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Volumn 23, Issue 10, 2009, Pages 1532-1543

Negative regulation of hedgehog signaling by liver X receptors

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; LIVER RECEPTOR HOMOLOG 1; LIVER X RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; PROTEIN PATCHED 1; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

EID: 70349777490     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2008-0453     Document Type: Article
Times cited : (31)

References (76)
  • 1
    • 0036899614 scopus 로고    scopus 로고
    • Pathways and consequences: Hedgehog signaling in human disease
    • DOI 10.1016/S0962-8924(02)02405-4, PII S0962892402024054
    • Mullor JL, Sánchez P, Ruiz i Altaba A 2002 Pathways and consequences: Hedgehog signaling in human disease. Trends Cell Biol 12:562-569 (Pubitemid 35461854)
    • (2002) Trends in Cell Biology , vol.12 , Issue.12 , pp. 562-569
    • Mullor, J.L.1    Sanchez, P.2    Ruiz I Altaba, A.3
  • 3
    • 0036406843 scopus 로고    scopus 로고
    • Hedgehog signaling and human disease
    • Bale AE 2002 Hedgehog signaling and human disease. Annu Rev Genomics Hum Genet 3:47-65
    • (2002) Annu Rev Genomics Hum Genet , vol.3 , pp. 47-65
    • Bale, A.E.1
  • 4
    • 33751549095 scopus 로고    scopus 로고
    • Targeting the Hedgehog pathway in cancer
    • Rubin LL, de Sauvage FJ 2006 Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 5:1026-1033
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 1026-1033
    • Rubin, L.L.1    De Sauvage, F.J.2
  • 6
    • 33748296367 scopus 로고    scopus 로고
    • Anteroposterior patterning in the limb and digit specification: Contribution of mouse genetics
    • DOI 10.1002/dvdy.20890
    • Robert B, Lallemand Y 2006 Anteroposterior patterning in the limb and digit specification: contribution of mouse genetics. Dev Dynam 235:2337-2352 (Pubitemid 44325251)
    • (2006) Developmental Dynamics , vol.235 , Issue.9 , pp. 2337-2352
    • Robert, B.1    Lallemand, Y.2
  • 7
    • 0037278166 scopus 로고    scopus 로고
    • Sonic hedgehog: Restricted expression and limb dysmorphologies
    • DOI 10.1046/j.1469-7580.2003.00148.x
    • Hill RE, Heaney SJ, Lettice LA 2003 Sonic hedgehog: restricted expression and limb dysmorphologies. J Anat 202:13-20 (Pubitemid 36503963)
    • (2003) Journal of Anatomy , vol.202 , Issue.1 , pp. 13-20
    • Hill, R.E.1    Heaney, S.J.H.2    Lettice, L.A.3
  • 10
    • 27944475513 scopus 로고    scopus 로고
    • Sonic hedgehog, the penis and erectile dysfunction: A review of sonic hedgehog signaling in the penis
    • DOI 10.2174/138161205774913408
    • Podlasek CA, Meroz CL, Korolis H, Tang Y, McKenna KE, McVary KT 2005 Sonic hedgehog, the penis and erectile dysfunction: a review of sonic hedgehog signaling in the penis. Curr Pharm Des 11:4011-4027 (Pubitemid 41672473)
    • (2005) Current Pharmaceutical Design , vol.11 , Issue.31 , pp. 4011-4027
    • Podlasek, C.A.1    Meroz, C.L.2    Korolis, H.3    Tang, Y.4    McKenna, K.E.5    Mc Vary, K.T.6
  • 13
    • 0347995025 scopus 로고    scopus 로고
    • Transcription of Sonic Hedgehog, a Potential Factor for Gastric Morphogenesis and Gastric Mucosa Maintenance, Is Up-regulated in Acidic Conditions
    • DOI 10.1097/01.LAB.0000101729.25140.0C
    • Dimmler A, Brabletz T, Hlubek F, Häfner M, Rau T, Kirchner T, Faller G 2003 Transcription of sonic hedgehog, a potential factor for gastric morphogenesis and gastric mucosa maintenance, is upregulated in acidic conditions. Lab Invest 83:1829-1837 (Pubitemid 38018546)
    • (2003) Laboratory Investigation , vol.83 , Issue.12 , pp. 1829-1837
