메뉴 건너뛰기




Volumn 24, Issue 9, 2010, Pages 3479-3489

A bispecific nanobody to provide full protection against lethal scorpion envenoming

Author keywords

[No Author keywords available]

Indexed keywords

BISPECIFIC ANTIBODY; IMMUNOGLOBULIN F(AB')2 FRAGMENT; NANOBODY F12 10; SCORPION VENOM; TOXIN; UNCLASSIFIED DRUG;

EID: 77956631367     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-148213     Document Type: Article
Times cited : (104)

References (32)
  • 1
    • 0022239908 scopus 로고
    • Polymorphism and quantitative variations of toxins in the venom of the scorpion Androctonus australis Hector
    • El Ayeb, M., and Rochat, H. (1985) Polymorphism and quantitative variations of toxins in the venom of the scorpion Androctonus australis Hector. Toxicon 23, 755-760
    • (1985) Toxicon , vol.23 , pp. 755-760
    • El Ayeb, M.1    Rochat, H.2
  • 2
    • 0023008978 scopus 로고
    • Use of antibodies specific to defined regions of scorpion alpha-toxin to study its interaction with its receptor site on the sodium channel
    • El Ayeb, M., Bahraoui, E. M., Granier, C., and Rochat, H. (1986) Use of antibodies specific to defined regions of scorpion alphatoxin to study its interaction with its receptor site on the sodium channel. Biochemistry 25, 6671-6678 (Pubitemid 17217919)
    • (1986) Biochemistry , vol.25 , Issue.21 , pp. 6671-6678
    • Ayeb, E.M.1    Bahraoui, E.M.2    Granier, C.3    Rochat, H.4
  • 3
    • 11144245555 scopus 로고    scopus 로고
    • Pharmacokinetic studies of scorpion venom before and after antivenom immunotherapy
    • DOI 10.1016/j.toxicon.2004.10.007, PII S0041010104004374
    • Krifi, M. N., Savin, S., Debray, M., Cassian, B., El Ayeb, M., and Choumet, V. (2005) Pharmacokinetic studies of scorpion venom before and after antivenom immunotherapy. Toxicon 45, 187-198 (Pubitemid 40051148)
    • (2005) Toxicon , vol.45 , Issue.2 , pp. 187-198
    • Krifi, M.N.1    Savin, S.2    Debray, M.3    Bon, C.4    El Ayeb, M.5    Choumet, V.6
  • 4
    • 0034990816 scopus 로고    scopus 로고
    • Effects of antivenom on Buthus occitanus tunetanus (Bot) scorpion venom pharmacokinetics: Towards an optimization of antivenom immunotherapy in a rabbit model
    • DOI 10.1016/S0041-0101(01)00083-6, PII S0041010101000836
    • Krifi, M. N., Miled, K., Abderrazak, M., and El Ayeb, M. (2001) Effects of antivenom on Buthus occitanus tunetanus (Bot) scorpion venom pharmacokinetics: towards an optimization of antivenom immunotherapy in a rabbit model. Toxicon 39, 1317-1326 (Pubitemid 32510961)
    • (2001) Toxicon , vol.39 , Issue.9 , pp. 1317-1326
    • Krifi, M.N.1    Miled, K.2    Abderrazek, M.3    El Ayeb, M.4
  • 5
    • 47649126821 scopus 로고    scopus 로고
    • Epidemiology of scorpionism: A global appraisal
    • Chippaux, J. P., and Goyffon, M. (2008) Epidemiology of scorpionism: a global appraisal. Acta Trop. 107, 71-79
    • (2008) Acta Trop. , vol.107 , pp. 71-79
    • Chippaux, J.P.1    Goyffon, M.2
  • 6
    • 0033546905 scopus 로고    scopus 로고
    • Serotherapy in scorpion envenomation: A randomised controlled trial
    • Abroug, F., Elatrous, S., Nouira, S., Haguiga, H., Touzi, N., and Bouchoucha, S. (1999) Serotherapy in scorpion envenomation: a randomised controlled trial. Lancet 354, 906-909
