Preferential killing of cancer cells with mitochondrial dysfunction by natural compounds

Mitochondrion

Volumn 10, Issue 6, 2010, Pages 614-625

  Chen, Gang ^a   Wang, Feng ^a,b   Trachootham, Dunyaporn ^a,c   Huang, Peng ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c THAMMASAT UNIVERSITY   (Thailand)

Author keywords

2 Phenethyl isothiocyanate; Apoptosis; Energy metabolism; Honokiol; Mitochondrial dysfunction; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TOCOPHEROL SUCCINATE; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; CASPASE 3; CASPASE 8; CURCUMIN; CYTOCHROME C; EPIGALLOCATECHIN GALLATE; GLUCOSE TRANSPORTER; GLUTATHIONE; HONOKIOL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MENADIONE; MITOCHONDRIAL DNA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NATURAL PRODUCT; PANCRATISTATIN; PEROXIREDOXIN 3; PHENETHYL ISOTHIOCYANATE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; RESVERATROL; TP53 INDUCED GLYCOLYSIS AND APOPTOSIS REGULATOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VON HIPPEL LINDAU PROTEIN;

AEROBIC GLYCOLYSIS; AEROBIC METABOLISM; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AUTOPHAGY; CANCER CELL; CELL DEATH; CELL KILLING; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG METABOLISM; DRUG SENSITIVITY; DRUG TARGETING; ENERGY METABOLISM; GENE MUTATION; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; LIVER CANCER; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FAMILY; REDOX STRESS; REVIEW; TRANSCRIPTION REGULATION; WARBURG EFFECT;

ANTINEOPLASTIC AGENTS; APOPTOSIS; HUMANS; MITOCHONDRIA; NEOPLASMS;

EID: 78149360700     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mito.2010.08.001     Document Type: Review

References (197)

1. Achanta G., Sasaki R., Feng L., Carew J.S., Lu W., Pelicano H., Keating M.J., Huang P. Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma. The EMBO J. 2005, 24(19):3482-3492.
2. Acharya B.R., Choudhury D., Das A., Chakrabarti G. Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. Biochemistry 2009, 48(29):6963-6974.
3. Adam-Vizi V., Chinopoulos C. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol. Sci. 2006, 27(12):639-645.
4. Altenberg B., Greulich K.O. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics 2004, 84(6):1014-1020.
5. Amblard F., Govindarajan B., Lefkove B., Rapp K.L., Detorio M., Arbiser J.L., Schinazi R.F. Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol. Bioorg. Med. Chem. Lett. 2007, 17(16):4428-4431.
6. Amin A.R., Kucuk O., Khuri F.R., Shin D.M. Perspectives for cancer prevention with natural compounds. J. Clin. Oncol. 2009, 27(16):2712-2725.
7. Baliga M.S., Meleth S., Katiyar S.K. Growth inhibitory and antimetastatic effect of green tea polyphenols on metastasis-specific mouse mammary carcinoma 4T1 cells in vitro and in vivo systems. Clin. Cancer Res. 2005, 11(5):1918-1927.
8. Behrend L., Henderson G., Zwacka R.M. Reactive oxygen species in oncogenic transformation. Biochem. Soc. Trans. 2003, 31(Pt 6):1441-1444.
9. Bensaad K., Tsuruta A., Selak M.A., Vidal M.N., Nakano K., Bartrons R., Gottlieb E., Vousden K.H. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 2006, 126(1):107-120.
10. Berridge M.V., Herst P.M., Lawen A. Targeting mitochondrial permeability in cancer drug development. Mol. Nutr. Food Res. 2009, 53(1):76-86.
11. Brandon M., Baldi P., Wallace D.C. Mitochondrial mutations in cancer. Oncogene 2006, 25(34):4647-4662.
12. Brown K.K., Eriksson S.E., Arner E.S., Hampton M.B. Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates. Free Radic. Biol. Med. 2008, 45(4):494-502.
13. Carew J.S., Zhou Y., Albitar M., Carew J.D., Keating M.J., Huang P. Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications. Leukemia 2003, 17(8):1437-1447.
