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Volumn 2, Issue 3, 2007, Pages 205-228

Future therapeutic treatment of COPD: Struggle between oxidants and cytokines

Author keywords

Antagonists; Antioxidants; COPD; Cytokines; Inflammation; Remodeling

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; 5,6,7,13 TETRAHYDRO 12 (3 HYDROXYPROPYL) 9 ISOPROPOXYMETHYLINDENO[2,1 A]PYRROLO[3,4 C]CARBAZOL 5(12H) ONE DIMETHYLGLYCINE ESTER; ACETYLCYSTEINE; ADALIMUMAB; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA CAROTENE; BEVACIZUMAB; BORTEZOMIB; CILOMILAST; CORTICOSTEROID; CYTOKINE; ELASTASE INHIBITOR; ERDOSTEINE; ETANERCEPT; HISTONE DEACETYLASE INHIBITOR; INFLIXIMAB; LACTACYSTIN; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NSC 11118; OXIDIZING AGENT; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PLACEBO; ROFLUMILAST; SB 681323; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VATALANIB;

EID: 36148988782     PISSN: 11769106     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (48)

References (234)
  • 1
    • 33750001398 scopus 로고    scopus 로고
    • Infliximab treatment for chronic obstructive pulmonary disease (COPD) - a pilot study
    • Abdelhady H, Flores R, Tan H, et al. 2005. Infliximab treatment for chronic obstructive pulmonary disease (COPD) - a pilot study. Proc Am Thorac Soc, 2:A133.
    • (2005) Proc Am Thorac Soc , vol.2
    • Abdelhady, H.1    Flores, R.2    Tan, H.3
  • 2
    • 0033152760 scopus 로고    scopus 로고
    • Adams J, Palombella VJ, Sausville EA, et al, Proteasome inhibitors. 1999. a novel class of potent and effective antitumor agents. Cancer Res, 59:2615-22.
    • Adams J, Palombella VJ, Sausville EA, et al, Proteasome inhibitors. 1999. a novel class of potent and effective antitumor agents. Cancer Res, 59:2615-22.
  • 3
    • 0033029695 scopus 로고    scopus 로고
    • Oxidative stress in smokers supplemented with vitamin C
    • Aghdassi E, Royall D, Allard JP. 1999. Oxidative stress in smokers supplemented with vitamin C. Int J Vitam Nutr Res, 69:45-51.
    • (1999) Int J Vitam Nutr Res , vol.69 , pp. 45-51
    • Aghdassi, E.1    Royall, D.2    Allard, J.P.3
  • 4
    • 12244264853 scopus 로고    scopus 로고
    • Systemic effects of chronic obstructive pulmonary disease
    • Agusti AG, Noguera A, Sauleda J, et al. 2003. Systemic effects of chronic obstructive pulmonary disease. Eur Respir J, 21:347-60.
    • (2003) Eur Respir J , vol.21 , pp. 347-360
    • Agusti, A.G.1    Noguera, A.2    Sauleda, J.3
  • 5
    • 0037087145 scopus 로고    scopus 로고
    • Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappaB nuclear binding in alveolar epithelial cells
    • Antonicelli F, Parmentier M, Drost EM, et al. 2002. Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappaB nuclear binding in alveolar epithelial cells. Free Radic Biol Med, 32:492-502.
    • (2002) Free Radic Biol Med , vol.32 , pp. 492-502
    • Antonicelli, F.1    Parmentier, M.2    Drost, E.M.3
  • 6
    • 0034802186 scopus 로고    scopus 로고
    • Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats
    • Auten RL, Richardson RM, White JR, et al. 2001. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther, 299:90-5.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 90-95
    • Auten, R.L.1    Richardson, R.M.2    White, J.R.3
  • 7
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: New discoveries and insights
    • Baldwin AS Jr. 1996. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol, 14:649-83.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 8
    • 33744822714 scopus 로고    scopus 로고
    • Antimicrobial peptides in COPD - basic biology and therapeutic applications
    • Bals R, Hiemstra PS. 2006. Antimicrobial peptides in COPD - basic biology and therapeutic applications. Curr Drug Targets, 7:743-50.
    • (2006) Curr Drug Targets , vol.7 , pp. 743-750
    • Bals, R.1    Hiemstra, P.S.2
  • 9
    • 3242726932 scopus 로고    scopus 로고
    • Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers
    • Barber R, Baillie GS, Bergmann R, et al. 2004. Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers. Am J Physiol Lung Cell Mol Physiol, 287:L332-43.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Barber, R.1    Baillie, G.S.2    Bergmann, R.3
  • 10
    • 0141928029 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: Molecular and cellular mechanisms
    • Barnes PJ, Shapiro SD, Pauwels RA. 2003. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J, 22:672-88.
    • (2003) Eur Respir J , vol.22 , pp. 672-688
    • Barnes, P.J.1    Shapiro, S.D.2    Pauwels, R.A.3
  • 11
    • 20444480168 scopus 로고    scopus 로고
    • COPD: Current therapeutic interventions and future approaches
    • Barnes PJ, Stockley RA. 2005. COPD: current therapeutic interventions and future approaches. Eur Respir J, 25:1084-106.
    • (2005) Eur Respir J , vol.25 , pp. 1084-1106
    • Barnes, P.J.1    Stockley, R.A.2
  • 12
    • 31944440761 scopus 로고    scopus 로고
    • Corticosteroid effects on cell signalling
    • Barnes PJ. 2006. Corticosteroid effects on cell signalling. Eur Respir J, 27:413-26.
    • (2006) Eur Respir J , vol.27 , pp. 413-426
    • Barnes, P.J.1
  • 13
    • 0343446113 scopus 로고    scopus 로고
    • Lipid metabolite involvement in the activation of the human heme oxygenase-1 gene
    • Basu-Modak S, Luscher P, Tyrrell RM. 1996. Lipid metabolite involvement in the activation of the human heme oxygenase-1 gene. Free Radic Biol Med, 20:887-97.
    • (1996) Free Radic Biol Med , vol.20 , pp. 887-897
    • Basu-Modak, S.1    Luscher, P.2    Tyrrell, R.M.3
  • 14
    • 30344436368 scopus 로고    scopus 로고
    • Hit-to-Lead studies: The discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists
    • Baxter A, Cooper A, Kinchin E, et al. 2006. Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists. Bioorg Med Chem Lett, 16:960-3.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 960-963
    • Baxter, A.1    Cooper, A.2    Kinchin, E.3
  • 15
    • 32644490529 scopus 로고    scopus 로고
    • Evidence of a role of tumor necrosis factor alpha in refractory asthma
    • Berry MA, Hargadon B, Shelley M, et al. 2006. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med, 354:697-708.
    • (2006) N Engl J Med , vol.354 , pp. 697-708
    • Berry, M.A.1    Hargadon, B.2    Shelley, M.3
  • 16
    • 0242331294 scopus 로고    scopus 로고
    • Oxidant metabolism in chronic obstructive pulmonary disease
    • s
    • Boots AW, Haenen GF, Bast A. 2003. Oxidant metabolism in chronic obstructive pulmonary disease. Eur Respir J Suppl, 46:14s-27s.
    • (2003) Eur Respir J Suppl , vol.46
    • Boots, A.W.1    Haenen, G.F.2    Bast, A.3
  • 17
    • 33749155173 scopus 로고    scopus 로고
    • Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice
    • Bracke KR, D'Hulst AI, Maes T, et al. 2006. Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice. J Immunol, 177:4350-9.
    • (2006) J Immunol , vol.177 , pp. 4350-4359
    • Bracke, K.R.1    D'Hulst, A.I.2    Maes, T.3
  • 18
    • 29144491811 scopus 로고    scopus 로고
    • p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts
    • Briata P, Forcales SV, Ponassi M, et al. 2005. p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Mol Cell, 20:891-903.
    • (2005) Mol Cell , vol.20 , pp. 891-903
    • Briata, P.1    Forcales, S.V.2    Ponassi, M.3
  • 19
    • 0028361231 scopus 로고
    • Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue
    • Bridgeman MM, Marsden M, Selby C, et al. 1994. Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue. Thorax, 49:670-5.
    • (1994) Thorax , vol.49 , pp. 670-675
    • Bridgeman, M.M.1    Marsden, M.2    Selby, C.3
  • 20
    • 0027512081 scopus 로고
    • Age, sex, cigarette smoking and indices of free radical activity in healthy humans
    • Bridges AB, Scott NA, Parry GJ, et al. 1993. Age, sex, cigarette smoking and indices of free radical activity in healthy humans. Eur J Med, 2:205-8.
    • (1993) Eur J Med , vol.2 , pp. 205-208
    • Bridges, A.B.1    Scott, N.A.2    Parry, G.J.3
  • 21
    • 20144382091 scopus 로고    scopus 로고
    • Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease
    • Brightling CE, McKenna S, Hargadon B, et al. 2005. Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease. Thorax, 60:193-8.
    • (2005) Thorax , vol.60 , pp. 193-198
    • Brightling, C.E.1    McKenna, S.2    Hargadon, B.3
  • 22
    • 0029057210 scopus 로고
    • Dietary antioxidant vitamin intake and lung function in the general population
    • Britton JR, Pavord ID, Richards KA, et al. 1995. Dietary antioxidant vitamin intake and lung function in the general population. Am J Respir Crit Care Med, 151:13 83-7.
    • (1995) Am J Respir Crit Care Med , vol.151 , Issue.13 , pp. 83-87
    • Britton, J.R.1    Pavord, I.D.2    Richards, K.A.3
  • 23
    • 26844448558 scopus 로고    scopus 로고
    • Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344
    • Brodmerkel CM, Huber R, Covington M, et al. 2005. Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344. J Immunol, 175:5370-8.
    • (2005) J Immunol , vol.175 , pp. 5370-5378
    • Brodmerkel, C.M.1    Huber, R.2    Covington, M.3
  • 24
    • 18944390164 scopus 로고    scopus 로고
    • The effect of marimastat, a metalloprotease inMbitor, on allergen-induced asthmatic hyper-reactivity
    • Bruce C, Thomas PS. 2005. The effect of marimastat, a metalloprotease inMbitor, on allergen-induced asthmatic hyper-reactivity. Toxicol Appl Pharmacol, 205:126-32.
    • (2005) Toxicol Appl Pharmacol , vol.205 , pp. 126-132
    • Bruce, C.1    Thomas, P.S.2
  • 25
    • 33746850573 scopus 로고    scopus 로고
    • 4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties
    • Butora G, Morriello GJ, Kothandaraman S, et al. 2006. 4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties. Bioorg Med Chem Lett, 16:4715-22.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 4715-4722
    • Butora, G.1    Morriello, G.J.2    Kothandaraman, S.3
  • 26
    • 0027176789 scopus 로고
    • Elevation of cysteine and replenishment of glutathione in rat lung slices by cysteme isopropylester and other cysteine precursors
    • Butterworth M, Upshall DG, Hobbs M, et al. 1993. Elevation of cysteine and replenishment of glutathione in rat lung slices by cysteme isopropylester and other cysteine precursors. Biochem Pharmacol, 45:1769-74.
    • (1993) Biochem Pharmacol , vol.45 , pp. 1769-1774
    • Butterworth, M.1    Upshall, D.G.2    Hobbs, M.3
  • 27
    • 0031002403 scopus 로고    scopus 로고
    • Further investigation of the use of intratracheally administered hyaluronic acid to ameliorate elastase-induced emphysema
    • Cantor JO, Cerreta JM, Armand G, et al. 1997. Further investigation of the use of intratracheally administered hyaluronic acid to ameliorate elastase-induced emphysema. Exp Lung Res, 23:229-44.
    • (1997) Exp Lung Res , vol.23 , pp. 229-244
    • Cantor, J.O.1    Cerreta, J.M.2    Armand, G.3
  • 28
    • 0033808249 scopus 로고    scopus 로고
    • The effect of hyaluronan on elastic fiber injury in vitro and elastase-induced airspace enlargement in vivo
    • Cantor JO, Shteyngart B, Cerreta JM, et al. 2000. The effect of hyaluronan on elastic fiber injury in vitro and elastase-induced airspace enlargement in vivo. Proc Soc Exp Biol Med, 225:65-71.