    • (1999) Lancet , vol.354 , pp. 906-909
    • Abroug, F.1    Elatrous, S.2    Nouira, S.3    Haguiga, H.4    Touzi, N.5    Bouchoucha, S.6
  • 7
    • 0031593834 scopus 로고    scopus 로고
    • Pharmacokinetics of 125I-labelled IgG, F(ab′)2 and Fab fractions of scorpion and snake antivenins: Merits and potential for therapeutic use
    • Ismail, M., and Abd-Elsalam, M. A. (1998) Pharmacokinetics of 125I-labelled IgG, F(ab′)2 and Fab fractions of scorpion and snake antivenins: merits and potential for therapeutic use. Toxicon 36, 1523-1528
    • (1998) Toxicon , vol.36 , pp. 1523-1528
    • Ismail, M.1    Abd-Elsalam, M.A.2
  • 8
    • 0031771071 scopus 로고    scopus 로고
    • The development and use of immunotherapy in Africa
    • Chippaux, J. P. (1998) The development and use of immunotherapy in Africa. Toxicon 36, 1503-1506
    • (1998) Toxicon , vol.36 , pp. 1503-1506
    • Chippaux, J.P.1
  • 9
  • 10
    • 0032831205 scopus 로고    scopus 로고
    • Monoclonal antibodies against the Androctonus australis hector scorpion neurotoxin I: Characterisation and use for venom neutralization
    • Clot-Faybesse, O., Juin, M., Rochat, H., and Devaux, C. (1999) Monoclonal antibodies against the Androctonus australis hector scorpion neurotoxin I: characterisation and use for venom neutralization. FEBS Lett. 458, 313-318
    • (1999) FEBS Lett. , vol.458 , pp. 313-318
    • Clot-Faybesse, O.1    Juin, M.2    Rochat, H.3    Devaux, C.4
  • 11
    • 0032910690 scopus 로고    scopus 로고
    • A recombinant single-chain antibody fragment that neutralizes toxin II from the venom of the scorpion Androctonus australis hector
    • Mousli, M., Devaux, C., Rochat, H., Goyffon, M., and Billiald, P. (1999) A recombinant single-chain antibody fragment that neutralizes toxin II from the venom of the scorpion Androctonus australis hector. FEBS Lett. 442, 183-188
    • (1999) FEBS Lett. , vol.442 , pp. 183-188
    • Mousli, M.1    Devaux, C.2    Rochat, H.3    Goyffon, M.4    Billiald, P.5
  • 12
    • 0034834559 scopus 로고    scopus 로고
    • Construction and functional evaluation of a single-chain antibody fragment that neutralizes toxin Aahl from the venom of the scorpion Androctonus australis hector
    • DOI 10.1046/j.1432-1327.2001.01923.x
    • Devaux, C., Moreau, E., Goyffon, M., Rochat, H., and Billiald, P. (2001) Construction and functional evaluation of a single-chain antibody fragment that neutralizes toxin AahI from the venom of the scorpion Androctonus australis hector. Eur. J. Biochem. 268, 694-702 (Pubitemid 32862627)
    • (2001) European Journal of Biochemistry , vol.268 , Issue.3 , pp. 694-702
    • Devaux, C.1    Moreau, E.2    Goyffon, M.3    Rochat, H.4    Billiald, P.5
  • 14
    • 33747616656 scopus 로고    scopus 로고
    • Engineering of therapeutic antibodies to minimize immunogenicity and optimize function
    • Presta, L. G. (2006) Engineering of therapeutic antibodies to minimize immunogenicity and optimize function. Adv. Drug Deliv. Rev. 58, 640-656
    • (2006) Adv. Drug Deliv. Rev. , vol.58 , pp. 640-656
    • Presta, L.G.1
  • 15
    • 0037303456 scopus 로고    scopus 로고
    • Emergence and evolution of functional heavy-chain antibodies in Camelidae