14. Cavalieri E., Bergamini C., Mariotto S., Leoni S., Perbellini L., Darra E., Suzuki H., Fato R., Lenaz G. Involvement of mitochondrial permeability transition pore opening in alpha-bisabolol induced apoptosis. FEBS J. 2009, 276(15):3990-4000.
15. Chen C., Shen G., Hebbar V., Hu R., Owuor E.D., Kong A.N. Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. Carcinogenesis 2003, 24(8):1369-1378.
16. Chen F., Wang T., Wu Y.F., Gu Y., Xu X.L., Zheng S., Hu X. Honokiol: a potent chemotherapy candidate for human colorectal carcinoma. World J. Gastroenterol. 2004, 10(23):3459-3463.
17. Chen G., Izzo J., Demizu Y., Wang F., Guha S., Wu X., Hung M.C., Ajani J.A., Huang P. Different redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol. Antioxid. Redox Signal. 2009, 11(5):1083-1095.
18. Chen Y.J., Wu C.L., Liu J.F., Fong Y.C., Hsu S.F., Li T.M., Su Y.C., Liu S.H., Tang C.H. Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress. Cancer Lett. 2009.
19. Cheung K.L., Khor T.O., Huang M.T., Kong A.N. Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM. Carcinogenesis 2010, 31(5):880-885.
20. Chlebowski R.T., Dietrich M., Akman S., Block J.B. Vitamin K3 inhibition of malignant murine cell growth and human tumor colony formation. Cancer Treat. Rep. 1985, 69(5):527-532.
21. Clerkin J.S., Naughton R., Quiney C., Cotter T.G. Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett. 2008, 266(1):30-36.
22. Corsi L., Geminiani E., Baraldi M. Peripheral benzodiazepine receptor (PBR) new insight in cell proliferation and cell differentiation review. Curr. Clin. Pharmacol. 2008, 3(1):38-45.
23. Crane C., Panner A., Pieper R.O., Arbiser J., Parsa A.T. Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function. J. Immunother. 2009, 32(6):585-592.
24. DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008, 7(1):11-20.
25. Deng S., Yu B., Lou Y., Hui Y. First Total Synthesis of an Exceptionally Potent Antitumor Saponin, OSW-1. J. Org. Chem. 1999, 64(1):202-208.
26. Deng J., Qian Y., Geng L., Chen J., Wang X., Xie H., Yan S., Jiang G., Zhou L., Zheng S. Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2). Liver Int. 2008, 28(10):1458-1464.
27. Di Monte D., Ross D., Bellomo G., Eklow L., Orrenius S. Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes. Arch. Biochem. Biophys. 1984, 235(2):334-342.
28. Divya C.S., Pillai M.R. Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis. Mol. Carcinog. 2006, 45(5):320-332.
29. Dong L.F., Low P., Dyason J.C., Wang X.F., Prochazka L., Witting P.K., Freeman R., Swettenham E., Valis K., Liu J., Zobalova R., Turanek J., Spitz D.R., Domann F.E., Scheffler I.E., Ralph S.J., Neuzil J. Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. Oncogene 2008, 27(31):4324-4335.
30. Dong L.F., Freeman R., Liu J., Zobalova R., Marin-Hernandez A., Stantic M., Rohlena J., Valis K., Rodriguez-Enriquez S., Butcher B., Goodwin J., Brunk U.T., Witting P.K., Moreno-Sanchez R., Scheffler I.E., Ralph S.J., Neuzil J. Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. Clin. Cancer Res. 2009, 15(5):1593-1600.
31. Elstrom R.L., Bauer D.E., Buzzai M., Karnauskas R., Harris M.H., Plas D.R., Zhuang H., Cinalli R.M., Alavi A., Rudin C.M., Thompson C.B. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res. 2004, 64(11):3892-3899.
32. Estrela J.M., Ortega A., Obrador E. Glutathione in cancer biology and therapy. Crit. Rev. Clin. Lab. Sci. 2006, 43(2):143-181.
33. Fantin V.R., St-Pierre J., Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006, 9(6):425-434.
34. Filomeni G., Graziani I., Rotilio G., Ciriolo M.R. trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways. Genes Nutr. 2007, 2(3):295-305.
35. Flier J.S., Mueckler M.M., Usher P., Lodish H.F. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 1987, 235(4795):1492-1495.
