메뉴 건너뛰기




Volumn 198, Issue 3, 2009, Pages 157-174

Single domain antibodies: Promising experimental and therapeutic tools in infection and immunity

Author keywords

Enzyme inhibitors; Nanobody; Recombinant antibodies; Single domain antibodies; VHH; Virus neutralization

Indexed keywords

ANTIBODY; BACTERIUM ANTIBODY; BEVACIZUMAB; BISPECIFIC ANTIBODY; CELL SURFACE PROTEIN; CETUXIMAB; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HYBRID PROTEIN; NAT 267; NEUTRALIZING ANTIBODY; OMALIZUMAB; PARASITE ANTIBODY; POLY A BINDING PROTEIN 1 ANTIBODY; PROTEIN BAX ANTIBODY; RECOMBINANT ANTIBODY; RITUXIMAB; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SINGLE DOMAIN ANTIBODY; TOXIN ANTIBODY; TRASTUZUMAB; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VON WILLEBRAND FACTOR ANTIBODY;

EID: 68349117269     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-009-0116-7     Document Type: Review
Times cited : (423)

References (128)
  • 1
    • 0037264969 scopus 로고    scopus 로고
    • Therapeutic antibodies for human diseases at the dawn of the twenty-first century
    • DOI 10.1038/nrd984
    • OH Brekke I Sandlie 2003 Therapeutic antibodies for human diseases at the dawn of the twenty-first century Nat Rev Drug Discov 2 1 52 62 10.1038/nrd984 (Pubitemid 37361624)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.1 , pp. 52-62
    • Brekke, O.H.1    Sandlie, I.2
  • 3
    • 0035715877 scopus 로고    scopus 로고
    • Single domain camel antibodies: Current status
    • S Muyldermans 2001 Single domain camel antibodies: current status J Biotechnol 74 4 277 302
    • (2001) J Biotechnol , vol.74 , Issue.4 , pp. 277-302
    • Muyldermans, S.1
  • 4
    • 27144432842 scopus 로고    scopus 로고
    • Engineered antibody fragments and the rise of single domains
    • DOI 10.1038/nbt1142, PII N1142
    • P Holliger PJ Hudson 2005 Engineered antibody fragments and the rise of single domains Nat Biotechnol 23 9 1126 1136 10.1038/nbt1142 (Pubitemid 41486394)
    • (2005) Nature Biotechnology , vol.23 , Issue.9 , pp. 1126-1136
    • Holliger, P.1    Hudson, P.J.2
  • 7
    • 0027212854 scopus 로고
    • Length distribution of CDRH3 in antibodies
    • 10.1002/prot.340160102
    • TT Wu G Johnson EA Kabat 1993 Length distribution of CDRH3 in antibodies Proteins 16 1 1 7 10.1002/prot.340160102
    • (1993) Proteins , vol.16 , Issue.1 , pp. 1-7
    • Wu, T.T.1    Johnson, G.2    Kabat, E.A.3
  • 8
    • 35348819390 scopus 로고    scopus 로고
    • Properties, production, and applications of camelid single-domain antibody fragments
    • DOI 10.1007/s00253-007-1142-2
    • MM Harmsen HJ De Haard 2007 Properties, production, and applications of camelid single-domain antibody fragments Appl Microbiol Biotechnol 77 1 13 22 10.1007/s00253-007-1142-2 (Pubitemid 47573319)
    • (2007) Applied Microbiology and Biotechnology , vol.77 , Issue.1 , pp. 13-22
    • Harmsen, M.M.1    De Haard, H.J.2
  • 9
    • 0034285785 scopus 로고    scopus 로고
    • Phage display of antibody fragments
    • 10.2174/1389203003381397
    • A Pini L Bracci 2000 Phage display of antibody fragments Curr Protein Pept Sci 1 2 155 169 10.2174/1389203003381397
    • (2000) Curr Protein Pept Sci , vol.1 , Issue.2 , pp. 155-169
    • Pini, A.1    Bracci, L.2
  • 10
    • 27144431943 scopus 로고    scopus 로고
    • Selecting and screening recombinant antibody libraries
    • DOI 10.1038/nbt1126, PII N1126
    • HR Hoogenboom 2005 Selecting and screening recombinant antibody libraries Nat Biotechnol 23 9 1105 1116 10.1038/nbt1126 (Pubitemid 41486392)
    • (2005) Nature Biotechnology , vol.23 , Issue.9 , pp. 1105-1116
    • Hoogenboom, H.R.1
  • 13
    • 0035831483 scopus 로고    scopus 로고
    • Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs
    • 10.1074/jbc.M007734200
    • EK Conrath M Lauwereys L Wyns S Muyldermans 2001 Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs J Biol Chem 276 10 7346 7350 10.1074/jbc.M007734200
    • (2001) J Biol Chem , vol.276 , Issue.10 , pp. 7346-7350
    • Conrath, E.K.1    Lauwereys, M.2    Wyns, L.3    Muyldermans, S.4
  • 15
    • 37549005602 scopus 로고    scopus 로고
    • Selection of genetically encoded fluorescent single domain antibodies engineered for efficient expression in Escherichia coli
    • 10.1074/jbc.M704908200
    • A Olichon T Surrey 2007 Selection of genetically encoded fluorescent single domain antibodies engineered for efficient expression in Escherichia coli J Biol Chem 282 50 36314 36320 10.1074/jbc.M704908200
    • (2007) J Biol Chem , vol.282 , Issue.50 , pp. 36314-36320
    • Olichon, A.1    Surrey, T.2
  • 18
    • 33845673605 scopus 로고    scopus 로고
    • Identification of single-domain, Bax-specific intrabodies that confer resistance to mammalian cells against oxidative-stress-induced apoptosis
    • DOI 10.1096/fj.06-6306fje
