-
1
-
-
0031045482
-
Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD
-
Keatings V.M., Jatakanon A., Worsdell Y.M., Barnes P.J. Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am. J. Respir. Crit. Care Med. 1997, 155:542-548.
-
(1997)
Am. J. Respir. Crit. Care Med.
, vol.155
, pp. 542-548
-
-
Keatings, V.M.1
Jatakanon, A.2
Worsdell, Y.M.3
Barnes, P.J.4
-
2
-
-
33745746529
-
Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma
-
Hew M., Bhavsar P., Torrego A., Meah S., Khorasani N., Barnes P.J., Adcock I., Chung K.F. Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am. J. Respir. Crit. Care Med. 2006, 174:134-141.
-
(2006)
Am. J. Respir. Crit. Care Med.
, vol.174
, pp. 134-141
-
-
Hew, M.1
Bhavsar, P.2
Torrego, A.3
Meah, S.4
Khorasani, N.5
Barnes, P.J.6
Adcock, I.7
Chung, K.F.8
-
3
-
-
33750620057
-
Oxidative stress and redox regulation of lung inflammation in COPD
-
Rahman I., Adcock I.M. Oxidative stress and redox regulation of lung inflammation in COPD. Eur. Respir. J. 2006, 28:219-242.
-
(2006)
Eur. Respir. J.
, vol.28
, pp. 219-242
-
-
Rahman, I.1
Adcock, I.M.2
-
4
-
-
0033821409
-
Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12
-
Ito K., Barnes P.J., Adcock I.M. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol. Cell Biol. 2000, 20:6891-6903.
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 6891-6903
-
-
Ito, K.1
Barnes, P.J.2
Adcock, I.M.3
-
5
-
-
65849427529
-
Glucocorticoid resistance in inflammatory diseases
-
Barnes P.J., Adcock I.M. Glucocorticoid resistance in inflammatory diseases. Lancet 2009, 373:1905-1917.
-
(2009)
Lancet
, vol.373
, pp. 1905-1917
-
-
Barnes, P.J.1
Adcock, I.M.2
-
6
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., Oyake T., Hayashi N., Satoh K., Hatayama I., Yamamoto M., Nabeshima Y. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 1997, 236:313-322.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
Oyake, T.7
Hayashi, N.8
Satoh, K.9
Hatayama, I.10
Yamamoto, M.11
Nabeshima, Y.12
-
7
-
-
1942520367
-
Nrf2 signaling in coordinated activation of antioxidant gene expression
-
Jaiswal A.K. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic. Biol. Med. 2004, 36:1199-1207.
-
(2004)
Free Radic. Biol. Med.
, vol.36
, pp. 1199-1207
-
-
Jaiswal, A.K.1
-
8
-
-
53649099660
-
Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema
-
Goven D., Boutten A., Lecon-Malas V., Marchal-Somme J., Amara N., Crestani B., Fournier M., Leseche G., Soler P., Boczkowski J., Bonay M. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Thorax 2008, 63:916-924.
-
(2008)
Thorax
, vol.63
, pp. 916-924
-
-
Goven, D.1
Boutten, A.2
Lecon-Malas, V.3
Marchal-Somme, J.4
Amara, N.5
Crestani, B.6
Fournier, M.7
Leseche, G.8
Soler, P.9
Boczkowski, J.10
Bonay, M.11
-
9
-
-
51849129227
-
Decline in Nrf2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator DJ-1
-
Malhotra D., Thimmulappa R., Navas-Acien A., Sandford A., Elliott M., Singh A., Chen L., Zhuang X., Hogg J., Pare P., Tuder R.M., Biswal S. Decline in Nrf2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator DJ-1. Am. J. Respir. Crit. Care Med. 2008, 178:592-604.
-
(2008)
Am. J. Respir. Crit. Care Med.
, vol.178
, pp. 592-604
-
-
Malhotra, D.1
Thimmulappa, R.2
Navas-Acien, A.3
Sandford, A.4
Elliott, M.5
Singh, A.6
Chen, L.7
Zhuang, X.8
Hogg, J.9
Pare, P.10
Tuder, R.M.11
Biswal, S.12
-
10
-
-
77949517866
-
Cigarette smoking blocks the protective expression of Nrf2/ARE pathway in peripheral mononuclear cells of young heavy smokers favouring inflammation
-
Garbin U., Fratta Pasini A., Stranieri C., Cominacini M., Pasini A., Manfro S., Lugoboni F., Mozzini C., Guidi G., Faccini G., Cominacini L. Cigarette smoking blocks the protective expression of Nrf2/ARE pathway in peripheral mononuclear cells of young heavy smokers favouring inflammation. PLoS One 2009, 4:e8225-e8236.