    • (2000) Proc Soc Exp Biol Med , vol.225 , pp. 65-71
    • Cantor, J.O.1    Shteyngart, B.2    Cerreta, J.M.3
  • 29
    • 17644363337 scopus 로고    scopus 로고
    • Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema
    • Cantor JO, Cerreta JM, Ochoa M, et al. 2005. Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema. Exp Lung Res, 31:417-30.
    • (2005) Exp Lung Res , vol.31 , pp. 417-430
    • Cantor, J.O.1    Cerreta, J.M.2    Ochoa, M.3
  • 31
    • 4344689086 scopus 로고    scopus 로고
    • The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    • Celedon JC, Lange C, Raby BA, et al. 2004. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet, 13:1649-56.
    • (2004) Hum Mol Genet , vol.13 , pp. 1649-1656
    • Celedon, J.C.1    Lange, C.2    Raby, B.A.3
  • 32
    • 13044295425 scopus 로고    scopus 로고
    • BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: A promising neuroprotective strategy
    • Chabrier PE, Auguet M, Spinnewyn B, et al. 1999. BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: a promising neuroprotective strategy. Proc Natl Acad Sci U S A, 96:10824-9.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 10824-10829
    • Chabrier, P.E.1    Auguet, M.2    Spinnewyn, B.3
  • 33
    • 0030976501 scopus 로고    scopus 로고
    • Corticosteroid reversibility in COPD is related to features of asthma
    • Chanez P, Vignola AM, O'Shaugnessy T, et al. 1997. Corticosteroid reversibility in COPD is related to features of asthma. Am J Respir Crit Care Med, 155:1529-34.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 1529-1534
    • Chanez, P.1    Vignola, A.M.2    O'Shaugnessy, T.3
  • 34
    • 25444495661 scopus 로고    scopus 로고
    • TGF-beta1 stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process
    • Cheng J, Diaz Encarnacion MM, Warner GM, et al. 2005. TGF-beta1 stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process. Am J Physiol Cell Physiol, 289:C959-70.
    • (2005) Am J Physiol Cell Physiol , vol.289
    • Cheng, J.1    Diaz Encarnacion, M.M.2    Warner, G.M.3
  • 35
    • 0028366350 scopus 로고
    • Messenger RNA levels of lung extracellular matrix proteins during ozone exposure
    • Choi AM, Elbon CL, Bruce SA, et al. 1994. Messenger RNA levels of lung extracellular matrix proteins during ozone exposure. Lung, 172:15-30.
    • (1994) Lung , vol.172 , pp. 15-30
    • Choi, A.M.1    Elbon, C.L.2    Bruce, S.A.3
  • 36
    • 12344305212 scopus 로고    scopus 로고
    • Potential role of inhibitors of neutrophil elastase in treating diseases of the airway
    • Chughtai B, O'Riordan TG. 2004. Potential role of inhibitors of neutrophil elastase in treating diseases of the airway. J Aerosol Med, 17:289-98.
    • (2004) J Aerosol Med , vol.17 , pp. 289-298
    • Chughtai, B.1    O'Riordan, T.G.2
  • 37
    • 33744799127 scopus 로고    scopus 로고
    • Cytokines as targets in chronic obstructive pulmonary disease
    • Chung KF. 2006. Cytokines as targets in chronic obstructive pulmonary disease. Curr Drug Targets, 7:675-81.
    • (2006) Curr Drug Targets , vol.7 , pp. 675-681
    • Chung, K.F.1
  • 38
    • 0042031488 scopus 로고    scopus 로고
    • alpha-] -Antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse
    • Churg A, Wang RD, Xje C, et al. 2003. alpha-] -Antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med, 168:199-207.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 199-207
    • Churg, A.1    Wang, R.D.2    Xje, C.3
  • 39
    • 33845473487 scopus 로고    scopus 로고
    • Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall
    • Churg A, Tai H, Coulthard T, et al. 2006. Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall. Am J Respir Crit Care Med, 174:1327-34.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1327-1334
    • Churg, A.1    Tai, H.2    Coulthard, T.3
  • 40
    • 0037614742 scopus 로고    scopus 로고
    • Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease
    • Corradi M, Rubinstein I, Andreoli I, et al. 2003. Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 167:1380-6.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1380-1386
    • Corradi, M.1    Rubinstein, I.2    Andreoli, I.3
  • 41
    • 4544379912 scopus 로고    scopus 로고
    • Theophylline restores histone deacetylase activity and steroid responses in COPI) macrophages
    • Cosio BG, Tsaprouni L, Ito K, et al. 2004. Theophylline restores histone deacetylase activity and steroid responses in COPI) macrophages. J Exp Med, 200:689-95.
    • (2004) J Exp Med , vol.200 , pp. 689-695
    • Cosio, B.G.1    Tsaprouni, L.2    Ito, K.3
  • 42
    • 0345018815 scopus 로고    scopus 로고
    • N-acetylcysteine: Pharmacological considerations and experimental and clinical applications
    • Cotgreave IA. 1997. N-acetylcysteine: pharmacological considerations and experimental and clinical applications. Adv Pharmacol, 38:205-27.
    • (1997) Adv Pharmacol , vol.38 , pp. 205-227
    • Cotgreave, I.A.1
  • 43
    • 0027216458 scopus 로고
    • Cigarette smoke oxidation of human plasma constituents
    • discussion 89-90
    • Cross CE, O'Neill CA, Reznick AZ, et al. 1993. Cigarette smoke oxidation of human plasma constituents. Ann N Y Acad Sci, 686:72-89; discussion 89-90.
    • (1993) Ann N Y Acad Sci , vol.686 , pp. 72-89
    • Cross, C.E.1    O'Neill, C.A.2    Reznick, A.Z.3
  • 44
    • 0028558599 scopus 로고
    • Oxidants, antioxidants, and respiratory tract lining fluids
    • Cross CE, van der Vliet A, O'Neill CA, et al. 1994. Oxidants, antioxidants, and respiratory tract lining fluids. Environ Health Perspect, 102 Suppl 10:185-91.
    • (1994) Environ Health Perspect , vol.102 , Issue.SUPPL. 10 , pp. 185-191
    • Cross, C.E.1    van der Vliet, A.2    O'Neill, C.A.3
  • 45
    • 0037216753 scopus 로고    scopus 로고
    • Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease
    • Culpitt SV, Rogers DF, Shah P, et al. 2003. Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 167:24-31.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 24-31
    • Culpitt, S.V.1    Rogers, D.F.2    Shah, P.3
  • 46
    • 18244396326 scopus 로고    scopus 로고
    • Sputum matrix metalloproteases: Comparison between chronic obstructive pulmonary disease and asthma
    • Culpitt SV, Rogers DF, Traves SL, et al. 2005. Sputum matrix metalloproteases: comparison between chronic obstructive pulmonary disease and asthma. Respir Med, 99:703-10.
    • (2005) Respir Med , vol.99 , pp. 703-710
    • Culpitt, S.V.1    Rogers, D.F.2    Traves, S.L.3
  • 47
    • 10644250916 scopus 로고    scopus 로고
    • Long-term oral n-acetylcysteine reduces exhaled hydrogen peroxide in stable COPD
    • De Benedetto F, Aceto A, Dragani B, et al. 2005. Long-term oral n-acetylcysteine reduces exhaled hydrogen peroxide in stable COPD. Pulm Pharmacol Ther, 18:41-7.
    • (2005) Pulm Pharmacol Ther , vol.18 , pp. 41-47
    • De Benedetto, F.1    Aceto, A.2    Dragani, B.3
  • 48
    • 0032416948 scopus 로고    scopus 로고
    • Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease
    • De Boer WI, van Schadewijk A, Sont JK, et al. 1998. Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 158:1951-7.
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 1951-1957
    • De Boer, W.I.1    van Schadewijk, A.2    Sont, J.K.3
  • 49
    • 0036261088 scopus 로고    scopus 로고
    • Cytokines and therapy in COPD: A promising combination?
    • De Boer WI. 2002. Cytokines and therapy in COPD: a promising combination? Chest, 121:209S-218S.
    • (2002) Chest , vol.121
    • De Boer, W.I.1
  • 50
    • 13844298793 scopus 로고    scopus 로고
    • Perspectives for cytokine antagonist therapy in COPD
    • de Boer WI. 2005. Perspectives for cytokine antagonist therapy in COPD. Drug Discov Today, 10:93-106.
    • (2005) Drug Discov Today , vol.10 , pp. 93-106
    • de Boer, W.I.1
  • 51
    • 31544462308 scopus 로고    scopus 로고
    • Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease
    • De Boer WI, Hau CM, van Schadewijk A, et al. 2006. Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. Am J Clin Pathol, 125:184-92.
    • (2006) Am J Clin Pathol , vol.125 , pp. 184-192
    • De Boer, W.I.1    Hau, C.M.2    van Schadewijk, A.3
  • 52
    • 34147093566 scopus 로고    scopus 로고
    • Molecular mechanisms in chronic obstructive pulmonary disease: Potential targets for therapy
    • De Boer WI, Alagappan V& Sharma HS. 2007. Molecular mechanisms in chronic obstructive pulmonary disease: potential targets for therapy. Cell Biochem Biophys, 47:131-48.
    • (2007) Cell Biochem Biophys , vol.47 , pp. 131-148
    • De Boer, W.I.1    Alagappan, V.2    Sharma, H.S.3
  • 53
    • 3142546235 scopus 로고    scopus 로고
    • The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation
    • Dean JL, Sully G, Clark AR, et al. 2004. The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation. Cell Signal, 16:1113-21.
    • (2004) Cell Signal , vol.16 , pp. 1113-1121
    • Dean, J.L.1    Sully, G.2    Clark, A.R.3
  • 54
    • 0034961209 scopus 로고    scopus 로고
    • The bronchitis randomized on NAC cost-utility study (BRONCUS): Hypothesis and design BRONCUS-trial Committee
    • Decramer M, Dekhuijzen PN, Troosters T, et al. 2001. The bronchitis randomized on NAC cost-utility study (BRONCUS): hypothesis and design BRONCUS-trial Committee. Eur Respir J, 17:329-36.
    • (2001) Eur Respir J , vol.17 , pp. 329-336
    • Decramer, M.1    Dekhuijzen, P.N.2    Troosters, T.3
  • 55
    • 20944433417 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): A randomised placebo-controlled trial
    • Decramer M, Rutten-van Molken M, Dekhuijzen PN, et al. 2005. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet, 365:1552-60.
    • (2005) Lancet , vol.365 , pp. 1552-1560
    • Decramer, M.1    Rutten-van Molken, M.2    Dekhuijzen, P.N.3
  • 56
    • 1842481121 scopus 로고    scopus 로고
    • Antioxidant properties of N-acetylcysteme: Their relevance in relation to chronic obstructive pulmonary disease
    • Dekhuijzen PN. 2004. Antioxidant properties of N-acetylcysteme: their relevance in relation to chronic obstructive pulmonary disease. Eur Respir J, 23:629-36.
    • (2004) Eur Respir J , vol.23 , pp. 629-636
    • Dekhuijzen, P.N.1
  • 57
    • 0034720896 scopus 로고    scopus 로고
    • Kinase regulation in inflammatory response
    • Delhase M, Li N, Karin M. 2000. Kinase regulation in inflammatory response. Nature, 406:367-8.
    • (2000) Nature , vol.406 , pp. 367-368
    • Delhase, M.1    Li, N.2    Karin, M.3
  • 58
    • 33645068585 scopus 로고    scopus 로고
    • Elevated MMP-12 protein levels in induced sputum from patients with COPD
    • Demedts IK, Morel-Montero A, Lebecque S, et al. 2006. Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax, 61:196-201.
    • (2006) Thorax , vol.61 , pp. 196-201
    • Demedts, I.K.1    Morel-Montero, A.2    Lebecque, S.3
  • 59
    • 13544251372 scopus 로고    scopus 로고
    • Enhanced levels of hyaluronan in lungs of patients with COPD: Relationship with lung ftmction and local inflammation
    • Dentener MA, Vemooy JH, Hendriks S, et al. 2005. Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung ftmction and local inflammation. Thorax, 60:114-19.