    • D Gueorguieva S Li N Walsh A Mukerji J Tanha S Pandey 2006 Identification of single-domain, Bax-specific intrabodies that confer resistance to mammalian cells against oxidative-stress-induced apoptosis FASEB J 20 14 2636 2638 10.1096/fj.06-6306fje (Pubitemid 44953805)
    • (2006) FASEB Journal , vol.20 , Issue.14
    • Gueorguieva, D.1    Li, S.2    Walsh, N.3    Mukerji, A.4    Tanha, J.5    Pandey, S.6
  • 19
    • 0037225784 scopus 로고    scopus 로고
    • Immunomodulation of enzyme function in plants by single-domain antibody fragments
    • DOI 10.1038/nbt772
    • SA Jobling C Jarman MM Teh N Holmberg C Blake ME Verhoeyen 2003 Immunomodulation of enzyme function in plants by single-domain antibody fragments Nat Biotechnol 21 1 77 80 10.1038/nbt772 (Pubitemid 36055831)
    • (2003) Nature Biotechnology , vol.21 , Issue.1 , pp. 77-80
    • Jobling, S.A.1    Jarman, C.2    Teh, M.-M.3    Holmberg, N.4    Blake, C.5    Verhoeyen, M.E.6
  • 20
    • 58949094406 scopus 로고    scopus 로고
    • Llama-derived single-domain intrabodies inhibit secretion of hepatitis B virions in mice
    • 10.1002/hep.22609
    • B Serruys F Van Houtte P Verbrugghe G Leroux-Roels P Vanlandschoot 2009 Llama-derived single-domain intrabodies inhibit secretion of hepatitis B virions in mice Hepatology 49 1 39 49 10.1002/hep.22609
    • (2009) Hepatology , vol.49 , Issue.1 , pp. 39-49
    • Serruys, B.1    Van Houtte, F.2    Verbrugghe, P.3    Leroux-Roels, G.4    Vanlandschoot, P.5
  • 21
    • 0036584028 scopus 로고    scopus 로고
    • Development of anti-TNF therapy for rheumatoid arthritis
    • 10.1038/nri802
    • M Feldmann 2002 Development of anti-TNF therapy for rheumatoid arthritis Nat Rev Immunol 2 5 364 371 10.1038/nri802
    • (2002) Nat Rev Immunol , vol.2 , Issue.5 , pp. 364-371
    • Feldmann, M.1
  • 22
    • 48649094750 scopus 로고    scopus 로고
    • Fully human antibodies from transgenic mouse and phage display platforms
    • 10.1016/j.coi.2008.06.004
    • N Lonberg 2008 Fully human antibodies from transgenic mouse and phage display platforms Curr Opin Immunol 20 4 450 459 10.1016/j.coi.2008.06.004
    • (2008) Curr Opin Immunol , vol.20 , Issue.4 , pp. 450-459
    • Lonberg, N.1
  • 23
    • 54349083317 scopus 로고    scopus 로고
    • The cost burden of trastuzumab and bevacizumab therapy for solid tumours in Canada
    • 10.3747/co.v15i3.249
    • A Drucker C Skedgel K Virik D Rayson M Sellon T Younis 2008 The cost burden of trastuzumab and bevacizumab therapy for solid tumours in Canada Curr Oncol 15 3 136 142 10.3747/co.v15i3.249
    • (2008) Curr Oncol , vol.15 , Issue.3 , pp. 136-142
    • Drucker, A.1    Skedgel, C.2    Virik, K.3    Rayson, D.4    Sellon, M.5    Younis, T.6
  • 24
    • 0031908460 scopus 로고    scopus 로고
    • Ecto-enzymes of lymphoid cells
    • 10.1111/j.1600-065X.1998.tb01567.x
    • JW Goding MC Howard 1998 Ecto-enzymes of lymphoid cells Immunol Rev 161 5 10 10.1111/j.1600-065X.1998.tb01567.x
    • (1998) Immunol Rev , vol.161 , pp. 5-10
    • Goding, J.W.1    Howard, M.C.2
  • 25
    • 25844523991 scopus 로고    scopus 로고
    • Cell-surface enzymes in control of leukocyte trafficking
    • DOI 10.1038/nri1705
    • M Salmi S Jalkanen 2005 Cell-surface enzymes in control of leukocyte trafficking Nat Rev Immunol 5 10 760 771 10.1038/nri1705 (Pubitemid 41400850)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.10 , pp. 760-771
    • Salmi, M.1    Jalkanen, S.2
  • 26
    • 0037881920 scopus 로고    scopus 로고
    • Functional aspects of protein mono-ADP-ribosylation
    • DOI 10.1093/emboj/cdg209
    • D Corda M Di Girolamo 2003 Functional aspects of protein mono-ADP-ribosylation EMBO J 22 9 1953 1958 10.1093/emboj/cdg209 (Pubitemid 36565521)
    • (2003) EMBO Journal , vol.22 , Issue.9 , pp. 1953-1958
    • Corda, D.1    Di Girolamo, M.2
  • 27
    • 29144526631 scopus 로고    scopus 로고
    • Ecto-ADP-ribose transferases: Cell-surface response to local tissue injury
    • DOI 10.1152/physiol.00028.2005
    • A Zolkiewska 2005 Ecto-ADP-ribose transferases: cell-surface response to local tissue injury Physiology (Bethesda) 20 374 381 10.1152/physiol.00028.2005 (Pubitemid 41812420)
    • (2005) Physiology , Issue.6 , pp. 374-381
    • Zolkiewska, A.1
  • 30
    • 34250855032 scopus 로고    scopus 로고
    • NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo
    • S Adriouch S Hubert S Pechberty F Koch-Nolte F Haag M Seman 2007 NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo J Immunol 179 1 186 194
    • (2007) J Immunol , vol.179 , Issue.1 , pp. 186-194
    • Adriouch, S.1    Hubert, S.2    Pechberty, S.3    Koch-Nolte, F.4    Haag, F.5    Seman, M.6
  • 31
    • 33646386147 scopus 로고    scopus 로고
    • ADP-ribosylation of membrane proteins: Unveiling the secrets of a crucial regulatory mechanism in mammalian cells
    • DOI 10.1080/07853890600655499, PII M5155312275
