Generation of a family-specific phage library of llama single chain antibody fragments that neutralize HIV-1

Journal of Biological Chemistry

Volumn 285, Issue 25, 2010, Pages 19116-19124

  Koh, Willie W L ^a   Steffensen, Soren ^b   Gonzalez Pajuelo, Maria ^b   Hoorelbeke, Bart ^b,d   Gorlani, Andrea ^c   Szynol, Agnieszka ^c   Forsman, Anna ^a   Aasa Chapman, Marlén M I ^a   De Haard, Hans ^c   Verrips, Theo ^c   Weiss, Robin A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ABLYNX NV   (Belgium)

^c UTRECHT UNIVERSITY   (Netherlands)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY FRAGMENT; BINDING AFFINITIES; ENVELOPE GLYCOPROTEINS; HUMAN IMMUNODEFICIENCY VIRUS; NUCLEOTIDE SEQUENCES; PHAGE LIBRARIES; POSITIVE CORRELATIONS; SEQUENCE ANALYSIS; SINGLE-CHAIN ANTIBODIES; VACCINE DEVELOPMENT; VIRUS STRAINS;

AMINO ACIDS; BACTERIOPHAGES; BINDING ENERGY; ORGANIC ACIDS;

ANTIBODIES;

CD4 ANTIGEN; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; VIRUS ENVELOPE PROTEIN;

AMINO ACID SEQUENCE; ANTIBODY LIBRARY; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BIOENGINEERING; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG RESEARCH; ELUTION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN INTERACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; VIRUS ENVELOPE; VIRUS NEUTRALIZATION; VIRUS STRAIN; VIRUS TYPING;

AIDS VACCINES; ANTIBODIES; ANTIGENS, CD4; BASE SEQUENCE; BINDING SITES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE LIBRARY; SEQUENCE HOMOLOGY, NUCLEIC ACID; SINGLE-CHAIN ANTIBODIES;

HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA (MAMMAL);

EID: 77953513983     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.116699     Document Type: Article

References (57)

