Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients

Human Genetics

Volumn 111, Issue 1, 2002, Pages 1-8

  Chen, Ying Hwa ^b,c   Lin, Shing Jong ^b,c   Lin, Ming Wei ^b   Tsai, Hui Ling ^a   Kuo, San San ^a   Chen, Jaw Wen ^b,c   Charng, Min Ji ^b   Wu, Tao Cheng ^b   Chen, Lung Ching ^b   Ding, Philip Yu An ^b   Pan, Wen Harn ^a   Jou, Yuh Shan ^d   Chau, Lee Young ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE 1; LIPID; LUCIFERASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADULT; ALLELE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; AORTA; ARTICLE; BLOOD LEVEL; BLOOD VESSEL FUNCTION; CELL CULTURE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY RISK; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENOTYPE; HUMAN; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; RANDOM AMPLIFIED MICROSATELLITE; RAT; SMOOTH MUSCLE FIBER;

AGED; ANIMALS; CORONARY ARTERIOSCLEROSIS; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; LUCIFERASES; MALE; MEMBRANE PROTEINS; MICROSATELLITE REPEATS; MUSCLE, SMOOTH, VASCULAR; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RATS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRANSFECTION;

EID: 0036664867     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00439-002-0769-4     Document Type: Article

References (49)

