Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice

Biochemical and Biophysical Research Communications

Volumn 366, Issue 3, 2008, Pages 814-820

  Goto, Hideo ^a   Nishikawa, Takeshi ^a   Sonoda, Kazuhiro ^a   Kondo, Tatsuya ^a   Kukidome, Daisuke ^a   Fujisawa, Kazuo ^a   Yamashiro, Takeshi ^a   Motoshima, Hiroyuki ^a   Matsumura, Takeshi ^a   Tsuruzoe, Kaku ^a   Araki, Eiichi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Diabetes; Diabetic complications; Endothelium; Manganese superoxide dismutase; Reactive oxygen species

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANGIOPOIETIN RECEPTOR; FIBRONECTIN; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE MARKER; ENDOTHELIUM CELL; ENHANCER REGION; GENE OVEREXPRESSION; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENDOTHELIAL CELLS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REACTIVE OXYGEN SPECIES; RETINA; STREPTOZOCIN; SUPEROXIDE DISMUTASE; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MUS; MUS MUSCULUS;

EID: 37549066364     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.12.041     Document Type: Article

References (31)

1. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329 (1993) 977-986
2. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352 (1998) 837-853
3. Ohkubo Y., Kishikawa H., Araki E., Miyata T., Isami S., Motoyoshi S., Kojima Y., Furuyoshi N., and Shichiri M. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res. Clin. Pract. 28 (1995) 103-117
4. Nishikawa T., Edelstein D., Du X.L., Yamagishi S., Matsumura T., Kaneda Y., Yorek M.A., Beebe D., Oates P.J., Hammes H.P., Giardino I., and Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404 (2000) 787-790
5. Giugliano D., Ceriello A., and Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care 19 (1996) 257-267
6. Dandona P., Thusu K., Cook S., Snyder B., Makowski J., Armstrong D., and Nicotera T. Oxidative damage to DNA in diabetes mellitus. Lancet 347 (1996) 444-445
7. Beckman K.B., and Ames B.N. The free radical theory of aging matures. Physiol. Rev. 78 (1998) 547-581
8. Nishikawa T., Sasahara T., Kiritoshi S., Sonoda K., Senokuchi T., Matsuo T., Kukidome D., Wake N., Matsumura T., Miyamura N., Sakakida M., Kishikawa H., and Araki E. Evaluation of urinary 8-hydroxydeoxy-guanosine as a novel biomarker of macrovascular complications in type 2 diabetes. Diabetes Care 26 (2003) 1507-1512
9. Schalkwijk C.G., and Stehouwer C.D. Vascular complications in diabetes mellitus: the role of endothelial dysfunction. Clin. Sci. (Lond.) 109 (2005) 143-159
10. van Hecke M.V., Dekker J.M., Nijpels G., Moll A.C., Heine R.J., Bouter L.M., Polak B.C., and Stehouwer C.D. Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study. Diabetologia 48 (2005) 1300-1306
11. Heckl K. Isolation of cDNAs encoding human manganese superoxide dismutase. Nucleic Acids Res. 16 (1988) 6224
12. Schlaeger T.M., Bartunkova S., Lawitts J.A., Teichmann G., Risau W., Deutsch U., and Sato T.N. Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc. Natl. Acad. Sci. USA 94 (1997) 3058-3063
13. Kondo T., Vicent D., Suzuma K., Yanagisawa M., King G.L., Holzenberger M., and Kahn C.R. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J. Clin. Invest. 111 (2003) 1835-1842
14. Kukidome D., Nishikawa T., Sonoda K., Imoto K., Fujisawa K., Yano M., Motoshima H., Taguchi T., Matsumura T., and Araki E. Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. Diabetes 55 (2006) 120-127
15. Shih S.C., Robinson G.S., Perruzzi C.A., Calvo A., Desai K., Green J.E., Ali I.U., Smith L.E., and Senger D.R. Molecular profiling of angiogenesis markers. Am. J. Pathol. 161 (2002) 35-41
16. Nishikawa T., Giardino I., Edelstein D., and Brownlee M. Changes in diabetic retinal matrix protein mRNA levels in a common transgenic mouse strain. Curr. Eye Res. 21 (2000) 581-587
17. Usui H.K., Shikata K., Sasaki M., Okada S., Matsuda M., Shikata Y., Ogawa D., Kido Y., Nagase R., Yozai K., Ohga S., Tone A., Wada J., Takeya M., Horiuchi S., Kodama T., and Makino H. Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation. Diabetes 56 (2007) 363-372
18. Aiello L.P., Avery R.L., Arrigg P.G., Keyt B.A., Jampel H.D., Shah S.T., Pasquale L.R., Thieme H., Iwamoto M.A., Park J.E., et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331 (1994) 1480-1487
19. Poulaki V., Qin W., Joussen A.M., Hurlbut P., Wiegand S.J., Rudge J., Yancopoulos G.D., and Adamis A.P. Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. J. Clin. Invest. 109 (2002) 805-815
20. Mandarino L.J. Current hypotheses for the biochemical basis of diabetic retinopathy. Diabetes Care 15 (1992) 1892-1901
21. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414 (2001) 813-820
22. Elchuri S., Oberley T.D., Qi W., Eisenstein R.S., Jackson Roberts L., Van Remmen H., Epstein C.J., and Huang T.T. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene 24 (2005) 367-380
23. Carlsson L.M., Jonsson J., Edlund T., and Marklund S.L. Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. Proc. Natl. Acad. Sci. USA 92 (1995) 6264-6268
24. Li Y., Huang T.T., Carlson E.J., Melov S., Ursell P.C., Olson J.L., Noble L.J., Yoshimura M.P., Berger C., Chan P.H., Wallace D.C., and Epstein C.J. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. Genet. 11 (1995) 376-381
25. Copin J.C., Gasche Y., and Chan P.H. Overexpression of copper/zinc superoxide dismutase does not prevent neonatal lethality in mutant mice that lack manganese superoxide dismutase. Free Radic. Biol. Med. 28 (2000) 1571-1576
26. Duh E., and Aiello L.P. Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox. Diabetes 48 (1999) 1899-1906
27. Caldwell R.B., Bartoli M., Behzadian M.A., El-Remessy A.E., Al-Shabrawey M., Platt D.H., and Caldwell R.W. Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Diabetes Metab. Res. Rev. 19 (2003) 442-455
28. Kowluru R.A., Tang J., and Kern T.S. Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy. Diabetes 50 (2001) 1938-1942
29. Obrosova I.G., Minchenko A.G., Marinescu V., Fathallah L., Kennedy A., Stockert C.M., Frank R.N., and Stevens M.J. Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats. Diabetologia 44 (2001) 1102-1110
30. Duyndam M.C., Hulscher T.M., Fontijn D., Pinedo H.M., and Boven E. Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. J. Biol. Chem. 276 (2001) 48066-48076
31. Roybal C.N., Hunsaker L.A., Barbash O., Vander Jagt D.L., and Abcouwer S.F. The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. J. Biol. Chem. 280 (2005) 20331-20339