    • Dimmler, A.1    Brabletz, T.2    Hlubek, F.3    Hafner, M.4    Rau, T.5    Kirchner, T.6    Faller, G.7
  • 15
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques B, Hammerschmidt M, McMahon, AP 1999 Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 13:2072-2086 (Pubitemid 29407348)
    • (1999) Genes and Development , vol.13 , Issue.16 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 16
    • 1842611651 scopus 로고    scopus 로고
    • Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton
    • DOI 10.1242/dev.01006
    • Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP 2004 Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131:1309-1318 (Pubitemid 38443885)
    • (2004) Development , vol.131 , Issue.6 , pp. 1309-1318
    • Long, F.1    Chung, U.-I.2    Ohba, S.3    McMahon, J.4    Kronenberg, H.M.5    McMahon, A.P.6
  • 17
    • 0036070186 scopus 로고    scopus 로고
    • Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation
    • Lawson ND, Vogel AM, Weinstein BM 2002 Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 3:127-136
    • (2002) Dev Cell , vol.3 , pp. 127-136
    • Lawson, N.D.1    Vogel, A.M.2    Weinstein, B.M.3
  • 18
    • 21644458019 scopus 로고    scopus 로고
    • Hedgehog signaling in murine vasculogenesis and angiogenesis
    • DOI 10.1016/j.tcm.2004.09.003, PII S1050173804001434
    • Byrd N, Grabel L 2004 Hedgehog signaling in murine vasculogenesis and angiogenesis. Trends Cardiovasc Med 14:308-313 (Pubitemid 41110609)
    • (2004) Trends in Cardiovascular Medicine , vol.14 , Issue.8 , pp. 308-313
    • Byrd, N.1    Grabel, L.2
  • 19
    • 0029777408 scopus 로고    scopus 로고
    • Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    • DOI 10.1038/383407a0
    • Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA 1996 Cyclopia and defective axial patterning in mice lacking Sonic Hedgehog gene function. Nature 383:407-413 (Pubitemid 26330823)
    • (1996) Nature , vol.383 , Issue.6599 , pp. 407-413
    • Chiang, C.1    Litingtung, Y.2    Lee, E.3    Young, K.E.4    Corden, J.L.5    Westphal, H.6    Beachy, P.A.7
  • 21
    • 2942738996 scopus 로고    scopus 로고
    • The hedgehog response network: Sensors, switches, and routers
    • DOI 10.1126/science.1098020
    • Lum L, Beachy PA 2004 The Hedgehog response network: sensors, switches, and routers. Science 304:1755-1759 (Pubitemid 38787882)
    • (2004) Science , vol.304 , Issue.5678 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 24
    • 33748796068 scopus 로고    scopus 로고
    • How does cholesterol affect the way Hedgehog works?
    • Wendler F, Franch-Marro X, Vincent JP 2006 How does cholesterol affect the way Hedgehog works? Development 133:3055-3061
    • (2006) Development , vol.133 , pp. 3055-3061
    • Wendler, F.1    Franch-Marro, X.2    Vincent, J.P.3
  • 25
    • 0029844192 scopus 로고    scopus 로고
    • Cholesterol modification of hedgehog signaling proteins in animal development
    • Porter JA, Young KE, Beachy PA 1996 Cholesterol modification of hedgehog signaling proteins in animal development. Science 274:255-259
    • (1996) Science , vol.274 , pp. 255-259
    • Porter, J.A.1    Young, K.E.2    Beachy, P.A.3
  • 26
    • 31644442906 scopus 로고    scopus 로고
    • Signaling from Smo to Ci/Gli: Conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
    • Huangfu D, Anderson KV 2006 Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 133:3-14
    • (2006) Development , vol.133 , pp. 3-14
    • Huangfu, D.1    Anderson, K.V.2
  • 28
    • 14744270467 scopus 로고    scopus 로고
    • Hedgehog signaling: An arrestin connection?