1. Wei, X., Decker, J. M., Wang, S., Hui, H., Kappes, J. C., Wu, X., Salazar-Gonzalez, J. F., Salazar, M. G., Kilby, J. M., Saag, M. S., Komarova, N. L., Nowak, M. A., Hahn, B. H., Kwong, P. D., and Shaw, G. M. (2003) Nature 422, 307-312
2. Richman, D. D., Wrin, T., Little, S. J., and Petropoulos, C. J. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 4144-4149
3. Frost, S. D., Wrin, T., Smith, D. M., Kosakovsky Pond, S. L., Liu, Y., Paxinos, E., Chappey, C., Galovich, J., Beauchaine, J., Petropoulos, C. J., Little, S. J., and Richman, D. D. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 18514-18519
4. Dalgleish, A. G., Beverley, P. C., Clapham, P. R., Crawford, D. H., Greaves, M. F., and Weiss, R. A. (1984) Nature 312, 763-767
5. Klatzmann, D., Champagne, E., Chamaret, S., Gruest, J., Guetard, D., Hercend, T., Gluckman, J. C., and Montagnier, L. (1984) Nature 312, 767-768
6. Deng, H., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R. E., Hill, C. M., Davis, C. B., Peiper, S. C., Schall, T. J., Littman, D. R., and Landau, N. R. (1996) Nature 381, 661-666
7. Dragic, T., Litwin, V., Allaway, G. P., Martin, S. R., Huang, Y., Nagashima, K. A., Cayanan, C., Maddon, P. J., Koup, R. A., Moore, J. P., and Paxton, W. A. (1996) Nature 381, 667-673
8. Alkhatib, G., Combadiere, C., Broder, C. C., Feng, Y., Kennedy, P. E., Murphy, P. M., and Berger, E. A. (1996) Science 272, 1955-1958
9. Feng, Y., Broder, C. C., Kennedy, P. E., and Berger, E. A. (1996) Science 272, 872-877
10. Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P. D., Wu, L., Mackay, C. R., LaRosa, G., Newman, W., Gerard, N., Gerard, C., and Sodroski, J. (1996) Cell 85, 1135-1148
11. Doranz, B. J., Rucker, J., Yi, Y., Smyth, R. J., Samson, M., Peiper, S. C., Parmentier, M., Collman, R. G., and Doms, R. W. (1996) Cell 85, 1149-1158
12. Willey, S., and Aasa-Chapman, M. M. (2008) Trends Microbiol. 16, 596-604
13. Burton, D. R., and Montefiori, D. C. (1997) AIDS 11, S87-S98
14. Binley, J. M., Wrin, T., Korber, B., Zwick, M. B., Wang, M., Chappey, C., Stiegler, G., Kunert, R., Zolla-Pazner, S., Katinger, H., Petropoulos, C. J., and Burton, D. R. (2004) J. Virol. 78, 13232-13252
15. Brodie, S. J., Lewinsohn, D. A., Patterson, B. K., Jiyamapa, D., Krieger, J., Corey, L., Greenberg, P. D., and Riddell, S. R. (1999) Nat. Med. 5, 34-41
16. Shibata, R., Igarashi, T., Haigwood, N., Buckler-White, A., Ogert, R., Ross, W., Willey, R., Cho, M. W., and Martin, M. A. (1999) Nat. Med. 5, 204-210
17. Putkonen, P., Thorstensson, R., Ghavamzadeh, L., Albert, J., Hild, K., Biberfeld, G., and Norrby, E. (1991) Nature 352, 436-438
18. Ferrantelli, F., Rasmussen, R. A., Buckley, K. A., Li, P. L., Wang, T., Montefiori, D. C., Katinger, H., Stiegler, G., Anderson, D. C., McClure, H. M., and Ruprecht, R. M. (2004) J. Infect. Dis. 189, 2167-2173
19. Yamamoto, H., Kawada, M., Takeda, A., Igarashi, H., and Matano, T. (2007) PLoS ONE 2, e540
20. Buchacher, A., Predl, R., Strutzenberger, K., Steinfellner, W., Trkola, A., Purtscher, M., Gruber, G., Tauer, C., Steindl, F., and Jungbauer, A. (1994) AIDS Res. Hum. Retroviruses 10, 359-369
21. Muster, T., Steindl, F., Purtscher, M., Trkola, A., Klima, A., Himmler, G., Rüker, F., and Katinger, H. (1993) J. Virol. 67, 6642-6647