36. Fried L.E., Arbiser J.L. Honokiol, a multifunctional antiangiogenic and antitumor agent. Antioxid. Redox Signal. 2009, 11(5):1139-1148.
37. Fruehauf J.P., Meyskens F.L. Reactive oxygen species: a breath of life or death?. Clin. Cancer Res. 2007, 13(3):789-794.
38. Gambhir S.S. Molecular imaging of cancer with positron emission tomography. Nat. Rev. Cancer 2002, 2(9):683-693.
39. Garcia A., Zheng Y., Zhao C., Toschi A., Fan J., Shraibman N., Brown H.A., Bar-Sagi D., Foster D.A., Arbiser J.L. Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin. Cancer Res. 2008, 14(13):4267-4274.
40. Gatenby R.A., Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat. Rev. Cancer 2004, 4(11):891-899.
41. Gold J. In vivo synergy of vitamin K3 and methotrexate in tumor-bearing animals. Cancer Treat. Rep. 1986, 70(12):1433-1435.
42. Gottlieb E., Tomlinson I.P. Mitochondrial tumour suppressors: a genetic and biochemical update. Nat. Rev. Cancer 2005, 5(11):857-866.
43. Guo C., LaCour T.G., Fuchs P.L. On the relationship of OSW-1 to the cephalostatins. Bioorg. Med. Chem. Lett. 1999, 9(3):419-424.
44. Hahm E.R., Singh S.V. Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity. Mol. Cancer Ther. 2007, 6(10):2686-2695.
45. Halestrap A.P. What is the mitochondrial permeability transition pore?. J. Mol. Cell. Cardiol. 2009, 46(6):821-831.
46. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100(1):57-70.
47. Hecht S.S. Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. J. Nutr. 1999, 129(3):768S-774S.
48. Heiser D., Labi V., Erlacher M., Villunger A. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Gerontol. 2004, 39(8):1125-1135.
49. Hemann M.T., Bric A., Teruya-Feldstein J., Herbst A., Nilsson J.A., Cordon-Cardo C., Cleveland J.L., Tansey W.P., Lowe S.W. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature 2005, 436(7052):807-811.
50. Herbst A., Hemann M.T., Tworkowski K.A., Salghetti S.E., Lowe S.W., Tansey W.P. A conserved element in Myc that negatively regulates its proapoptotic activity. EMBO Rep. 2005, 6(2):177-183.
51. Hour T.C., Huang C.Y., Lin C.C., Chen J., Guan J.Y., Lee J.M., Pu Y.S. Characterization of molecular events in a series of bladder urothelial carcinoma cell lines with progressive resistance to arsenic trioxide. Anticancer Drugs 2004, 15(8):779-785.
52. Hsu S., Lewis J., Singh B., Schoenlein P., Osaki T., Athar M., Porter A.G., Schuster G. Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis. Anticancer Res. 2003, 23(2B):1533-1539.
53. Hu R., Kim B.R., Chen C., Hebbar V., Kong A.N. The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. Carcinogenesis 2003, 24(8):1361-1367.
54. Huang P., Feng L., Oldham E.A., Keating M.J., Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 2000, 407(6802):390-395.
55. Hurd T.R., Costa N.J., Dahm C.C., Beer S.M., Brown S.E., Filipovska A., Murphy M.P. Glutathionylation of mitochondrial proteins. Antioxid. Redox Signal. 2005, 7(7-8):999-1010.
56. Imai K., Suga K., Nakachi K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev. Med. 1997, 26(6):769-775.
57. Indo H.P., Davidson M., Yen H.C., Suenaga S., Tomita K., Nishii T., Higuchi M., Koga Y., Ozawa T., Majima H.J. Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion 2007, 7(1-2):106-118.
58. Irani K., Xia Y., Zweier J.L., Sollott S.J., Der C.J., Fearon E.R., Sundaresan M., Finkel T., Goldschmidt-Clermont P.J. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science (New York, NY) 1997, 275(5306):1649-1652.
59. Irmak M.B., Ince G., Ozturk M., Cetin-Atalay R. Acquired tolerance of hepatocellular carcinoma cells to selenium deficiency: a selective survival mechanism?. Cancer Res. 2003, 63(20):6707-6715.
