Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-κB

EMBO Journal

Volumn 21, Issue 23, 2002, Pages 6539-6548

  Chen, Lin feng ^a   Mu, Yajun ^a   Greene, Warner C ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acetylation; Deacetylation; I B ; p300; RelA

Indexed keywords

ACYLTRANSFERASE; ARGININE; BINDING PROTEIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSINE; MUTANT PROTEIN; PROTEIN P300; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ACETYLATION; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN MODIFICATION; REGULATORY MECHANISM;

ACETYLATION; ACETYLTRANSFERASES; CELL CYCLE PROTEINS; CELL NUCLEUS; ENHANCER ELEMENTS (GENETICS); HISTONE ACETYLTRANSFERASES; MUTATION; NF-KAPPA B; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS;

EID: 0037011056     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf660     Document Type: Article

References (53)

1. Arenzana-Seisdedos, F., Thompson, J., Rodriguez, M.S., Bachelerie, F., Thomas, D. and Hay, R.T. (1995) Inducible nuclear expression of newly synthesized IκBα negatively regulates DNA-binding and transcriptional activities of NF-κB. Mol. Cell. Biol., 15, 2689-2696.
2. Arenzana-Seisdedos, F., Turpin, P., Rodriguez, M., Thomas, D., Hay, R.T., Virelizier, J.L. and Dargemont, C. (1997) Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm. J. Cell Sci., 110, 369-378.
3. Ashburner, B.P., Westerheide, S.D. and Baldwin, A.S., Jr. (2001) The p65 (RelA) subunit of NF-κB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol. Cell. Biol., 21, 7065-7077.
4. Baeuerle, P.A. (1998) IκB-NF-κB structures: At the interface of inflammation control. Cell, 95, 729-731.
5. Baeuerle, P.A. and Baltimore, D. (1988) Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor. Cell, 53, 211-217.
6. Baldwin, A.S., Jr (1996) The NF-κB and κB proteins: New discoveries and insights. Annu. Rev. Immunol., 14, 649-683.
7. Bannister, A.J. and Miska, E.A. (2000) Regulation of gene expression by transcription factor acetylation. Cell. Mol. Life Sci., 57, 1184-1192.
8. Beg, A.A., Finco, T.S., Nantermet, P.V. and Baldwin, A.S., Jr (1993) Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκBα: A mechanism for NF-κB activation. Mol. Cell. Biol., 13, 3301-3310.
9. Berger, S.L. (1999) Gene activation by histone and factor acetyltransferases. Curr. Opin. Cell Biol., 11, 336-341.
10. Blair, W.S., Bogerd, H.P., Madore, S.J. and Cullen, B.R. (1994) Mutational analysis of the transcription activation domain of RelA: Identification of a highly synergistic minimal acidic activation module. Mol. Cell. Biol., 14, 7226-7234.
11. Boyes, J., Byfield, P., Nakatani, Y. and Ogryzko, V. (1998) Regulation of activity of the transcription factor GATA-1 by acetylation. Nature, 396, 594-598.
12. Brown, K., Park, S., Kanno, T., Franzoso, G. and Siebenlist, U. (1993) Mutual regulation of the transcriptional activator NF-κ B and its inhibitor, IκBα. Proc. Natl. Acad. Sci. USA, 90, 2532-2536.
13. Chakravarti, D., Ogryzko, V., Kao, H.Y., Nash, A., Chen, H., Nakatani, Y. and Evans, R.M. (1999) A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. Cell, 96, 393-403.
14. Chen, F.E., Huang, D.B., Chen, Y.Q. and Ghosh, G. (1998) Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA. Nature, 391, 410-413.
15. Chen, H., Tini, M. and Evans, R.M. (2001) HATs on and beyond chromatin. Curr. Opin. Cell Biol., 13, 218-224.
16. Chen, L., Fischle, W., Verdin, E. and Greene, W.C. (2001) Duration of nuclear NF-κB action regulated by reversible acetylation. Science, 293, 1653-1657.
17. Chu, Z.L., McKinsey, T.A., Liu, L., Qi, X. and Ballard, D.W. (1996) Basal phosphorylation of the PEST domain in the IκBβ regulates its functional interaction with the c-rel proto-oncogene product. Mol. Cell. Biol., 16, 5974-5984.
18. De Bosscher, K., Vanden Berghe, W., Vermeulen, L., Plaisance, S., Boone, E. and Haegeman, G. (2000) Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc. Natl. Acad. Sci. USA, 97, 3919-3924.
19. Dhalluin, C., Carlson, J.E., Zeng, L., He, C., Aggarwal, A.K. and Zhou, M.M. (1999) Structure and ligand of a histone acetyltransferase bromodomain. Nature, 399, 491-496.
20. Ernst, M.K., Dunn, L.L. and Rice, N.R. (1995) The PEST-like sequence of IκBα is responsible for inhibition of DNA binding but not for cytoplasmic retention of c-Rel or RelA homodimers. Mol. Cell. Biol., 15, 872-882.
21. Gerritsen, M.E., Williams, A.J., Neish, A.S., Moore, S., Shi, Y. and Collins, T. (1997) CREB-binding protein/p300 are transcriptional coactivators of p65. Proc. Natl. Acad. Sci. USA, 94, 2927-2932.
22. Ghosh, S., May, M.J. and Kopp, E.B. (1998) NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol., 16, 225-260.
23. Gu, W. and Roeder, R.G. (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell, 90, 595-606.
24. Hamamori, Y., Sartorelli, V., Ogryzko, V., Puri, P.L., Wu, H.Y., Wang, J.Y., Nakatani, Y. and Kedes, L. (1999) Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Cell, 96, 405-413.
