Evaluation of Potent and Selective Small-Molecule Antagonists for the CXCR2 Chemokine Receptor

Journal of Medicinal Chemistry

Volumn 47, Issue 6, 2004, Pages 1319-1321

  Widdowson, Katherine L ^a   Elliott, John D ^a   Veber, Daniel F ^a   Nie, Hong ^a   Rutledge, Melvin C ^a   McCleland, Brent W ^a   Xiang, Jia Ning ^a   Jurewicz, Anthony J ^a   Hertzberg, Robert P ^a   Foley, James J ^a   Griswold, Don E ^a   Martin, Lenox ^a   Lee, Judithann M ^a   White, John R ^a   Sarau, Henry M ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; INTERLEUKIN 8; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; EAR DISEASE; EDEMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; NEUTROPENIA; NEUTROPHIL CHEMOTAXIS; NONHUMAN; RABBIT; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BINDING, COMPETITIVE; CALCIUM; CHEMOKINES; CHEMOTACTIC FACTORS; CHEMOTAXIS; CHO CELLS; CRICETINAE; HUMANS; HYPERSENSITIVITY, DELAYED; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-8; NEUTROPENIA; NEUTROPHILS; PHENYLUREA COMPOUNDS; RABBITS; RADIOLIGAND ASSAY; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 12144291157     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034248l     Document Type: Article

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