60. Ishikawa K., Takenaga K., Akimoto M., Koshikawa N., Yamaguchi A., Imanishi H., Nakada K., Honma Y., Hayashi J. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science (New York, NY) 2008, 320(5876):661-664.
61. Ishitsuka K., Hideshima T., Hamasaki M., Raje N., Kumar S., Hideshima H., Shiraishi N., Yasui H., Roccaro A.M., Richardson P., Podar K., Le Gouill S., Chauhan D., Tamura K., Arbiser J., Anderson K.C. Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis. Blood 2005, 106(5):1794-1800.
62. Itoh K., Tong K.I., Yamamoto M. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic. Biol. Med. 2004, 36(10):1208-1213.
63. Jang M., Cai L., Udeani G.O., Slowing K.V., Thomas C.F., Beecher C.W., Fong H.H., Farnsworth N.R., Kinghorn A.D., Mehta R.G., Moon R.C., Pezzuto J.M. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997, 275(5297):218-220.
64. Jelluma N., Yang X., Stokoe D., Evan G.I., Dansen T.B., Haas-Kogan D.A. Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol. Cancer Res. 2006, 4(5):319-330.
65. Ji Y., Morris M.E. Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography-tandem mass spectrometry. Anal. Biochem. 2003, 323(1):39-47.
66. Jian L., Xie L.P., Lee A.H., Binns C.W. Protective effect of green tea against prostate cancer: a case-control study in southeast China. Int. J. Cancer 2004, 108(1):130-135.
67. Jourdain A., Martinou J.C. Mitochondrial outer-membrane permeabilization and remodelling in apoptosis. Int. J. Biochem. Cell Biol. 2009, 41(10):1884-1889.
68. Juan M.E., Wenzel U., Daniel H., Planas J.M. Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells. J. Agric. Food Chem. 2008, 56(12):4813-4818.
69. Kasai H.F., Tsubuki M., Matsuo S., Honda T. Analysis of antitumor active OSW-1 and its analogues by liquid chromatography coupled with electrospray and atmospheric pressure chemical ionization quadrupole mass spectrometry. Rapid Commun. Mass Spectrom. 2007, 21(7):1100-1114.
70. Kawauchi K., Araki K., Tobiume K., Tanaka N. p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat. Cell Biol. 2008, 10(5):611-618.
71. Kekre N., Griffin C., McNulty J., Pandey S. Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl serine followed by rapid apoptosis specifically in human lymphoma cells. Cancer Chemother. Pharmacol. 2005, 56(1):29-38.
72. Kim G.J., Chandrasekaran K., Morgan W.F. Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review. Mutagenesis 2006, 21(6):361-367.
73. Kim R., Emi M., Tanabe K., Murakami S., Uchida Y., Arihiro K. Regulation and interplay of apoptotic and non-apoptotic cell death. J. Pathol. 2006, 208(3):319-326.
74. Kim M.Y., Trudel L.J., Wogan G.N. Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. Anticancer Res. 2009, 29(10):3733-3740.
75. Knudson C.M., Brown N.M. Mitochondria potential, bax "activation," and programmed cell death. Methods Mol. Biol. 2008, 414:95-108.
76. Ko Y.H., Pedersen P.L., Geschwind J.F. Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett. 2001, 173(1):83-91.
77. Komatsu D., Kato M., Nakayama J., Miyagawa S., Kamata T. NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression. Oncogene 2008, 27(34):4724-4732.
78. Koo J.Y., Kim H.J., Jung K.O., Park K.Y. Curcumin inhibits the growth of AGS human gastric carcinoma cells in vitro and shows synergism with 5-fluorouracil. J. Med. Food 2004, 7(2):117-121.
79. Koudelka S., Masek J., Neuzil J., Turanek J. Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation. J. Pharm. Sci. 2010, 99(5):2434-2443.
80. Kroemer G., Galluzzi L., Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 2007, 87(1):99-163.
81. Kumar B., Koul S., Khandrika L., Meacham R.B., Koul H.K. Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res. 2008, 68(6):1777-1785.
82. Kunnumakkara A.B., Guha S., Krishnan S., Diagaradjane P., Gelovani J., Aggarwal B.B. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res. 2007, 67(8):3853-3861.
83. Kuttan R., Bhanumathy P., Nirmala K., George M.C. Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett. 1985, 29(2):197-202.