1. Abraham NG, Lavrovsky Y, Schwartzman ML, Stoltz RA, Levere RD, Gerritsen ME, Shibahara S, Kappas A (1995) Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: Protective effect against heme and hemoglobin toxicity. Proc Natl Acad Sci USA 92:6798-6802
2. Abraham NG, Drummond GS, Lutton JD, Kappas A (1996) The biological significance and physiological role of heme oxygenase. Cell Physiol Biochem 6:129-168
3. Balla G, Jacob HS, Eaton JW, Belcher JD, Vercellotti GM (1991) Hemin: A possible physiological mediator of low density lipoprotein oxidation and endothelial injury. Arterioscler Thromb 11:1700-1711
4. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ (1995) Atherosclerosis: Basic mechanism, oxidation, inflammation and genetics. Circulation 91:2488-2496
5. Bitar M, Weiner M (1984) Heme and hemoproteins in streptozotocin-diabetic female rats. Biochem Pharmacol 32:1912-1928
6. Brune B, Ullrich V (1987) Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Mol Pharmacol 32:497-504
7. Bucala R, Tracey KJ, Cerami A (1991) Advanced glycosylation products quench NO and mediate defective endothelium-dependent vasodilation in experimental diabetes. J Clin Invest 87:432-438
8. Ceriello A, Bortolotti N, Falleti E, Tabiga C, Tonutti L, Crescentini A, Motz E, Lizzio S, Russo A, Bartoli E (1997a) Total radical-trapping antioxidant parameter in NIDDM patients. Diabetes Care 20:194-197
9. Ceriello A, Bortolotti N, Pirisi M, Crescentini A, Tonutti L, Motz E, Russo A, Giacomello R, Stel G, Taboga C (1997b) Total plasma antioxidant capacity predicts thrombosis-prone status in NIDDM patients. Diabetes Care 20:1589-1593
10. Corbett JA, Tilton RG, Chang K, Hasan KS, Ido Y, Wang JL, Sweetland MA, Lancaster JR Jr, Williamson JR, McDaniel ML (1992) Aminoguanidine, a novel inhibitor of NO formation, prevents diabetic vascular dysfunction. Diabetes 41:552-556
11. Cosentino F, Luscher TF (1998) Endothelial dysfunction in diabetes mellitus. J Cardiovasc Pharmacol 32:S54-S61
12. Cosso L, Maineri EP, Traverso N, Rossatto N, Pronzato MA, Cottalasso D, Marinari UM, Odetti P (2001) Induction of heme oxygenase 1 in liver of spontaneously diabetic rats. Free Radic Res 34:189-191
13. Furchgott RF, Jothianandan D (1991) Endothelium-dependent and -independent vasodilation involving cyclic GMP: Relaxation induced by nitric oxide, carbon monoxide and light. Blood Vessel 28:52-61
14. Ghigo D, Alessio P, Foco A, Bussolino F, Costamagna C, Heller R, Garbarino G, Pescarmona GP, Bosia A (1993) Nitric oxide synthesis is impaired in glutathione depleted human umbilical vein endothelial cells. Am J Physiol 256:C728-C732
15. Gugliano D, Paolisso G, Ceriello A (1996) Oxidative stress and diabetic vascular complication. Diabetes Care 19:257-267
16. Hammond B, Kontos HA, Hess ML (1985) Oxygen radicals in the adult respiratory distress syndrome, in myocardial ischemia and reperfusion injury, and in cerebral vascular damage. Can J Physiol Pharmacol 63:173-187
17. Hayashi S, Takamiya R, Yamaguchi T, Matsumoto K, Tojo SJ, Tamatani T, Kitajima M, Makino N, Ishimura Y, Suematsu M (1999) Induction of heme oxygenase-1 suppresses vascular leukocyte adhesion elicited by oxidative stress. Role of bilirubin generated by the enzyme. Circ Res 85:663-671
18. Hayashi K, Haneda M, Koya D, Maeda S, Issiki K, Kikkawa R (2001) Enhancement of glomerular heme oxygenase-1 expression in diabetic rats Diabetes Res Clin Pract 52:85-96
19. Hunt JV, Smith CCT, Wolff SP (1990) Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes 39:1420-1424
20. Ishikawa K, Navab M, Leitinger N, Fogelman AM, Lusis AJ (1997) Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL. J Clin Invest 100:1209-1216
21. Ishikawa K, Sugawara D, Wang XP, Suzuki K, Itabe H, Maruyama Y, Lusis AJ (2001) Heme oxygenase-1 inhibits atherosclerotic lesion formation in LDL-receptor knockout mice. Circ Res 88:506-512
22. Jornot L, Junod AF (1993) Variable glutathione levels and expression of antioxidant enzymes in human endothelial cells. Am J Physiol 264:L482-L489
23. Juan S-H, Lee T-S, Tseng K-W, Liou J-Y, Shyue S-K, Wu KK, Chau L-Y (2001) Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation 104:1519-1525
24. Kennedy AL, Lyons TJ (1997) Glycation, oxidation, and lipoxidation in the development of diabetic complications. Metabolism 46:14-21
25. Kimpara T, Takeda A, Watanabe K, Itoyama Y, Ikawa S, Watanabe M, Arai H, Sasaki H, Higuchi S, Okita N, Takase S, Saito H, Takahashi K, Shibahara S (1997) Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease. Hum Genet 100:145-147
26. Kontos HA (1987) Oxygen radicals from arachidonate metabolism in abnormal vascular responses. Am Rev Resp Dis 136:474-477
27. Kontos HA, Wei EP, Ellis EF, Jenkins LW, Povlishock JT, Rowe GT, Hess ML (1985) Appearance of superoxide anion radical in cerebral extracellular space during increased prstaglandin synthesis in cats. Circ Res 57:142-151
28. Kukreja RC, Kontos HA, Hess MZ, Ellis EF (1986) PGH synthase and lipoxygenase generate superoxide in the presence of NADH and NADPH. Circ Res 59:612-619
29. Kutty RK, Kutty G, Rodrigues IR, Chader GJ, Wiggert B (1994) Chromosomal localization of the human heme oxygenase genes: Heme oxygenase-1 (HMOX1) maps to chromosome 22 q12 and heme oxygenase2 (HMOX2) maps to chromosome 16p13.3. Genomics 20:513-516
30. Lavrovsky Y, Schwartzman MC, Levere RD, Kappas A, Abraham NG (1994) Identification of binding sites for transcription factors NF-κB and AP-2 in the promoter region of the human heme oxygenase-1 gene. Proc Natl Acad Sci USA 91:5987-5991
31. Lee T-S, Chau L-Y (2001) Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 280:C709-C718
32. Lee T-S, Lee F-Y, Pang J-HS, Chau L-Y (1999) Erythrophagocytosis and iron deposition in atherosclerotic lesions. Chin J Physiol 42:17-24
33. Lusis AJ (2000) Atherosclerosis. Nature 407:233-241
34. Maines MD (1988) Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J 2:2557-2568
35. Meister A (1994) Glutathione-ascorbid acid antioxidant system in animals. J Biol Chem 269:9397-9400
36. Morita T, Kourembanas S (1995) Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J Clin Invest 96:2676-2682
37. Naito C, Kawamura M, Yamamoto Y (1993) Lipid peroxides as the initiating factor of atherosclerosis. Ann N Y Acad Sci 676:27-45
38. Nishio Y, Kashiwagi A, Taki H, Shinozaki K, Maeno Y, Kojima H, Maegawa H, Haneda M, Hidaka H, Yasuda H, Horike K, Kikkawa R (1998) Altered activities of transcription factors and their related gene expression in cardiac tissues of diabetic rats. Diabetes 47:1318-1325
39. Pagano PJ, Tornheim K, Cohen RA (1993) Superoxide anion production by rabbit thoracic aorta: Effect of endothelium-derived NO. Am J Physiol 265:H707-H712
40. Paredi P, Biernacki W, Invernizzi G, Kharitonov SA, Barnes PJ (1999) Exhaled carbon monoxide levels elevated in diabetes and correlated with glucose concentration in blood. A new test for monitoring the disease? Chest 1007-1011
41. Pritchard JK, Rosenberg NA (1999) Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 165:220-228
42. Rosen P, Du X, Tschope D (1998) Role of oxygen derived radicals for vascular dysfunction in diabetic heart: Prevention by alpha-tocopherol? Mol Cell Biochem 188:103-111
43. Tesfamariam B, Cohen RA (1992) Role of superoxide anion and endothelium in vasocontrictor action of prostaglandin endoperoxide. Am J Physiol Heart Circ Physiol 262:H1915-H1919
44. Tilton RG, Chang K, Hasan KS, Smith SR, Petrash JM, Misko TP, Moore WM, Currie MG, Corbett JA, McDaniel ML (1993) Prevention of diabetic vascular dysfunction by guanidines: Inhibition of NO synthase versus advanced glycation end-product formation. Diabetes 42:221-232
45. Wang L-J, Lee T-S, Lee F-Y, Pai R-C, Chau L-Y (1998) Expression of heme oxygenase-1 in atherosclerotic lesions. Am J Pathol 52: 711-720
46. Wang R, Wu L, Wang Z (1997) The direct effect of carbon monoxide on Kca channels in vascular smooth muscle cells. Pflugers Arch 434:285-291
47. Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S (1999) Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 103:129-135
48. Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S, Sasaki H (2000) Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 66:187-195
49. Zager RA (1996) Mitochondrial free radical production induces lipid peroxidation during myohemoglobinuria. Kidney Int 49:741-751