    • F Koch-Nolte S Adriouch P Bannas C Krebs F Scheuplein M Seman F Haag 2006 ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells Ann Med 38 3 188 199 10.1080/07853890600655499 (Pubitemid 43675584)
    • (2006) Annals of Medicine , vol.38 , Issue.3 , pp. 188-199
    • Koch-Nolte, F.1    Adriouch, S.2    Bannas, P.3    Krebs, C.4    Scheuplein, F.5    Seman, M.6    Haag, F.7
  • 32
    • 64849095102 scopus 로고    scopus 로고
    • NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells
    • 10.4049/jimmunol.0801711
    • F Scheuplein N Schwarz S Adriouch C Krebs P Bannas B Rissiek M Seman F Haag F Koch-Nolte 2009 NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells J Immunol 182 5 2898 2908 10.4049/jimmunol.0801711
    • (2009) J Immunol , vol.182 , Issue.5 , pp. 2898-2908
    • Scheuplein, F.1    Schwarz, N.2    Adriouch, S.3    Krebs, C.4    Bannas, P.5    Rissiek, B.6    Seman, M.7    Haag, F.8    Koch-Nolte, F.9
  • 33
    • 40449130117 scopus 로고    scopus 로고
    • ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site
    • DOI 10.1096/fj.07-9294com
    • S Adriouch P Bannas N Schwarz R Fliegert AH Guse M Seman F Haag F Koch-Nolte 2008 ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site FASEB J 22 3 861 869 10.1096/fj.07-9294com (Pubitemid 351348137)
    • (2008) FASEB Journal , vol.22 , Issue.3 , pp. 861-869
    • Adriouch, S.1    Bannas, P.2    Schwarz, N.3    Fliegert, R.4    Guse, A.H.5    Seman, M.6    Haag, F.7    Koch-Nolte, F.8
  • 34
    • 0142188258 scopus 로고    scopus 로고
    • NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor
    • DOI 10.1016/S1074-7613(03)00266-8
    • M Seman S Adriouch F Scheuplein C Krebs D Freese G Glowacki P Deterre F Haag F Koch-Nolte 2003 NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor Immunity 19 4 571 582 10.1016/S1074-7613(03)00266-8 (Pubitemid 37311438)
    • (2003) Immunity , vol.19 , Issue.4 , pp. 571-582
    • Seman, M.1    Adriouch, S.2    Scheuplein, F.3    Krebs, C.4    Freese, D.5    Glowacki, G.6    Deterre, P.7    Haag, F.8    Koch-Nolte, F.9
  • 38
    • 0036480118 scopus 로고    scopus 로고
    • Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium
    • A Muruganandam J Tanha S Narang D Stanimirovic 2002 Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium FASEB J 16 2 240 242
    • (2002) FASEB J , vol.16 , Issue.2 , pp. 240-242
    • Muruganandam, A.1    Tanha, J.2    Narang, S.3    Stanimirovic, D.4
  • 39
    • 28244432240 scopus 로고    scopus 로고
    • The blood-brain barrier transmigrating single domain antibody: Mechanisms of transport and antigenic epitopes in human brain endothelial cells
    • DOI 10.1111/j.1471-4159.2005.03463.x
    • A Abulrob H Sprong P Van Bergen en Henegouwen D Stanimirovic 2005 The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells J Neurochem 95 4 1201 1214 10.1111/j.1471-4159.2005.03463.x (Pubitemid 41713502)
    • (2005) Journal of Neurochemistry , vol.95 , Issue.4 , pp. 1201-1214
    • Abulrob, A.1    Sprong, H.2    Van Bergen En Henegouwen, P.3    Stanimirovic, D.4
  • 41
    • 11444267033 scopus 로고    scopus 로고
    • Production of a novel camel single-domain antibody specific for the type III mutant EGFR
    • DOI 10.1159/000081395
    • K Omidfar MJ Rasaee H Modjtahedi M Forouzandeh M Taghikhani N Golmakani 2004 Production of a novel camel single-domain antibody specific for the type III mutant EGFR Tumour Biol 25 5-6 296 305 10.1159/000081395 (Pubitemid 40082334)
    • (2004) Tumor Biology , vol.25 , Issue.5-6 , pp. 296-305
    • Omidfar, K.1    Rasaee, M.J.2    Modjtahedi, H.3    Forouzandeh, M.4    Taghikhani, M.5    Golmakani, N.6
  • 44
    • 53349171633 scopus 로고    scopus 로고
    • Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: Taking advantage of modular Nanobody technology
    • 10.1158/1535-7163.MCT-07-2384
    • BM Tijink T Laeremans M Budde M Stigter-van Walsum T Dreier HJ de Haard CR Leemans GA van Dongen 2008 Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology Mol Cancer Ther 7 8 2288 2297 10.1158/1535-7163.MCT-07-2384
    • (2008) Mol Cancer Ther , vol.7 , Issue.8 , pp. 2288-2297
    • Tijink, B.M.1    Laeremans, T.2    Budde, M.3    Stigter-Van Walsum, M.4    Dreier, T.5    De Haard, H.J.6    Leemans, C.R.7    Van Dongen, G.A.8
  • 45
    • 27644539907 scopus 로고    scopus 로고
    • The production and characterization of novel heavy-chain antibodies against the tandem repeat region of MUC1 mucin
    • DOI 10.1080/08820130500265356
    • F Rahbarizadeh MJ Rasaee M Forouzandeh A Allameh R Sarrami H Nasiry M Sadeghizadeh 2005 The production and characterization of novel heavy-chain antibodies against the tandem repeat region of MUC1 mucin Immunol Invest 34 4 431 452 10.1080/08820130500265356 (Pubitemid 41572137)
    • (2005) Immunological Investigations , vol.34 , Issue.4 , pp. 431-452
    • Rahbarizadeh, F.1    Rasaee, M.J.2    Forouzandeh, M.3    Allameh, A.4    Sarrami, R.5    Nasiry, H.6    Sadeghizadeh, M.7
