Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid

Journal of the Neurological Sciences

Volumn 207, Issue 1-2, 2003, Pages 51-58

  Rizzardini, M ^a   Lupi, M ^a   Bernasconi, S ^a   Mangolini, A ^a   Cantoni, L ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Amyotrophic lateral sclerosis; Apoptosis; Glutathione; Mitochondria; Motor neuron(s); Neurodegeneration; Reactive oxygen species

Indexed keywords

BIOLOGICAL MARKER; DNA FRAGMENT; ETACRYNIC ACID; GLUTATHIONE; HEME OXYGENASE 1; REACTIVE OXYGEN METABOLITE; RHODAMINE 123;

ANIMAL CELL; BRAIN MITOCHONDRION; CELL DAMAGE; CELL IMMORTALIZATION; CELL NUCLEUS; CELL TYPE; CONCENTRATION RESPONSE; CONFERENCE PAPER; CYTOSOL; DRUG CYTOTOXICITY; DRUG MECHANISM; EXPERIMENTAL MODEL; MEASUREMENT; MITOCHONDRIAL MEMBRANE; MOTONEURON; MOUSE; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL NECROSIS; NEUROTOXICITY; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHACRYNIC ACID; GLUTATHIONE; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MOTOR NEURONS; TUMOR CELLS, CULTURED;

EID: 12244297111     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(02)00357-X     Document Type: Conference Paper

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