    • (2005) Thorax , vol.60 , pp. 114-119
    • Dentener, M.A.1    Vemooy, J.H.2    Hendriks, S.3
  • 60
    • 33745150041 scopus 로고    scopus 로고
    • Differences in local versus systemic TNFalpha production in COPD: Inhibitory effect of hyaluronan on LPS induced blood cell TNFalpha release
    • DenteneT MA, Louis R, Cloots RH, et al. 2006. Differences in local versus systemic TNFalpha production in COPD: inhibitory effect of hyaluronan on LPS induced blood cell TNFalpha release. Thorax, 61:478-84.
    • (2006) Thorax , vol.61 , pp. 478-484
    • DenteneT, M.A.1    Louis, R.2    Cloots, R.H.3
  • 61
    • 0033883014 scopus 로고    scopus 로고
    • Delayed wound healing in CXCR2 knockout once
    • Devalaraja RM, Nanney LB, Du J, et al. 2000. Delayed wound healing in CXCR2 knockout once. J Invest Dermatol, 115:234-44.
    • (2000) J Invest Dermatol , vol.115 , pp. 234-244
    • Devalaraja, R.M.1    Nanney, L.B.2    Du, J.3
  • 62
    • 18344375064 scopus 로고    scopus 로고
    • Decreased T lymphocyte infiltration in bronchial biopsies of subjects with severe chronic obstructive pulmonary disease
    • Di Stefano A, Capelli A, Luguardi M, et al. 2001. Decreased T lymphocyte infiltration in bronchial biopsies of subjects with severe chronic obstructive pulmonary disease. Clin Exp Allergy, 31:893-902.
    • (2001) Clin Exp Allergy , vol.31 , pp. 893-902
    • Di Stefano, A.1    Capelli, A.2    Luguardi, M.3
  • 63
    • 0026479075 scopus 로고
    • Plasma elastin-derived peptide levels in normal adults, children, and emphysematous subjects. Physiologic and computed torriographic scan correlates
    • Dillon TJ, Walsh RL, Scicchitano R, et al. 1992. Plasma elastin-derived peptide levels in normal adults, children, and emphysematous subjects. Physiologic and computed torriographic scan correlates. Am Rev Respir Dis, 146:1143-8.
    • (1992) Am Rev Respir Dis , vol.146 , pp. 1143-1148
    • Dillon, T.J.1    Walsh, R.L.2    Scicchitano, R.3
  • 64
    • 0026606759 scopus 로고
    • N-acetylcysteine by metered dose inhaler in the treatment of chronic bronchitis: A multi-centre study
    • Dueholin M, Nielsen C, Thorshauge H, et al. 1992. N-acetylcysteine by metered dose inhaler in the treatment of chronic bronchitis: a multi-centre study. Respir Med, 86:89-92.
    • (1992) Respir Med , vol.86 , pp. 89-92
    • Dueholin, M.1    Nielsen, C.2    Thorshauge, H.3
  • 65
    • 33845963398 scopus 로고    scopus 로고
    • Discovery of 2-Hydroxy-N, N-dimethyl-3-{2- (R)-1-(5-methylfuran- 2-yl)propyl]amino]-3, 4-dioxocyclobut-1 -enylamino}benzamide (SCH 527123): A Potent, Orally Bioavailable CXCR2/CXCRl Receptor Antagonist
    • Dwyer MP, Yu Y, Chao J, et al. 2006. Discovery of 2-Hydroxy-N, N-dimethyl-3-{2- (R)-1-(5-methylfuran- 2-yl)propyl]amino]-3, 4-dioxocyclobut-1 -enylamino}benzamide (SCH 527123): A Potent, Orally Bioavailable CXCR2/CXCRl Receptor Antagonist. J Med Chem, 49:7603-6.
    • (2006) J Med Chem , vol.49 , pp. 7603-7606
    • Dwyer, M.P.1    Yu, Y.2    Chao, J.3
  • 66
    • 15144355533 scopus 로고    scopus 로고
    • Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase
    • Edwards PD, Andisik DW, Bryant CA, et al. 1997. Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase. J Med Chem, 40:1876-85.
    • (1997) J Med Chem , vol.40 , pp. 1876-1885
    • Edwards, P.D.1    Andisik, D.W.2    Bryant, C.A.3
  • 67
    • 0032962228 scopus 로고    scopus 로고
    • N-isobutyrylcysteine, a donor of systemic thiols, does not reduce the exacerbation rate in chronic bronchitis
    • Ekberg-Jansson A, Larson M, MacNee W, et al. 1999. N-isobutyrylcysteine, a donor of systemic thiols, does not reduce the exacerbation rate in chronic bronchitis. Eur Respir J, 13:829-34.
    • (1999) Eur Respir J , vol.13 , pp. 829-834
    • Ekberg-Jansson, A.1    Larson, M.2    MacNee, W.3
  • 68
    • 33749438560 scopus 로고    scopus 로고
    • The effects of a monoclonal antibody directed against rumor necrosis factor-alpha in asthma
    • Erin EM, Leaker BR, Nicholson GC, et al. 2006. The effects of a monoclonal antibody directed against rumor necrosis factor-alpha in asthma. Am J Respir Crit Care Med, 174:753-62.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 753-762
    • Erin, E.M.1    Leaker, B.R.2    Nicholson, G.C.3
  • 69
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. 2003. The biology of VEGF and its receptors. Nat Med, 9:669-76.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 70
    • 0031041367 scopus 로고    scopus 로고
    • Activation of MMP-9 by neutrophil elastase in an in vivo model of acute lung injury
    • Ferry G, Lonchampt M, Pennel L, et al. 1997. Activation of MMP-9 by neutrophil elastase in an in vivo model of acute lung injury. FEBS Lett, 402:111-15.
    • (1997) FEBS Lett , vol.402 , pp. 111-115
    • Ferry, G.1    Lonchampt, M.2    Pennel, L.3
  • 71
    • 34249087274 scopus 로고    scopus 로고
    • Efficacy of the p38 MAP Kinase Inhibitor, SD-282, in an Inflammatory Model of COPD in A/J Mice
    • Fitzgerald MF, Spicer D, Ma JY, et al. 2006. Efficacy of the p38 MAP Kinase Inhibitor, SD-282, in an Inflammatory Model of COPD in A/J Mice. Proc Am Thorac Soc, 3:A850.
    • (2006) Proc Am Thorac Soc , vol.3
    • Fitzgerald, M.F.1    Spicer, D.2    Ma, J.Y.3
  • 72
    • 0142012148 scopus 로고    scopus 로고
    • Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    • Gamble E, Grootendorst DC, Brightling CE, et al. 2003. Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 168:976-82.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 976-982
    • Gamble, E.1    Grootendorst, D.C.2    Brightling, C.E.3
  • 73
    • 26844486618 scopus 로고    scopus 로고
    • Effects of inhaled corticosteroids on sputum cell counts in stable chronic obstructive pulmonary disease: A systematic review and a meta-analysis
    • Gan WQ, Man SF, Sin DD. 2005. Effects of inhaled corticosteroids on sputum cell counts in stable chronic obstructive pulmonary disease: a systematic review and a meta-analysis. BMC Palm Med, 5:3.
    • (2005) BMC Palm Med , vol.5 , pp. 3
    • Gan, W.Q.1    Man, S.F.2    Sin, D.D.3
  • 74
    • 33744770621 scopus 로고    scopus 로고
    • Efficacy and safety of inhaled corticosteroids inpatients with COPD: A systematic review and meta-analysis of health outcomes
    • Gartlehner G, Hansen RA, Carson SS, et al. 2006. Efficacy and safety of inhaled corticosteroids inpatients with COPD: a systematic review and meta-analysis of health outcomes. Ann Fam Med, 4:253-62.
    • (2006) Ann Fam Med , vol.4 , pp. 253-262
    • Gartlehner, G.1    Hansen, R.A.2    Carson, S.S.3
  • 75
    • 0037718518 scopus 로고    scopus 로고
    • N-acetyleysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease
    • Gerrits CM, Herings RM, Leufkens HG, et al. 2003. N-acetyleysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease. Eur Respir J, 21:795-8.
    • (2003) Eur Respir J , vol.21 , pp. 795-798
    • Gerrits, C.M.1    Herings, R.M.2    Leufkens, H.G.3
  • 76
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh S, May MJ, Kopp EB. 1998. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol, 16:225-60.
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 77
    • 0031964168 scopus 로고    scopus 로고
    • Antioxidant gene expression in rat lung after exposure to cigarette smoke
    • Gilks CB, Price K, Wright JL, et al. 1998. Antioxidant gene expression in rat lung after exposure to cigarette smoke. Am J Pathol, 152:269-78.
    • (1998) Am J Pathol , vol.152 , pp. 269-278
    • Gilks, C.B.1    Price, K.2    Wright, J.L.3
  • 78
    • 0030902329 scopus 로고    scopus 로고
    • Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro
    • Gillissen A, Jaworska M, Orth M, et al. 1997. Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro. Respir Med, 91:159-68.
    • (1997) Respir Med , vol.91 , pp. 159-168
    • Gillissen, A.1    Jaworska, M.2    Orth, M.3
  • 79
    • 33947596912 scopus 로고    scopus 로고
    • A disintegrin and metalloproteinase 33 and chronic obstructive pulmonary disease pathophysiology
    • Gosman MM, Boezen HM, van Diemen CC, et al. 2006. A disintegrin and metalloproteinase 33 and chronic obstructive pulmonary disease pathophysiology. Thorax, 62:242-7.
    • (2006) Thorax , vol.62 , pp. 242-247
    • Gosman, M.M.1    Boezen, H.M.2    van Diemen, C.C.3
  • 80
    • 30744456815 scopus 로고    scopus 로고
    • Increased number of B-cells in bronchial biopsies in COPD
    • 27:60-A
    • Gosman MM, Willemse BW, Jansen DF, et al. 2006. Increased number of B-cells in bronchial biopsies in COPD. Eur Respir J, 27:60-A.
    • (2006) Eur Respir J
    • Gosman, M.M.1    Willemse, B.W.2    Jansen, D.F.3
  • 81
    • 0030680913 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: Role of bronchiolar mast cells and macrophages
    • Grashoff WF, Sont JK, Sterk PJ, et al. 1997. Chronic obstructive pulmonary disease: role of bronchiolar mast cells and macrophages. Am J Pathol, 151:1785-90.
    • (1997) Am J Pathol , vol.151 , pp. 1785-1790
    • Grashoff, W.F.1    Sont, J.K.2    Sterk, P.J.3
  • 82
    • 0031944512 scopus 로고    scopus 로고
    • Dietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: The MORGEN study
    • Grievink L, Smit HA, Ocke MC, et al. 1998. Dietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the MORGEN study. Thorax, 53:166-71.
    • (1998) Thorax , vol.53 , pp. 166-171
    • Grievink, L.1    Smit, H.A.2    Ocke, M.C.3
  • 83
    • 28444450926 scopus 로고    scopus 로고
    • Treatment with PDE4 inhibitor roflumilast reduces sputum neutrophil and eosinophil numbers in patients with COPD
    • Grootendorst DC, Gauw SA, Sterk PJ. 2005. Treatment with PDE4 inhibitor roflumilast reduces sputum neutrophil and eosinophil numbers in patients with COPD. Proc Am Thoracic Soc, 2:A543.
    • (2005) Proc Am Thoracic Soc , vol.2
    • Grootendorst, D.C.1    Gauw, S.A.2    Sterk, P.J.3
  • 84
    • 33750916339 scopus 로고    scopus 로고
    • Mechanoregulation of monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells
    • Guest TM, Vlastos G, Alarrieddine FM, et al. 2006. Mechanoregulation of monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells. Antioxid Redox Signal, 8:1461-71.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 1461-1471
    • Guest, T.M.1    Vlastos, G.2    Alarrieddine, F.M.3
  • 85
    • 0033859712 scopus 로고    scopus 로고
    • Mitochondrial glutathione replacement restores surfactant synthesis and secretion in alveolar epithelial cells of ethanol-fed rats
    • Guidot DM, Brown LA. 2000. Mitochondrial glutathione replacement restores surfactant synthesis and secretion in alveolar epithelial cells of ethanol-fed rats. Alcohol Clin Exp Res, 24:1070-6.
