The three-dimensional structure of the liver X receptor β reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands

Journal of Biological Chemistry

Volumn 278, Issue 40, 2003, Pages 38821-38828

  Färnegårdh, Mathias ^a   Bonn, Tomas ^a   Sun, Sherry ^a   Ljunggren, Jan ^a   Ahola, Harri ^a   Wilhelmsson, Anna ^a   Gustafsson, Jan Åke ^b   Carlquist, Mats ^a  

^a Karo Bio   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; STRUCTURE (COMPOSITION);

LIGANDS;

BIOCHEMISTRY;

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; CELL NUCLEUS RECEPTOR; LIGAND; LIVER X RECEPTOR BETA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOIC ACID RECEPTOR ALPHA; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CRYSTAL STRUCTURE; GENE ACTIVATION; GENE SILENCING; HYDROPHOBICITY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; TRANSCRIPTION INITIATION;

ALANINE; BINDING SITES; CHOLESTEROL; DIMERIZATION; DNA-BINDING PROTEINS; ELECTRONS; ESCHERICHIA COLI; HISTIDINE; HUMANS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MODELS, STATISTICAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; X-RAYS;

EID: 0142223221     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304842200     Document Type: Article

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