X-ray crystal structure of the liver X receptor β ligand binding domain: Regulation by a histidine-tryptophan switch

Journal of Biological Chemistry

Volumn 278, Issue 29, 2003, Pages 27138-27143

  Williams, Shawn ^a   Bledsoe, Randy K ^c   Collins, Jon L ^c   Boggs, Sharon ^c   Lambert, Millard H ^c   Miller, Ann B ^b   Moore, John ^c   McKee, David D ^c   Moore, Linda ^c   Nichols, Jason ^c   Parks, Derek ^c   Watson, Mike ^c   Wisely, Bruce ^c   Willson, Timothy M ^c  

^a GLAXOSMITHKLINE   (United States)

^b Pharmaceutical Product Development   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; HYDROGEN BONDS;

ELECTROSTATIC INTERACTIONS;

BIOCHEMISTRY;

BENZENE; CHOLESTEROL DERIVATIVE; HISTIDINE; IMIDAZOLE DERIVATIVE; LIVER X RECEPTOR BETA; OXYSTEROL; PYRROLE DERIVATIVE; RECEPTOR; STEROID RECEPTOR; STEROL; TRYPTOPHAN; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ELECTRICITY; HYDROGEN BOND; LIGAND BINDING; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MUTAGENESIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ANTICHOLESTEREMIC AGENTS; BINDING SITES; CHOLESTEROL; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; HISTIDINE; HUMANS; HYDROGEN BONDING; LIGANDS; LIVER; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT PROTEINS; SULFONAMIDES; TRYPTOPHAN;

EID: 0038711589     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302260200     Document Type: Article

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