Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 35, 2010, Pages 15571-15576

  Yao, Hongwei ^a   Arunachalam, Gnanapragasam ^a   Hwang, Jae Woong ^a   Chung, Sangwoon ^a   Sundar, Isaac K ^a   Kinnula, Vuokko L ^b   Crapo, James D ^c   Rahman, Irfan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

^c NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Antioxidants; Chronic obstructive pulmonary disease; Cigarette smoke; Glutathione; Oxidants

Indexed keywords

CIGARETTE SMOKE; ELASTASE; ELASTIN; EXTRACELLULAR SUPEROXIDE DISMUTASE; HEPARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXERCISE TOLERANCE; LUNG EMPHYSEMA; LUNG FUNCTION; LUNG RECEPTOR; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; PROTECTION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; ELASTIN; EXTRACELLULAR MATRIX; HEPARITIN SULFATE; IMMUNOBLOTTING; LUNG; LUNG COMPLIANCE; METALLOPORPHYRINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEUTROPHILS; OXIDATIVE STRESS; PANCREATIC ELASTASE; PULMONARY EMPHYSEMA; SMOKE; SUPEROXIDE DISMUTASE; SWINE; TIME FACTORS; TOBACCO;

MUS;

EID: 77957273815     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007625107     Document Type: Article

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