutic antibodies to minimize immunogenicity and optimize function. Adv. Drug Deliv. Rev. 58, 640-656
-
(2006)
Adv. Drug Deliv. Rev.
, vol.58
, pp. 640-656
-
-
Presta, L.G.1
-
15
-
-
0037303456
-
Emergence and evolution of functional heavy-chain antibodies in Camelidae
-
Conrath, K., Wernery, U., Muyldermans, S., and Nguyen, V. K. (2003) Emergence and evolution of functional heavy-chain antibodies in Camelidae. Dev. Comp. Immunol. 27, 87-103
-
(2003)
Dev. Comp. Immunol.
, vol.27
, pp. 87-103
-
-
Conrath, K.1
Wernery, U.2
Muyldermans, S.3
Nguyen, V.K.4
-
16
-
-
59149104037
-
General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold
-
Vincke, C., Loris, R., Saerens, D., Martinez-Rodriguez, S., Muyldermans, S., and Conrath, K. (2009) General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold. J. Biol. Chem. 284, 3273-3284
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 3273-3284
-
-
Vincke, C.1
Loris, R.2
Saerens, D.3
Martinez-Rodriguez, S.4
Muyldermans, S.5
Conrath, K.6
-
17
-
-
54849403487
-
Single-domain antiobodies as building blocks for novel therapeutics
-
Saerens, D., Hassanzadeh, G. G., and Muyldermans, S. (2008) Single-domain antiobodies as building blocks for novel therapeutics. Curr. Opin. Pharmacol. 8, 600-608
-
(2008)
Curr. Opin. Pharmacol.
, vol.8
, pp. 600-608
-
-
Saerens, D.1
Hassanzadeh, G.G.2
Muyldermans, S.3
-
18
-
-
1642493838
-
Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxins
-
DOI 10.1016/j.toxicon.2003.10.021
-
Meddeb-Mouelhi, F., Bouhaouala-Zahar, B., Benlasfar, Z., Hammadi, M., Mejri, T., Moslah, M., Karoui, H., Khorchani, T., and El Ayeb, M. (2003) Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxins. Toxicon 42, 785-791 (Pubitemid 38125038)
-
(2003)
Toxicon
, vol.42
, Issue.7
, pp. 785-791
-
-
Meddeb-Mouelhi, F.1
Bouhaouala-Zahar, B.2
Benlasfar, Z.3
Hammadi, M.4
Mejri, T.5
Moslah, M.6
Karoui, H.7
Khorchani, T.8
Ayeb, M.E.9
-
19
-
-
70450178687
-
Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion
-
Ben Abderrazek, R., Hmila, H., Vincke, C., Benlasfar, Z., Pellis, M., Dabbek, H., Saerens, D., El Ayeb, M., Muyldermans, S., and Bouhaouala-Zahar, B. (2009) Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion. Biochem. J. 424, 263-272
-
(2009)
Biochem. J.
, vol.424
, pp. 263-272
-
-
Ben Abderrazek, R.1
Hmila, H.2
Vincke, C.3
Benlasfar, Z.4
Pellis, M.5
Dabbek, H.6
Saerens, D.7
El Ayeb, M.8
Muyldermans, S.9
Bouhaouala-Zahar, B.10
-
20
-
-
48049096810
-
VHH, bivalent domains and chimeric heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI′
-
Hmila, I., Ben Abderrazek-Ben Abdallah, R., Saerens, D., Benlasfar, Z., Conrath, K., El Ayeb, M., Muyldermans, S., and Bouhaouala-Zahar, B. (2008) VHH, bivalent domains and chimeric heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI′. Mol. Immunol. 45, 3847-3856
-
(2008)
Mol. Immunol.
