-
1
-
-
16244403039
-
Cancer incidence and mortality in Europe, 2004
-
DOI 10.1093/annonc/mdi098
-
Boyle, P. and Ferlay, J. (2005) Cancer incidence and mortality in Europe, 2004. Annals Oncol. 16, 481-488 (Pubitemid 40458328)
-
(2005)
Annals of Oncology
, vol.16
, Issue.3
, pp. 481-488
-
-
Boyle, P.1
Ferlay, J.2
-
2
-
-
85013716567
-
-
Saunders, Elsevier, Philadelphia
-
Mendelsohn, J., Howley, P. M., Israel, M. A., Gray, J. W., and Thompson, C. B. (2008) The Molecular Basis of Cancer. Saunders, Elsevier, Philadelphia
-
(2008)
The Molecular Basis of Cancer
-
-
Mendelsohn, J.1
Howley, P.M.2
Israel, M.A.3
Gray, J.W.4
Thompson, C.B.5
-
3
-
-
0034766736
-
Biology of HER2 and its importance in breast cancer
-
Yarden, Y. (2001) Biology of HER2 and its importance in breast cancer. Oncology 61(Suppl 2), 1-13
-
(2001)
Oncology
, vol.61
, Issue.SUPPL. 2
, pp. 1-13
-
-
Yarden, Y.1
-
4
-
-
40449087743
-
HER2+ breast cancer: Review of biologic relevance and optimal use of diagnostic tools
-
DOI 10.1309/99AE032R9FM8WND1
-
Hicks, D. G., and Kulkarni, S. (2008) HER2+ breast cancer: review of biologic relevance and optimal use of diagnostic tools. Am. J. Clin. Pathol. 129, 263-273 (Pubitemid 352029317)
-
(2008)
American Journal of Clinical Pathology
, vol.129
, Issue.2
, pp. 263-273
-
-
Hicks, D.G.1
Kulkarni, S.2
-
5
-
-
20244378677
-
Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
-
DOI 10.1200/JCO.2005.03.184
-
Agus, D. B., Gordon, M. S., Taylor, C., Natale, R. B., Karlan, B., Mendelson, D. S., Press, M. F., Allison, D. E., Sliwkowski, M. X., Lieberman, G., Kelsey, S. M., and Fyfe, G. (2005) Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer. J. Clin. Oncol. 23, 2534-2543 (Pubitemid 47050843)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.11
, pp. 2534-2543
-
-
Agus, D.B.1
Gordon, M.S.2
Taylor, C.3
Natale, R.B.4
Karlan, B.5
Mendelson, D.S.6
Press, M.F.7
Allison, D.E.8
Sliwkowski, M.X.9
Lieberman, G.10
Kelsey, S.M.11
Fyfe, G.12
-
6
-
-
26944465031
-
Comparison of HER-2 overexpression in primary breast cancer and metastatic sites and its effect on biological targeting therapy of metastatic disease
-
DOI 10.1038/sj.bjc.6602738, PII 6602738
-
Zidan, J., Dashkovsky, I., Stayerman, C., Basher, W., Cozacov, C., and Hadary, A. (2005) Comparison of HER-2 overexpression in primary breast cancer and metastatic sites and its effect on biological targeting therapy of metastatic disease. Brit. J. Cancer 93, 552-556 (Pubitemid 43079998)
-
(2005)
British Journal of Cancer
, vol.93
, Issue.5
, pp. 552-556
-
-
Zidan, J.1
Dashkovsky, I.2
Stayerman, C.3
Basher, W.4
Cozacov, C.5
Hadary, A.6
-
7
-
-
0035990831
-
Comparison of HER-2 status between primary breast cancer and corresponding distant metastatic sites
-
Gancberg, D., Di Leo, A., Cardoso, F., Rouas, G., Pedrocchi, M., Paesmans, M., Verhelst, A., Bernard-Marty, C., Piccart, M. J., and Larsimont, D. (2002) Comparison of HER-2 status between primary breast cancer and corresponding distant metastatic sites. Annals Oncol. 13, 1036-1043
-
(2002)
Annals Oncol.