25. Huxford, T., Huang, D.B., Malek, S. and Ghosh, G. (1998) The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation. Cell, 95, 759-770.
26. Imhof, A. and Wolffe, A.P. (1998) Transcription: Gene control by targeted histone acetylation. Curr. Biol., 8, R422-R424.
27. Jacobs, M.D. and Harrison, S.C. (1998) Structure of an IκBα/NFκB complex. Cell, 95, 749-758.
28. Johnson, C., Van Antwerp, D. and Hope, T.J. (1999) An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IκBα. EMBO J., 18, 6682-6693.
29. Karin, M. (1999) How NF-κB is activated: The role of the IκB kinase (IKK) complex. Oncogene, 18, 6867-6874.
30. Kraus, W.L., Manning, E.T. and Kadonaga, J.T. (1999) Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templates. Mol. Cell. Biol., 19, 8123-8135.
31. Kuo, M.H. and Allis, C.D. (1998) Roles of histone acetyltransferases and deacetylases in gene regulation. BioEssays, 20, 615-626.
32. Leo, C. and Chen, J.D. (2000) The SRC family of nuclear receptor coactivators. Gene, 245, 1-11.
33. Li, S., Aufiero, Schiltz, R.L. and Walsh. M.J. (2000) Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP. Proc. Natl. Acad. Sci. USA, 97, 7166-7171.
34. Lin, R., Beauparlant, P., Makris, C., Meloche, S. and Hiscott, J. (1996) Phosphorylation of IκBα in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Mol. Cell. Biol., 16, 1401-1409.
35. Madge, L.A. and Pober, J.S. (2000) A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NF-κB in human endothelial cells. J. Biol. Chem., 275, 15458-15465.
36. Martínez-Balbás, M.A., Bauer, U.M., Nielsen, S.J., Brehm, A. and Kouzarides, T. (2000) Regulation of E2F1 activity by acetylation. EMBO J., 19, 662-671.
37. Marzio, G., Wagener, C., Gutierrez, M.I., Cartwright, P., Helin, K. and Giacca, M. (2000) E2F family members are differentially regulated by reversible acetylation. J. Biol. Chem., 275, 10887-10892.
38. Munshi, N., Merika, M., Yie, J., Senger, K., Chen, G. and Thanos, D. (1998) Acetylation of HMG I(Y) by CBP turns off IFNβ expression by disrupting the enhanceosome. Mol. Cell, 2, 457-467.
39. Na, S.Y., Lee, S.K., Han, S.J., Choi, H.S., Im, S.Y. and Lee, J.W. (1998) Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor κB-mediated transactivations. J. Biol. Chem., 273, 10831-10834.
40. Perkins, N.D., Felzien, L.K., Betts, J.C., Leung, K., Beach, D.H. and Nabel, G.J. (1997) Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science, 275, 523-527.
41. Polesskaya, A., Naguibneva, I., Duquet, A., Bengal, E., Robin, P. and Harel-Bellan, A. (2001) Interaction between acetylated MyoD and the bromodomain of CBP and/or p300. Mol. Cell. Biol., 21, 5312-5320.
42. Schmitz, M.L., Stelzer, G., Altmann, H., Meisterernst, M. and Baeuerle, P.A. (1995) Interaction of the COOH-terminal transactivation domain of p65 NF-κB with TATA-binding protein, transcription factor IIB, and coactivators. J. Biol. Chem., 270, 7219-7226.
43. Schwarz, E.M., Van Antwerp, D. and Verma, I.M. (1996) Constitutive phosphorylation of IκBα by casein kinase II occurs preferentially at serine 293: Requirement for degradation of free IκBα. Mol. Cell. Biol., 16, 3554-3559.
44. Sheppard, K.A., Phelps, K.M., Williams, A.J., Thanos, D., Glass, C.K., Rosenfeld, M.G., Gerritsen, M.E. and Collins, T. (1998) Nuclear integration of glucocorticoid receptor and nuclear factor-κB signaling by CREB-binding protein and steroid receptor coactivator-1. J. Biol. Chem., 273, 29291-29294.
45. Sheppard, K.A. et al. (1999) Transcriptional activation by NF-κB requires multiple coactivators. Mol. Cell. Biol., 19, 6367-6378.
46. Soutoglou, E., Viollet, B., Vaxillaire, M., Yaniv, M., Pontoglio, M. and Talianidis, I. (2001) Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity. EMBO J., 20, 1984-1992.
47. Spilianakis, C., Papamatheakis, J. and Kretsovali, A. (2000) Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes. Mol. Cell. Biol., 20, 8489-8498.
48. Sterner, D.E. and Berger, S.L. (2000) Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev., 64, 435-459.
49. Sun, S.C., Ganchi, P.A., Ballard, D.W. and Greene, W.C. (1993) NF-κB controls expression of inhibitor IκBα: Evidence for an inducible autoregulatory pathway. Science, 259, 1912-1915.
50. Vanden Berghe, W., De Bosscher, K., Boone, E., Plaisance, S. and Haegeman, G. (1999) The nuclear factor-κB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. J. Biol. Chem., 274, 32091-32098.
51. Waltzer, L. and Bienz, M. (1998) Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. Nature, 395, 521-525.
52. Werbajh, S., Nojek, I., Lanz, R. and Costas, M.A. (2000) RAC-3 is a NF-κB coactivator. FEBS Lett., 485, 195-199.
53. Xu, X., Prorock, C., Ishikawa, H., Maldonado, E., Ito, Y. and Gelinas, C. (1993) Functional interaction of the v-Rel and c-Rel oncoproteins with the TATA-binding protein and association with transcription factor IIB. Mol. Cell. Biol., 13, 6733-6741.