    • (2000) Alcohol Clin Exp Res , vol.24 , pp. 1070-1076
    • Guidot, D.M.1    Brown, L.A.2
  • 86
    • 0033060918 scopus 로고    scopus 로고
    • Effect of vitamin E on exhaled ethane in cigarette smokers
    • Habib MP, Tank LJ, Lane LC, et al. 1999. Effect of vitamin E on exhaled ethane in cigarette smokers. Chest, 115:684-90.
    • (1999) Chest , vol.115 , pp. 684-690
    • Habib, M.P.1    Tank, L.J.2    Lane, L.C.3
  • 87
    • 0035039117 scopus 로고    scopus 로고
    • Role of p38 MAPkmase in LPS-induced airway inflammation in the rat
    • Haddad EB, BirrelIM, McCluskie K, et al. 2001. Role of p38 MAPkmase in LPS-induced airway inflammation in the rat. Br J Pharmacol, 132:1715-24.
    • (2001) Br J Pharmacol , vol.132 , pp. 1715-1724
    • Haddad, E.B.1    Birrel, I.M.2    McCluskie, K.3
  • 88
    • 33746938320 scopus 로고    scopus 로고
    • A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis
    • Haringman JJ, Gerlag DM, Smeets TJ, et al. 2006. A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis. Arthritis Rheum, 54:2387-92.
    • (2006) Arthritis Rheum , vol.54 , pp. 2387-2392
    • Haringman, J.J.1    Gerlag, D.M.2    Smeets, T.J.3
  • 89
    • 0036723948 scopus 로고    scopus 로고
    • Diminished immunoreactivity of gamma-glutamylcysteine synthetase in the airways of smokers' lung
    • Harju T, Kaarteenaho-Wiik R, Soini Y, et al. 2002. Diminished immunoreactivity of gamma-glutamylcysteine synthetase in the airways of smokers' lung. Am J Respir Crit Care Med, 166:754-9.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 754-759
    • Harju, T.1    Kaarteenaho-Wiik, R.2    Soini, Y.3
  • 90
    • 0030794896 scopus 로고    scopus 로고
    • Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer
    • Harrison DJ, Cantlay AM, Rae F, et al. 1997. Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer. Hum Exp Toxicol, 16:356-60.
    • (1997) Hum Exp Toxicol , vol.16 , pp. 356-360
    • Harrison, D.J.1    Cantlay, A.M.2    Rae, F.3
  • 91
    • 0030823772 scopus 로고    scopus 로고
    • Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
    • Hautamaki RD, Kobayashi DK, Senior RM, et al. 1997. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science, 277:2002-4.
    • (1997) Science , vol.277 , pp. 2002-2004
    • Hautamaki, R.D.1    Kobayashi, D.K.2    Senior, R.M.3
  • 92
    • 33644588726 scopus 로고    scopus 로고
    • CC chemokine receptor-2 deficiency attenuates oxidative stress and infarct size caused by myocardial ischemia-reperfusion in mice
    • Hayasaki T, Kaikita K, Okuma T, et al. 2006. CC chemokine receptor-2 deficiency attenuates oxidative stress and infarct size caused by myocardial ischemia-reperfusion in mice. Circ J, 70:342-51.
    • (2006) Circ J , vol.70 , pp. 342-351
    • Hayasaki, T.1    Kaikita, K.2    Okuma, T.3
  • 93
    • 33644753147 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetrapTolin expression, stability, and binding to adenine/uridine-rich element
    • Hitti E, Iakovleva T, Brook M, et al. 2006. Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetrapTolin expression, stability, and binding to adenine/uridine-rich element. Mol Cell Biol, 26:2399-407.
    • (2006) Mol Cell Biol , vol.26 , pp. 2399-2407
    • Hitti, E.1    Iakovleva, T.2    Brook, M.3
  • 94
    • 33645885315 scopus 로고    scopus 로고
    • Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists
    • Ho KK, Auld DS, Bohnstedt AC, et al. 2006. Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists. Bioorg Med Chem Lett, 16:2724-8.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 2724-2728
    • Ho, K.K.1    Auld, D.S.2    Bohnstedt, A.C.3
  • 95
    • 4344675455 scopus 로고    scopus 로고
    • Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
    • Hogg JC. 2004. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet, 364:709-21.
    • (2004) Lancet , vol.364 , pp. 709-721
    • Hogg, J.C.1
  • 96
    • 0034234254 scopus 로고    scopus 로고
    • Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase
    • Holmes-McNary M, Baldwin AS Jr. 2000. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Res, 60:3477-83.
    • (2000) Cancer Res , vol.60 , pp. 3477-3483
    • Holmes-McNary, M.1    Baldwin Jr., A.S.2
  • 97
    • 30744439266 scopus 로고    scopus 로고
    • Projections of future resource use and the costs of asthma and COPD in the Netherlands]
    • Hoogendoorn M, FeenstTa TL, Rutten-van Molken MP. 2006. [Projections of future resource use and the costs of asthma and COPD in the Netherlands]. Ned Tijdschr Geneeskd, 150:1243-50.
    • (2006) Ned Tijdschr Geneeskd , vol.150 , pp. 1243-1250
    • Hoogendoorn, M.1    FeenstTa, T.L.2    Rutten-van Molken, M.P.3
  • 98
    • 28244479315 scopus 로고    scopus 로고
    • Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma
    • Howarth PH, Babu KS, Arshad HS, et al. 2005. Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax, 60:1012-18.
    • (2005) Thorax , vol.60 , pp. 1012-1018
    • Howarth, P.H.1    Babu, K.S.2    Arshad, H.S.3
  • 99
    • 33845916054 scopus 로고    scopus 로고
    • Effects of flavonoids on the expression of the pro-inflammatory response in human monocytes induced by ligation of the receptor for AGEs
    • Huang SM, Wu CH, Yen GC. 2006. Effects of flavonoids on the expression of the pro-inflammatory response in human monocytes induced by ligation of the receptor for AGEs. Mol Nutr Food Res, 50:1129-39.
    • (2006) Mol Nutr Food Res , vol.50 , pp. 1129-1139
    • Huang, S.M.1    Wu, C.H.2    Yen, G.C.3
  • 100
    • 27944471364 scopus 로고    scopus 로고
    • Psychological characteristics of patients with chronic obstructive pulmonary disease: A review
    • Hynninen KM, Breitve MH, Wiborg AB, et al. 2005. Psychological characteristics of patients with chronic obstructive pulmonary disease: a review. J Psychosom Res, 59:429-43.
    • (2005) J Psychosom Res , vol.59 , pp. 429-443
    • Hynninen, K.M.1    Breitve, M.H.2    Wiborg, A.B.3
  • 101
    • 0035315925 scopus 로고    scopus 로고
    • Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages
    • Ito K, Lim S, Caramori G, et al. 2001. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. Faseb J, 15:1110-12.
    • (2001) Faseb J , vol.15 , pp. 1110-1112
    • Ito, K.1    Lim, S.2    Caramori, G.3
  • 102
    • 21044458874 scopus 로고    scopus 로고
    • Decreased histone deacetylase activity in chronic obstructive pulmonary disease
    • Ito K, Ito M, Elliott WM, et al. 2005. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med, 352:1967-76.
    • (2005) N Engl J Med , vol.352 , pp. 1967-1976
    • Ito, K.1    Ito, M.2    Elliott, W.M.3
  • 103
    • 10644223086 scopus 로고    scopus 로고
    • Inhibition of IKK2 and JNK differentially regulates GM-CSF and IL-8 release in epithelial cells and alveolar macrophages
    • Jazrawi E, Cosio BG, Barnes PJ, et al. 2003. Inhibition of IKK2 and JNK differentially regulates GM-CSF and IL-8 release in epithelial cells and alveolar macrophages. Am J Respir Crit Care Med, 167:A798.
    • (2003) Am J Respir Crit Care Med , vol.167
    • Jazrawi, E.1    Cosio, B.G.2    Barnes, P.J.3
  • 104
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • Johnson GL, Lapadat R. 2002. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science, 298:1911-12.
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 105
    • 33646384402 scopus 로고    scopus 로고
    • Health status: What does it mean for payers and patients?
    • Jones PW 2006. Health status: what does it mean for payers and patients? Proc Am Thorac Soc, 3:222-6.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 222-226
    • Jones, P.W.1
  • 106
    • 0036501372 scopus 로고    scopus 로고
    • The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
    • Joos L, He JQ, Shepherdson MB, et al. 2002. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Hum Mol Genet, 11:569-76.
    • (2002) Hum Mol Genet , vol.11 , pp. 569-576
    • Joos, L.1    He, J.Q.2    Shepherdson, M.B.3
  • 107
    • 33745483812 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages
    • Karimi K, Sarir H, Mortaz E, et al. 2006. Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages. Respir Res, 7:66.
    • (2006) Respir Res , vol.7 , pp. 66
    • Karimi, K.1    Sarir, H.2    Mortaz, E.3
  • 108
    • 0033660171 scopus 로고    scopus 로고
    • Inhibition of VEGF receptors causes lung cell apoptosis and emphysema
    • Kasahara Y, Tuder RM, Taraseviciene-Stewart L, et al. 2000. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest, 106:1311-19.
    • (2000) J Clin Invest , vol.106 , pp. 1311-1319
    • Kasahara, Y.1    Tuder, R.M.2    Taraseviciene-Stewart, L.3
  • 109
    • 0034942666 scopus 로고    scopus 로고
    • Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease
    • Kasielski M, Nowak D. 2001. Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease. Respir Med, 95:448-56.
    • (2001) Respir Med , vol.95 , pp. 448-456
    • Kasielski, M.1    Nowak, D.2
  • 110
    • 24044539196 scopus 로고    scopus 로고
    • NADPH oxidase restrains the matrix metalloprotemase activity of macrophages
    • Kassim SY, Fu X, Liles WC, et al. 2005. NADPH oxidase restrains the matrix metalloprotemase activity of macrophages. J Biol Chem, 280:30201-5.
    • (2005) J Biol Chem , vol.280 , pp. 30201-30205
    • Kassim, S.Y.1    Fu, X.2    Liles, W.C.3
  • 111
    • 0033782555 scopus 로고    scopus 로고
    • A polymorphism in the tumor necrosis factor-alpha gene promoter region may predispose to a poor prognosis in COPD
    • Keatings VM, Cave SJ, Henry MJ, et al. 2000. A polymorphism in the tumor necrosis factor-alpha gene promoter region may predispose to a poor prognosis in COPD. Chest, 118:971-5.
    • (2000) Chest , vol.118 , pp. 971-975
    • Keatings, V.M.1    Cave, S.J.2    Henry, M.J.3
  • 112
    • 1942504217 scopus 로고    scopus 로고
    • Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products
    • Kirkham PA, Spooner G, Rahman I, et al. 2004. Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products. Biochem Biophys Res Commun, 318:32-7.
    • (2004) Biochem Biophys Res Commun , vol.318 , pp. 32-37
    • Kirkham, P.A.1    Spooner, G.2    Rahman, I.3
  • 113
    • 1842428854 scopus 로고    scopus 로고
    • Does systemic inflammation trigger local exercise-induced oxidative stress in COPD?
    • Koechlin C, Couillard A, Cristol JP, et al. 2004. Does systemic inflammation trigger local exercise-induced oxidative stress in COPD? Eur Respir J, 23:538-44.
    • (2004) Eur Respir J , vol.23 , pp. 538-544
    • Koechlin, C.1    Couillard, A.2    Cristol, J.P.3
  • 114
    • 0033694206 scopus 로고    scopus 로고
    • Neutrophil priming by cigarette smoke condensate and a tobacco anti-idiotypic antibody
    • Koethe SM, Kuhrunuench JR, Becker CG. 2000. Neutrophil priming by cigarette smoke condensate and a tobacco anti-idiotypic antibody. Am J Pathol, 157:1735-43.