  • 46
    • 54249167046 scopus 로고    scopus 로고
    • Production and characterization of a high-affinity nanobody against human endoglin
    • 10.1089/hyb.2008.0014
    • D Ahmadvand MJ Rasaee F Rahbarizadeh M Mohammadi 2008 Production and characterization of a high-affinity nanobody against human endoglin Hybridoma (Larchmt) 27 5 353 360 10.1089/hyb.2008.0014
    • (2008) Hybridoma (Larchmt) , vol.27 , Issue.5 , pp. 353-360
    • Ahmadvand, D.1    Rasaee, M.J.2    Rahbarizadeh, F.3    Mohammadi, M.4
  • 48
    • 34347248421 scopus 로고    scopus 로고
    • Alpaca (Lama pacos) as a convenient source of recombinant camelid heavy chain antibodies (VHHs)
    • DOI 10.1016/j.jim.2007.04.008, PII S0022175907001196
    • DR Maass J Sepulveda A Pernthaner CB Shoemaker 2007 Alpaca (Lama pacos) as a convenient source of recombinant camelid heavy chain antibodies (VHHs) J Immunol Methods 324 1-2 13 25 10.1016/j.jim.2007.04.008 (Pubitemid 47001424)
    • (2007) Journal of Immunological Methods , vol.324 , Issue.1-2 , pp. 13-25
    • Maass, D.R.1    Sepulveda, J.2    Pernthaner, A.3    Shoemaker, C.B.4
  • 49
    • 33845485045 scopus 로고    scopus 로고
    • Ablynx Makes Nanobodies from Llama Bodies
    • DOI 10.1016/j.chembiol.2006.12.003, PII S1074552106004339
    • W Wolfson 2006 Ablynx makes nanobodies from llama bodies Chem Biol 13 12 1243 1244 10.1016/j.chembiol.2006.12.003 (Pubitemid 44918391)
    • (2006) Chemistry and Biology , vol.13 , Issue.12 , pp. 1243-1244
    • Wolfson, W.1
  • 50
    • 27144461083 scopus 로고    scopus 로고
    • A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B
    • DOI 10.1182/blood-2005-03-1153
    • JJ Hulstein PG de Groot K Silence A Veyradier R Fijnheer PJ Lenting 2005 A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B Blood 106 9 3035 3042 10.1182/blood-2005-03-1153 (Pubitemid 41565896)
    • (2005) Blood , vol.106 , Issue.9 , pp. 3035-3042
    • Hulstein, J.J.J.1    De Groot, P.G.2    Silence, K.3    Veyradier, A.4    Fijnheer, R.5    Lenting, P.J.6
  • 51
    • 0036780877 scopus 로고    scopus 로고
    • Amyloid-β immunotherapy for Alzheimer's disease: The end of the beginning
    • DOI 10.1038/nrn938
    • D Schenk 2002 Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning Nat Rev Neurosci 3 10 824 828 10.1038/nrn938 (Pubitemid 135706694)
    • (2002) Nature Reviews Neuroscience , vol.3 , Issue.10 , pp. 824-828
    • Schenk, D.1
  • 53
    • 58249104047 scopus 로고    scopus 로고
    • Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation
    • 10.1016/j.molimm.2008.09.008
    • P Lafaye I Achour P England C Duyckaerts F Rougeon 2009 Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation Mol Immunol 46 4 695 704 10.1016/j.molimm.2008.09.008
    • (2009) Mol Immunol , vol.46 , Issue.4 , pp. 695-704
    • Lafaye, P.1    Achour, I.2    England, P.3    Duyckaerts, C.4    Rougeon, F.5
  • 56
    • 0141816702 scopus 로고    scopus 로고
    • A novel strategy using single-chain antibody to show the importance of Bcl-2 in mast cell survival
    • DOI 10.1182/blood-2002-12-3921
    • C Cohen-Saidon H Nechushtan S Kahlon N Livni A Nissim E Razin 2003 A novel strategy using single-chain antibody to show the importance of Bcl-2 in mast cell survival Blood 102 7 2506 2512 10.1182/blood-2002-12-3921 (Pubitemid 37193589)
    • (2003) Blood , vol.102 , Issue.7 , pp. 2506-2512
    • Cohen-Saidon, C.1    Nechushtan, H.2    Kahlon, S.3    Livni, N.4    Nissim, A.5    Razin, E.6
  • 62
    • 33644508625 scopus 로고    scopus 로고
    • A synthetic camel anti-lysozyme peptide antibody (peptibody) with flexible loop structure identified by high-resolution affinity mass spectrometry
    • DOI 10.1002/chem.200500785
    • A Marquardt S Muyldermans M Przybylski 2006 A synthetic camel anti-lysozyme peptide antibody (peptibody) with flexible loop structure identified by high-resolution affinity mass spectrometry Chem Eur J 12 7 1915 1923 10.1002/chem.200500785 (Pubitemid 43305281)
    • (2006) Chemistry - A European Journal , vol.12 , Issue.7 , pp. 1915-1923
    • Marquardt, A.1    Muyldermans, S.2    Przybylski, M.3
  • 64
    • 19444383993 scopus 로고    scopus 로고
    • Llama single domain antibodies as a tool for molecular mimicry
    • DOI 10.1016/j.jmb.2005.03.072, PII S0022283605003633
    • LM Zarebski M Urrutia FA Goldbaum 2005 Llama single domain antibodies as a tool for molecular mimicry J Mol Biol 349 4 814 824 10.1016/j.jmb.2005.03.072 (Pubitemid 40725956)
    • (2005) Journal of Molecular Biology , vol.349 , Issue.4 , pp. 814-824
    • Zarebski, L.M.1    Urrutia, M.2    Goldbaum, F.A.3
  • 66
    • 0037030412 scopus 로고    scopus 로고
    • Magic bullets hit the target
    • DOI 10.1038/417584a
    • T Gura 2002 Therapeutic antibodies: magic bullets hit the target Nature 417 6889 584 586 10.1038/417584a (Pubitemid 34614794)
    • (2002) Nature , vol.417 , Issue.6889 , pp. 584-586
