Resurrecting the ancestral steroid receptor: Ancient origin of estrogen signaling

Science

Volumn 301, Issue 5640, 2003, Pages 1714-1717

  Thornton, Joseph W ^a   Need, Eleanor ^a   Crews, David ^b  

^a UNIVERSITY OF OREGON   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; HORMONES;

ESTROGENS;

DRUG PRODUCTS;

CORTICOSTEROID; ESTROGEN; STEROID RECEPTOR;

BIOLOGY; SEX HORMONE; SIGNALING;

AMINO ACID SEQUENCE; APLYSIA; ARTHROPOD; ARTICLE; CONTROLLED STUDY; ESTROGEN ACTIVITY; GENE SEQUENCE; GENOME; HORMONAL REGULATION; HUMAN; INVERTEBRATE; MOLLUSC; NEMATODE; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; APLYSIA; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; DNA; ESTROGENS; EVOLUTION; EVOLUTION, MOLECULAR; GENE DUPLICATION; HUMANS; LIGANDS; LIKELIHOOD FUNCTIONS; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ESTROGEN; RECEPTORS, STEROID; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STEROIDS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA; APLYSIA; APLYSIA CALIFORNICA; ARTHROPODA; INVERTEBRATA; MOLLUSCA; NEMATODA;

EID: 0141431993     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1086185     Document Type: Article

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21. We thank D. Kelley for hosting the first phase of this research; L. Chasin for his expertise; D. Hillis, P. Phillips, and J. Fox for comments on the manuscript; and J. Schwartz, B. Katznellenbogen, C. Klinge, and D. Furlow for libraries and plasmids. Supported in part by NIMH41770.