-
(2009)
PLoS One
, vol.4
-
-
Garbin, U.1
Fratta Pasini, A.2
Stranieri, C.3
Cominacini, M.4
Pasini, A.5
Manfro, S.6
Lugoboni, F.7
Mozzini, C.8
Guidi, G.9
Faccini, G.10
Cominacini, L.11
-
11
-
-
0036723948
-
Diminished immunoreactivity of gamma-glutamylcysteine synthetase in the airways of smokers' lung
-
Harju T., Kaarteenaho-Wiik R., Soini Y., Sormunen R., Kinnula V.L. Diminished immunoreactivity of gamma-glutamylcysteine synthetase in the airways of smokers' lung. Am. J. Respir. Crit Care Med. 2002, 166:754-759.
-
(2002)
Am. J. Respir. Crit Care Med.
, vol.166
, pp. 754-759
-
-
Harju, T.1
Kaarteenaho-Wiik, R.2
Soini, Y.3
Sormunen, R.4
Kinnula, V.L.5
-
12
-
-
34447537656
-
Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung
-
Tomaki M., Sugiura H., Koarai A., Komaki Y., Akita T., Matsumoto T., Nakanishi A., Ogawa H., Hattori T., Ichinose M. Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung. Pulm. Pharmacol. Ther. 2007, 20:596-605.
-
(2007)
Pulm. Pharmacol. Ther.
, vol.20
, pp. 596-605
-
-
Tomaki, M.1
Sugiura, H.2
Koarai, A.3
Komaki, Y.4
Akita, T.5
Matsumoto, T.6
Nakanishi, A.7
Ogawa, H.8
Hattori, T.9
Ichinose, M.10
-
13
-
-
15244356847
-
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
-
Rangasamy T., Cho C.Y., Thimmulappa R.K., Zhen L., Srisuma S.S., Kensler T.W., Yamamoto M., Petrache I., Tuder R.M., Biswal S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J. Clin. Invest. 2004, 114:1248-1259.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1248-1259
-
-
Rangasamy, T.1
Cho, C.Y.2
Thimmulappa, R.K.3
Zhen, L.4
Srisuma, S.S.5
Kensler, T.W.6
Yamamoto, M.7
Petrache, I.8
Tuder, R.M.9
Biswal, S.10
-
14
-
-
33847695362
-
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity
-
Trivedi C.M., Luo Y., Yin Z., Zhang M., Zhu W., Wang T., Floss T., Goettlicher M., Noppinger P.R., Wurst W., Ferrari V.A., Abrams C.S., Gruber P.J., Epstein J.A. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat. Med. 2007, 13:324-331.
-
(2007)
Nat. Med.
, vol.13
, pp. 324-331
-
-
Trivedi, C.M.1
Luo, Y.2
Yin, Z.3
Zhang, M.4
Zhu, W.5
Wang, T.6
Floss, T.7
Goettlicher, M.8
Noppinger, P.R.9
Wurst, W.10
Ferrari, V.A.11
Abrams, C.S.12
Gruber, P.J.13
Epstein, J.A.14
-
15
-
-
45249105749
-
IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung
-
Yang S.R., Valvo S., Yao H., Kode A., Rajendrasozhan S., Edirisinghe I., Caito S., Adenuga D., Henry R., Fromm G., Maggirwar S., Li J.D., Bulger M., Rahman I. IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung. Am. J. Respir. Cell Mol. Biol. 2008, 38:689-698.
-
(2008)
Am. J. Respir. Cell Mol. Biol.
, vol.38
, pp. 689-698
-
-
Yang, S.R.1
Valvo, S.2
Yao, H.3
Kode, A.4
Rajendrasozhan, S.5
Edirisinghe, I.6
Caito, S.7
Adenuga, D.8
Henry, R.9
Fromm, G.10
Maggirwar, S.11
Li, J.D.12
Bulger, M.13
Rahman, I.14
-
16
-
-
48949119468
-
Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice
-
Yao H., Edirisinghe I., Rajendrasozhan S., Yang S.R., Caito S., Adenuga D., Rahman I. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. Am. J. Physiol. Lung. Cell Mol. Physiol. 2008, 294:L1174-1186.
-
(2008)
Am. J. Physiol. Lung. Cell Mol. Physiol.
, vol.294
-
-
Yao, H.1
Edirisinghe, I.2
Rajendrasozhan, S.3
Yang, S.R.4
Caito, S.5
Adenuga, D.6
Rahman, I.7
-
17
-
-
45849091423
-
Disruption of p21 attenuates lung inflammation induced by cigarette smoke LPS and fMLP in mice
-
Yao H., Yang S.R., Edirisinghe I., Rajendrasozhan S., Caito S., Adenuga D., O'Reilly M.A., Rahman I. Disruption of p21 attenuates lung inflammation induced by cigarette smoke LPS and fMLP in mice. Am. J. Respir. Cell Mol. Biol. 2008, 39:7-18.
-
(2008)
Am. J. Respir. Cell Mol. Biol.