, vol.13
, pp. 1036-1043
-
-
Gancberg, D.1
Di Leo, A.2
Cardoso, F.3
Rouas, G.4
Pedrocchi, M.5
Paesmans, M.6
Verhelst, A.7
Bernard-Marty, C.8
Piccart, M.J.9
Larsimont, D.10
-
8
-
-
33847165329
-
Intratumoral heterogeneity of HER2/neu in breast cancer - A rare event
-
DOI 10.1111/j.1524-4741.2007.00396.x
-
Hanna, W., Nofech-Mozes, S., and Kahn, H. J. (2007) Intratumoral heterogeneity of HER2/neu in breast cancer - a rare event. Breast J. 13, 122-129 (Pubitemid 46280606)
-
(2007)
Breast Journal
, vol.13
, Issue.2
, pp. 122-129
-
-
Hanna, W.1
Nofech-Mozes, S.2
Kahn, H.J.3
-
9
-
-
58149095508
-
Imaging of HER-2 overexpression in tumors for guiding therapy
-
Tolmachev, V. (2008) Imaging of HER-2 overexpression in tumors for guiding therapy. Curr. Pharm. Des. 14, 2999-3019
-
(2008)
Curr. Pharm. Des.
, vol.14
, pp. 2999-3019
-
-
Tolmachev, V.1
-
10
-
-
0008331304
-
Does immunoscintigraphy allow for prognostic predictions with respect to the toxicity and therapeutic efficacy of herceptin immunotherapy of metastatic breast cancer?
-
Behr, T. M., Behe, M., Angerstein, C., Griesinger, F., Kaufmann, C. C., Wörmann, B., Emons, G., and Becker, W. (2001) Does immunoscintigraphy allow for prognostic predictions with respect to the toxicity and therapeutic efficacy of herceptin immunotherapy of metastatic breast cancer? Eur. J. Nucl. Med. 28, 976
-
(2001)
Eur. J. Nucl. Med.
, vol.28
, pp. 976
-
-
Behr, T.M.1
Behe, M.2
Angerstein, C.3
Griesinger, F.4
Kaufmann, C.C.5
Wörmann, B.6
Emons, G.7
Becker, W.8
-
12
-
-
0033571383
-
High thermal stability is essential for tumor targeting of antibody fragments: Engineering of a humanized antiepithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment
-
Willuda, J., Honegger, A., Waibel, R., Schubiger, P. A., Stahel, R., Zangemeister-Wittke, U., and Plückthun, A. (1999) High thermal stability is essential for tumor targeting of antibody fragments: engineering of a humanized antiepithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment. Cancer Res. 59, 5758-5767
-
(1999)
Cancer Res.
, vol.59
, pp. 5758-5767
-
-
Willuda, J.1
Honegger, A.2
Waibel, R.3
Schubiger, P.A.4
Stahel, R.5
Zangemeister-Wittke, U.6
Plückthun, A.7
-
13
-
-
0027332881
-
An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability
-
Whitlow, M., Bella, B. A., Feng, S. L., Filpula, D., Hardman, K. D, Hubert, S. L., Rollence, M. L., Wood, J. F., Schott, M. E., Milenic, D. E., Yokota, T., and Schlom, J. (1993) An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability. Protein Eng. 6, 989-995 (Pubitemid 23347376)
-
(1993)
Protein Engineering
, vol.6
, Issue.8
, pp. 989-995
-
-
Whitlow, M.1
Bell, B.A.2
Feng, S.-L.3
Filpula, D.4
Hardman, K.D.5
Hubert, S.L.6
Rollence, M.L.7
Wood, J.F.8
Schott, M.E.9
Milenic, D.E.10
Yokota, T.11
Schlom, J.12
-
14
-
-
44149116877
-
99mTc-labeled nanobodies: A new type of targeted probes for imaging antigen expression
-
Cortez-Retamozo, V., Lahoutte, T., Caveliers, V., Gainkam, L. O. T., Hernot, S., Packeu, A., De Vos, F., Vanhove, C., Muyldermans, S., De Baetselier, P., and Revets, H. (2008) 99mTc-labeled nanobodies: a new type of targeted probes for imaging antigen expression. Curr. Radiopharmaceut. 1, 37-41
-
(2008)
Curr. Radiopharmaceut.