    • Gura, T.1
  • 67
    • 44449085539 scopus 로고    scopus 로고
    • Paul Ehrlich's magic bullet concept: 100 Years of progress
    • DOI 10.1038/nrc2394, PII NRC2394
    • K Strebhardt A Ullrich 2008 Paul Ehrlich's magic bullet concept: 100 years of progress Nat Rev Cancer 8 6 473 480 10.1038/nrc2394 (Pubitemid 351752547)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.6 , pp. 473-480
    • Strebhardt, K.1    Ullrich, A.2
  • 70
    • 39049132442 scopus 로고    scopus 로고
    • Selection of cholera toxin specific IgNAR single-domain antibodies from a naive shark library
    • DOI 10.1016/j.molimm.2006.07.299, PII S0161589006005694
    • JL Liu GP Anderson JB Delehanty R Baumann A Hayhurst ER Goldman 2007 Selection of cholera toxin specific IgNAR single-domain antibodies from a naïve shark library Mol Immunol 44 7 1775 1783 10.1016/j.molimm.2006.07.299 (Pubitemid 44803164)
    • (2007) Molecular Immunology , vol.44 , Issue.7 , pp. 1786-1794
    • Liu, J.L.1    Anderson, G.P.2    Delehanty, J.B.3    Baumann, R.4    Hayhurst, A.5    Goldman, E.R.6
  • 71
    • 56449104900 scopus 로고    scopus 로고
    • Thermostable llama single domain antibodies for detection of botulinum A neurotoxin complex
    • 10.1021/ac8014774
    • ER Goldman GP Anderson J Conway LJ Sherwood M Fech B Vo JL Liu A Hayhurst 2008 Thermostable llama single domain antibodies for detection of botulinum A neurotoxin complex Anal Chem 80 22 8583 8591 10.1021/ac8014774
    • (2008) Anal Chem , vol.80 , Issue.22 , pp. 8583-8591
    • Goldman, E.R.1    Anderson, G.P.2    Conway, J.3    Sherwood, L.J.4    Fech, M.5    Vo, B.6    Liu, J.L.7    Hayhurst, A.8
  • 73
    • 38749138813 scopus 로고    scopus 로고
    • The unique properties of camelid IgG have potential to improve the treatment of snake bite
    • RA Harrison U Wernery 2007 The unique properties of camelid IgG have potential to improve the treatment of snake bite J Camel Pract Res 14 1 15 16
    • (2007) J Camel Pract Res , vol.14 , Issue.1 , pp. 15-16
    • Harrison, R.A.1    Wernery, U.2
  • 74
    • 1642493838 scopus 로고    scopus 로고
    • Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxins
    • DOI 10.1016/j.toxicon.2003.10.021
    • F Meddeb-Mouelhi B Bouhaouala-Zahar Z Benlasfar M Hammadi T Mejri M Moslah H Karoui T Khorchani M El Ayeb 2003 Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxins Toxicon 42 7 785 791 10.1016/j.toxicon.2003.10.021 (Pubitemid 38125038)
    • (2003) Toxicon , vol.42 , Issue.7 , pp. 785-791
    • Meddeb-Mouelhi, F.1    Bouhaouala-Zahar, B.2    Benlasfar, Z.3    Hammadi, M.4    Mejri, T.5    Moslah, M.6    Karoui, H.7    Khorchani, T.8    Ayeb, M.E.9
  • 75
    • 33644512108 scopus 로고    scopus 로고
    • Neutralisation of venom-induced haemorrhage by IgG from camels and llamas immunised with viper venom and also by endogenous, non-IgG components in camelid sera
    • DOI 10.1016/j.toxicon.2005.10.017, PII S0041010105003740
    • RA Harrison SS Hasson M Harmsen GD Laing K Conrath RD Theakston 2006 Neutralisation of venom-induced haemorrhage by IgG from camels and llamas immunised with viper venom and also by endogenous, non-IgG components in camelid sera Toxicon 47 3 364 368 10.1016/j.toxicon.2005.10.017 (Pubitemid 43294466)
    • (2006) Toxicon , vol.47 , Issue.3 , pp. 364-368
    • Harrison, R.A.1    Hasson, S.S.2    Harmsen, M.3    Laing, G.D.4    Conrath, K.5    Theakston, R.D.G.6
  • 76
    • 33947306907 scopus 로고    scopus 로고
    • Isolation, characterization and pentamerization of α-cobrotoxin specific single-domain antibodies from a naive phage display library: Preliminary findings for antivenom development
    • DOI 10.1016/j.toxicon.2006.11.023, PII S0041010106004314
    • CS Stewart CR MacKenzie JC Hall 2007 Isolation, characterization and pentamerization of alpha-cobrotoxin specific single-domain antibodies from a naïve phage display library: preliminary findings for antivenom development Toxicon 49 5 699 709 10.1016/j.toxicon.2006.11.023 (Pubitemid 46441367)
    • (2007) Toxicon , vol.49 , Issue.5 , pp. 699-709
    • Stewart, C.S.1    MacKenzie, C.R.2    Christopher Hall, J.3
  • 77
    • 48049096810 scopus 로고    scopus 로고
    • VHH, bivalent domains and chimeric heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI
    • 10.1016/j.molimm.2008.04.011
    • I Hmila RBA Abdallah D Saerens Z Benlasfar K Conrath ME Ayeb S Muyldermans B Bouhaouala-Zahar 2008 VHH, bivalent domains and chimeric heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI Mol Immunol 45 14 3847 3856 10.1016/j.molimm.2008.04.011
    • (2008) Mol Immunol , vol.45 , Issue.14 , pp. 3847-3856
    • Hmila, I.1    Abdallah, R.B.A.2    Saerens, D.3    Benlasfar, Z.4    Conrath, K.5    Ayeb, M.E.6    Muyldermans, S.7    Bouhaouala-Zahar, B.8
  • 78
    • 48049099663 scopus 로고    scopus 로고