    • (2000) Am J Pathol , vol.157 , pp. 1735-1743
    • Koethe, S.M.1    Kuhrunuench, J.R.2    Becker, C.G.3
  • 115
    • 0028097891 scopus 로고
    • Current smoking of elderly men reduces antioxidants in alveolar macrophages
    • Kondo T, Tagami S, Yoshioka A, et al. 1994. Current smoking of elderly men reduces antioxidants in alveolar macrophages. Am J Respir Crit Care Med, 149:178-82.
    • (1994) Am J Respir Crit Care Med , vol.149 , pp. 178-182
    • Kondo, T.1    Tagami, S.2    Yoshioka, A.3
  • 116
    • 0036846226 scopus 로고    scopus 로고
    • Enhanced expression of fibroblast growth factors and receptor FGFR-1 during vascular remodeling in chronic obstructive pulmonary disease
    • Kranenburg AR, De Boer WI, Van Krieken JH, et al. 2002. Enhanced expression of fibroblast growth factors and receptor FGFR-1 during vascular remodeling in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol, 27:51, 7-25.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , Issue.51 , pp. 7-25
    • Kranenburg, A.R.1    De Boer, W.I.2    Van Krieken, J.H.3
  • 117
    • 13544275539 scopus 로고    scopus 로고
    • Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease
    • Kranenburg AR, de Boer WI, Alagappan VK, et al. 2005. Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease. Thorax, 60:106-13.
    • (2005) Thorax , vol.60 , pp. 106-113
    • Kranenburg, A.R.1    de Boer, W.I.2    Alagappan, V.K.3
  • 118
    • 33750717856 scopus 로고    scopus 로고
    • Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease
    • Kranenburg AR, Willems-Widyastuti A, Moori WJ, et al. 2006. Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease. Am J Clin Pathol, 126:725-35.
    • (2006) Am J Clin Pathol , vol.126 , pp. 725-735
    • Kranenburg, A.R.1    Willems-Widyastuti, A.2    Moori, W.J.3
  • 119
    • 0037573152 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease
    • Kucukaycan M, Van Krugten M, Pennings HJ, et al. 2002. Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease. Respir Res, 3:29.
    • (2002) Respir Res , vol.3 , pp. 29
    • Kucukaycan, M.1    Van Krugten, M.2    Pennings, H.J.3
  • 120
    • 9144219652 scopus 로고    scopus 로고
    • A lipid peroxidation-derived inflammatory mediator: Identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages
    • Kumagai T, Matsukawa N, Kaneko Y, et al. 2004. A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages. J Biol Chem, 279:48389-96.
    • (2004) J Biol Chem , vol.279 , pp. 48389-48396
    • Kumagai, T.1    Matsukawa, N.2    Kaneko, Y.3
  • 121
    • 0142026209 scopus 로고    scopus 로고
    • p38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
    • Kumar S, Boehm J, Lee JC. 2003. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov, 2:717-26.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 717-726
    • Kumar, S.1    Boehm, J.2    Lee, J.C.3
  • 122
    • 0028270358 scopus 로고
    • Collagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs
    • Lang MR, Fiaux GW, Gillooly M, et al. 1994. Collagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs. Thorax, 49:319-26.
    • (1994) Thorax , vol.49 , pp. 319-326
    • Lang, M.R.1    Fiaux, G.W.2    Gillooly, M.3
  • 123
    • 0141596739 scopus 로고    scopus 로고
    • ROS in the local and systemic pathogenesis of COPD
    • Langen RC, Kom SH, Wouters EF. 2003. ROS in the local and systemic pathogenesis of COPD. Free Radic Biol Med, 35:226-35.
    • (2003) Free Radic Biol Med , vol.35 , pp. 226-235
    • Langen, R.C.1    Kom, S.H.2    Wouters, E.F.3
  • 124
    • 0033030207 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase inhibitors - mechanisms and therapeutic potentials
    • Lee JC, Kassis S, Kumar S, et al. 1999. p38 mitogen-activated protein kinase inhibitors - mechanisms and therapeutic potentials. Pharmacol Ther, 82:389-97.
    • (1999) Pharmacol Ther , vol.82 , pp. 389-397
    • Lee, J.C.1    Kassis, S.2    Kumar, S.3
  • 125
    • 33751344423 scopus 로고    scopus 로고
    • Tissue remodeling and repair mechanisms in chronic obstructive pulmonary disease
    • Leff AR. 2006. Tissue remodeling and repair mechanisms in chronic obstructive pulmonary disease. Proc Am Thorac Soc, 3:734-6.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 734-736
    • Leff, A.R.1
  • 126
    • 33747618012 scopus 로고    scopus 로고
    • CXCR2 blockade reduces radical formation in hyperoxia-exposed newborn rat lung
    • Liao L, Ning Q, Li Y, et al. 2006. CXCR2 blockade reduces radical formation in hyperoxia-exposed newborn rat lung. Pediatr Res, 60:299-303.
    • (2006) Pediatr Res , vol.60 , pp. 299-303
    • Liao, L.1    Ning, Q.2    Li, Y.3
  • 127
    • 30544431742 scopus 로고    scopus 로고
    • Prevalence and underdiagnosis of COPD by disease severity and the attributable fraction of smoking Report from the Obstructive Lung Disease in Northern Sweden Studies
    • Lindberg A, Bjerg-Backlund A, Ronmark E, et al. 2006. Prevalence and underdiagnosis of COPD by disease severity and the attributable fraction of smoking Report from the Obstructive Lung Disease in Northern Sweden Studies. Respir Med, 100:264-72.
    • (2006) Respir Med , vol.100 , pp. 264-272
    • Lindberg, A.1    Bjerg-Backlund, A.2    Ronmark, E.3
  • 128
    • 0037496220 scopus 로고    scopus 로고
    • Relationships between activators and inhibitors of plasminogen, and the progression of small abdominal aortic aneurysms
    • Lindholt JS, Jorgensen B, Shi GP, et al. 2003. Relationships between activators and inhibitors of plasminogen, and the progression of small abdominal aortic aneurysms. Eur J Pasc Endovasc Surg, 25:546-51.
    • (2003) Eur J Pasc Endovasc Surg , vol.25 , pp. 546-551
    • Lindholt, J.S.1    Jorgensen, B.2    Shi, G.P.3
  • 129
    • 33746575765 scopus 로고    scopus 로고
    • Augmentation ofmonocyte intracellular ascorbate in vitro protects cells from oxidative damage and inflammatory responses
    • Loke WM, Proudfoot JM, McKinley AJ, et al. 2006. Augmentation ofmonocyte intracellular ascorbate in vitro protects cells from oxidative damage and inflammatory responses. Biochem Biophys Res Commun, 345:1039-43.
    • (2006) Biochem Biophys Res Commun , vol.345 , pp. 1039-1043
    • Loke, W.M.1    Proudfoot, J.M.2    McKinley, A.J.3
  • 130
    • 0033958529 scopus 로고    scopus 로고
    • Ascorbate is depleted by smoking and repleted by moderate supplementation: A study in male smokers and nonsmokers with matched dietary antioxidant intakes
    • Lykkesfeldt J, Christen S, Wallock LM, et al. 2000. Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. Am J Clin Nutr, 71:530-6.
    • (2000) Am J Clin Nutr , vol.71 , pp. 530-536
    • Lykkesfeldt, J.1    Christen, S.2    Wallock, L.M.3
  • 131
    • 34250197133 scopus 로고    scopus 로고
    • +T cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice
    • +T cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol, 178:8090-6.
    • (2007) J Immunol , vol.178 , pp. 8090-8096
    • Maeno, T.1    Houghton, A.M.2    Quintero, P.A.3
  • 132
    • 33746122194 scopus 로고    scopus 로고
    • Increased collagen deposition correlated with lung destruction in human emphysema
    • Martin-Mosquero C, Peces-Barba G, Rubio ML, et al. 2006. Increased collagen deposition correlated with lung destruction in human emphysema. Histo/Histopathol, 21:823-8.
    • (2006) Histo/Histopathol , vol.21 , pp. 823-828
    • Martin-Mosquero, C.1    Peces-Barba, G.2    Rubio, M.L.3
  • 133
    • 9744220302 scopus 로고    scopus 로고
    • Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs
    • Marwick JA, Kirkham PA, Stevenson CS, et al. 2004. Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. Am J Respir Cell Mol Biol, 31:63 3-42.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , Issue.63 , pp. 3-42
    • Marwick, J.A.1    Kirkham, P.A.2    Stevenson, C.S.3
  • 134
    • 33646592588 scopus 로고    scopus 로고
    • Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: Morphological impact of VEGFR-2 inhibition
    • Marwick JA, Stevenson CS, Giddings J, et al. 2006. Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. Am J Physiol Lung Cell Mol Physiol, 290:L897-908.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Marwick, J.A.1    Stevenson, C.S.2    Giddings, J.3
  • 135
    • 0036310801 scopus 로고    scopus 로고
    • A p38 MAPK inhibitor, FR- 167653, ameliorates murine bleomycin-induced pulmonary fibrosis
    • Matsuoka H, Arai T, Mori M, et al. 2002. A p38 MAPK inhibitor, FR- 167653, ameliorates murine bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol, 283:L103-12.
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.283
    • Matsuoka, H.1    Arai, T.2    Mori, M.3
  • 136
    • 0025332179 scopus 로고
    • Selective increase of antioxidant enzyme activity in the alveolar macrophages from cigarette smokers and smoke-exposed hamsters
    • McCusker K, Hoidal J. 1990. Selective increase of antioxidant enzyme activity in the alveolar macrophages from cigarette smokers and smoke-exposed hamsters. Am Rev Respir Dis, 141:678-82.
    • (1990) Am Rev Respir Dis , vol.141 , pp. 678-682
    • McCusker, K.1    Hoidal, J.2
  • 137
    • 0033696228 scopus 로고    scopus 로고
    • p38 MAP kinase and MKK- I co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism
    • Meja KK, Seldon PM, Nasuhara Y, et al. 2000. p38 MAP kinase and MKK- I co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism. Br J Pharmacol, 131:1143-53.
    • (2000) Br J Pharmacol , vol.131 , pp. 1143-1153
    • Meja, K.K.1    Seldon, P.M.2    Nasuhara, Y.3
  • 138
    • 28044444899 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): A prevalence study
    • Menezes AM, Perez-Padilla R, Jardirn JR, et al. 2005. Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study. Lancet, 366:1875-81.
    • (2005) Lancet , vol.366 , pp. 1875-1881
    • Menezes, A.M.1    Perez-Padilla, R.2    Jardirn, J.R.3
  • 139
    • 0028881563 scopus 로고
    • Vitamins E, C and lipid peroxidation in plasma and arterial tissue of smokers and non-smokers
    • Mezzetti A, Lapenna D, Pierdomenico SD, et al. 1995. Vitamins E, C and lipid peroxidation in plasma and arterial tissue of smokers and non-smokers. Atherosclerosis, 112:91-9.
    • (1995) Atherosclerosis , vol.112 , pp. 91-99
    • Mezzetti, A.1    Lapenna, D.2    Pierdomenico, S.D.3
  • 140
    • 0038021303 scopus 로고    scopus 로고
    • Impaired healing of nitrogen mustard wounds in CXCR2 null mice
    • Milatovic S, Nanney LB, Yu Y, et al. 2003. Impaired healing of nitrogen mustard wounds in CXCR2 null mice. Wound Repair Regen, 11:213-19.
    • (2003) Wound Repair Regen , vol.11 , pp. 213-219
    • Milatovic, S.1    Nanney, L.B.2    Yu, Y.3
  • 141
    • 0034894059 scopus 로고    scopus 로고
    • Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease
    • Monteleone G, Kumberova A, Croft NM, et al. 2001. Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J Clin Invest, 108:601-9.
    • (2001) J Clin Invest , vol.108 , pp. 601-609
    • Monteleone, G.1    Kumberova, A.2    Croft, N.M.3
  • 142
    • 10044241543 scopus 로고    scopus 로고
    • Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells
    • Moodie FM, Marwick JA, Anderson CS, et al. 2004. Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells. Faseb J, 18: 1997-9.