, vol.45
, pp. 3847-3856
-
-
Hmila, I.1
Ben Abderrazek-Ben Abdallah, R.2
Saerens, D.3
Benlasfar, Z.4
Conrath, K.5
El Ayeb, M.6
Muyldermans, S.7
Bouhaouala-Zahar, B.8
-
21
-
-
0014884098
-
Purification of animal neurotoxins. Isolation and characterization of eleven neurotoxins from the venoms of the scorpions Androctonus australis hector, Buthus occitanus tunetanus and Leiurus quinquestriatus quinquestriatus
-
Miranda, F., Kopeyan, C., Rochat, C., Rochat, H., and Lissitzky, S. (1970) Purification of animal neurotoxins. Isolation and characterization of eleven neurotoxins from the venoms of the scorpions Androctonus australis hector, Buthus occitanus tunetanus and Leiurus quinquestriatus quinquestriatus. Eur J Biochem. 16, 279-291
-
(1970)
Eur J Biochem
, vol.16
, pp. 279-291
-
-
Miranda, F.1
Kopeyan, C.2
Rochat, C.3
Rochat, H.4
Lissitzky, S.5
-
22
-
-
0030767656
-
Selection and identification of single domain antibody fragments from camel heavy-chain antibodies
-
DOI 10.1016/S0014-5793(97)01062-4, PII S0014579397010624
-
Ghahroudi, M. A., Desmyter, A., Wyns, L., Hamers, R., and Muyldermans, S. (1997) Selection and identification of single domain antibody fragments from camel heavy-chain antibodies. FEBS Lett. 414, 521-526 (Pubitemid 27390659)
-
(1997)
FEBS Letters
, vol.414
, Issue.3
, pp. 521-526
-
-
Arbabi Ghahroudi, M.1
Desmyter, A.2
Wyns, L.3
Hamers, R.4
Muyldermans, S.5
-
23
-
-
10644287538
-
Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen
-
DOI 10.1074/jbc.M409292200
-
Saerens, D., Kinne, J., Bosmans, E., Wernery, U., Muyldermans, S., and Conrath, K. (2004) Single-domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen. J. Biol. Chem. 279, 51965-51972 (Pubitemid 39656566)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.50
, pp. 51965-51972
-
-
Saerens, D.1
Kinne, J.2
Bosmans, E.3
Wernery, U.4
Muyldermans, S.5
Conrath, K.6
-
24
-
-
0035831483
-
Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs
-
Conrath, K. E., Lauwereys, M., Wyns, L., and Muyldermans, S. (2001) Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs. J. Biol. Chem. 276, 7346-7350
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7346-7350
-
-
Conrath, K.E.1
Lauwereys, M.2
Wyns, L.3
Muyldermans, S.4
-
25
-
-
8944239876
-
A recombinant insect-specific α-toxin of Buthus occitanus tunetanus scorpion confers protection against homologous mammal toxins
-
Bouhaouala-Zahar, B., Ducancel, F., Zenouaki, I., Ben Khalifa, R., Borchani, L., Pelhate, M., Boulain, J. C., El Ayeb, M., Menez, M., and Karoui, H. (1996) A recombinant insect-specific α-toxin of Buthus occitanus tunetanus scorpion confers protection against homologous mammal toxins. Eur. J. Biochem. 238, 653-660
-
(1996)
Eur. J. Biochem.