    • Cloning, expression, and characterization of a single-domain antibody fragment with affinity for 15-acetyl-deoxynivalenol
    • 10.1016/j.molimm.2008.06.005
    • PJ Doyle M Arbabi-Ghahroudi N Gaudette G Furzer ME Savard S Gleddie MD McLean CR MacKenzie JC Hall 2008 Cloning, expression, and characterization of a single-domain antibody fragment with affinity for 15-acetyl-deoxynivalenol Mol Immunol 45 14 3703 3713 10.1016/j.molimm.2008.06.005
    • (2008) Mol Immunol , vol.45 , Issue.14 , pp. 3703-3713
    • Doyle, P.J.1    Arbabi-Ghahroudi, M.2    Gaudette, N.3    Furzer, G.4    Savard, M.E.5    Gleddie, S.6    Hall, J.C.7
  • 79
    • 0034673109 scopus 로고    scopus 로고
    • Camelid heavy-chain variable domains provide efficient combining sites to haptens
    • DOI 10.1021/bi991830w
    • S Spinelli LG Frenken P Hermans T Verrips K Brown M Tegoni C Cambillau 2000 Camelid heavy-chain variable domains provide efficient combining sites to haptens Biochemistry 39 6 1217 1222 10.1021/bi991830w (Pubitemid 30090687)
    • (2000) Biochemistry , vol.39 , Issue.6 , pp. 1217-1222
    • Spinelli, S.1    Frenken, L.G.J.2    Hermans, P.3    Verrips, T.4    Brown, K.5    Tegoni, M.6    Cambillau, C.7
  • 80
    • 33745686158 scopus 로고    scopus 로고
    • Isolation and characterization of a thermally stable recombinant anti-caffeine heavy-chain antibody fragment
    • 10.1021/ac058044j
    • RC Ladenson DL Crimmins Y Landt JH Ladenson 2006 Isolation and characterization of a thermally stable recombinant anti-caffeine heavy-chain antibody fragment Anal Chem 78 13 4501 4508 10.1021/ac058044j
    • (2006) Anal Chem , vol.78 , Issue.13 , pp. 4501-4508
    • Ladenson, R.C.1    Crimmins, D.L.2    Landt, Y.3    Ladenson, J.H.4
  • 81
    • 53049108890 scopus 로고    scopus 로고
    • TNT detection using llama antibodies and a two-step competitive fluid array immunoassay
    • 10.1016/j.jim.2008.08.001
    • GP Anderson ER Goldman 2008 TNT detection using llama antibodies and a two-step competitive fluid array immunoassay J Immunol Methods 339 1 47 54 10.1016/j.jim.2008.08.001
    • (2008) J Immunol Methods , vol.339 , Issue.1 , pp. 47-54
    • Anderson, G.P.1    Goldman, E.R.2
  • 83
    • 33644869654 scopus 로고    scopus 로고
    • Antibody pretargeting advances cancer radioimmunodetection and radioimmunotherapy
    • DOI 10.1200/JCO.2005.03.8471
    • DM Goldenberg RM Sharkey G Paganelli J Barbet JF Chatal 2006 Antibody pretargeting advances cancer radioimmunodetection and radioimmunotherapy J Clin Oncol 24 5 823 834 10.1200/JCO.2005.03.8471 (Pubitemid 46671186)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.5 , pp. 823-834
    • Goldenberg, D.M.1    Sharkey, R.M.2    Paganelli, G.3    Barbet, J.4    Chatal, J.-F.5
  • 85
    • 52649114833 scopus 로고    scopus 로고
    • Llama-derived single-chain antibody fragments directed to rotavirus VP6 protein possess broad neutralizing activity in vitro and confer protection against diarrhea in mice
    • 10.1128/JVI.00436-08
    • L Garaicoechea A Olichon G Marcoppido A Wigdorovitz M Mozgovoj L Saif T Surrey V Parreño 2008 Llama-derived single-chain antibody fragments directed to rotavirus VP6 protein possess broad neutralizing activity in vitro and confer protection against diarrhea in mice J Virol 82 19 9753 9764 10.1128/JVI.00436-08
    • (2008) J Virol , vol.82 , Issue.19 , pp. 9753-9764
    • Garaicoechea, L.1    Olichon, A.2    Marcoppido, G.3    Wigdorovitz, A.4    Mozgovoj, M.5    Saif, L.6    Surrey, T.7    Parreño, V.8
  • 87
    • 51649091611 scopus 로고    scopus 로고
    • Passive immunization of pigs with bispecific llama single-domain antibody fragments against foot-and-mouth disease and porcine immunoglobulin
    • 10.1016/j.vetmic.2008.04.030
    • MM Harmsen HP Fijten A Dekker PL Eblé 2008 Passive immunization of pigs with bispecific llama single-domain antibody fragments against foot-and-mouth disease and porcine immunoglobulin Vet Microbiol 132 1-2 56 64 10.1016/j.vetmic.2008.04.030
    • (2008) Vet Microbiol , vol.132 , Issue.12 , pp. 56-64
    • Harmsen, M.M.1    Fijten, H.P.2    Dekker, A.3    Eblé, P.L.4
  • 91
    • 0242300184 scopus 로고    scopus 로고
    • Intracellularly Expressed Single-Domain Antibody against p15 Matrix Protein Prevents the Production of Porcine Retroviruses
    • DOI 10.1128/JVI.77.22.12132-12139.2003
    • S Dekker W Toussaint G Panayotou T de Wit P Visser F Grosveld D Drabek 2003 Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses J Virol 77 22 12132 12139 10.1128/JVI.77.22.12132-12139.2003 (Pubitemid 37339866)
    • (2003) Journal of Virology , vol.77 , Issue.22 , pp. 12132-12139
    • Dekker, S.1    Toussaint, W.2    Panayotou, G.3    De Wit, T.4    Visser, P.5    Grosveld, F.6    Drabek, D.7
  • 92
    • 38449097605 scopus 로고    scopus 로고
    • Rapid assembly of sensitive antigen-capture assays for Marburg virus, using in vitro selection of llama single-domain antibodies, at biosafety level 4