    • (2004) Faseb J , vol.18 , pp. 1997-1999
    • Moodie, F.M.1    Marwick, J.A.2    Anderson, C.S.3
  • 143
    • 20844451178 scopus 로고    scopus 로고
    • The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: The EQUALIFE Study
    • Moretti M, Bottrighi P, Dallari R, et al. 2004. The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: the EQUALIFE Study. Drugs Exp Clin Res, 30:143-52.
    • (2004) Drugs Exp Clin Res , vol.30 , pp. 143-152
    • Moretti, M.1    Bottrighi, P.2    Dallari, R.3
  • 144
    • 31044435908 scopus 로고    scopus 로고
    • Production of lipid peroxidation products in osteoarthritic tissues: New evidence linking 4-hydroxynonenal to cartilage degradation
    • Morquette B, Shi Q, Lavigne P, et al. 2006. Production of lipid peroxidation products in osteoarthritic tissues: new evidence linking 4-hydroxynonenal to cartilage degradation. Arthritis Rheum, 54:271-81.
    • (2006) Arthritis Rheum , vol.54 , pp. 271-281
    • Morquette, B.1    Shi, Q.2    Lavigne, P.3
  • 145
    • 0032970632 scopus 로고    scopus 로고
    • Morrison D, Rahman 1, Lannan S, et al. 1999. Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Am J Respir Crit Care Med, 159:473-79.
    • Morrison D, Rahman 1, Lannan S, et al. 1999. Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Am J Respir Crit Care Med, 159:473-79.
  • 146
    • 0030591438 scopus 로고    scopus 로고
    • Cytotoxic and chemotactic potencies of several aldehydic components of oxidised low density lipoprotein for human monocyte-macrophages
    • Muller K, Hardwick SJ, Marchant CE, et al. 1996. Cytotoxic and chemotactic potencies of several aldehydic components of oxidised low density lipoprotein for human monocyte-macrophages. FEBS Lett, 388:165-8.
    • (1996) FEBS Lett , vol.388 , pp. 165-168
    • Muller, K.1    Hardwick, S.J.2    Marchant, C.E.3
  • 147
    • 0033538340 scopus 로고    scopus 로고
    • Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1 beta and tumor necrosis factor-alpha in human U937 monocytic cells Evidence for additional regulatory steps in kappaB-dependent transcription
    • Nasuhara Y, Adcock IM, Catley M, et al. 1999. Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1 beta and tumor necrosis factor-alpha in human U937 monocytic cells Evidence for additional regulatory steps in kappaB-dependent transcription. J Biol Chem, 274:19965-72.
    • (1999) J Biol Chem , vol.274 , pp. 19965-19972
    • Nasuhara, Y.1    Adcock, I.M.2    Catley, M.3
  • 148
    • 0042812432 scopus 로고    scopus 로고
    • Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers
    • Neurohr C, Lenz AG, Ding I, et al. 2003. Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers. Eur Respir J, 22:82-7.
    • (2003) Eur Respir J , vol.22 , pp. 82-87
    • Neurohr, C.1    Lenz, A.G.2    Ding, I.3
  • 149
    • 33750490450 scopus 로고    scopus 로고
    • A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: Upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist
    • Nicholson GC, Tennant RC, Carpenter DC, et al. 2007. A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist. Pulm Pharmacol Ther, 20:52-9.
    • (2007) Pulm Pharmacol Ther , vol.20 , pp. 52-59
    • Nicholson, G.C.1    Tennant, R.C.2    Carpenter, D.C.3
  • 150
    • 25144494690 scopus 로고    scopus 로고
    • Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia
    • Nishi T, Maier CM, Hayashi T, et al. 2005. Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia. J Cereb Blood Flow Metab, 25:1312-24.
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 1312-1324
    • Nishi, T.1    Maier, C.M.2    Hayashi, T.3
  • 151
    • 0033071046 scopus 로고    scopus 로고
    • Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-kappaB activation and IL-8 mRNA expression in guinea pigs in vivo
    • Nishikawa M, Kakemizu N, Ito T, et al. 1999. Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-kappaB activation and IL-8 mRNA expression in guinea pigs in vivo. Am J Respir Cell Mol Biol, 20:189-98.
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 189-198
    • Nishikawa, M.1    Kakemizu, N.2    Ito, T.3
  • 152
    • 0031760505 scopus 로고    scopus 로고
    • Expression of adhesion molecules and G proteins in circulating neutrophils in chronic obstructive pulmonary disease
    • Noguera A, Busquets X, Sauleda, J, et al. 1998. Expression of adhesion molecules and G proteins in circulating neutrophils in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 158:1664-8.
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 1664-1668
    • Noguera, A.1    Busquets, X.2    Sauleda, J.3
  • 153
    • 0030606239 scopus 로고    scopus 로고
    • The transcriptional coactivaters p300 and CBP are histone acetyltransferases
    • Ogryzko VV, Schiltz RL, Russanova. V, et al. 1996. The transcriptional coactivaters p300 and CBP are histone acetyltransferases. Cell, 87:953-9.
    • (1996) Cell , vol.87 , pp. 953-959
    • Ogryzko, V.V.1    Schiltz, R.L.2    Russanova, V.3
  • 154
    • 0023837944 scopus 로고
    • Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine protemases
    • Okada Y, Watanabe S, Nakanishi I, et al. 1988. Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine protemases. FEBS Lett, 229:157-60.
    • (1988) FEBS Lett , vol.229 , pp. 157-160
    • Okada, Y.1    Watanabe, S.2    Nakanishi, I.3
  • 155
    • 0033711405 scopus 로고    scopus 로고
    • Partial reversibility of airflow limitation and increased exhaled NO and sputum eosinophilia in chronic obstructive pulmonary disease
    • Papi A, Romagnoli M, Baraldo S, et al. 2000. Partial reversibility of airflow limitation and increased exhaled NO and sputum eosinophilia in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 162:1773-7.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 1773-1777
    • Papi, A.1    Romagnoli, M.2    Baraldo, S.3
  • 156
    • 0037380693 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p3 8 mitogen-activated protein kinase inhibitor: A first-in-human study
    • Parasrampuria DA, de Boer P, Desai-Krieger D, et al. 2003. Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p3 8 mitogen-activated protein kinase inhibitor: a first-in-human study. J Clin Pharmacol, 43:406-13.
    • (2003) J Clin Pharmacol , vol.43 , pp. 406-413
    • Parasrampuria, D.A.1    de Boer, P.2    Desai-Krieger, D.3
  • 157
    • 0027226140 scopus 로고
    • Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1 (1) gene expression in human liver fat-storing cells
    • Parola M, Pinzani M, Casini A, et al. 1993. Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1 (1) gene expression in human liver fat-storing cells. Biochem Biophys Res Commun, 194:1044-50.
    • (1993) Biochem Biophys Res Commun , vol.194 , pp. 1044-1050
    • Parola, M.1    Pinzani, M.2    Casini, A.3
  • 158
    • 33746895149 scopus 로고    scopus 로고
    • Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists
    • Pasternak A, Marino D, Vicario PP, et al. 2006. Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists. J Med Chem, 49:4801-4.
    • (2006) J Med Chem , vol.49 , pp. 4801-4804
    • Pasternak, A.1    Marino, D.2    Vicario, P.P.3
  • 159
    • 4143051640 scopus 로고    scopus 로고
    • Burden and clinical features of chronic obstructive pulmonary disease (COPD)
    • Pauwels RA, Rabe KF. 2004. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet, 364:613-20.
    • (2004) Lancet , vol.364 , pp. 613-620
    • Pauwels, R.A.1    Rabe, K.F.2
  • 160
    • 33646674072 scopus 로고    scopus 로고
    • Inhaled recombinant alpha 1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse
    • Pemberton PA, Kobayashi D, Wilk BJ, et al. 2006. Inhaled recombinant alpha 1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. Copd, 3:101-8.
    • (2006) Copd , vol.3 , pp. 101-108
    • Pemberton, P.A.1    Kobayashi, D.2    Wilk, B.J.3
  • 161
    • 0025080732 scopus 로고
    • Pulmonary lipid peroxidation in cigarette smokers and lung cancer patients
    • Petruzzelli S, Hietanen E, Bartsch H, et al. 1990. Pulmonary lipid peroxidation in cigarette smokers and lung cancer patients. Chest, 98:930-5.
    • (1990) Chest , vol.98 , pp. 930-935
    • Petruzzelli, S.1    Hietanen, E.2    Bartsch, H.3
  • 162
    • 0031731419 scopus 로고    scopus 로고
    • Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis
    • Pizzichini E, Pizzichini MM, Gibson P, et al. 1998. Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis: Am J Respir Crit Care Med, 158:1511-17.
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 1511-1517
    • Pizzichini, E.1    Pizzichini, M.M.2    Gibson, P.3
  • 163
    • 33750138265 scopus 로고    scopus 로고
    • Poole PJ, Black PN. 2006. Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev, 3:CD001287.
    • Poole PJ, Black PN. 2006. Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev, 3:CD001287.
  • 164
    • 33745855449 scopus 로고    scopus 로고
    • Remodeling in asthma and chronic obstructive pulmonary disease
    • Postma DS, Timens W. 2006. Remodeling in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc, 3:434-9.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 434-439
    • Postma, D.S.1    Timens, W.2
  • 165
    • 23744451716 scopus 로고    scopus 로고
    • Roflumilast - an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: A randomised controlled trial
    • Rabe KF, Bateman ED, O'Donnell D, et al. 2005. Roflumilast - an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet, 366:563-71.
    • (2005) Lancet , vol.366 , pp. 563-571
    • Rabe, K.F.1    Bateman, E.D.2    O'Donnell, D.3
  • 166
    • 33750620057 scopus 로고    scopus 로고
    • Oxidative stress and redox regulation of lung inflammation in COPD
    • Rahman I, Adcock IM. 2006. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J, 28:219-42.
    • (2006) Eur Respir J , vol.28 , pp. 219-242
    • Rahman, I.1    Adcock, I.M.2
  • 167
    • 0029935615 scopus 로고    scopus 로고
    • Oxidant/antioxidant imbalance in smokers and chronic obstructive pulmonary disease
    • Rahman I, MacNee W 1996a. Oxidant/antioxidant imbalance in smokers and chronic obstructive pulmonary disease. Thorax, 51:348-50.
    • (1996) Thorax , vol.51 , pp. 348-350
    • Rahman, I.1    MacNee, W.2
  • 168
    • 0029740875 scopus 로고    scopus 로고
    • Role of oxidants/antioxidants in smoking-induced lung diseases
    • Rahman I, MacNee W 1996b. Role of oxidants/antioxidants in smoking-induced lung diseases. Free Radic Biol Med, 21:669-81.
    • (1996) Free Radic Biol Med , vol.21 , pp. 669-681
    • Rahman, I.1    MacNee, W.2
  • 169
    • 0031840980 scopus 로고    scopus 로고
    • Role of transcription factors in inflammatory lung diseases
    • Rahman I, MacNee W. 1998. Role of transcription factors in inflammatory lung diseases. Thorax, 53:601-12.
    • (1998) Thorax , vol.53 , pp. 601-612
    • Rahman, I.1    MacNee, W.2
  • 170
    • 0033369168 scopus 로고    scopus 로고
    • Lung glutathione and oxidative stress: Implications in cigarette smoke-induced airway disease
    • Rahman I, MacNee W 1999. Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease. Am J Physiol, 277: L1067-88.
    • (1999) Am J Physiol , vol.277
    • Rahman, I.1    MacNee, W.2
  • 171
    • 0033806242 scopus 로고    scopus 로고
    • Oxidative stress and regulation of glutathione in lung inflammation
    • Rahman I, MacNee W 2000a. Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J, 16:534-54.
    • (2000) Eur Respir J , vol.16 , pp. 534-554
    • Rahman, I.1    MacNee, W.2
  • 172
    • 0034190372 scopus 로고    scopus 로고
    • Regulation of redox glutathione levels and gene transcription in lung inflammation: Therapeutic approaches
    • Rahman I, MacNee W 2000b. Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Free Radic Biol Med, 28:1405-20.