84. Kuttan R., Sudheeran P.C., Josph C.D. Turmeric and curcumin as topical agents in cancer therapy. Tumori 1987, 73(1):29-31.
85. Lenehan P.F., Gutierrez P.L., Wagner J.L., Milak N., Fisher G.R., Ross D.D. Resistance to oxidants associated with elevated catalase activity in HL-60 leukemia cells that overexpress multidrug-resistance protein does not contribute to the resistance to daunorubicin manifested by these cells. Cancer Chemother. Pharmacol. 1995, 35(5):377-386.
86. Li L., Han W., Gu Y., Qiu S., Lu Q., Jin J., Luo J., Hu X. Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore. Cancer Res. 2007, 67(10):4894-4903.
87. Liebes L., Conaway C.C., Hochster H., Mendoza S., Hecht S.S., Crowell J., Chung F.L. High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate. Anal. Biochem. 2001, 291(2):279-289.
88. Lim D., Morgan R.J., Akman S., Margolin K., Carr B.I., Leong L., Odujinrin O., Doroshow J.H. Phase I trial of menadiol diphosphate (vitamin K3) in advanced malignancy. Invest. New Drugs 2005, 23(3):235-239.
89. Liu H., Zang C., Emde A., Planas-Silva M.D., Rosche M., Kuhnl A., Schulz C.O., Elstner E., Possinger K., Eucker J. Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer. Eur. J. Pharmacol. 2008, 591(1-3):43-51.
90. Lu H., Forbes R.A., Verma A. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J. Biol. Chem. 2002, 277(26):23111-23115.
91. Luduena R.F., Roach M.C., Prasad V., Pettit G.R. Interaction of dolastatin 10 with bovine brain tubulin. Biochem. Pharmacol. 1992, 43(3):539-543.
92. Luo H., Zhong Q., Chen L.J., Qi X.R., Fu A.F., Yang H.S., Yang F., Lin H.G., Wei Y.Q., Zhao X. Liposomal honokiol, a promising agent for treatment of cisplatin-resistant human ovarian cancer. J. Cancer Res. Clin. Oncol. 2008, 134(9):937-945.
93. Ma X., Yu B., Hui Y., Xiao D., Ding J. Synthesis of glycosides bearing the disaccharide of OSW-1 or its 1->4-linked analogue and their antitumor activities. Carbohydr. Res. 2000, 329(3):495-505.
94. Ma X., Yu B., Hui Y., Miao Z., Ding J. Synthesis of OSW-1 analogues and a dimer and their antitumor activities. Bioorg. Med. Chem. Lett. 2001, 11(16):2153-2156.
95. Madan E., Prasad S., Roy P., George J., Shukla Y. Regulation of apoptosis by resveratrol through JAK/STAT and mitochondria mediated pathway in human epidermoid carcinoma A431 cells. Biochem. Biophys. Res. Commun. 2008, 377(4):1232-1237.
96. Madden K., Flowers L., Salani R., Horowitz I., Logan S., Kowalski K., Xie J., Mohammed S.I. Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. Prostaglandins Leukot. Essent. Fatty Acids 2009, 80(1):9-18.
97. Manikandan R., Thiagarajan R., Beulaja S., Sudhandiran G., Arumugam M. Curcumin prevents free radical-mediated cataractogenesis through modulations in lens calcium. Free Radic. Biol. Med. 2009.
98. Mathupala S.P., Heese C., Pedersen P.L. Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. J. Biol. Chem. 1997, 272(36):22776-22780.
99. Matoba S., Kang J.G., Patino W.D., Wragg A., Boehm M., Gavrilova O., Hurley P.J., Bunz F., Hwang P.M. p53 regulates mitochondrial respiration. Science 2006, 312(5780):1650-1653.
100. McLachlan A., Kekre N., McNulty J., Pandey S. Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis. Apoptosis 2005, 10(3):619-630.
101. Meffert G., Gellerich F.N., Margreiter R., Wyss M. Elevated creatine kinase activity in primary hepatocellular carcinoma. BMC Gastroenterol. 2005, 5:9.
