Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR

Molecular and Cellular Endocrinology

Volumn 334, Issue 1-2, 2011, Pages 39-48

  Krasowski, Matthew D ^a   Ni, Ai ^b   Hagey, Lee R ^c   Ekins, Sean ^b,d,e  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d Collaborations in Chemistry ^*  (United States)

^e UNIVERSITY OF MARYLAND   (United States)

Author keywords

Bile acids and salts; Cholesterol; Ciona intestinalis; Drug modeling; Molecular evolution; Oxysterols; Phylogeny

Indexed keywords

BILE ACID; CONSTITUTIVE ANDROSTANE RECEPTOR; ECDYSONE RECEPTOR; FARNESOID X RECEPTOR; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; PREGNANE X RECEPTOR; RETINOID; STEROID HORMONE; THYROID HORMONE; VITAMIN D; VITAMIN D RECEPTOR;

BINDING AFFINITY; CHOLESTEROL METABOLISM; CIONA INTESTINALIS; COEVOLUTION; DEVELOPMENTAL STAGE; EVOLUTIONARY DEVELOPMENTAL BIOLOGY; GENE FUNCTION; HUMAN; LIGAND BINDING; MOLECULAR EVOLUTION; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RECEPTOR BINDING; REVIEW; SPECIES COMPARISON; STRUCTURAL HOMOLOGY; TRANSCRIPTION REGULATION; VERTEBRATE;

ANIMALS; BILE ACIDS AND SALTS; CHOLESTEROL; ENERGY METABOLISM; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; GONADAL STEROID HORMONES; HOMEOSTASIS; HUMANS; INVERTEBRATES; ORPHAN NUCLEAR RECEPTORS; PHYLOGENY; RECEPTORS, CALCITRIOL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RETINOIDS; SENSITIVITY AND SPECIFICITY; THYROID HORMONES; TRANSCRIPTION FACTORS; VERTEBRATES; VITAMIN D;

EID: 79951683482     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.06.016     Document Type: Review

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