, vol.1
, pp. 37-41
-
-
Cortez-Retamozo, V.1
Lahoutte, T.2
Caveliers, V.3
Gainkam, L.O.T.4
Hernot, S.5
Packeu, A.6
De Vos, F.7
Vanhove, C.8
Muyldermans, S.9
De Baetselier, P.10
Revets, H.11
-
15
-
-
43249091515
-
99mTc-labeled EGFR specific nanobody for in vivo monitoring of EGFR expression
-
99mTc-labeled EGFR specific nanobody for in vivo monitoring of EGFR expression. Mol. Imag. Biol. 10, 167-175
-
(2008)
Mol. Imag. Biol.
, vol.10
, pp. 167-175
-
-
Huang, L.1
Gainkam, L.O.T.2
Caveliers, V.3
Vanhove, C.4
Keyaerts, M.5
De Baetselier, P.6
Bossuyt, A.7
Revets, H.8
Lahoutte, T.9
-
16
-
-
44149088593
-
99mTc-labeled anti-EGFR nanobodies in mice, using pinhole SPECT/micro-CT
-
DOI 10.2967/jnumed.107.048538
-
Gainkam, L. O. T., Huang, L., Caveliers, V., Keyaerts, M., Hernot, S., Vaneycken, I., Vanhove, C., Revets, H., De Baetselier, P., and Lahoutte, T. (2008) Comparison of the biodistribution and tumor targeting of two 99mTc-labeled anti-EGFR nanobodies in mice, using pinhole SPECT/microCT. J. Nucl. Med. 49, 788-795 (Pubitemid 351717545)
-
(2008)
Journal of Nuclear Medicine
, vol.49
, Issue.5
, pp. 788-795
-
-
Gainkam, L.O.T.1
Huang, L.2
Caveliers, V.3
Keyaerts, M.4
Hernot, S.5
Vaneycken, I.6
Vanhove, C.7
Revets, H.8
De Baetselier, P.9
Lahoutte, T.10
-
17
-
-
77955000361
-
In vitro analysis and in vivo tumor targeting of a humanized, grafted nanobody in mice using pinhole SPECT/micro-CT
-
Vaneycken, I., Govaert, J., Vincke, C., Caveliers, V., Lahoutte, T., De Baetselier, P., Raes, G., Bossuyt, A., Muyldermans, S., and Devoogdt, N. (2010) In vitro analysis and in vivo tumor targeting of a humanized, grafted nanobody in mice using pinhole SPECT/micro-CT. J. Nucl. Med. 51, 1099-1106
-
(2010)