    • (2000) Free Radic Biol Med , vol.28 , pp. 1405-1420
    • Rahman, I.1    MacNee, W.2
  • 173
    • 0029911460 scopus 로고    scopus 로고
    • Systemic oxidative stress in asthma, COPD, and smokers
    • Rahman I, Morrison D, Donaldson K, et al. 1996. Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med, 154:1055-60.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 1055-1060
    • Rahman, I.1    Morrison, D.2    Donaldson, K.3
  • 174
    • 0030754025 scopus 로고    scopus 로고
    • Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease
    • Rahman I, Skwarska E, MacNee W 1997. Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease. Thorax, 52:565-8.
    • (1997) Thorax , vol.52 , pp. 565-568
    • Rahman, I.1    Skwarska, E.2    MacNee, W.3
  • 175
    • 0036066957 scopus 로고    scopus 로고
    • Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: Potential mechanism in gene transcription in lung inflammation
    • Rahman I, Gilmour PS, Jimenez LA, et al. 2002. Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. Mol Cell Biochem, 234-5:239-48.
    • (2002) Mol Cell Biochem , vol.234 -5 , pp. 239-248
    • Rahman, I.1    Gilmour, P.S.2    Jimenez, L.A.3
  • 176
    • 0037102347 scopus 로고    scopus 로고
    • 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease
    • Rahman I, van Schadewijk AA, Crowther AJ, et al. 2002. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am JRespir Crit Care Med, 166:490-5.
    • (2002) Am JRespir Crit Care Med , vol.166 , pp. 490-495
    • Rahman, I.1    van Schadewijk, A.A.2    Crowther, A.J.3
  • 177
    • 4143070452 scopus 로고    scopus 로고
    • Redox modulation of chromatin remodeling: Impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression
    • Rahman I, Marwick J, Kirkham P. 2004. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. Biochem Pharmacol, 68:1255-67.
    • (2004) Biochem Pharmacol , vol.68 , pp. 1255-1267
    • Rahman, I.1    Marwick, J.2    Kirkham, P.3
  • 178
    • 10544246489 scopus 로고    scopus 로고
    • Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability
    • Rajagopalan S, Meng XP, Ramasamy S, et al. 1996., Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest, 98:2572-9.
    • (1996) J Clin Invest , vol.98 , pp. 2572-2579
    • Rajagopalan, S.1    Meng, X.P.2    Ramasamy, S.3
  • 179
    • 0023912569 scopus 로고
    • Reduction in days of illness after long-term treatment with N-acetylcysteine controlled-release tablets in patients with chronic bronchitis
    • Rasmussen JB, Glennow C. 1988. Reduction in days of illness after
    • (1988) Eur Respir J , vol.1 , pp. 351-355
    • Rasmussen, J.B.1    Glennow, C.2
  • 180
    • 0030684692 scopus 로고    scopus 로고
    • The effect of alpha-tocopherol and beta-carotene supplementation on COPI) symptoms
    • Rautalahti M, Virtamo J, Haukka J, et al. 1997. The effect of alpha-tocopherol and beta-carotene supplementation on COPI) symptoms. Am J Respir Crit Care Med, 156:1447-52.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1447-1452
    • Rautalahti, M.1    Virtamo, J.2    Haukka, J.3
  • 181
    • 0037609493 scopus 로고    scopus 로고
    • Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia
    • Ray P, Devaux Y, Stolz DB, et al. 2003. Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia. Proc Natl Acad Sci U S A, 100:6098-103.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6098-6103
    • Ray, P.1    Devaux, Y.2    Stolz, D.B.3
  • 182
    • 34247607712 scopus 로고    scopus 로고
    • The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease
    • for the COPI Investigators
    • Rennard SI, Fogarty C, Kelsen S, et al; for the COPI) Investigators. 2007. The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 175:926-34.
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 926-934
    • Rennard, S.I.1    Fogarty, C.2    Kelsen, S.3
  • 183
    • 33144469314 scopus 로고    scopus 로고
    • Cilomilast for COPD: Results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4
    • Rennard SI, Schachter N, Strck M, et al. 2006. Cilomilast for COPD: results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4. Chest, 129:56-66.
    • (2006) Chest , vol.129 , pp. 56-66
    • Rennard, S.I.1    Schachter, N.2    Strck, M.3
  • 184
    • 0030889388 scopus 로고    scopus 로고
    • Role of melanoma growth stirmilatory activity (MGSA/gro) on keratinocyte function in wound healing
    • Rennekampff HO, Hansbrough JF, Woods V Jr, et al. 1997. Role of melanoma growth stirmilatory activity (MGSA/gro) on keratinocyte function in wound healing. Arch Dermatol Res, 289:204-12.
    • (1997) Arch Dermatol Res , vol.289 , pp. 204-212
    • Rennekampff, H.O.1    Hansbrough, J.F.2    Woods Jr, V.3
  • 185
    • 0033865481 scopus 로고    scopus 로고
    • Bioactive interleukin-8 is expressed in wounds and enhances wound healing
    • Rennekampff HO, Hansbrough JF, Kiessig V, et al. 2000. Bioactive interleukin-8 is expressed in wounds and enhances wound healing. J Surg Res, 93:41-54.
    • (2000) J Surg Res , vol.93 , pp. 41-54
    • Rennekampff, H.O.1    Hansbrough, J.F.2    Kiessig, V.3
  • 186
    • 0030752487 scopus 로고    scopus 로고
    • Repine JE, Bast A, Lankhorst 1. 1997. Oxidative stress in chronic obstructive pulmonary disease. Oxidative Stress Study Group. Am J Respir Crit Care Med, 156:341-57.
    • Repine JE, Bast A, Lankhorst 1. 1997. Oxidative stress in chronic obstructive pulmonary disease. Oxidative Stress Study Group. Am J Respir Crit Care Med, 156:341-57.
  • 187
    • 33644746168 scopus 로고    scopus 로고
    • Prostanoids as pharmacological targets in COPD and asthma
    • Rolin S, Masereel B, Dogne JM. 2006. Prostanoids as pharmacological targets in COPD and asthma. Eur J Pharmacol, 533:89-100.
    • (2006) Eur J Pharmacol , vol.533 , pp. 89-100
    • Rolin, S.1    Masereel, B.2    Dogne, J.M.3
  • 189
    • 0036010527 scopus 로고    scopus 로고
    • Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease
    • Russell RE, Culpitt SV, DeMatos C, et al. 2002. Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol, 26:602-9.
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 602-609
    • Russell, R.E.1    Culpitt, S.V.2    DeMatos, C.3
  • 190
    • 0033785188 scopus 로고    scopus 로고
    • Effect of cigarette smoke on the permeability and IL-1 beta and sICAM-1 release from cultured human bronchial epithelial cells of never-smokers, smokers, and patients with chronic obstructive pulmonary disease
    • Rusznak C, Mills PR, Devalia JL, et al. 2000. Effect of cigarette smoke on the permeability and IL-1 beta and sICAM-1 release from cultured human bronchial epithelial cells of never-smokers, smokers, and patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol, 23:530-6.
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 530-536
    • Rusznak, C.1    Mills, P.R.2    Devalia, J.L.3
  • 191
    • 33750484015 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo dose-effects: a review
    • Sadowska AM, Manuel YKB, De Backer WA. 2007. Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review. Pulm Pharmacol Ther, 20:9-22.
    • (2007) Pulm Pharmacol Ther , vol.20 , pp. 9-22
    • Sadowska, A.M.1    Manuel, Y.K.B.2    De Backer, W.A.3
  • 192
    • 0032798485 scopus 로고    scopus 로고
    • CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease
    • Saetta M, Baraldo S, Corbino L, et al. 1999. CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 160:711-17.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 711-717
    • Saetta, M.1    Baraldo, S.2    Corbino, L.3
  • 193
    • 20944448800 scopus 로고    scopus 로고
    • Expression of Smad7 in mouse eyes accelerates healing of comeal tissue after exposure to alkali
    • Saika S, Ikeda K, Yamanaka O, et al. 2005. Expression of Smad7 in mouse eyes accelerates healing of comeal tissue after exposure to alkali. Am J Pathol, 166:1405-18.
    • (2005) Am J Pathol , vol.166 , pp. 1405-1418
    • Saika, S.1    Ikeda, K.2    Yamanaka, O.3
  • 194
    • 0035135566 scopus 로고    scopus 로고
    • Susceptibility genes for rapid decline of lung function in the lung health study
    • Sandford AJ, Chagani T, Weir TD, et al. 2001. Susceptibility genes for rapid decline of lung function in the lung health study. Am J Respir Crit Care Med, 163:469-73.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 469-473
    • Sandford, A.J.1    Chagani, T.2    Weir, T.D.3
  • 195
    • 0033805776 scopus 로고    scopus 로고
    • Interaction of vitamin C with the relation between smoking and obstructive airways disease in EPIC Norfolk. European Prospective Investigation into Cancer and Nutrition
    • Sargeant LA, Jaeckel A, Wareham NJ. 2000. Interaction of vitamin C with the relation between smoking and obstructive airways disease in EPIC Norfolk. European Prospective Investigation into Cancer and Nutrition. Eur Respir J, 16:397-403.
    • (2000) Eur Respir J , vol.16 , pp. 397-403
    • Sargeant, L.A.1    Jaeckel, A.2    Wareham, N.J.3
  • 196
    • 0028447354 scopus 로고
    • The lipid peroxidation product 4-hydroxynonenal is formed by - and is able to attract - rat neutrophils in vivo
    • Schaur RJ, Dussing G, Kink E, et al. 1994. The lipid peroxidation product 4-hydroxynonenal is formed by - and is able to attract - rat neutrophils in vivo. Free Radic Res, 20:365-73.
    • (1994) Free Radic Res , vol.20 , pp. 365-373
    • Schaur, R.J.1    Dussing, G.2    Kink, E.3
  • 197
    • 0033822739 scopus 로고    scopus 로고
    • Dramatic decline in circulating intercellular adhesion molecule-1 concentration on quitting tobacco smoking
    • Scott DA, Stapleton JA, Wilson RF, et al. 2000. Dramatic decline in circulating intercellular adhesion molecule-1 concentration on quitting tobacco smoking. Blood Cells Mol Dis, 26:255-8.
    • (2000) Blood Cells Mol Dis , vol.26 , pp. 255-258
    • Scott, D.A.1    Stapleton, J.A.2    Wilson, R.F.3
  • 198
    • 0032989152 scopus 로고    scopus 로고
    • Docosahexaenoic acid and smoking-related chronic obstructive pulmonary disease. The Atherosclerosis Risk in Communities Study Investigators
    • Shahar E, Boland LL, Folsom AR, et al. 1999. Docosahexaenoic acid and smoking-related chronic obstructive pulmonary disease. The Atherosclerosis Risk in Communities Study Investigators. Am J Respir Crit Care Med, 159:1780-5.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1780-1785
    • Shahar, E.1    Boland, L.L.2    Folsom, A.R.3
  • 199
    • 0344413022 scopus 로고    scopus 로고
    • Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice
    • Shapiro SD, Goldstein NM, Houghton AM, et al. 2003. Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol, 163:2329-35.
    • (2003) Am J Pathol , vol.163 , pp. 2329-2335
    • Shapiro, S.D.1    Goldstein, N.M.2    Houghton, A.M.3
  • 200
    • 0030011148 scopus 로고    scopus 로고
    • Cigarette smoke condensate-induced adhesion molecule expression and transendothelial migration of monocytes
    • Shen Y, Rattan V, Sultana C, et al. 1996. Cigarette smoke condensate-induced adhesion molecule expression and transendothelial migration of monocytes. Am J Physiol, 270:H1624-33.
    • (1996) Am J Physiol , vol.270
    • Shen, Y.1    Rattan, V.2    Sultana, C.3
  • 201
    • 33845361633 scopus 로고    scopus 로고
    • Mortality in COPD: Role of comorbidities
    • Sin DD, Anthonisen NR, Soriano JB, et al. 2006. Mortality in COPD: role of comorbidities. Eur Respir J, 28:1245-57.
    • (2006) Eur Respir J , vol.28 , pp. 1245-1257
    • Sin, D.D.1    Anthonisen, N.R.2    Soriano, J.B.3
  • 202
    • 0037108012 scopus 로고    scopus 로고
    • Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidant
    • Smith KR, Uyeminami DL, Kodavanti UP, et al. 2002. Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidant. Free Radic Biol Med, 33:1106-14.