    • Kalderon D 2005 Hedgehog signaling: an arrestin connection? Curr Biol 15:R175-R178
    • (2005) Curr Biol , vol.15
    • Kalderon, D.1
  • 29
    • 0036556688 scopus 로고    scopus 로고
    • LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis
    • Edwards PA, Kennedy MA, Mak PA 2002 LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis. Vasc Pharm 38:249-256
    • (2002) Vasc Pharm , vol.38 , pp. 249-256
    • Edwards, P.A.1    Kennedy, M.A.2    Mak, P.A.3
  • 30
    • 33645983221 scopus 로고    scopus 로고
    • LXRS and FXR: The yin and yang of cholesterol and fat metabolism
    • Kalaany NY, Mangelsdorf DJ 2006 LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol 68:159-191
    • (2006) Annu Rev Physiol , vol.68 , pp. 159-191
    • Kalaany, N.Y.1    Mangelsdorf, D.J.2
  • 31
    • 0036164154 scopus 로고    scopus 로고
    • BAREing it all: The adoption of LXR and FXR and their roles in lipid homeostasis
    • Edwards PA, Kast HR, Anisfeld AM 2002 BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. J Lipid Res 43:2-12
    • (2002) J Lipid Res , vol.43 , pp. 2-12
    • Edwards, P.A.1    Kast, H.R.2    Anisfeld, A.M.3
  • 32
  • 34
    • 0037324340 scopus 로고    scopus 로고
    • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    • DOI 10.1038/nm820
    • Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P 2003 Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 9:213-219 (Pubitemid 36227724)
    • (2003) Nature Medicine , vol.9 , Issue.2 , pp. 213-219
    • Joseph, S.B.1    Castrillo, A.2    Laffitte, B.A.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 35
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • DOI 10.1172/JCI27883
    • Zelcer N, Tontonoz P 2006 Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 116:607-614 (Pubitemid 43326865)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 36
    • 34547475143 scopus 로고    scopus 로고
    • Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor
    • Gong H, Guo P, Zhai Y, Zhou J, Uppal H, Jarzynka MJ, Song WC, Cheng SY, Xie W 2007 Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor. Mol Endocrinol 21:1781-1790
    • (2007) Mol Endocrinol , vol.21 , pp. 1781-1790
    • Gong, H.1    Guo, P.2    Zhai, Y.3    Zhou, J.4    Uppal, H.5    Jarzynka, M.J.6    Song, W.C.7    Cheng, S.Y.8    Xie, W.9
  • 37
    • 33746176754 scopus 로고    scopus 로고
    • Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist
    • DOI 10.1158/0008-5472.CAN-06-0632
    • Chuu CP, Hiipakka RA, Kokontis JM, Fukuchi J, Chen RY, Liao S 2006 Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist. Cancer Res 66:6482-6486 (Pubitemid 44085600)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6482-6486
    • Chuu, C.-P.1    Hiipakka, R.A.2    Kokontis, J.M.3    Fukuchi, J.4    Chen, R.-Y.5    Liao, S.6
  • 38
    • 34548675597 scopus 로고    scopus 로고
    • Modulation of liver X receptor signaling as novel therapy for prostate cancer
    • DOI 10.1007/s11373-007-9160-8
    • Chuu CP, Kokontis JM, Hiipakka RA, Liao S 2007 Modulation of liver X receptor signaling as novel therapy for prostate cancer. J Biomed Sci 14:543-553 (Pubitemid 47414761)
    • (2007) Journal of Biomedical Science , vol.14 , Issue.5 , pp. 543-553
    • Chuu, C.-P.1    Kokontis, J.M.2    Hiipakka, R.A.3    Liao, S.4
  • 40
    • 36348932064 scopus 로고    scopus 로고
    • Liver X receptor and farnesoid X receptor as therapeutic targets
    • Rader DJ 2007 Liver X receptor and farnesoid X receptor as therapeutic targets. Am J Cardiol 100:15N-19N
    • (2007) Am J Cardiol , vol.100
    • Rader, D.J.1
  • 44
    • 34247844371 scopus 로고    scopus 로고
    • Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells
    • DOI 10.1074/jbc.M611741200
    • Dwyer JR, Sever N, Carlson M, Nelson SF, Beachy PA, Parhami F 2007 Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J Biol Chem 282:8959-8968 (Pubitemid 47093527)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.12 , pp. 8959-8968
    • Dwyer, J.R.1    Sever, N.2    Carlson, M.3    Nelson, S.F.4    Beachy, P.A.5    Parhami, F.6
  • 46
    • 38449113816 scopus 로고    scopus 로고
    • 20(S)-hydroxycholesterol inhibits PPARγ expression and adipogenic differentiation of bone marrow stromal cells through a hedgehog-dependent mechanism