J. Nucl. Med.
, vol.51
, pp. 1099-1106
-
-
Vaneycken, I.1
Govaert, J.2
Vincke, C.3
Caveliers, V.4
Lahoutte, T.5
De Baetselier, P.6
Raes, G.7
Bossuyt, A.8
Muyldermans, S.9
Devoogdt, N.10
-
18
-
-
0027310612
-
Naturally occurring antibodies devoid of light chains
-
DOI 10.1038/363446a0
-
Hamers-Casterman, C., Atarhouch, T., Muyldermans, S., Robinson, G., Hamers, C., Songa, E. B., Bendahman, N., and Hamers, R. (1993) Naturally occurring antibodies devoid of light chains. Nature 363, 446-448 (Pubitemid 23179389)
-
(1993)
Nature
, vol.363
, Issue.6428
, pp. 446-448
-
-
Hamers-Casterman, C.1
Atarhouch, T.2
Muyldermans, S.3
Robinson, G.4
Hamers, C.5
Songa, E.B.6
Bendahman, N.7
Hamers, R.8
-
19
-
-
0030767656
-
Selection and identification of single domain antibody fragments from camel heavy-chain antibodies
-
DOI 10.1016/S0014-5793(97)01062-4, PII S0014579397010624
-
Arbabi Ghahroudi, M., Desmyter, A., Wyns, L., Hamers, R., and Muyldermans, S. (1997) Selection and identification of single domain antibody fragments from camel heavy-chain antibodies. FEBS Lett. 414, 521-526 (Pubitemid 27390659)
-
(1997)
FEBS Letters
, vol.414
, Issue.3
, pp. 521-526
-
-
Arbabi, G.M.1
Desmyter, A.2
Wyns, L.3
Hamers, R.4
Muyldermans, S.5
-
20
-
-
24044472050
-
Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies
-
DOI 10.1016/j.jmb.2005.07.038, PII S0022283605008260
-
Saerens, D., Pellis, M., Loris. R., Pardon E, Dumoulin, M., Matagne, A., Wyns, L., Muyldermans, S., and Conrath, K. (2005) Identification of a universal VHH framework to graft noncanonical antigen-binding loops of camel single-domain antibodies. J. Mol. Biol. 352, 597-607 (Pubitemid 41225471)
-
(2005)
Journal of Molecular Biology
, vol.352
, Issue.3
, pp. 597-607
-
-
Saerens, D.1
Pellis, M.2
Loris, R.3
Pardon, E.4
Dumoulin, M.5
Matagne, A.6
Wyns, L.7
Muyldermans, S.8
Conrath, K.9
-
21
-
-
59149104037
-
General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold
-
Vincke, C., Loris, R., Saerens, D., Martinez-Rodriguez, S., Muyldermans, S., and Conrath, K. (2009) General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold. J. Biol. Chem. 284, 3273-3284
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 3273-3284
-
-
Vincke, C.1
Loris, R.2
Saerens, D.3
Martinez-Rodriguez, S.4
Muyldermans, S.5
Conrath, K.6
-
22
-
-
70350714454
-
18F-FDG small-animal PET/CT differentiates trastuzumab-responsive from unresponsive human breast cancer xenografts in athymic mice
-
McLarty, K., Fasih, A., Scollard, D. A., Done, S. J., Vines, D. C., Green, D. E., Costantini, D. L., and Reilly, R. M. (2009) 18F-FDG small-animal PET/CT differentiates trastuzumab-responsive from unresponsive human breast cancer xenografts in athymic mice. J. Nucl. Med. 50, 1848-1856
-
(2009)
J. Nucl. Med.
, vol.50
, pp. 1848-1856
-
-
McLarty, K.1
Fasih, A.2
Scollard, D.A.3
Done, S.J.4
Vines, D.C.5
Green, D.E.6
Costantini, D.L.7
Reilly, R.M.8
-
23
-
-
18144416577
-
Imaging of HER2/neu expression in BT-474 human breast cancer xenografts in athymic mice using [(99m)Tc]-HYNIC-trastuzumab (herceptin) Fab fragments
-
Tang, Y., Scollard, D., Chen, P., Wang, J., Holloway, C., and Reilly, R. M. (2005) Imaging of HER2/neu expression in BT-474 human breast cancer xenografts in athymic mice using [(99m)Tc]-HYNIC-trastuzumab (herceptin) Fab fragments. Nucl. Med. Commun. 26, 427-432
-
(2005)
Nucl. Med. Commun.
, vol.26
, pp. 427-432
-
-
Tang, Y.1
Scollard, D.2
Chen, P.3
Wang, J.4
Holloway, C.5
Reilly, R.M.6
-
24
-
-
0033708769
-
Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity
-
Nielsen, U. B., Adams, G. P., Weiner, L. M., and Marks, J. D. (2000) Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity. Cancer Res. 60, 6434-6440
-
(2000)
Cancer Res.
