Crystal structure of an ancient protein: Evolution by conformational epistasis

Science

Volumn 317, Issue 5844, 2007, Pages 1544-1548

  Ortlund, Eric A ^a   Bridgham, Jamie T ^b   Redinbo, Matthew R ^a   Thornton, Joseph W ^b  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; PROTEIN;

CRYSTAL STRUCTURE; EPISTASIS; EVOLUTION; HORMONE; PHYLOGENETICS; PROTEIN; VERTEBRATE;

ANALYTIC METHOD; ARTICLE; CRYSTAL STRUCTURE; EPISTASIS; MOLECULAR EVOLUTION; PHYLOGENY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

ALDOSTERONE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CRYSTALLOGRAPHY, X-RAY; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; HUMANS; HYDROCORTISONE; LIGANDS; LIKELIHOOD FUNCTIONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID;

VERTEBRATA;

EID: 34548040966     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1142819     Document Type: Article

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35. We thank D. Ornoff and J. Bischof for technical assistance and the Thornton, Redinbo, Phillips, and Cresko labs for comments. Supported by NIH-R01-GM081592, NSF-IOB-0546906, and a Sloan fellowship (J.W.T.), NIH-R01-DK622229 (M.R.R.), and NIH-F32-GM074398 (J.T.B.). AncCR crystal structure has Protein Databank identification codes 2Q1H, 2Q1V, and 2Q3Y.