    • 10.1086/520586
    • LJ Sherwood LE Osborn R Carrion JL Patterson A Hayhurst 2007 Rapid assembly of sensitive antigen-capture assays for Marburg virus, using in vitro selection of llama single-domain antibodies, at biosafety level 4 J Infect Dis 196 Suppl 2 S213 S219 10.1086/520586
    • (2007) J Infect Dis , vol.196 , Issue.SUPPL 2
    • Sherwood, L.J.1    Osborn, L.E.2    Carrion, R.3    Patterson, J.L.4    Hayhurst, A.5
  • 94
    • 4344659634 scopus 로고    scopus 로고
    • Bactericidal effects of a fusion protein of llama heavy-chain antibodies coupled to glucose oxidase on oral bacteria
    • DOI 10.1128/AAC.48.9.3390-3395.2004
    • A Szynol JJ de Soet E Sieben-van Tuyl JW Bos LG Frenken 2004 Bactericidal effects of a fusion protein of llama heavy-chain antibodies coupled to glucose oxidase on oral bacteria Antimicrob Agents Chemother 48 9 3390 3395 10.1128/AAC.48.9.3390-3395.2004 (Pubitemid 39129335)
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , Issue.9 , pp. 3390-3395
    • Szynol, A.1    De Soet, J.J.2    Sieben-Van Tuyl, E.3    Bos, J.W.4    Frenken, L.G.5
  • 96
    • 59649092183 scopus 로고    scopus 로고
    • Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody
    • 10.1016/j.str.2008.11.011
    • KV Korotkov E Pardon J Steyaert WG Hol 2009 Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody Structure 17 2 255 265 10.1016/j.str.2008.11.011
    • (2009) Structure , vol.17 , Issue.2 , pp. 255-265
    • Korotkov, K.V.1    Pardon, E.2    Steyaert, J.3    Hol, W.G.4
  • 97
    • 60949108827 scopus 로고    scopus 로고
    • Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus
    • 10.1016/j.jsb.2008.11.008
    • AY Lam E Pardon KV Korotkov WG Hol J Steyaert 2009 Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus J Struct Biol 166 1 8 15 10.1016/j.jsb.2008.11.008
    • (2009) J Struct Biol , vol.166 , Issue.1 , pp. 8-15
    • Lam, A.Y.1    Pardon, E.2    Korotkov, K.V.3    Hol, W.G.4    Steyaert, J.5
  • 98
    • 30044442097 scopus 로고    scopus 로고
    • Lactococcal bacteriophage p2 receptor-binding protein structure suggests a common ancestor gene with bacterial and mammalian viruses
    • DOI 10.1038/nsmb1029
    • S Spinelli A Desmyter CT Verrips HJ de Haard S Moineau C Cambillau 2006 Lactococcal bacteriophage p2 receptor-binding protein structure suggests a common ancestor gene with bacterial and mammalian viruses Nat Struct Mol Biol 13 1 85 89 10.1038/nsmb1029 (Pubitemid 43049407)
    • (2006) Nature Structural and Molecular Biology , vol.13 , Issue.1 , pp. 85-89
    • Spinelli, S.1    Desmyter, A.2    Verrips, C.T.3    De Haard, H.J.W.4    Moineau, S.5    Cambillau, C.6
  • 103
    • 55849135165 scopus 로고    scopus 로고
    • Relevance of the diversity among members of the Trypanosoma cruzi trans-sialidase family analyzed with camelids single-domain antibodies
    • 10.1371/journal.pone.0003524
    • L Ratier M Urrutia G Paris L Zarebski AC Frasch FA Goldbaum 2008 Relevance of the diversity among members of the Trypanosoma cruzi trans-sialidase family analyzed with camelids single-domain antibodies PLoS One 3 10 e3524 10.1371/journal.pone.0003524
    • (2008) PLoS One , vol.3 , Issue.10 , pp. 3524
    • Ratier, L.1    Urrutia, M.2    Paris, G.3    Zarebski, L.4    Frasch, A.C.5    Goldbaum, F.A.6
  • 106
    • 0028962371 scopus 로고
    • A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
    • 10.1038/374168a0
    • AS Greenberg D Avila M Hughes A Hughes EC McKinney MF Flajnik 1995 A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks Nature 374 6518 168 173 10.1038/374168a0
    • (1995) Nature , vol.374 , Issue.6518 , pp. 168-173
    • Greenberg, A.S.1    Avila, D.2    Hughes, M.3    Hughes, A.4    Flajnik, M.F.5
  • 107
    • 59149104037 scopus 로고    scopus 로고
    • General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold
    • 10.1074/jbc.M806889200
    • C Vincke R Loris D Saerens S Martinez-Rodriguez S Muyldermans K Conrath 2009 General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold J Biol Chem 284 5 3273 3284 10.1074/jbc.M806889200
    • (2009) J Biol Chem , vol.284 , Issue.5 , pp. 3273-3284
    • Vincke, C.1    Loris, R.2    Saerens, D.3    Martinez-Rodriguez, S.4    Muyldermans, S.5    Conrath, K.6
  • 108
  • 112
    • 28444477403 scopus 로고    scopus 로고
    • Over expression of anti-MUC1 single-domain antibody fragments in the yeast Pichia pastoris
    • DOI 10.1016/j.molimm.2005.03.003, PII S0161589005000635
    • F Rahbarizadeh MJ Rasaee M Forouzandeh AA Allameh 2006 Over expression of anti-MUC1 single-domain antibody fragments in the yeast Pichia pastoris Mol Immunol 43 5 426 435 10.1016/j.molimm.2005.03.003 (Pubitemid 41740431)
    • (2006) Molecular Immunology , vol.43 , Issue.5 , pp. 426-435
    • Rahbarizadeh, F.1    Rasaee, M.J.2    Forouzandeh, M.3    Allameh, A.-A.4
  • 113