, vol.60
, pp. 6434-6440
-
-
Nielsen, U.B.1
Adams, G.P.2
Weiner, L.M.3
Marks, J.D.4
-
25
-
-
13944266719
-
Quantitative immuno-positron emission tomography imaging of HER2-positlve tumor xenografts with an iodine-124 labeled anti-HER2 diabody
-
DOI 10.1158/0008-5472.CAN-04-2008
-
Robinson, M. K., Doss, M., Shaller, C., Narayanan, D., Marks, J. D., Adler, L. P., González Trotter, D. E., and Adams, G. P. (2005) Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody. Cancer Res. 65, 1471-1478 (Pubitemid 40270176)
-
(2005)
Cancer Research
, vol.65
, Issue.4
, pp. 1471-1478
-
-
Robinson, M.K.1
Doss, M.2
Shaller, C.3
Narayanan, D.4
Marks, J.D.5
Adler, L.P.6
Gonzalez, T.D.E.7
Adams, G.P.8
-
26
-
-
76749132728
-
Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: Effects of affinity and molecular size
-
Zahnd, C., Kawe, M., Stumpp, M. T., de Pasquale, C., Tamaskovic, R., Nagy-Davidescu, G., Dreier, B., Schibli, R., Binz, H. K., Waibel, R., and Plückthun, A. (2010) Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size. Cancer Res. 70, 1595-1605
-
(2010)
Cancer Res.
, vol.70
, pp. 1595-1605
-
-
Zahnd, C.1
Kawe, M.2
Stumpp, M.T.3
De Pasquale, C.4
Tamaskovic, R.5
Nagy-Davidescu, G.6
Dreier, B.7
Schibli, R.8
Binz, H.K.9
Waibel, R.10
Plückthun, A.11
-
27
-
-
0035874887
-
High affinity restricts the localization and tumor penetration of single-chain Fv antibody molecules
-
Adams, G. P., Schier, R., McCall, A. M., Simmons, H. H., Horak, E. M., Alpaugh, R. K., Marks, J. D., and Weiner, L. M. (2001) High affinity restricts the localization and tumor penetration of single-chain Fv antibody molecules. Cancer Res. 61, 4750-4755
-
(2001)
Cancer Res.
, vol.61
, pp. 4750-4755
-
-
Adams, G.P.1
Schier, R.2
McCall, A.M.3
Simmons, H.H.4
Horak, E.M.5
Alpaugh, R.K.6
Marks, J.D.7
Weiner, L.M.8
-
28
-
-
77954963897
-
Targeting of HER2-expressing tumors using 111In-ABY-025, a second-generation affibody molecule with a fundamentally reengineered scaffold
-
Ahlgren, S., Orlova, A., Wållberg, H., Hansson, M., Sandström, M., Lewsley, R., Wennborg, A., Abrahmsén, L., Tolmachev, V., and Feldwisch, J. (2010) Targeting of HER2-expressing tumors using 111In-ABY-025, a second-generation affibody molecule with a fundamentally reengineered scaffold. J. Nucl. Med. 51, 1131-1138
-
(2010)