    • (2002) Free Radic Biol Med , vol.33 , pp. 1106-1114
    • Smith, K.R.1    Uyeminami, D.L.2    Kodavanti, U.P.3
  • 203
    • 0024344262 scopus 로고
    • Chronic obstructive pulmonary disease: Risk factors, pathophysiology and pathogenesis
    • Snider GL. 1989. Chronic obstructive pulmonary disease: risk factors, pathophysiology and pathogenesis. Annu Rev Med, 40:411-29.
    • (1989) Annu Rev Med , vol.40 , pp. 411-429
    • Snider, G.L.1
  • 204
    • 4344653389 scopus 로고    scopus 로고
    • SMAD-signaling in chronic obstructive pulmonary disease: Transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke
    • Springer J, Scholz FR, Peiser C, et al. 2004. SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke. Biol Chem, 385:649-53.
    • (2004) Biol Chem , vol.385 , pp. 649-653
    • Springer, J.1    Scholz, F.R.2    Peiser, C.3
  • 205
    • 0031020377 scopus 로고    scopus 로고
    • Aldose reductase induction: A novel response to oxidative stress of smooth muscle cells
    • Spycher SE, Tabataba-Vakili S, O'Donnell VB, et al. 1997. Aldose reductase induction: a novel response to oxidative stress of smooth muscle cells. Faseb J, 11:181-8.
    • (1997) Faseb J , vol.11 , pp. 181-188
    • Spycher, S.E.1    Tabataba-Vakili, S.2    O'Donnell, V.B.3
  • 206
    • 0031819335 scopus 로고    scopus 로고
    • Antioxidant vitamin supplementation and lipid peroxidation in smokers
    • Steinberg FM, Chait A. 1998. Antioxidant vitamin supplementation and lipid peroxidation in smokers. Am J Clin Nutr, 68:319-27.
    • (1998) Am J Clin Nutr , vol.68 , pp. 319-327
    • Steinberg, F.M.1    Chait, A.2
  • 207
    • 0035006460 scopus 로고    scopus 로고
    • Antibodies against oxidized LDL - theory and clinical use
    • Steinerova A, Racek J, Stozicky F, et al. 2001. Antibodies against oxidized LDL - theory and clinical use. Physiol Res, 50:131-41.
    • (2001) Physiol Res , vol.50 , pp. 131-141
    • Steinerova, A.1    Racek, J.2    Stozicky, F.3
  • 208
    • 0033898870 scopus 로고    scopus 로고
    • The effect of oral N-acetyl-cysteine in chronic bronchitis: A quantitative systematic review
    • Stey C, Steurer J, Bachmann S, et al. 2000. The effect of oral N-acetyl-cysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J, 16:253-62.
    • (2000) Eur Respir J , vol.16 , pp. 253-262
    • Stey, C.1    Steurer, J.2    Bachmann, S.3
  • 209
    • 0028951568 scopus 로고
    • Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease
    • Stone PJ, Gottlieb DJ, O'Connor GT, et al. 1995. Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 151:952-9.
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 952-959
    • Stone, P.J.1    Gottlieb, D.J.2    O'Connor, G.T.3
  • 210
    • 24144433461 scopus 로고    scopus 로고
    • Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema
    • Sullivan AK, Simonian PL, Falta MT, et al. 2005. Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema. Am J Respir Crit Care Med, 172:590-6.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 590-596
    • Sullivan, A.K.1    Simonian, P.L.2    Falta, M.T.3
  • 211
    • 17044453955 scopus 로고    scopus 로고
    • Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    • Takizawa H, Tanaka M, Takami K, et al. 2001. Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med, 163:1476-83.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1476-1483
    • Takizawa, H.1    Tanaka, M.2    Takami, K.3
  • 213
    • 0032874302 scopus 로고    scopus 로고
    • Formation and export of the glutathione conjugate of 4-hydroxy-2, 3-E-nonenal (4-HNE) in hepatoma cells
    • Tjalkens RB, Cook LW, Petersen DR. 1999. Formation and export of the glutathione conjugate of 4-hydroxy-2, 3-E-nonenal (4-HNE) in hepatoma cells. Arch Biochem Biophys, 361:113-19.
    • (1999) Arch Biochem Biophys , vol.361 , pp. 113-119
    • Tjalkens, R.B.1    Cook, L.W.2    Petersen, D.R.3
  • 214
    • 0033023541 scopus 로고    scopus 로고
    • Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol
    • Tsai SH, Lin-Shiau SY, Lin JK. 1999. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol. Br J Pharmacol, 126:673-80.
    • (1999) Br J Pharmacol , vol.126 , pp. 673-680
    • Tsai, S.H.1    Lin-Shiau, S.Y.2    Lin, J.K.3
  • 215
    • 0038465920 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade
    • Tuder RM, Zhen L, Cho CY, et al. 2003. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol, 29:88-97.
    • (2003) Am J Respir Cell Mol Biol , vol.29 , pp. 88-97
    • Tuder, R.M.1    Zhen, L.2    Cho, C.Y.3
  • 216
    • 33747833375 scopus 로고    scopus 로고
    • State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: An evolutionary perspective
    • Tuder RM, Yoshida T, Arap W, et al. 2006. State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. Proc Am Thorac Soc, 3:503-10.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 503-510
    • Tuder, R.M.1    Yoshida, T.2    Arap, W.3
  • 217
    • 4544384233 scopus 로고    scopus 로고
    • Antioxidant vitamins (A, C and E) and malondialdehyde levels in acute exacerbation and stable periods of patients with chronic obstructive pulmonary disease
    • Tug T, Karatas F, Terzi SM. 2004. Antioxidant vitamins (A, C and E) and malondialdehyde levels in acute exacerbation and stable periods of patients with chronic obstructive pulmonary disease. Clin Invest Med, 27:123-8.
    • (2004) Clin Invest Med , vol.27 , pp. 123-128
    • Tug, T.1    Karatas, F.2    Terzi, S.M.3
  • 218
    • 13844288120 scopus 로고    scopus 로고
    • SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung
    • Underwood DC, Osborn RR, Bochnowicz S, et al. 2000. SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. Am J Physiol Lung Cell Mol Physiol, 279:L895-902.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279
    • Underwood, D.C.1    Osborn, R.R.2    Bochnowicz, S.3
  • 219
    • 18544406054 scopus 로고    scopus 로고
    • SB 239063, a potent p3 8 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence
    • Underwood DC, Osborn RR, Kotzer CJ, et al. 2000. SB 239063, a potent p3 8 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. J Pharmacol Exp Ther, 293:281-8.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 281-288
    • Underwood, D.C.1    Osborn, R.R.2    Kotzer, C.J.3
  • 220
    • 33645216548 scopus 로고    scopus 로고
    • Effects of vitamin E on cigarette smoke induced oxidative damage in larynx and lung
    • Uneri C, Sari M, Baglam T, et al. 2006. Effects of vitamin E on cigarette smoke induced oxidative damage in larynx and lung. Laryngoscope, 116:97-100.
    • (2006) Laryngoscope , vol.116 , pp. 97-100
    • Uneri, C.1    Sari, M.2    Baglam, T.3
  • 221
    • 0027234040 scopus 로고
    • Cigarette smoke-mediated oxidant stress, phagocytes, vitamin C, vitamin E, and tissue injury
    • van Antwerpen L, Theron AJ, Myer MS, et al. 1993. Cigarette smoke-mediated oxidant stress, phagocytes, vitamin C, vitamin E, and tissue injury. Ann N YAcad Sci, 686:53-65.
    • (1993) Ann N YAcad Sci , vol.686 , pp. 53-65
    • van Antwerpen, L.1    Theron, A.J.2    Myer, M.S.3
  • 223
    • 23744498786 scopus 로고    scopus 로고
    • van der Vaart H, Koeter GH, PostmaDS, et al. 2005. First study of infliximab treatment in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 172:465-9.
    • van der Vaart H, Koeter GH, PostmaDS, et al. 2005. First study of infliximab treatment in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 172:465-9.
  • 224
    • 0036195556 scopus 로고    scopus 로고
    • Effects of oral administration of N-acetyl-L-cysteine: A multi-biomarker study in smokers
    • Van Schooten FJ, Besaratinia A, De Flora S, et al. 2002. Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers. Cancer Epidemiol Biomarkers Prev, 11:167-75.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 167-175
    • Van Schooten, F.J.1    Besaratinia, A.2    De Flora, S.3
  • 225
    • 0030750564 scopus 로고    scopus 로고
    • Orally active inhibitors of human leukocyte elastase. II. Disposition of L-694,458 in rats and rhesus monkeys
    • Vincent SH, Painter SK, Luffer-Atlas D, et al. 1997. Orally active inhibitors of human leukocyte elastase. II. Disposition of L-694,458 in rats and rhesus monkeys. Drug Metab Dispos, 25:932-9.
    • (1997) Drug Metab Dispos , vol.25 , pp. 932-939
    • Vincent, S.H.1    Painter, S.K.2    Luffer-Atlas, D.3
  • 226
    • 0242362794 scopus 로고    scopus 로고
    • Pulmonary vascular involvement in chronic obstructive pulmonary disease
    • s
    • Voelkel NF, Coll CD. 2003. Pulmonary vascular involvement in chronic obstructive pulmonary disease. Eur Respir J Suppl, 46:28s-32s.
    • (2003) Eur Respir J Suppl , vol.46
    • Voelkel, N.F.1    Coll, C.D.2
  • 227
    • 0242721223 scopus 로고    scopus 로고
    • Cigarette smoke produces airway wall remodeling in rat tracheal explants
    • Wang RD, Tai H, Xie C, et al. 2003. Cigarette smoke produces airway wall remodeling in rat tracheal explants. Am J Respir Crit Care Med, 168:1232-6.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 1232-1236
    • Wang, R.D.1    Tai, H.2    Xie, C.3
  • 228
    • 33644828187 scopus 로고    scopus 로고
    • Weathington NM, van Houwelingen AH, Noerager Bl, et al. 2006. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med, 12:317-23.
    • Weathington NM, van Houwelingen AH, Noerager Bl), et al. 2006. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med, 12:317-23.
  • 229
    • 0036800045 scopus 로고    scopus 로고
    • Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs
    • Wright JL, Farmer SG, Churg A. 2002. Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs. Am J Respir Crit Care Med, 166:954-60.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 954-960
    • Wright, J.L.1    Farmer, S.G.2    Churg, A.3
  • 230
    • 33745650657 scopus 로고    scopus 로고
    • Advances in the pathology of COPD
    • Wright JL, Churg A. 2006. Advances in the pathology of COPD. Histopathology, 49:1-9.
    • (2006) Histopathology , vol.49 , pp. 1-9
    • Wright, J.L.1    Churg, A.2
  • 231
    • 33745728358 scopus 로고    scopus 로고
    • Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages
    • Yang SR, Chida AS, Bauter MR, et al. 2006. Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol, 291:L46-57.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291
    • Yang, S.R.1    Chida, A.S.2    Bauter, M.R.3
  • 232
    • 0035877211 scopus 로고    scopus 로고
    • Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways
    • Yoshida M, Korfhagen TR, Whitsett JA. 2001. Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways. J Immunol, 166:7514-19.
    • (2001) J Immunol , vol.166 , pp. 7514-7519
    • Yoshida, M.1    Korfhagen, T.R.2    Whitsett, J.A.3
  • 233
    • 33646591271 scopus 로고    scopus 로고
    • Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function
    • Young RP, Hopkins R, Black PN, et al. 2006. Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function. Thorax, 61:394-9.
    • (2006) Thorax , vol.61 , pp. 394-399
    • Young, R.P.1    Hopkins, R.2    Black, P.N.3
  • 234
    • 33751291399 scopus 로고    scopus 로고
    • Altered expression of the Smad signalling pathway: Implications for COPD pathogenesis
    • Zandvoort A, Postma DS, Jonker MR, et al. 2006. Altered expression of the Smad signalling pathway: implications for COPD pathogenesis. Eur Respir J, 28:533-41.
    • (2006) Eur Respir J , vol.28 , pp. 533-541
    • Zandvoort, A.1    Postma, D.S.2    Jonker, M.R.3


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