Mitochondrial free radical production and cell signaling

Molecular Aspects of Medicine

Volumn 25, Issue 1-2, 2004, Pages 17-26

  Cadenas, Enrique ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Antioxidants; Hydrogen peroxide; MAPKs; Mitochondria; Nitric oxide; Signaling; Superoxide

Indexed keywords

ANION CHANNEL; ANTIOXIDANT; CYTOCHROME C; FREE RADICAL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; OXYGEN RADICAL; PEROXYNITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; ENERGY; HUMAN; MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OUTER MEMBRANE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; FREE RADICALS; HUMANS; HYDROGEN PEROXIDE; MITOCHONDRIA; NITRIC OXIDE; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 1642422773     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mam.2004.02.005     Document Type: Review

References (42)

1. 2 induce apoptosis through Fenton chemistry independent of the cellular thiol state. Free Radical. Biol. Med. 30:2001;1008-1018.
2. Beckman J.S. Ischaemic injury mediator. Nature. 345:1990;27-28.
3. Boveris A., Cadenas E. Mitochondrial production of superoxide anions and its relationship to the antimycin-insensitive respiration. FEBS Lett. 54:1975;311-314.
4. Boveris A., Cadenas E. Production of superoxide radicals and hydrogen peroxide in mitochondria. Oberley L.W. Superoxide Dismutase. 1982;15-30 CRC Press, Boca Raton, Florida.
5. Boveris A., Cadenas E. Cellular sources and steady-state levels of reactive oxygen species. Biadasz-Clerch L., Massaro D.J. Oxygen, Gene Expression and Cellular Function. 1997;1-25 Marcel Dekker, New York.
6. Boveris A., Cadenas E. Mitochondrial production of hydrogen peroxide. Regulation by nitric oxide and the role of ubisemiquinone. IUBMB Life. 50:2000;1-6.
7. Boveris A., Cadenas E., Stoppani A.O.M. Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. Biochem. J. 156:1976;435-444.
8. Boveris A., Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem. J. 134:1973;707-716.
9. Boveris A., Costa L.E., Cadenas E. The mitochondrial production of oxygen radicals and cellular aging. Cadenas E., Packer L. Understanding the Process of Aging. 1999;1-16 Marcel Dekker, New York.
10. Boveris A., Costa L.E., Poderoso J.J., Cadenas E. Regulation of mitochondrial respiration by oxygen and nitric oxide. Ann. N. Y. Acad. Sci. 899:2000;121-135.
11. Boveris A., Oshino N., Chance B. The cellular production of hydrogen peroxide. Biochem. J. 128:1972;617-630.
12. Boyd C.S., Cadenas E. Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis. Biol. Chem. 383:2002;411-423.
13. Brown G.C. NO says yes to mitochondria. Science. 299:2003;838-839.
14. Brown G.C., Cooper C.E. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett. 356:1994;295-298.
15. Bustamante J., Bersier G., Aron-Badin R., Cymeryng C., Parodi A., Boveris A. Sequential NO production by mitochondria and endoplasmic reticulum during induced apoptosis. Nitric Oxide. 3:2002;333-341.
16. Cadenas E., Boveris A. Enhancement of hydrogen peroxide formation by protophores and ionophores in antimycin-supplemented mitochondria. Biochem. J. 188:1980;31-37.
17. Cadenas E., Boveris A., Ragan C.I., Stoppani A.O.M. Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef heart mitochondria. Arch. Biochem. Biophys. 180:1977;248-257.
18. Chance B., Williams G.R. Respiratory enzymes in oxidative phosphorylation. J. Biol. Chem. 217:1955;383-427.
19. Cleeter M.W.J., Cooper J.M., Darley-Usmar V.M., Moncada S., Shapira A.H.V. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial repiratory chain. Implications for neurodegenerative diseases. FEBS Lett. 345:1994;50-54.
20. Cross C.E., Halliwell B., Borisch H.T., Pryor W.A., Ames B.N., Saul R.L., McCord J.M., Harman D. Oxygen radicals and human disease. Ann. Intern. Med. 107:1987;526-545.