, vol.39
, pp. 7-18
-
-
Yao, H.1
Yang, S.R.2
Edirisinghe, I.3
Rajendrasozhan, S.4
Caito, S.5
Adenuga, D.6
O'Reilly, M.A.7
Rahman, I.8
-
18
-
-
58849085091
-
Budesonide prevents but does not reverse sustained airway hyperresponsiveness in mice
-
Southam D.S., Ellis R., Wattie J., Young S., Inman M.D. Budesonide prevents but does not reverse sustained airway hyperresponsiveness in mice. Eur. Respir. J. 2008, 32:970-978.
-
(2008)
Eur. Respir. J.
, vol.32
, pp. 970-978
-
-
Southam, D.S.1
Ellis, R.2
Wattie, J.3
Young, S.4
Inman, M.D.5
-
19
-
-
63349102653
-
Histone deacetylase 2 is phosphorylated ubiquitinated and degraded by cigarette smoke
-
Adenuga D., Yao H., March T.H., Seagrave J., Rahman I. Histone deacetylase 2 is phosphorylated ubiquitinated and degraded by cigarette smoke. Am. J. Respir. Cell Mol. Biol. 2009, 40:464-473.
-
(2009)
Am. J. Respir. Cell Mol. Biol.
, vol.40
, pp. 464-473
-
-
Adenuga, D.1
Yao, H.2
March, T.H.3
Seagrave, J.4
Rahman, I.5
-
20
-
-
9744220302
-
Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs
-
Marwick J.A., Kirkham P.A., Stevenson C.S., Danahay H., Giddings J., Butler K., Donaldson K., MacNee W., Rahman I. Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. Am. J. Respir. Cell Mol. Biol. 2004, 31:633-642.
-
(2004)
Am. J. Respir. Cell Mol. Biol.
, vol.31
, pp. 633-642
-
-
Marwick, J.A.1
Kirkham, P.A.2
Stevenson, C.S.3
Danahay, H.4
Giddings, J.5
Butler, K.6
Donaldson, K.7
MacNee, W.8
Rahman, I.9
-
21
-
-
33745728358
-
Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages
-
Yang S.R., Chida A.S., Bauter M.R., Shafiq N., Seweryniak K., Maggirwar S.B., Kilty I., Rahman I. Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am. J. Physiol. Lung. Cell Mol. Physiol. 2006, 291:L46-57.
-
(2006)
Am. J. Physiol. Lung. Cell Mol. Physiol.
, vol.291
-
-
Yang, S.R.1
Chida, A.S.2
Bauter, M.R.3
Shafiq, N.4
Seweryniak, K.5
Maggirwar, S.B.6
Kilty, I.7
Rahman, I.8
-
22
-
-
77952952508
-
Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes
-
Adenuga D., Rahman I. Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes. Arch. Biochem. Biophys. 2010, 498:62-73.
-
(2010)
Arch. Biochem. Biophys.
, vol.498
, pp. 62-73
-
-
Adenuga, D.1
Rahman, I.2
-
23
-
-
0035315925
-
Cigarette smoking reduces histone deacetylase 2 expression enhances cytokine expression and inhibits glucocorticoid actions in alveolar macrophages
-
Ito K., Lim S., Caramori G., Chung K.F., Barnes P.J., Adcock I.M. Cigarette smoking reduces histone deacetylase 2 expression enhances cytokine expression and inhibits glucocorticoid actions in alveolar macrophages. FASEB J. 2001, 15:1110-1112.
-
(2001)
FASEB J.
, vol.15
, pp. 1110-1112
-
-
Ito, K.1
Lim, S.2
Caramori, G.3
Chung, K.F.4
Barnes, P.J.5
Adcock, I.M.6
-
24
-
-
35148885660
-
Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice
-
Zimmermann S., Kiefer F., Prudenziati M., Spiller C., Hansen J., Floss T., Wurst W., Minucci S., Gottlicher M. Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice. Cancer Res. 2007, 67:9047-9054.
-
(2007)
Cancer Res.
, vol.67
, pp. 9047-9054
-
-
Zimmermann, S.1
Kiefer, F.2
Prudenziati, M.3
Spiller, C.4
Hansen, J.5
Floss, T.6
Wurst, W.7
Minucci, S.8
Gottlicher, M.9
-
25
-
-
70449675089
-
HDAC2: a critical factor in health and disease
-
Kramer O.H. HDAC2: a critical factor in health and disease. Trends Pharmacol. Sci. 2009, 30:647-655.
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 647-655
-
-
Kramer, O.H.1
-
26
-
-
41949141296
-
NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
-
Liu G.H., Qu J., Shen X. NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim. Biophys. Acta 2008, 1783:713-727.
-
(2008)
Biochim. Biophys. Acta
, vol.1783
, pp. 713-727
-
-
Liu, G.H.1
Qu, J.2
Shen, X.3
-
27
-
-
66349129338
-
Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response
-
Sun Z., Chin Y.E., Zhang D.D. Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol. Cell Biol. 2009, 29:2658-2672.
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 2658-2672
-
-
Sun, Z.1
Chin, Y.E.2
Zhang, D.D.3
|