22. Zwick, M. B., Labrijn, A. F., Wang, M., Spenlehauer, C., Saphire, E. O., Binley, J. M., Moore, J. P., Stiegler, G., Katinger, H., Burton, D. R., and Parren, P. W. (2001) J. Virol. 75, 10892-10905
23. Stiegler, G., Kunert, R., Purtscher, M., Wolbank, S., Voglauer, R., Steindl, F., and Katinger, H. (2001) AIDS Res. Hum. Retroviruses 17, 1757-1765
24. Burton, D. R., Pyati, J., Koduri, R., Sharp, S. J., Thornton, G. B., Parren, P. W., Sawyer, L. S., Hendry, R. M., Dunlop, N., and Nara, P. L. (1994) Science 266, 1024-1027
25. Corti, D., Langedijk, J. P., Hinz, A., Seaman, M. S., Vanzetta, F., Fernandez-Rodriguez, B. M., Silacci, C., Pinna, D., Jarrossay, D., Balla-Jhagjhoorsingh, S., Willems, B., Zekveld, M. J., Dreja, H., O'Sullivan, E., Pade, C., Orkin, C., Jeffs, S. A., Montefiori, D. C., Davis, D., Weissenhorn, W., McKnight, A., Heeney, J. L., Sallusto, F., Sattentau, Q. J., Weiss, R. A., and Lanzavecchia, A. (2010) PLoS One 5, e8805
26. Walker, L. M., Phogat, S. K., Chan-Hui, P. Y., Wagner, D., Phung, P., Goss, J. L., Wrin, T., Simek, M. D., Fling, S., Mitcham, J. L., Lehrman, J. K., Priddy, F. H., Olsen, O. A., Frey, S. M., Hammond, P. W., Kaminsky, S., Zamb, T., Moyle, M., Koff, W. C., Poignard, P., and Burton, D. R. (2009) Science 326, 285-289
27. Li, Y., Svehla, K., Louder, M. K., Wycuff, D., Phogat, S., Tang, M., Migueles, S. A., Wu, X., Phogat, A., Shaw, G. M., Connors, M., Hoxie, J., Mascola, J. R., and Wyatt, R. (2009) J. Virol. 83, 1045-1059
28. Sather, D. N., Armann, J., Ching, L. K., Mavrantoni, A., Sellhorn, G., Caldwell, Z., Yu, X., Wood, B., Self, S., Kalams, S., and Stamatatos, L. (2009) J. Virol. 83, 757-769
29. Li, Y., Migueles, S. A., Welcher, B., Svehla, K., Phogat, A., Louder, M. K., Wu, X., Shaw, G. M., Connors, M., Wyatt, R. T., and Mascola, J. R. (2007) Nat. Med. 13, 1032-1034
30. Forsman, A., Beirnaert, E., Aasa-Chapman, M. M., Hoorelbeke, B., Hijazi, K., Koh, W., Tack, V., Szynol, A., Kelly, C., McKnight, A., Verrips, T., de Haard, H., and Weiss, R. A. (2008) J. Virol. 82, 12069-12081
31. Hamers-Casterman, C., Atarhouch, T., Muyldermans, S., Robinson, G., Hamers, C., Songa, E. B., Bendahman, N., and Hamers, R. (1993) Nature 363, 446-448
32. van der Linden, R. H., Frenken, L. G., de Geus, B., Harmsen, M. M., Ruuls, R. C., Stok, W., de Ron, L., Wilson, S., Davis, P., and Verrips, C. T. (1999) Biochim. Biophys. Acta 1431, 37-46
33. Vu, K. B., Ghahroudi, M. A., Wyns, L., and Muyldermans, S. (1997) Mol. Immunol. 34, 1121-1131
34. De Genst, E., Silence, K., Decanniere, K., Conrath, K., Loris, R., Kinne, J., Muyldermans, S., and Wyns, L. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 4586-4591
35. Lauwereys, M., Arbabi Ghahroudi, M., Desmyter, A., Kinne, J., Hölzer, W., De Genst, E., Wyns, L., and Muyldermans, S. (1998) EMBO J. 17, 3512-3520
36. Coppieters, K., Dreier, T., Silence, K., de Haard, H., Lauwereys, M., Casteels, P., Beirnaert, E., Jonckheere, H., Van de Wiele, C., Staelens, L., Hostens, J., Revets, H., Remaut, E., Elewaut, D., and Rottiers, P. (2006) Arthritis Rheum. 54, 1856-1866
37. Harmsen, M. M., van Solt, C. B., Fijten, H. P., van Keulen, L., Rosalia, R. A., Weerdmeester, K., Cornelissen, A. H., De Bruin, M. G., Eblé, P. L., and Dekker, A. (2007) Vet. Microbiol. 120, 193-206