    • DOI 10.1359/jbmr.070710
    • Kim WK, Meliton V, Amantea CM, Hahn TJ, Parhami F 2007 20(S)-hydroxycholesterol inhibits PPARγ expression and adipogenic differentiation of bone marrow stromal cells through a hedgehog-dependent mechanism. J Bone Miner Res 22:1711-1719 (Pubitemid 351235137)
    • (2007) Journal of Bone and Mineral Research , vol.22 , Issue.11 , pp. 1711-1719
    • Kim, W.-K.1    Meliton, V.2    Amantea, C.M.3    Hahn, T.J.4    Parhami, F.5
  • 47
    • 33645211374 scopus 로고    scopus 로고
    • Purmorphamine activates the Hedgehog pathway by targeting Smoothened
    • Sinha S, Chen JK 2006 Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol 2:29-30
    • (2006) Nat Chem Biol , vol.2 , pp. 29-30
    • Sinha, S.1    Chen, J.K.2
  • 50
    • 33847084412 scopus 로고    scopus 로고
    • Suppressors of Hedgehog signaling: Linking aberrant development of neural progenitors and tumorigenesis
    • DOI 10.1385/MN:34:3:193, PII MN343193
    • Di Marcotullio L, Ferretti E, De Smaele E, Screpanti I, Gulino A 2006 Suppressors of hedgehog signaling: linking aberrant development of neural progenitors and tumorigenesis. Mol Neurobiol 34:193-204 (Pubitemid 46268974)
    • (2006) Molecular Neurobiology , vol.34 , Issue.3 , pp. 193-204
    • Di Marcotullio, L.1    Ferretti, E.2    De Smaele, E.3    Screpanti, I.4    Gulino, A.5
  • 51
    • 23844485210 scopus 로고    scopus 로고
    • Cilia and Hedgehog responsiveness in the mouse
    • Huangfu D, Anderson KV 2005 Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci USA 102:11325-11330
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11325-11330
    • Huangfu, D.1    Anderson, K.V.2
  • 52
    • 34547115205 scopus 로고    scopus 로고
    • Cell signaling. a ciliary signaling switch
    • Christensen ST, Ott CM 2007 Cell signaling. A ciliary signaling switch. Science 317:330-331
    • (2007) Science , vol.317 , pp. 330-331
    • Christensen, S.T.1    Ott, C.M.2
  • 53
    • 34247558062 scopus 로고    scopus 로고
    • The Graded Response to Sonic Hedgehog Depends on Cilia Architecture
    • DOI 10.1016/j.devcel.2007.03.004, PII S1534580707001049
    • Caspary T, Larkins CE, Anderson KV 2007 The graded response to Sonic Hedgehog depends on cilia architecture. Dev Cell 12:767-778 (Pubitemid 46667745)
    • (2007) Developmental Cell , vol.12 , Issue.5 , pp. 767-778
    • Caspary, T.1    Larkins, C.E.2    Anderson, K.V.3
  • 54
    • 0037557518 scopus 로고    scopus 로고
    • Bending the primary cilium opens Ca2+-sensitive intermediate-conductance K+ channels in MDCK cells
    • Praetorius HA, Spring KR 2003 Bending the primary cilium opens Ca2+-sensitive intermediate-conductance K+ channels in MDCK cells. J Membr Biol 191:69-76
    • (2003) J Membr Biol , vol.191 , pp. 69-76
    • Praetorius, H.A.1    Spring, K.R.2
  • 56
    • 0242581681 scopus 로고    scopus 로고
    • Hedgehog signalling in the mouse requires intraflagellar transport proteins
    • DOI 10.1038/nature02061
    • Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV 2003 Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426:83-87 (Pubitemid 37432545)
    • (2003) Nature , vol.426 , Issue.6962 , pp. 83-87
    • Huangfu, D.1    Liu, A.2    Rakeman, A.S.3    Murcia, N.S.4    Niswander, L.5    Anderson, K.V.6
  • 57
    • 40749144679 scopus 로고    scopus 로고
    • Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
    • Haycraft CJ, Banizs B, Aydin-Son Y, Zhang Q, Michaud EJ, Yoder BK 2005 Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 1:480-488
    • (2005) PLoS Genet , vol.1 , pp. 480-488
    • Haycraft, C.J.1    Banizs, B.2    Aydin-Son, Y.3    Zhang, Q.4    Michaud, E.J.5    Yoder, B.K.6
  • 59
    • 0031731091 scopus 로고    scopus 로고
    • 5-lipoxygenase metabolites inhibit bone formation in vitro
    • DOI 10.1210/en.139.7.3178
    • Traianedes K, Dallas MR, Garret IR, Mundy GR, Bonewald LF 1998 5-Lipoxygenase metabolites inhibit bone formation in vitro. Endocrinology 139:3178-3184 (Pubitemid 28512347)
    • (1998) Endocrinology , vol.139 , Issue.7 , pp. 3178-3184
    • Traianedes, K.1    Dallas, M.R.2    Garrett, I.R.3    Mundy, G.R.4    Bonewald, L.F.5
  • 60
    • 0028101844 scopus 로고
    • Effects of insulin on in vitro bone formation in fetal rat parietal bone
