Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apoptosis

Current Neurovascular Research

Volumn 6, Issue 4, 2009, Pages 267-278

  Okouchi, Masahiro ^a   Okayama, Naotsuka ^b   Tak, Yee Aw ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

AMP activated protein kinase activator; Biguanides; Glitazones; GSH GSSG redox status; Human brain endothelial cells; Insulin sensitizers and endothelial cell apoptosis; Methylglyoxal induced apoptosis; Mitochondrial apoptotic signaling; Mitochondrial permeability transition pore

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYLCYSTEINE; ANTIOXIDANT; BIGUANIDE DERIVATIVE; CASPASE 3; CASPASE 9; CYCLOSPORIN A; GLITAZONE DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN SENSITIZING AGENT; METFORMIN; METHYLGLYOXAL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENFORMIN; PIOGLITAZONE; THIOL; TROGLITAZONE;

APOPTOSIS; ARTICLE; CELL PROTECTION; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MICROANGIOPATHY; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 70350337363     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720209789630348     Document Type: Article

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