38. Muyldermans, S. (2001) J. Biotechnol. 74, 277-302
39. Garaicoechea, L., Olichon, A., Marcoppido, G., Wigdorovitz, A., Mozgovoj, M., Saif, L., Surrey, T., and Parreño, V. (2008) J. Virol. 82, 9753-9764
40. Aasa-Chapman, M. M., Hayman, A., Newton, P., Cornforth, D., Williams, I., Borrow, P., Balfe, P., and McKnight, A. (2004) AIDS 18, 371-381
41. De Haard, H. J., Bezemer, S., Ledeboer, A. M.,Müller, W. H., Boender, P. J., Moineau, S., Coppelmans, M. C., Verkleij, A. J., Frenken, L. G., and Verrips, C. T. (2005) J. Bacteriol. 187, 4531-4541
42. Gao, F., Yue, L., Craig, S., Thornton, C. L., Robertson, D. L., McCutchan, F. E., Bradac, J. A., Sharp, P. M., and Hahn, B. H. (1994) AIDS Res. Hum. Retroviruses 10, 1359-1368
43. McKeating, J. A., Zhang, Y. J., Arnold, C., Frederiksson, R., Fenyö, E. M., and Balfe, P. (1996) Virology 220, 450-460
44. Li, M., Gao, F., Mascola, J. R., Stamatatos, L., Polonis, V. R., Koutsoukos, M., Voss, G., Goepfert, P., Gilbert, P., Greene, K. M., Bilska, M., Kothe, D. L., Salazar-Gonzalez, J. F., Wei, X., Decker, J. M., Hahn, B. H., and Montefiori, D. C. (2005) J. Virol. 79, 10108-10125
45. Li, M., Salazar-Gonzalez, J. F., Derdeyn, C. A., Morris, L., Williamson, C., Robinson, J. E., Decker, J. M., Li, Y., Salazar, M. G., Polonis, V. R., Mlisana, K., Karim, S. A., Hong, K., Greene, K. M., Bilska, M., Zhou, J., Allen, S., Chomba, E., Mulenga, J., Vwalika, C., Gao, F., Zhang, M., Korber, B. T., Hunter, E., Hahn, B. H., and Montefiori, D. C. (2006) J. Virol. 80, 11776-11790
46. Derdeyn, C. A., Decker, J. M., Sfakianos, J. N., Wu, X., O'Brien, W. A., Ratner, L., Kappes, J. C., Shaw, G. M., and Hunter, E. (2000) J. Virol. 74, 8358-8367
47. Platt, E. J., Wehrly, K., Kuhmann, S. E., Chesebro, B., and Kabat, D. (1998) J. Virol. 72, 2855-2864
48. Wei, X., Decker, J. M., Liu, H., Zhang, Z., Arani, R. B., Kilby, J. M., Saag, M. S., Wu, X., Shaw, G. M., and Kappes, J. C. (2002) Antimicrob. Agents Chemother. 46, 1896-1905
49. Nuttall, S. D., Irving, R. A., and Hudson, P. J. (2000) Curr. Pharm. Biotechnol. 1, 253-263
50. Zhou, T., Xu, L., Dey, B., Hessell, A. J., Van Ryk, D., Xiang, S. H., Yang, X., Zhang, M. Y., Zwick, M. B., Arthos, J., Burton, D. R., Dimitrov, D. S., Sodroski, J., Wyatt, R., Nabel, G. J., and Kwong, P. D. (2007) Nature 445, 732-737
51. Desmyter, A., Decanniere, K., Muyldermans, S., and Wyns, L. (2001) J. Biol. Chem. 276, 26285-26290
52. Chothia, C., and Lesk, A. M. (1987) J. Mol. Biol. 196, 901-917
53. Barbas, C. F., 3rd, Collet, T. A., Amberg, W., Roben, P., Binley, J. M., Hoekstra, D., Cababa, D., Jones, T. M., Williamson, R. A., and Pilkington, G. R. (1993) J. Mol. Biol. 230, 812-823
54. Hinz, A., Hulsik, D. L., Forsman, A., Koh, W. W., Belrhali, H., Gorlani, A., de Haard, H., Weiss, R. A., Verrips, T., and Weissenhorn, W. (2010) PLoS ONE 5, e10482
55. Batista, F. D., and Neuberger, M. S. (1998) Immunity 8, 751-759
56. Foote, J., and Eisen, H. N. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 1254-1256
57. Gao, F., Robertson, D. L., Carruthers, C. D., Morrison, S. G., Jian, B., Chen, Y., Barré-Sinoussi, F., Girard, M., Srinivasan, A., Abimiku, A. G., Shaw, G. M., Sharp, P. M., and Hahn, B. H. (1998) J. Virol. 72, 5680-5698