Molecular Structure of the Rat Vitamin D Receptor Ligand Binding Domain Complexed with 2-Carbon-Substituted Vitamin D3 Hormone Analogues and A LXXLL-Containing Coactivator Peptide

Biochemistry

Volumn 43, Issue 14, 2004, Pages 4101-4110

  Vanhooke, Janeen L ^a   Benning, Matthew M ^b   Bauer, Cary B ^b   Pike, J Wesley ^a   DeLuca, Hector F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b BRUKER AXS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CRYSTAL STRUCTURE; ELECTROSTATICS; HYDROGEN BONDS; HYDROPHOBICITY; HYDROXYLATION; TERNARY SYSTEMS; VITAMINS; WATER;

HISTIDINES; LIGAND BINDING DOMAIN (LBD);

BIOCHEMISTRY;

1ALPHA HYDROXY 2 METHYLENE 19 NORBISHOMOPREGNACALCIFEROL; 2 METHYLENE 19 NOR 1ALPHA,25 DIHYDROXYVITAMIN D3; 2ALPHA METHYL 19 NOR 1ALPHA,25 DIHYDROXYVITAMIN D3; CALCITRIOL; COLECALCIFEROL DERIVATIVE; HISTIDINE DERIVATIVE; HYDROXYL GROUP; PEPTIDE DERIVATIVE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG BINDING SITE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; RAT; STRUCTURE ACTIVITY RELATION;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CALCITRIOL; CHOLECALCIFEROL; CRYSTALLOGRAPHY, X-RAY; DIHYDROXYCHOLECALCIFEROLS; LIGANDS; MACROMOLECULAR SUBSTANCES; MOLECULAR CONFORMATION; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, CALCITRIOL; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 1842426936     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi036056y     Document Type: Article

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