-
1
-
-
0033951112
-
Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta
-
Alberti S., Steffensen K.R., Gustafsson J.A. Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. Gene. 243:2000;93-103.
-
(2000)
Gene
, vol.243
, pp. 93-103
-
-
Alberti, S.1
Steffensen, K.R.2
Gustafsson, J.A.3
-
2
-
-
0028918963
-
OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor
-
Teboul M., Enmark E., Li Q., Wikstrom A.C., Pelto-Huikko M., Gustafsson J.A. OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Proc. Natl Acad. Sci. USA. 92:1995;2096-2100.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 2096-2100
-
-
Teboul, M.1
Enmark, E.2
Li, Q.3
Wikstrom, A.C.4
Pelto-Huikko, M.5
Gustafsson, J.A.6
-
3
-
-
0030747895
-
Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: No alteration in adipose tissue of obese and NIDDM patients
-
Auboeuf D., Rieusset J., Fajas L., Vallier P., Frering V., Riou J.P., et al. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes. 46:1997;1319-1327.
-
(1997)
Diabetes
, vol.46
, pp. 1319-1327
-
-
Auboeuf, D.1
Rieusset, J.2
Fajas, L.3
Vallier, P.4
Frering, V.5
Riou, J.P.6
-
4
-
-
0029035278
-
LXR, a nuclear receptor that defines a distinct retinoid response pathway
-
Willy P.J., Umesono K., Ong E.S., Evans R.M., Heyman R.A., Mangelsdorf D.J. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9:1995;1033-1045.
-
(1995)
Genes Dev.
, vol.9
, pp. 1033-1045
-
-
Willy, P.J.1
Umesono, K.2
Ong, E.S.3
Evans, R.M.4
Heyman, R.A.5
Mangelsdorf, D.J.6
-
5
-
-
0035914330
-
27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
-
Fu X., Menke J.G., Chen Y., Zhou G., MacNaul K.L., Wright S.D., et al. 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J. Biol. Chem. 276:2001;38378-38387.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38378-38387
-
-
Fu, X.1
Menke, J.G.2
Chen, Y.3
Zhou, G.4
Macnaul, K.L.5
Wright, S.D.6
-
6
-
-
14444285707
-
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
-
Lehmann J.M., Kliewer S.A., Moore L.B., Smith-Oliver T.A., Oliver B.B., Su J.L., et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272:1997;3137-3140.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3137-3140
-
-
Lehmann, J.M.1
Kliewer, S.A.2
Moore, L.B.3
Smith-Oliver, T.A.4
Oliver, B.B.5
Su, J.L.6
-
7
-
-
0035895202
-
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes
-
Laffitte B.A., Repa J.J., Joseph S.B., Wilpitz D.C., Kast H.R., Mangelsdorf D.J., Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc. Natl Acad. Sci. USA. 98:2001;507-512.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 507-512
-
-
Laffitte, B.A.1
Repa, J.J.2
Joseph, S.B.3
Wilpitz, D.C.4
Kast, H.R.5
Mangelsdorf, D.J.6
Tontonoz, P.7
-
8
-
-
0034640288
-
Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols
-
Venkateswaran A., Repa J.J., Lobaccaro J.M., Bronson A., Mangelsdorf D.J., Edwards P.A. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. J. Biol. Chem. 275:2000;14700-14707.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 14700-14707
-
-
Venkateswaran, A.1
Repa, J.J.2
Lobaccaro, J.M.3
Bronson, A.4
Mangelsdorf, D.J.5
Edwards, P.A.6
-
9
-
-
0034623288
-
Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
-
Costet P., Luo Y., Wang N., Tall A.R. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J. Biol. Chem. 275:2000;28240-28245.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 28240-28245
-
-
Costet, P.1
Luo, Y.2
Wang, N.3
Tall, A.R.4
-
10
-
-
0035205221
-
Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis
-
Attie A.D., Kastelein J.P., Hayden M.R. Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J. Lipid Res. 42:2001;1717-1726.
-
(2001)
J. Lipid Res.
, vol.42
, pp. 1717-1726
-
-
Attie, A.D.1
Kastelein, J.P.2
Hayden, M.R.3
-
11
-
-
0034669171
-
Role of LXRs in control of lipogenesis
-
Schultz J.R., Tu H., Luk A., Repa J.J., Medina J.C., Li L., et al. Role of LXRs in control of lipogenesis. Genes Dev. 14:2000;2831-2838.
