Histone H3 phosphorylation by ikk-α is critical for cytokine-induced gene expression

Nature

Volumn 423, Issue 6940, 2003, Pages 655-659

  Yumi, Yamamoto ^a   Verma, Udit N ^a   Prajapati, Shashi ^a   Youn Tae, Kwak ^a   Gaynor, Richard B ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; DEGRADATION; PROTEINS;

GENE EXPRESSION;

GENES;

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYTOKINE; HISTONE H3; I KAPPA B KINASE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UNCLASSIFIED DRUG;

BIOLOGY; GENE;

ACETYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; EMBRYO; FIBROBLAST; GENE EXPRESSION; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

ANIMALS; CREB-BINDING PROTEIN; FIBROBLASTS; GENE DELETION; GENE EXPRESSION REGULATION; HELA CELLS; HISTONES; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; INTERLEUKIN-8; MICE; NF-KAPPA B; NUCLEAR PROTEINS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; MURINAE;

EID: 0038511129     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01576     Document Type: Article

References (29)

1. Baldwin, A. S. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-681 (1996).
2. Ghosh, S., May, M. J. & Kopp, E. B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260 (1998).
3. Silverman, N. & Maniatis, T. NF-κB signaling pathways in mammalian and insect innate immunity. Genes Dev. 15, 2321-2342 (2001).
4. Zandi, E. & Karin, M. Bridging the gap: composition, regulation, and physiological function of the IκB kinase complex. Mol. Cell. Biol. 19, 4547-4551 (1999).
5. Takeda, K. et al. Limb and skin abnormalities in mice lacking IKKα. Science 284, 313-316 (1999).
6. Hu, Y. et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 284, 316-320 (1999).
7. Li, Q. et al. IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev. 13, 1322-1328 (1999).
8. Sizemore, N., Lerner, N., Dombrowski, N., Sakurai, H. & Stark, G. R. Distinct roles of the IκB kinase α and β subunits in liberating nuclear factor κB (NF-κB) from IκB and in phosphorylating the p65 subunit of NF-κB. J. Biol. Chem. 277, 3863-3869 (2002).
9. Li, X. et al. IKKα, IKKβ and NEMO/IKKγ are each required for the NF-κB mediated inflammatory response program. J. Biol. Chem. 277, 45129-45140 (2002).
10. Birbach, A. et al. Signaling molecules the NF-κB pathway shuttle constitutively between cytoplasm and nucleus. J. Biol. Chem. 277, 10842-10851 (2002).
11. Janknecht, R. & Hunter, T. Transcription. A growing coactivator network. Nature 383, 22-23 (1996).
12. Goodman, R. H. & Smolik, S. CBP/p300 in cell growth, transformation, and development. Genes Dev. 14, 1553-1577 (2000).
13. Zhong, H., Voll, R. E. & Ghosh, S. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1, 661-671 (1998).
14. Zhong, H., May, M. J., Jimi, E. & Ghosh, S. The phosphorylation status of nuclear NF-κB determines its association with CBP/p300 or HDAC-1. Mol. Cell 9, 625-636 (2002).
15. Sakurai, H., Chiba, H., Miyoshi, H., Sugita, T. & Toriumi, W. IκB kinases phosphorylate NF-κB p65 subunit on serine 536 in the transactivation domain. J. Biol. Chem. 274, 30353-30356 (1999).
16. Madrid, L. V., Mayo, M. W., Reuther, J. Y. & Baldwin, A. S. Jr Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38. J. Biol. Chem. 276, 18934-18940 (2001).
17. Gerritsen, M. E. et al. CREB-binding protein/p300 are transcriptional coactivators of p65. Proc Natl. Acad. Sci. USA 94, 2927-2932 (1997).
18. Wang, C. Y., Mayo, M. W. & Baldwin, A. S. J. TNFα- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274, 784-787 (1996).
19. Van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R. & Verma, I. M. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274, 787-789 (1996).
20. Strahl, B. D. & Allis, C. D. The language of covalent histone modifications. Nature 403, 41-45 (2000).
21. Cheung, P., Allis, C. D. & Sassone-Corsi, P. Signaling to chromatin through histone modifications. Cell 103, 263-271 (2000).
22. Cheung, P. et al. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol. Cell 5, 905-915 (2000).
23. Lo, W.-S. et al. Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14. Mol. Cell 5, 917-926 (2000).
24. Sassone-Corsi, P. et al. Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science 285, 886-891 (1999).
25. Thomson, S. et al. The nucleosomal response associated with immediate - early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO J. 18, 4779-4793 (1999).
26. Saccani, S., Pantano, S. & Natoli, G. p38-dependent marking of inflammatory genes for increased NF-κB recruitment. Nature Immunol. 3, 69-75 (2002).
27. Anest, V. et al. A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression. Nature 423, 659-663 (2003).
28. Senftleben, U. et al. Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway. Science 293, 1495-1499 (2001).
29. Yamamoto, Y. et al. IKKγ/NEMO facilitates the recruitment of the IκB proteins into the IκB kinase complex. J. Biol. Chem. 276, 36327-36336 (2001).