Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 20, 2005, Pages 7280-7285

  Devling, Tim W P ^a   Lindsay, Christopher D ^b   McLellan, Lesley I ^a   McMahon, Michael ^a   Hayes, John D ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

Aldo keto reductase; Antioxidant; Chemoprevention; Glutathione; Nuclear factor erythroid 2 p45 related factor 2

Indexed keywords

GLUTAMATE CYSTEINE LIGASE; OXIDOREDUCTASE; PROTEIN KEAP1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REGULATOR PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CATALYSIS; CELL STIMULATION; CHEMOPROPHYLAXIS; ENZYME SUBUNIT; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KERATINOCYTE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REPORTER GENE;

ALCOHOL OXIDOREDUCTASES; BLOTTING, WESTERN; CELLS, CULTURED; CHEMOPREVENTION; DNA PRIMERS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUCIFERASES; NEOPLASMS; NF-E2-RELATED FACTOR 2; PLASMIDS; PROTEINS; QUINONE REDUCTASES; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; TRANSFECTION;

EID: 18844454763     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501475102     Document Type: Article

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