J. Nucl. Med.
, vol.51
, pp. 1131-1138
-
-
Ahlgren, S.1
Orlova, A.2
Wållberg, H.3
Hansson, M.4
Sandström, M.5
Lewsley, R.6
Wennborg, A.7
Abrahmsén, L.8
Tolmachev, V.9
Feldwisch, J.10
-
29
-
-
35348819390
-
Properties, production, and applications of camelid single-domain antibody fragments
-
DOI 10.1007/s00253-007-1142-2
-
Harmsen, M. M., and De Haard, H. J. (2007) Properties, production, and applications of camelid single-domain antibody fragments. Appl. Microbiol. Biotechnol. 77, 13-22 (Pubitemid 47573319)
-
(2007)
Applied Microbiology and Biotechnology
, vol.77
, Issue.1
, pp. 13-22
-
-
Harmsen, M.M.1
De Haard, H.J.2
-
30
-
-
79954991349
-
Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice
-
E-pub ahead of print doi: 10.1002/cmmi.408
-
Gainkam, L. O. T., Caveliers, V., Devoogdt, N., Vanhove, C., Xavier, C., Boerman, O., Muyldermans, S., Bossuyt, A., and Lahoutte, T. (2010) Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice. [E-pub ahead of print] Contrast Media Mol. Imaging doi: 10.1002/cmmi.408
-
(2010)
Contrast Media Mol. Imaging
-
-
Gainkam, L.O.T.1
Caveliers, V.2
Devoogdt, N.3
Vanhove, C.4
Xavier, C.5
Boerman, O.6
Muyldermans, S.7
Bossuyt, A.8
Lahoutte, T.9
-
31
-
-
77952295436
-
Nanobodies as tools for in vivo imaging of specific immune cell types
-
De Groeve, K., Deschacht, N., De Koninck, C., Caveliers, V., Lahoutte, T., Devoogdt, N., Muyldermans, S., De Baetselier, P., and Raes, G. (2010) Nanobodies as tools for in vivo imaging of specific immune cell types. J. Nucl. Med. 51, 782-789
-
(2010)
J. Nucl. Med.
, vol.51
, pp. 782-789
-
-
De Groeve, K.1
Deschacht, N.2
De Koninck, C.3
Caveliers, V.4
Lahoutte, T.5
Devoogdt, N.6
Muyldermans, S.7
De Baetselier, P.8
Raes, G.9
-
32
-
-
33845939857
-
Selection and characterization of Her2 binding-designed ankyrin repeat proteins
-
DOI 10.1074/jbc.M602547200
-
Zahnd, C., Pecorari, F., Straumann, N., Wyler, E., and Plückthun, A. (2006) Selection and characterization of Her2 bindingdesigned ankyrin repeat proteins. J. Biol. Chem. 281, 35167-35175 (Pubitemid 46036556)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.46
, pp. 35167-35175
-
-
Zahnd, C.1
Pecorari, F.2
Straumann, N.3
Wyler, E.4
Pluckthun, A.5
-
33
-
-
33646261864
-
Tumor imaging using a picomolar affinity HER2 binding affibody molecule
-
Orlova, A., Magnusson, M., Eriksson, T. L., Nilsson, M., Larsson, B., Höidén-Guthenberg, I., Widström, C., Carlsson, J., Tolmachev, V., Ståhl, S., Nilsson, F. Y. (2006) Tumor imaging using a picomolar affinity HER2 binding affibody molecule. Cancer Res. 66, 4339-4348
-
(2006)
Cancer Res.
, vol.66
, pp. 4339-4348
-
-
Orlova, A.1
Magnusson, M.2
Eriksson, T.L.3
Nilsson, M.4
Larsson, B.5
Höidén-Guthenberg, I.6
Widström, C.7
Carlsson, J.8
Tolmachev, V.9
Ståhl, S.10
Nilsson, F.Y.11
-
34
-
-
77954966119
-
Renal toxicity of radiolabeled peptides and antibody fragments: Mechanisms, impact on radionuclide therapy, and strategies for prevention
-
Vegt, E., de Jong, M., Wetzels, J. F., Masereeuw, R., Melis, M., Oyen, W. J., Gotthardt, M., Boerman, O. C. (2010) Renal toxicity of radiolabeled peptides and antibody fragments: mechanisms, impact on radionuclide therapy, and strategies for prevention. J. Nucl. Med. 51, 1049-1058
-
(2010)
J. Nucl. Med.
, vol.51
, pp. 1049-1058
-
-
Vegt, E.1
De Jong, M.2
Wetzels, J.F.3
Masereeuw, R.4
Melis, M.5
Oyen, W.J.6
Gotthardt, M.7
Boerman, O.C.8
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