21. Dionisi O., Galeotti T., Terranova T., Azzi A. Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues. Biochim. Biophys. Acta. 403:1975;292-301.
22. Ghafourifar P., Richter C. Nitric oxide synthase activity in mitochondria. FEBS Lett. 418:1997;291-295.
23. Giulivi C., Poderoso J.J., Boveris A. Production of nitric oxide by mitochondria. J. Biol. Chem. 273:1998;11038-11043.
24. 2 terminal kinase. Am. J. Physiol. Heart. Circ. Physiol. 277:1999;H1647-H1653.
25. Han D., Williams E., Cadenas E. Mitochondrial respiratory chain-dependent generation of superoxide anion and its release to the intermembrane space. Biochem. J. 353:2001;411-416.
26. Ignarro L.J. Ignarro L.J. Nitric Oxide: Biology and Pathobiology. 2000;Academic Press, New York.
27. Kanai A.J., Pearce L.L., Clemens P.R., Birder L.A., Van Bibber M.M., Choi S.Y., de Groat W.C., Peterson J. Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection. Proc. Natl. Acad. Sci. USA. 98:2001;14126-14131.
28. Kissner R., Nauser T., Bugnon P., Lye P.G., Koppenol W.H. Formation and properties of peroxynitrite as studied by laser flash photolysis, high pressure stopped-flow technique, and pulse radiolysis. Chem. Res. Toxicol. 10:1997;1285-1292.
29. Kroemer G., Dallaporta B., Resche-Rigon M. The mitochondrial death/life regulators in apoptosis and necrosis. Annu. Rev. Physiol. 60:1998;619-642.
30. Lander H.M., Jacovina A.T., Davis R.J., Tauras J.M. Differential activation of mitogen-activated protein kinases by nitric oxide-related species. Proc. Natl. Acad. Sci. USA. 271:1996;19705-19709.
31. Lehninger A.L. The mitochondrion. 1965;WA Benjamin Inc, New York.
32. Martindale J.L., Holbrook N.J. Cellular responses to oxidative stress: signaling for suicide and survival. J. Cell. Physiol. 192:2002;1-15.
33. Mitchell P. Keilin's respiratory chain concept and its chemiosmotic consequences. Science. 206:1979;1148-1159.
34. Ott M., Robertson J.D., Gogvadze V., Zhivotovsky B., Orrenius S. Cytochrome c release from mitochondria proceeds by a two-step process. Proc. Natl. Acad. Sci. USA. 99:2002;1259-1263.
35. Park H.S., Park E., Kim M.S., Ahn K., Kim I.Y., Choi E.J. Selenite inhibits the c-Jun N-terminal kinase/stress activated kinase (JNK/SAPK) through a thiol redox mechanism. J. Biol. Chem. 275:2000;2527-2531.
36. Poderoso J.J., Carreras M.C., Lisdero C.L., Riobó N.A., Schöpfer F., Boveris A. Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch. Biochem. Biophys. 328:1996;85-92.
37. Poderoso J.J., Lisdero C.L., Schöpfer F., Riobó N.A., Carreras M.C., Cadenas E., Boveris A. The regulation of mitochondrial oxygen uptake by redox reactions involving nitric oxide and ubiquinol. J. Biol. Chem. 274:1999;37709-37716.
38. Radi R., Turrens J.F., Chang L.Y., Bush K.M., Crapo J.D., Freeman B.A. Detection of catalase in rat heart mitochondria. J. Biol. Chem. 266:1991;22028-22034.
39. Schroeter H., Boyd C.S., Ahmed R., Spencer J.P.E., Duncan R.F., Rice-Evans C., Cadenas E. JNK-mediated modulation of brain mitochondria function: new target proteins for JNK-signaling in mitochondria-dependent apoptosis. Biochem. J. 372:2003;359-369.
40. Tounier C., Hess P., Yang D.D., Xu J., Turner T.K., Nimnual A., Bar-Sagi D., Jones S.N., Flavell R.A., Davis R.J. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science. 288:2000;870-874.
41. Valdez L.B., Alvarez S., Lores-Arnaiz S., Schöpfer F., Carreras M.C., Poderoso J.J., Boveris A. Reactions of peroxynitrite in the mitochondrial matriz. Free Radical Biol. Med. 29:2000;349-356.
42. Whitfield J., Neame S.J., Paquet L., Bernard O., Ham J. Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting cytochrome c release. Neuron. 29:2001;629-643.