Transgenic expression of antioxidant protein thioredoxin in pancreatic β cells prevents progression of type 2 diabetes mellitus

Antioxidants and Redox Signaling

Volumn 10, Issue 1, 2008, Pages 43-49

  Yamamoto, Mayu ^a   Yamato, Eiji ^a   Shu Ichi, Toyoda ^a   Tashiro, Fumi ^a   Ikegami, Hiroshi ^a   Yodoi, Junji ^b   Miyazaki, Jun Ichi ^a,c  

^a OSAKA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

THIOREDOXIN; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL MOUSE; CELL FUNCTION; CELL PROTECTION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN RELEASE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NONOBESE DIABETIC MOUSE; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TRANSGENIC MOUSE; WEIGHT GAIN;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MAF TRANSCRIPTION FACTORS, LARGE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; THIOREDOXINS; TRANS-ACTIVATORS;

MUS MUSCULUS;

EID: 36148988058     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2007.1586     Document Type: Article

References (26)

1. Evans JL, Goldfine ID, Maddux BA, and Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23: 599-622, 2002.
2. Evans JL, Goldfine ID, Maddux BA, and Grodsky GM. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 52: 1-8, 2003.
3. Fridlyand LE and Philipson LH. Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells? Diabetes 53: 1942-1948, 2004.
4. Harmon JS, Gleason CE, Tanaka Y, Oseid EA, Hunter-Berger KK, and Robertson RP. In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. Diabetes 48: 1995-2000, 1999.
5. Harmon JS, Stein R, and Robertson RP. Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells. J Biol Chem 280: 11107-11113, 2005.
6. Harmon JS, Tanaka Y, Olson LK, and Robertson RP. Reconstitution of glucotoxic HIT-T15 cells with somatostatin transcription factor-1 partially restores insulin promoter activity. Diabetes 47: 900-904, 1998.
7. Hirota K, Nakamura H, Masutani H, and Yodoi J. Thioredoxin superfamily and thioredoxin-inducing agents. Ann NY Acad Sci 957: 189-199, 2002.
8. Holmgren A. Thioredoxin. Annu Rev Biochem 54: 237-271, 1985.
9. Hotta M, Tashiro F, Ikegami H, Niwa H, Ogihara T, Yodoi J, and Miyazaki J. Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes. J Exp Med 188: 1445-1451, 1998.
10. Ikegami H, Fujisawa T, and Ogihara T. Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes. ILAR J/National Research Council, Institute of Laboratory Animal Resources 45: 268-277, 2004.
11. Ivarsson R, Quintens R, Dejonghe S, Tsukamoto K, in 't Veld P, Renstrom E, and Schuit FC. Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin. Diabetes 54: 2132-2142, 2005.
12. Kajimoto Y and Kaneto H. Role of oxidative stress in pancreatic beta-cell dysfunction. Ann NY Acad Sci 52: 168-176, 2003.
13. Kaneto H, Kajimoto Y, Miyagawa J, Matsuoka T, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, and Hori M. Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes 48: 2398-2406, 1999.
14. Kawamori D, Kajimoto Y, Kaneto H, Umayahara Y, Fujitani Y, Miyatsuka T, Watada H, Leibiger IB, Yamasaki Y, and Hori M. Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes 48: 2896-2904, 1999.
15. Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, Gu W, and Accili D. FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab 2: 153-163, 2005.
16. Kooptiwut S, Kebede M, Zraika S, Visinoni S, Aston-Mourney K, Favaloro J, Tikellis C, Thomas MC, Forbes JM, Cooper ME, Dunlop M, Proietto J, and Andrikopoulos S. High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction. J Mol Endocrinol 35: 39-48, 2005.
17. Minn AH, Hafele C, and Shalev A. Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis. Endocrinology 146: 2397-2405, 2005.
18. Nakamura H, Nakamura K, and Yodoi J. Redox regulation of cellular activation. Annu Rev Immunol 15: 351-369, 1997.
19. Olson LK, Sharma A, Peshavaria M, Wright CV, Towle HC, Rodertson RP, and Stein R. Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. Proc Natl Acad Sci USA 92: 9127-9131, 1995.
20. Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J Biol Chem 279: 42351-42354, 2004.
21. Robertson RP, Harmon J, Tran PO, and Poitout V. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53: S119-S124, 2004.
22. Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, and Lee RT. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem 279: 30369-30374, 2004.
23. Tagaya Y, Maeda Y, Mitsui A, Kondo N, Matsui H, Hamuro J, Brown N, Arai K, Yokota T, and Wakasugi H. ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO J 8: 757-764, 1989.
24. Tanaka Y, Gleason CE, Tran PO, Harmon JS, and Robertson RP. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci USA 47: 10857-10862, 1998.
25. Watson WH, Yang X, Choi YE, Jones DP, and Kehrer JP. Thioredoxin and its role in toxicology. Toxicol Sci 78: 3-14, 2004.
26. Yamamoto T, Yamato E, Tashiro F, Sato T, Noso S, Ikegami H, Tamura S, Yanagawa Y, and Miyazaki JI. Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice. Diabetologia 47: 221-224, 2004.