    • 67649637576 scopus 로고    scopus 로고
    • Head-to-tail fusions of camelid antibodies can be expressed in planta and bind in rumen fluid
    • S Winichayakul A Pernthaner R Scott R Vlaming N Roberts 2008 Head-to-tail fusions of camelid antibodies can be expressed in planta and bind in rumen fluid Biotechnol Appl Biochem 53 Pt 2 111 122
    • (2008) Biotechnol Appl Biochem , vol.53 , Issue.PT 2 , pp. 111-122
    • Winichayakul, S.1    Pernthaner, A.2    Scott, R.3    Vlaming, R.4    Roberts, N.5
  • 115
    • 10644287538 scopus 로고    scopus 로고
    • Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen
    • DOI 10.1074/jbc.M409292200
    • D Saerens J Kinne E Bosmans U Wernery S Muyldermans K Conrath 2004 Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen J Biol Chem 279 50 51965 51972 10.1074/jbc.M409292200 (Pubitemid 39656566)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.50 , pp. 51965-51972
    • Saerens, D.1    Kinne, J.2    Bosmans, E.3    Wernery, U.4    Muyldermans, S.5    Conrath, K.6
  • 117
    • 65449169579 scopus 로고    scopus 로고
    • Prevention of oculopharyngeal muscular dystrophy by muscular expression of Llama single-chain intrabodies in vivo
    • 10.1093/hmg/ddp101
    • A Chartier V Raz E Sterrenburg CT Verrips SM van der Maarel M Simonelig 2009 Prevention of oculopharyngeal muscular dystrophy by muscular expression of Llama single-chain intrabodies in vivo Hum Mol Genet 18 10 1849 1859 10.1093/hmg/ddp101
    • (2009) Hum Mol Genet , vol.18 , Issue.10 , pp. 1849-1859
    • Chartier, A.1    Raz, V.2    Sterrenburg, E.3    Verrips, C.T.4    Van Der Maarel, S.M.5    Simonelig, M.6
  • 119
    • 38649143625 scopus 로고    scopus 로고
    • Isolation of anti-toxin single domain antibodies from a semi-synthetic spiny dogfish shark display library
    • DOI 10.1186/1472-6750-7-78
    • JL Liu GP Anderson ER Goldman 2007 Isolation of anti-toxin single domain antibodies from a semi-synthetic spiny dogfish shark display library BMC Biotechnol 7 78 10.1186/1472-6750-7-78 (Pubitemid 351167776)
    • (2007) BMC Biotechnology , vol.7 , pp. 78
    • Liu, J.L.1    Anderson, G.P.2    Goldman, E.R.3
  • 121
    • 27644445089 scopus 로고    scopus 로고
    • Escherichia coli F4 fimbriae specific llama single-domain antibody fragments effectively inhibit bacterial adhesion in vitro but poorly protect against diarrhoea
    • DOI 10.1016/j.vetmic.2005.09.005, PII S0378113505003068
    • MM Harmsen CB van Solt A Hoogendoorn FG van Zijderveld TA Niewold J van der Meulen 2005 Escherichia coli F4 fimbriae specific llama single-domain antibody fragments effectively inhibit bacterial adhesion in vitro but poorly protect against diarrhoea Vet Microbiol 111 1-2 89 98 10.1016/j.vetmic.2005.09. 005 (Pubitemid 41578945)
    • (2005) Veterinary Microbiology , vol.111 , Issue.1-2 , pp. 89-98
    • Harmsen, M.M.1    Van Solt, C.B.2    Hoogendoorn, A.3    Van Zijderveld, F.G.4    Niewold, T.A.5    Van Der Meulen, J.6
  • 124
    • 4544250973 scopus 로고    scopus 로고
    • Crystal structure of a shark single-domain antibody V region in complex with lysozyme
    • DOI 10.1126/science.1101148
    • RL Stanfield H Dooley MF Flajnik IA Wilson 2004 Crystal structure of a shark single-domain antibody V region in complex with lysozyme Science 305 5691 1770 1773 10.1126/science.1101148 (Pubitemid 39249643)
    • (2004) Science , vol.305 , Issue.5691 , pp. 1770-1773
    • Stanfield, R.L.1    Dooley, H.2    Flajnik, M.F.3    Wilson, I.A.4
  • 126
    • 0027971497 scopus 로고
    • Three-dimensional structures of the free and the antigen-complexed Fab from monoclonal anti-lysozyme antibody D44.1
    • DOI 10.1016/0022-2836(94)90046-9
    • BC Braden H Souchon JL Eisele GA Bentley TN Bhat J Navaza RJ Poljak 1994 Three-dimensional structures of the free and the antigen-complexed Fab from monoclonal anti-lysozyme antibody D44.1 J Mol Biol 243 4 767 781 10.1016/0022-2836(94)90046-9 (Pubitemid 24341717)
    • (1994) Journal of Molecular Biology , vol.243 , Issue.4 , pp. 767-781
    • Braden, B.C.1    Souchon, H.2    Eisele, J.-L.3    Bentley, G.A.4    Bhat, T.N.5    Navaza, J.6    Poljak, R.J.7
  • 127
    • 33847138258 scopus 로고    scopus 로고
    • Production of chimeric recombinant single domain antibody-green fluorescent fusion protein in Chinese hamster ovary cells
    • DOI 10.1089/hyb.2006.037
    • MR Bazl MJ Rasaee M Foruzandeh A Rahimpour J Kiani F Rahbarizadeh B Alirezapour M Mohammadi 2007 Production of chimeric recombinant single domain antibody-green fluorescent fusion protein in Chinese hamster ovary cells Hybridoma (Larchmt) 26 1 1 9 10.1089/hyb.2006.037 (Pubitemid 46294367)
    • (2007) Hybridoma , vol.26 , Issue.1 , pp. 1-9
    • Bazl, M.R.1    Rasaee, M.J.2    Foruzandeh, M.3    Rahimpour, A.4    Kiani, J.5    Rahbarizadeh, F.6    Alirezapour, B.7    Mohammadi, M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.