Selection and characterization of KDEL-specific VHH antibody fragments and their application in the study of ER resident protein expression

Journal of Immunological Methods

Volumn 342, Issue 1-2, 2009, Pages 1-12

  Klooster, Rinse ^a   Eman, Michael R ^a,b   le Duc, Quint ^a   Verheesen, Peter ^a   Verrips, C Theo ^a   Roovers, Rob C ^a   Post, Jan A ^a  

^a Institute of Biomembranes   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Common epitope; Endoplasmic reticulum; ER retention signal; Unfolded protein response; VHH, phage display

Indexed keywords

ANTIBODY; ASPARTIC ACID; EPITOPE; GLUTAMIC ACID; IMMUNOGLOBULIN HEAVY CHAIN; LEUCINE; LYSINE;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL AGING; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PEROXISOME; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; DOWN-REGULATION; ENDOPLASMIC RETICULUM; HELA CELLS; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PROTEIN FOLDING; RECEPTORS, PEPTIDE; RECOMBINANT PROTEINS; UP-REGULATION;

EID: 59949088708     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2008.10.009     Document Type: Article

References (46)

1. Arvas M., Pakula T., Lanthaler K., Saloheimo M., Valkonen M., Suortti T., Robson G., and Penttila M. Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae. BMC Genomics 7 (2006) 32
2. Benham A.M., Cabibbo A., Fassio A., Bulleid N., Sitia R., and Braakman I. The CXXCXXC motif determines the folding, structure and stability of human Ero1-Lalpha. Embo J. 19 (2000) 4493
3. Bertolotti A., Zhang Y., Hendershot L.M., Harding H.P., and Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2 (2000) 326
4. Conrath K.E., Lauwereys M., Galleni M., Matagne A., Frere J.M., Kinne J., Wyns L., and Muyldermans S. Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae. Antimicrob. Agents Chemother. 45 (2001) 2807
5. Cox J.S., Chapman R.E., and Walter P. The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane. Mol. Biol. Cell 8 (1997) 1805
6. De Genst E., Silence K., Decanniere K., Conrath K., Loris R., Kinne J., Muyldermans S., and Wyns L. Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 4586
7. De Haard H.J., Bezemer S., Ledeboer A.M., Muller W.H., Boender P.J., Moineau S., Coppelmans M.C., Verkleij A.J., Frenken L.G., and Verrips C.T. Llama antibodies against a lactococcal protein located at the tip of the phage tail prevent phage infection. J. Bacteriol. 187 (2005) 4531
8. Du J., Wang H., Zhong C., Peng B., Zhang M., Li B., Huo S., Guo Y., and Ding J. Structural basis for recognition of CD20 by therapeutic antibody Rituximab. J. Biol. Chem. 282 (2007) 15073
9. Eman M.R., Regan-Klapisz E., Pinkse M.W., Koop I.M., Haverkamp J., Heck A.J., Verkleij A.J., and Post J.A. Protein expression dynamics during replicative senescence of endothelial cells studied by 2-D difference in-gel electrophoresis. Electrophoresis 27 (2006) 1669
10. Friedlander R., Jarosch E., Urban J., Volkwein C., and Sommer T. A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat. Cell Biol. 2 (2000) 379
11. Hamers-Casterman C., Atarhouch T., Muyldermans S., Robinson G., Hamers C., Songa E.B., Bendahman N., and Hamers R. Naturally occurring antibodies devoid of light chains. Nature 363 (1993) 446
12. Harding H.P., Zhang Y., and Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397 (1999) 271
13. Hobbs H.H., Brown M.S., and Goldstein J.L. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Hum. Mutat. 1 (1992) 445
14. Hoozemans J.J., Veerhuis R., Van Haastert E.S., Rozemuller J.M., Baas F., Eikelenboom P., and Scheper W. The unfolded protein response is activated in Alzheimer's disease. Acta Neuropathol. 110 (2005) 165
15. Jaffe E.A., Nachman R.L., Becker C.G., and Minick C.R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52 (1973) 2745
16. Kim P.S., and Arvan P. Endocrinopathies in the family of endoplasmic reticulum (ER) storage diseases: disorders of protein trafficking and the role of ER molecular chaperones. Endocr. Rev. 19 (1998) 173
17. Kolkman A., Olsthoorn M.M., Heeremans C.E., Heck A.J., and Slijper M. Comparative proteome analysis of Saccharomyces cerevisiae grown in chemostat cultures limited for glucose or ethanol. Mol. Cell. Proteomics. 4 (2005) 1
18. Kozutsumi Y., Segal M., Normington K., Gething M.J., and Sambrook J. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature 332 (1988) 462
19. Li J., and Holbrook N.J. Elevated gadd153/chop expression and enhanced c-Jun N-terminal protein kinase activation sensitizes aged cells to ER stress. Exp. Gerontol. 39 (2004) 735
20. Li S., Schmitz K.R., Jeffrey P.D., Wiltzius J.J., Kussie P., and Ferguson K.M. Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. Cancer Cell 7 (2005) 301