    • Conrath, K., Wernery, U., Muyldermans, S., and Nguyen, V. K. (2003) Emergence and evolution of functional heavy-chain antibodies in Camelidae. Dev. Comp. Immunol. 27, 87-103
    • (2003) Dev. Comp. Immunol. , vol.27 , pp. 87-103
    • Conrath, K.1    Wernery, U.2    Muyldermans, S.3    Nguyen, V.K.4
  • 16
    • 59149104037 scopus 로고    scopus 로고
    • General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold
    • Vincke, C., Loris, R., Saerens, D., Martinez-Rodriguez, S., Muyldermans, S., and Conrath, K. (2009) General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold. J. Biol. Chem. 284, 3273-3284
    • (2009) J. Biol. Chem. , vol.284 , pp. 3273-3284
    • Vincke, C.1    Loris, R.2    Saerens, D.3    Martinez-Rodriguez, S.4    Muyldermans, S.5    Conrath, K.6
  • 17
    • 54849403487 scopus 로고    scopus 로고
    • Single-domain antiobodies as building blocks for novel therapeutics
    • Saerens, D., Hassanzadeh, G. G., and Muyldermans, S. (2008) Single-domain antiobodies as building blocks for novel therapeutics. Curr. Opin. Pharmacol. 8, 600-608
    • (2008) Curr. Opin. Pharmacol. , vol.8 , pp. 600-608
    • Saerens, D.1    Hassanzadeh, G.G.2    Muyldermans, S.3
  • 18
    • 1642493838 scopus 로고    scopus 로고
    • Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxins
    • DOI 10.1016/j.toxicon.2003.10.021
    • Meddeb-Mouelhi, F., Bouhaouala-Zahar, B., Benlasfar, Z., Hammadi, M., Mejri, T., Moslah, M., Karoui, H., Khorchani, T., and El Ayeb, M. (2003) Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxins. Toxicon 42, 785-791 (Pubitemid 38125038)
    • (2003) Toxicon , vol.42 , Issue.7 , pp. 785-791
    • Meddeb-Mouelhi, F.1    Bouhaouala-Zahar, B.2    Benlasfar, Z.3    Hammadi, M.4    Mejri, T.5    Moslah, M.6    Karoui, H.7    Khorchani, T.8    Ayeb, M.E.9
  • 21
    • 0014884098 scopus 로고
    • Purification of animal neurotoxins. Isolation and characterization of eleven neurotoxins from the venoms of the scorpions Androctonus australis hector, Buthus occitanus tunetanus and Leiurus quinquestriatus quinquestriatus
    • Miranda, F., Kopeyan, C., Rochat, C., Rochat, H., and Lissitzky, S. (1970) Purification of animal neurotoxins. Isolation and characterization of eleven neurotoxins from the venoms of the scorpions Androctonus australis hector, Buthus occitanus tunetanus and Leiurus quinquestriatus quinquestriatus. Eur J Biochem. 16, 279-291
    • (1970) Eur J Biochem , vol.16 , pp. 279-291
    • Miranda, F.1    Kopeyan, C.2    Rochat, C.3    Rochat, H.4    Lissitzky, S.5
  • 22
    • 0030767656 scopus 로고    scopus 로고
    • Selection and identification of single domain antibody fragments from camel heavy-chain antibodies
    • DOI 10.1016/S0014-5793(97)01062-4, PII S0014579397010624
    • Ghahroudi, M. A., Desmyter, A., Wyns, L., Hamers, R., and Muyldermans, S. (1997) Selection and identification of single domain antibody fragments from camel heavy-chain antibodies. FEBS Lett. 414, 521-526 (Pubitemid 27390659)
    • (1997) FEBS Letters , vol.414 , Issue.3 , pp. 521-526
    • Arbabi Ghahroudi, M.1    Desmyter, A.2    Wyns, L.3    Hamers, R.4    Muyldermans, S.5
  • 23
    • 10644287538 scopus 로고    scopus 로고
    • Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen
    • DOI 10.1074/jbc.M409292200
    • Saerens, D., Kinne, J., Bosmans, E., Wernery, U., Muyldermans, S., and Conrath, K. (2004) Single-domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen. J. Biol. Chem. 279, 51965-51972 (Pubitemid 39656566)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.50 , pp. 51965-51972
    • Saerens, D.1    Kinne, J.2    Bosmans, E.3    Wernery, U.4    Muyldermans, S.5    Conrath, K.6
  • 24
    • 0035831483 scopus 로고    scopus 로고
    • Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs
    • Conrath, K. E., Lauwereys, M., Wyns, L., and Muyldermans, S. (2001) Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs. J. Biol. Chem. 276, 7346-7350
    • (2001) J. Biol. Chem. , vol.276 , pp. 7346-7350
    • Conrath, K.E.1    Lauwereys, M.2    Wyns, L.3    Muyldermans, S.4
  • 27
    • 0002846347 scopus 로고    scopus 로고
    • Measuring the conformational stability of a protein
    • (Creighton, T. E., ed) IRL Press at Oxford University Press, New York
    • Pace, C. M., and Scholtz, J. M. (1997) Measuring the conformational stability of a protein. In Protein Structure: A Practical Approach (Creighton, T. E., ed) pp. 297-319, IRL Press at Oxford University Press, New York
    • (1997) Protein Structure: A Practical Approach , pp. 297-319
    • Pace, C.M.1    Scholtz, J.M.2
  • 28
    • 0034161488 scopus 로고    scopus 로고
    • Camel heavy-chain antibodies: Diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire
    • Nguyen, V. K., Hamers, R., Wyns, L., and Muyldermans, S. (2000) Camel heavy-chain antibodies: diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire. EMBO J. 19, 921-930 (Pubitemid 30119818)
    • (2000) EMBO Journal , vol.19 , Issue.5 , pp. 921-930
    • Nguyen, V.K.1    Hamers, R.2    Wyns, L.3    Muyldermans, S.4
  • 30
    • 0344080623 scopus 로고    scopus 로고
    • Design and evaluation of a diabody to improve protection against a potent scorpion neurotoxin
    • DOI 10.1007/s000180300053
    • Aubrey, N., Devaux, C., Sizaret, PY., Rochat, H., Goyffon, M., and Billiald, P. (2003) Design and evaluation of a diabody to improve protection against a potent scorpion neurotoxin. Cell. Mol. Life Sci. 60, 617-628 (Pubitemid 36459540)
    • (2003) Cellular and Molecular Life Sciences , vol.60 , Issue.3 , pp. 617-628
    • Aubrey, N.1    Devaux, C.2    Sizaret, P.-Y.3    Rochat, H.4    Goyffon, M.5    Billiald, P.6
  • 31
    • 1642389249 scopus 로고    scopus 로고
    • Engineering of a recombinant Fab from a neutralizing IgG directed against scorpion neurotoxin AahI, and functional evaluation versus other antibody fragments
    • DOI 10.1016/j.toxicon.2003.11.024, PII S0041010103003647
    • Aubrey, N., Muzard, J., Christophe Peter, J., Rochat, H., Goyffon, M., Devaux, C., and Billiald, P. (2004) Engineering of a recombinant Fab from a neutralizing IgG directed against scorpion neurotoxin AahI, and functional evaluation versus other antibody fragments. Toxicon 43, 233-241 (Pubitemid 38367954)
    • (2004) Toxicon , vol.43 , Issue.3 , pp. 233-241
    • Aubrey, N.1    Muzard, J.2    Peter, J.C.3    Rochat, H.4    Goyffon, M.5    Devaux, C.6    Billiald, P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.