, vol.238
, pp. 653-660
-
-
Bouhaouala-Zahar, B.1
Ducancel, F.2
Zenouaki, I.3
Ben Khalifa, R.4
Borchani, L.5
Pelhate, M.6
Boulain, J.C.7
El Ayeb, M.8
Menez, M.9
Karoui, H.10
-
26
-
-
33645241975
-
Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies
-
De Genst, E., Silence, K., Decanniere, K., Conrath, K., Loris, R., Kinne, J., Muyldermans, S., Wyns, L. (2006) Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies. Proc. Natl. Acad. Sci. U. S. A. 103, 4586-4591
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 4586-4591
-
-
De Genst, E.1
Silence, K.2
Decanniere, K.3
Conrath, K.4
Loris, R.5
Kinne, J.6
Muyldermans, S.7
Wyns, L.8
-
27
-
-
0002846347
-
Measuring the conformational stability of a protein
-
(Creighton, T. E., ed) IRL Press at Oxford University Press, New York
-
Pace, C. M., and Scholtz, J. M. (1997) Measuring the conformational stability of a protein. In Protein Structure: A Practical Approach (Creighton, T. E., ed) pp. 297-319, IRL Press at Oxford University Press, New York
-
(1997)
Protein Structure: A Practical Approach
, pp. 297-319
-
-
Pace, C.M.1
Scholtz, J.M.2
-
28
-
-
0034161488
-
Camel heavy-chain antibodies: Diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire
-
Nguyen, V. K., Hamers, R., Wyns, L., and Muyldermans, S. (2000) Camel heavy-chain antibodies: diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire. EMBO J. 19, 921-930 (Pubitemid 30119818)
-
(2000)
EMBO Journal
, vol.19
, Issue.5
, pp. 921-930
-
-
Nguyen, V.K.1
Hamers, R.2
Wyns, L.3
Muyldermans, S.4
-
29
-
-
20444413418
-
Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VH
-
DOI 10.1016/j.jmb.2005.04.050, PII S0022283605004845
-
Conrath, K., Vincke, C., Stijlemans, B., Schymkowitz, J., Decanniere, K., Wyns, L., Muyldermans, S., and Loris, R. (2005) Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VH. J. Mol. Biol. 350, 112-125 (Pubitemid 40804736)
-
(2005)
Journal of Molecular Biology
, vol.350
, Issue.1
, pp. 112-125
-
-
Conrath, K.1
Vincke, C.2
Stijlemans, B.3
Schymkowitz, J.4
Decanniere, K.5
Wyns, L.6
Muyldermans, S.7
Loris, R.8
-
30
-
-
0344080623
-
Design and evaluation of a diabody to improve protection against a potent scorpion neurotoxin
-
DOI 10.1007/s000180300053
-
Aubrey, N., Devaux, C., Sizaret, PY., Rochat, H., Goyffon, M., and Billiald, P. (2003) Design and evaluation of a diabody to improve protection against a potent scorpion neurotoxin. Cell. Mol. Life Sci. 60, 617-628 (Pubitemid 36459540)
-
(2003)
Cellular and Molecular Life Sciences
, vol.60
, Issue.3
, pp. 617-628
-
-
Aubrey, N.1
Devaux, C.2
Sizaret, P.-Y.3
Rochat, H.4
Goyffon, M.5
Billiald, P.6
-
31
-
-
1642389249
-
Engineering of a recombinant Fab from a neutralizing IgG directed against scorpion neurotoxin AahI, and functional evaluation versus other antibody fragments
-
DOI 10.1016/j.toxicon.2003.11.024, PII S0041010103003647
-
Aubrey, N., Muzard, J., Christophe Peter, J., Rochat, H., Goyffon, M., Devaux, C., and Billiald, P. (2004) Engineering of a recombinant Fab from a neutralizing IgG directed against scorpion neurotoxin AahI, and functional evaluation versus other antibody fragments. Toxicon 43, 233-241 (Pubitemid 38367954)
-
(2004)
Toxicon
, vol.43
, Issue.3
, pp. 233-241
-
-
Aubrey, N.1
Muzard, J.2
Peter, J.C.3
Rochat, H.4
Goyffon, M.5
Devaux, C.6
Billiald, P.7
-
32
-
-
0024333634
-
The antigenic structure of a scorpion toxin
-
Granier, C., Novotny, J., Fontecilla-Camps, JC., Fourquet, P., El Ayeb, M., and Bahraoui, E. (1989) The antigenic structure of a scorpion toxin. Mol. Immunol. 26, 503-513
-
(1989)
Mol. Immunol.
, vol.26
, pp. 503-513
-
-
Granier, C.1
Novotny, J.2
Fontecilla-Camps, J.C.3
Fourquet, P.4
El Ayeb, M.5
Bahraoui, E.6
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