-
(2000)
Genes Dev.
, vol.14
, pp. 2831-2838
-
-
Schultz, J.R.1
Tu, H.2
Luk, A.3
Repa, J.J.4
Medina, J.C.5
Li, L.6
-
12
-
-
0037432165
-
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice
-
Terasaka N., Hiroshima A., Koieyama T., Ubukata N., Morikawa Y., Nakai D., Inaba T. T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. FEBS Letters. 536:2003;6-11.
-
(2003)
FEBS Letters
, vol.536
, pp. 6-11
-
-
Terasaka, N.1
Hiroshima, A.2
Koieyama, T.3
Ubukata, N.4
Morikawa, Y.5
Nakai, D.6
Inaba, T.7
-
13
-
-
0037188553
-
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
-
Joseph S.B., McKilligin E., Pei L., Watson M.A., Collins A.R., Laffitte B.A., et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc. Natl Acad. Sci. USA. 99:2002;7604-7609.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 7604-7609
-
-
Joseph, S.B.1
Mckilligin, E.2
Pei, L.3
Watson, M.A.4
Collins, A.R.5
Laffitte, B.A.6
-
14
-
-
0037046543
-
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines
-
Collins J.L., Fivush A.M., Watson M.A., Galardi C.M., Lewis M.C., Moore L.B., et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J. Med. Chem. 45:2002;1963-1966.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1963-1966
-
-
Collins, J.L.1
Fivush, A.M.2
Watson, M.A.3
Galardi, C.M.4
Lewis, M.C.5
Moore, L.B.6
-
15
-
-
0342616837
-
A canonical structure for the ligand-binding domain of nuclear receptors
-
Wurtz J.M., Bourguet W., Renaud J.P., Vivat V., Chambon P., Moras D., Gronemeyer H. A canonical structure for the ligand-binding domain of nuclear receptors. Nature Struct. Biol. 3:1996;87-94.
-
(1996)
Nature Struct. Biol.
, vol.3
, pp. 87-94
-
-
Wurtz, J.M.1
Bourguet, W.2
Renaud, J.P.3
Vivat, V.4
Chambon, P.5
Moras, D.6
Gronemeyer, H.7
-
16
-
-
0035826802
-
Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands
-
Tocchini-Valentini G., Rochel N., Wurtz J.M., Mitschler A., Moras D. Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands. Proc. Natl Acad. Sci. USA. 98:2001;5491-5496.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 5491-5496
-
-
Tocchini-Valentini, G.1
Rochel, N.2
Wurtz, J.M.3
Mitschler, A.4
Moras, D.5
-
17
-
-
0034612290
-
Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma
-
Klaholz B.P., Mitschler A., Belema M., Zusi C., Moras D. Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma. Proc. Natl Acad. Sci. USA. 97:2000;6322-6327.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 6322-6327
-
-
Klaholz, B.P.1
Mitschler, A.2
Belema, M.3
Zusi, C.4
Moras, D.5
-
18
-
-
0032052809
-
X-ray crystallographic and functional studies of thyroid hormone receptor
-
Ribeiro R.C., Apriletti J.W., Wagner R.L., Feng W., Kushner P.J., Nilsson S., et al. X-ray crystallographic and functional studies of thyroid hormone receptor. J. Steroid Biochem. Mol. Biol. 65:1998;133-141.
-
(1998)
J. Steroid Biochem. Mol. Biol.
, vol.65
, pp. 133-141
-
-
Ribeiro, R.C.1
Apriletti, J.W.2
Wagner, R.L.3
Feng, W.4
Kushner, P.J.5
Nilsson, S.6
-
19
-
-
0035431321
-
Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; Ligand selectivity and agonist activation in the PPAR family
-
Cronet P., Petersen J.F., Folmer R., Blomberg N., Sjoblom K., Karlsson U., et al. Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family. Structure (Camb). 9:2001;699-706.
