Microarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and mice in vivo

Xenobiotica

Volumn 36, Issue 10-11, 2006, Pages 902-937

  Slatter, J G ^a,c   Cheng, O ^a   Cornwell, P D ^a   De Souza, A ^a   Rockett, J ^a   Rushmore, T ^b   Hartley, D ^b   Evers, R ^b   He, Y ^a   Dai, X ^a   Hu, R ^a   Caguyong, M ^a   Roberts, C J ^a   Castle, J ^a   Ulrich, R G ^a  

^a ROSETTA INPHARMATICS   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c AMGEN INC   (United States)

Author keywords

Absorption; Compendium of ADME; CYP3A4; Distribution; Enzyme induction; Induction (micro array); Metabolism and excretion (ADME) gene expression; Nuclear receptors; Receptor cross talk

Indexed keywords

3 INDOLEMETHANOL; 3 METHYLCHOLANTHRENE; ANDROSTANE DERIVATIVE; AROMATIC HYDROCARBON RECEPTOR; ARTEMISININ; BENZO[A]PYRENE; BETA NAPHTHOFLAVONE; CELL NUCLEUS RECEPTOR; CHLORPROMAZINE; CLOTRIMAZOLE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYPROTERONE ACETATE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2B10; CYTOCHROME P450 2B15; CYTOCHROME P450 3A1; DEXAMETHASONE; FLUTAMIDE; HYPERFORIN; LIGAND; LITHOCHOLIC ACID; MICONAZOLE; MIFEPRISTONE; OLIGONUCLEOTIDE; OMEPRAZOLE; PHENOBARBITAL; PREGNANE X RECEPTOR; RIFAMPICIN; SPIRONOLACTONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONSENSUS; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; ENZYME INDUCTION; FEMALE; GENE CLUSTER; GENE CONSTRUCT; GENE EXPRESSION PROFILING; GENE EXPRESSION SYSTEM; GENE INDUCTION; GENETIC TRANSCRIPTION; IN VIVO CULTURE; LIGAND BINDING; LIVER; LIVER TOXICITY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; RNA ANALYSIS; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; UNINDEXED SEQUENCE;

ANIMALS; BASE SEQUENCE; CELL NUCLEUS; CLUSTER ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIGANDS; LIVER; MICE; MICE, INBRED C57BL; MICROARRAY ANALYSIS; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS;

ANIMALIA; RODENTIA;

EID: 33751557134     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250600861694     Document Type: Article

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