    • Yano H, Ohya K, Amagasa T 1994 Effects of insulin on in vitro bone formation in fetal rat parietal bone. Endocr J 41:293-300 (Pubitemid 24237309)
    • (1994) Endocrine Journal , vol.41 , Issue.3 , pp. 293-300
    • Yano, H.1    Ohya, K.2    Amagasa, T.3
  • 61
    • 41549118422 scopus 로고    scopus 로고
    • The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer
    • Omenetti A, Diehl AM 2008 The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol 294:G595-G598
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294
    • Omenetti, A.1    Diehl, A.M.2
  • 62
    • 2342481730 scopus 로고    scopus 로고
    • Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis
    • DOI 10.1016/j.ydbio.2004.03.009, PII S0012160604001691
    • Li Y, Zhang H, Choi SC, Litingtung Y, Chiang C 2004 Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev Biol 270:214-231 (Pubitemid 38596939)
    • (2004) Developmental Biology , vol.270 , Issue.1 , pp. 214-231
    • Li, Y.1    Zhang, H.2    Choi, S.C.3    Litingtung, Y.4    Chiang, C.5
  • 63
    • 59649088676 scopus 로고    scopus 로고
    • Maintenance of BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling
    • Perry JM, Harandi OF, Porayette P, Hegde S, Kannan AK, Paulson RF 2009 Maintenance of BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling. Blood 113:911-918
    • (2009) Blood , vol.113 , pp. 911-918
    • Perry, J.M.1    Harandi, O.F.2    Porayette, P.3    Hegde, S.4    Kannan, A.K.5    Paulson, R.F.6
  • 64
    • 33750917626 scopus 로고    scopus 로고
    • Retinoid-related orphan receptors (RORs): Roles in cellular differentiation and development
    • Jetten AM, Joo JH 2006 Retinoid-related orphan receptors (RORs): roles in cellular differentiation and development. Adv Dev Biol 16:313-355
    • (2006) Adv Dev Biol , vol.16 , pp. 313-355
    • Jetten, A.M.1    Joo, J.H.2
  • 65
    • 45549091674 scopus 로고    scopus 로고
    • Retinoic acid in development: Towards an integrated view
    • DOI 10.1038/nrg2340, PII NRG2340
    • Niederreither K, Dollé P 2008 Retinoic acid in development towards an integrated view. Nat Rev Genet 9:541-553 (Pubitemid 351861538)
    • (2008) Nature Reviews Genetics , vol.9 , Issue.7 , pp. 541-553
    • Niederreither, K.1    Dolle, P.2
  • 66
    • 33746682493 scopus 로고    scopus 로고
    • PPARβ/δ Regulates Paneth Cell Differentiation Via Controlling the Hedgehog Signaling Pathway
    • DOI 10.1053/j.gastro.2006.05.004, PII S0016508506009930
    • Varnat F, Heggeler BB, Grisel P, Boucard N, Corthésy-Theulaz I, Wahli W, Desvergne B 2006 PPARβ/δ regulates paneth cell differentiation via controlling the hedgehog signaling pathway. Gastroenterology 131:538-553 (Pubitemid 44160696)
    • (2006) Gastroenterology , vol.131 , Issue.2 , pp. 538-553
    • Varnat, F.1    Heggeler, B.B.2    Grisel, P.3    Boucard, N.4    Corthesy-Theulaz, I.5    Wahli, W.6    Desvergne, B.7
  • 67
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott MP 2007 Patched1 regulates hedgehog signaling at the primary cilium. Science 317:372-376
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 68
    • 0036829397 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
    • DOI 10.1101/gad.1025302
    • Chen JK, Taipale J, Cooper MK, Beachy PA 2002 Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 16:2743-2748 (Pubitemid 35253140)
    • (2002) Genes and Development , vol.16 , Issue.21 , pp. 2743-2748
    • Chen, J.K.1    Taipale, J.2    Cooper, M.K.3    Beachy, P.A.4
  • 69
    • 34548306769 scopus 로고    scopus 로고
    • Patching the gaps in Hedgehog signaling
    • Rohatgi R, Scott MP 2007 Patching the gaps in Hedgehog signaling. Nat Cell Biol 9:1005-1009
    • (2007) Nat Cell Biol , vol.9 , pp. 1005-1009
    • Rohatgi, R.1    Scott, M.P.2
  • 74
    • 34848893044 scopus 로고    scopus 로고
    • Loss of suppressor-of-fused function promotes tumorigenesis
    • DOI 10.1038/sj.onc.1210467, PII 1210467
    • Lee Y, Kawagoe R, Sasai K, Li Y, Russell HR, Curran T, McKinnon PJ 2007 Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene 26:6442-6447 (Pubitemid 47494220)
    • (2007) Oncogene , vol.26 , Issue.44 , pp. 6442-6447
    • Lee, Y.1    Kawagoe, R.2    Sasai, K.3    Li, Y.4    Russell, H.R.5    Curran, T.6    McKinnon, P.J.7


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