-
(2001)
Structure (Camb)
, vol.9
, pp. 699-706
-
-
Cronet, P.1
Petersen, J.F.2
Folmer, R.3
Blomberg, N.4
Sjoblom, K.5
Karlsson, U.6
-
20
-
-
0035933511
-
The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity
-
Watkins R.E., Wisely G.B., Moore L.B., Collins J.L., Lambert M.H., Williams S.P., et al. The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science. 292:2001;2329-2333.
-
(2001)
Science
, vol.292
, pp. 2329-2333
-
-
Watkins, R.E.1
Wisely, G.B.2
Moore, L.B.3
Collins, J.L.4
Lambert, M.H.5
Williams, S.P.6
-
21
-
-
0035502971
-
X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation
-
Stehlin C., Wurtz J.M., Steinmetz A., Greiner E., Schule R., Moras D., Renaud J.P. X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. EMBO J. 20:2001;5822-5831.
-
(2001)
EMBO J.
, vol.20
, pp. 5822-5831
-
-
Stehlin, C.1
Wurtz, J.M.2
Steinmetz, A.3
Greiner, E.4
Schule, R.5
Moras, D.6
Renaud, J.P.7
-
22
-
-
0035923672
-
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors
-
Xu H.E., Lambert M.H., Montana V.G., Plunket K.D., Moore L.B., Collins J.L., et al. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc. Natl Acad. Sci. USA. 98:2001;13919-13924.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 13919-13924
-
-
Xu, H.E.1
Lambert, M.H.2
Montana, V.G.3
Plunket, K.D.4
Moore, L.B.5
Collins, J.L.6
-
23
-
-
0033711971
-
Structural studies on nuclear receptors
-
Renaud J.P., Moras D. Structural studies on nuclear receptors. Cell. Mol. Life Sci. 57:2000;1748-1769.
-
(2000)
Cell. Mol. Life Sci.
, vol.57
, pp. 1748-1769
-
-
Renaud, J.P.1
Moras, D.2
-
24
-
-
0037738531
-
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
-
Downes M., Verdecia M.A., Roecker A.J., Hughes R., Hogenesch J.B., Kast-Woelbern H.R., et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol. Cell. 11:2003;1079-1092.
-
(2003)
Mol. Cell
, vol.11
, pp. 1079-1092
-
-
Downes, M.1
Verdecia, M.A.2
Roecker, A.J.3
Hughes, R.4
Hogenesch, J.B.5
Kast-Woelbern, H.R.6
-
25
-
-
0034213831
-
Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid
-
Egea P.F., Mitschler A., Rochel N., Ruff M., Chambon P., Moras D. Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. EMBO J. 19:2000;2592-2601.
-
(2000)
EMBO J.
, vol.19
, pp. 2592-2601
-
-
Egea, P.F.1
Mitschler, A.2
Rochel, N.3
Ruff, M.4
Chambon, P.5
Moras, D.6
-
26
-
-
0029012163
-
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha
-
Bourguet W., Ruff M., Chambon P., Gronemeyer H., Moras D. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature. 375:1995;377-382.
-
(1995)
Nature
, vol.375
, pp. 377-382
-
-
Bourguet, W.1
Ruff, M.2
Chambon, P.3
Gronemeyer, H.4
Moras, D.5
-
27
-
-
1842848068
-
X-Ray structure of the hRORalpha LBD at 1.63 Å. Structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha
-
Kallen J.A., Schlaeppi J.M., Bitsch F., Geisse S., Geiser M., Delhon I., Fournier B. X-Ray structure of the hRORalpha LBD at 1.63 Å. Structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha. Structure (Camb). 10:2002;1697-1707.
-
(2002)
Structure (Camb)
, vol.10
, pp. 1697-1707
-
-
Kallen, J.A.1
Schlaeppi, J.M.2
Bitsch, F.3
Geisse, S.4
Geiser, M.5
Delhon, I.6
Fournier, B.7
-
28
-
-
0033681001
-
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
-
Gampe R.T. Jr, Montana V.G., Lambert M.H., Miller A.B., Bledsoe R.K., Milburn M.V., et al. Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol. Cell. 5:2000;545-555.