21. Lukacs G.L., Mohamed A., Kartner N., Chang X.B., Riordan J.R., and Grinstein S. Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP. Embo J. 13 (1994) 6076
22. Majoul I., Sohn K., Wieland F.T., Pepperkok R., Pizza M., Hillemann J., and Soling H.D. KDEL receptor (Erd2p)-mediated retrograde transport of the cholera toxin A subunit from the Golgi involves COPI, p23, and the COOH terminus of Erd2p. J. Cell Biol. 143 (1998) 601
23. Marks J.D., Hoogenboom H.R., Bonnert T.P., McCafferty J., Griffiths A.D., and Winter G. By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 222 (1991) 581
24. Martinez I.M., and Chrispeels M.J. Genomic analysis of the unfolded protein response in Arabidopsis shows its connection to important cellular processes. Plant. Cell. 15 (2003) 561
25. Munro S., and Pelham H.R. A C-terminal signal prevents secretion of luminal ER proteins. Cell 48 (1987) 899
26. Okamura K., Kimata Y., Higashio H., Tsuru A., and Kohno K. Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast. Biochem. Biophys. Res. Commun. 279 (2000) 445
27. Orrenius S., Zhivotovsky B., and Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat. Rev., Mol. Cell Biol. 4 (2003) 552
28. Pakula T.M., Laxell M., Huuskonen A., Uusitalo J., Saloheimo M., and Penttila M. The effects of drugs inhibiting protein secretion in the filamentous fungus Trichoderma reesei. Evidence for down-regulation of genes tha encode secreted proteins in the stressed cells. J. Biol. Chem. 278 (2003) 45011
29. Rabek J.P., Boylston III W.H., and Papaconstantinou J. Carbonylation of ER chaperone proteins in aged mouse liver. Biochem. Biophys. Res. Commun. 305 (2003) 566
30. Roovers R.C., Laeremans T., Huang L., De Taeye S., Verkleij A.J., Revets H., de Haard H.J., and van Bergen en Henegouwen P.M. Efficient inhibition of EGFR signaling and of tumour growth by antagonistic anti-EFGR Nanobodies. Cancer Immunol. Immunother. 56 (2007) 303
31. Rutishauser J., and Spiess M. Endoplasmic reticulum storage diseases. Swiss Med. Wkly. 132 (2002) 211
32. Sanger F., Nicklen S., and Coulson A.R. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. U. S. A. 74 (1977) 5463
33. Scheel A.A., and Pelham H.R. Purification and characterization of the human KDEL receptor. Biochemistry 35 (1996) 10203
34. Schroder M., and Kaufman R.J. ER stress and the unfolded protein response. Mutat. Res. 569 (2005) 29
35. Shen J., Chen X., Hendershot L., and Prywes R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell. 3 (2002) 99
36. Shevchenko A., Wilm M., Vorm O., and Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 68 (1996) 850
37. Stausbol-Gron B., Wind T., Kjaer S., Kahns L., Hansen N.J., Kristensen P., and Clark B.F. A model phage display subtraction method with potential for analysis of differential gene expression. FEBS. Lett. 391 (1996) 71
38. Travers K.J., Patil C.K., Wodicka L., Lockhart D.J., Weissman J.S., and Walter P. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101 (2000) 249
39. van der Vlies D., Pap E.H., Post J.A., Celis J.E., and Wirtz K.W. Endoplasmic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide. Biochem. J. 366 (2002) 825
40. van der Vlies D., Woudenberg J., and Post J.A. Protein oxidation in aging: endoplasmic reticulum as a target. Amino Acids 25 (2003) 397
41. Van Ewijk W., de Kruif J., Germeraad W.T., Berendes P., Ropke C., Platenburg P.P., and Logtenberg T. Subtractive isolation of phage-displayed single-chain antibodies to thymic stromal cells by using intact thymic fragments. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 3903
42. van Koningsbruggen S., de Haard H., de Kievit P., Dirks R.W., van Remoortere A., Groot A.J., van Engelen B.G., den Dunnen J.T., Verrips C.T., Frants R.R., and van der Maarel S.M. Llama-derived phage display antibodies in the dissection of the human disease oculopharyngeal muscular dystrophy. J. Immunol. Methods 279 (2003) 149
43. Vattemi G., Engel W.K., McFerrin J., and Askanas V. Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle. Am. J. Pathol. 164 (2004) 1
44. Vaughan T.J., Williams A.J., Pritchard K., Osbourn J.K., Pope A.R., Earnshaw J.C., McCafferty J., Hodits R.A., Wilton J., and Johnson K.S. Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library. Nat. Biotechnol. 14 (1996) 309
45. Wilson D.W., Lewis M.J., and Pelham H.R. pH-dependent binding of KDEL to its receptor in vitro. J. Biol. Chem. 268 (1993) 7465
46. Yoneda T., Imaizumi K., Oono K., Yui D., Gomi F., Katayama T., and Tohyama M. Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J. Biol. Chem. 276 (2001) 13935