-
(2000)
Mol. Cell
, vol.5
, pp. 545-555
-
-
Gampe Jr., R.T.1
Montana, V.G.2
Lambert, M.H.3
Miller, A.B.4
Bledsoe, R.K.5
Milburn, M.V.6
-
29
-
-
0038711589
-
X-ray crystal structure of the liver x receptor ligand binding domain: Regulation by a histidine-tryptophan switch
-
Williams S.P., Bledsoe R.K., Collins J.L., Boggs S., Lambert M.H., Miller A.B., et al. X-ray crystal structure of the liver x receptor ligand binding domain: regulation by a histidine-tryptophan switch. J. Biol. Chem. 278:2003;27138-27143.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 27138-27143
-
-
Williams, S.P.1
Bledsoe, R.K.2
Collins, J.L.3
Boggs, S.4
Lambert, M.H.5
Miller, A.B.6
-
30
-
-
0033524420
-
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
-
Janowski B.A., Grogan M.J., Jones S.A., Wisely G.B., Kliewer S.A., Corey E.J., Mangelsdorf D.J. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc. Natl Acad. Sci. USA. 96:1999;266-271.
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 266-271
-
-
Janowski, B.A.1
Grogan, M.J.2
Jones, S.A.3
Wisely, G.B.4
Kliewer, S.A.5
Corey, E.J.6
Mangelsdorf, D.J.7
-
31
-
-
0030667676
-
Molecular basis of agonism and antagonism in the oestrogen receptor
-
Brzozowski A.M., Pike A.C., Dauter Z., Hubbard R.E., Bonn T., Engstrom O., et al. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature. 389:1997;753-758.
-
(1997)
Nature
, vol.389
, pp. 753-758
-
-
Brzozowski, A.M.1
Pike, A.C.2
Dauter, Z.3
Hubbard, R.E.4
Bonn, T.5
Engstrom, O.6
-
32
-
-
0035866585
-
Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha
-
Spencer T.A., Li D., Russel J.S., Collins J.L., Bledsoe R.K., Consler T.G., et al. Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. J. Med. Chem. 44:2001;886-897.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 886-897
-
-
Spencer, T.A.1
Li, D.2
Russel, J.S.3
Collins, J.L.4
Bledsoe, R.K.5
Consler, T.G.6
-
33
-
-
0026465007
-
Refined 2.3 Å X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics
-
Brandstetter H., Turk D., Hoeffken H.W., Grosse D., Sturzebecher J., Martin P.D., et al. Refined 2.3 Å X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. J. Mol. Biol. 226:1992;1085-1099.
-
(1992)
J. Mol. Biol.
, vol.226
, pp. 1085-1099
-
-
Brandstetter, H.1
Turk, D.2
Hoeffken, H.W.3
Grosse, D.4
Sturzebecher, J.5
Martin, P.D.6
-
34
-
-
0028103275
-
CCP4 suite: Programs for protein crystallography
-
CCP4 suite: programs for protein crystallography. Acta Crystallog. sect. D. 50:1994;760-763.
-
(1994)
Acta Crystallog. sect. D
, vol.50
, pp. 760-763
-
-
-
35
-
-
0030924992
-
Refinement of macromolecular structures by the maximum-likelihood method
-
Murshudov G.N., Vagin A.A., Dodson E.J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallog. sect. D. 53:1997;240-255.
-
(1997)
Acta Crystallog. sect. D
, vol.53
, pp. 240-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Dodson, E.J.3
-
37
-
-
0026244229
-
MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
-
Kraulis P.J. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallog. 24:1991;946-950.
-
(1991)
J. Appl. Crystallog.
, vol.24
, pp. 946-950
-
-
Kraulis, P.J.1
-
38
-
-
0030815133
-
Raster3D: Photorealistic molecular graphics
-
Merritt E.A., Bacon D.J. Raster3D: photorealistic molecular graphics. Methods Enzymol. 1997;505-524.
-
(1997)
Methods Enzymol.
, pp. 505-524
-
-
Merritt, E.A.1
Bacon, D.J.2
-
39
-
-
0032961270
-
ESPript: Analysis of multiple sequence alignments in PostScript
-
Gouet P., Courcelle E., Stuart D.I., Metoz F. ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics. 15:1999;305-308.
-
(1999)
Bioinformatics
, vol.15
, pp. 305-308
-
-
Gouet, P.1
Courcelle, E.2
Stuart, D.I.3
Metoz, F.4
|