102. Meister A. Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacol. Ther. 1991, 51(2):155-194.
103. Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.J., Wheat L.M., Karran E.L., Garcia J.F., Sanchez L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J., Martinez-Climent J.A. Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. Blood 2007, 109(1):271-280.
104. Mi L., Wang X., Govind S., Hood B.L., Veenstra T.D., Conrads T.P., Saha D.T., Goldman R., Chung F.L. The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells. Cancer Res. 2007, 67(13):6409-6416.
105. Moreno-Sanchez R., Saavedra E., Rodriguez-Enriquez S., Gallardo-Perez J.C., Quezada H., Westerhoff H.V. Metabolic control analysis indicates a change of strategy in the treatment of cancer. Mitochondrion 2010, [Epub ahead of print].
106. Munroe M.E., Arbiser J.L., Bishop G.A. Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis. J. Immunol. 2007, 179(2):753-763.
107. Nakachi K., Suemasu K., Suga K., Takeo T., Imai K., Higashi Y. Influence of drinking green tea on breast cancer malignancy among Japanese patients. Jpn J. Cancer Res. 1998, 89(3):254-261.
108. Nakazato T., Ito K., Ikeda Y., Kizaki M. Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. Clin. Cancer Res. 2005, 11(16):6040-6049.
109. Neuzil J., Wang X.F., Dong L.F., Low P., Ralph S.J. Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. FEBS Lett. 2006, 580(22):5125-5129.
110. Neuzil J., Dong L.F., Ramanathapuram L., Hahn T., Chladova M., Wang X.F., Zobalova R., Prochazka L., Gold M., Freeman R., Turanek J., Akporiaye E.T., Dyason J.C., Ralph S.J. Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria. Mol. Aspects Med. 2007, 28(5-6):607-645.
111. Neuzil J., Dyason J.C., Freeman R., Dong L.F., Prochazka L., Wang X.F., Scheffler I., Ralph S.J. Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. J. Bioenerg. Biomembr. 2007, 39(1):65-72.
112. Ngo E.O., Sun T.P., Chang J.Y., Wang C.C., Chi K.H., Cheng A.L., Nutter L.M. Menadione-induced DNA damage in a human tumor cell line. Biochem. Pharmacol. 1991, 42(10):1961-1968.
113. Nihal M., Ahmad N., Mukhtar H., Wood G.S. Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma. Int. J. Cancer 2005, 114(4):513-521.
114. Nishikawa M. Reactive oxygen species in tumor metastasis. Cancer Lett. 2008, 266(1):53-59.
115. Nutter L.M., Cheng A.L., Hung H.L., Hsieh R.K., Ngo E.O., Liu T.W. Menadione: spectrum of anticancer activity and effects on nucleotide metabolism in human neoplastic cell lines. Biochem. Pharmacol. 1991, 41(9):1283-1292.
116. Ogasawara M.A., Zhang H. Redox Regulation and its Emerging Roles in Stem Cells and Stem-Like Cancer Cells. Antioxid. Redox Signal. 2008.
117. Ortiz-Ortiz M.A., Moran J.M., Bravosanpedro J.M., Gonzalez-Polo R.A., Niso-Santano M., Anantharam V., Kanthasamy A.G., Soler G., Fuentes J.M. Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species. Neurotoxicology 2009, 30(6):1008-1018.
118. Osthus R.C., Shim H., Kim S., Li Q., Reddy R., Mukherjee M., Xu Y., Wonsey D., Lee L.A., Dang C.V. Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J. Biol. Chem. 2000, 275(29):21797-21800.
119. Palmieri D., Fitzgerald D., Shreeve S.M., Hua E., Bronder J.L., Weil R.J., Davis S., Stark A.M., Merino M.J., Kurek R., Mehdorn H.M., Davis G., Steinberg S.M., Meltzer P.S., Aldape K., Steeg P.S. Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis. Mol. Cancer Res. 2009, 7(9):1438-1445.
120. Pandey S., Kekre N., Naderi J., McNulty J. Induction of apoptotic cell death specifically in rat and human cancer cells by pancratistatin. Artif. Cells Blood Substit. Immobil. Biotechnol. 2005, 33(3):279-295.
121. Pani G., Koch O.R., Galeotti T. The p53-p66shc-Manganese Superoxide Dismutase (MnSOD) network: a mitochondrial intrigue to generate reactive oxygen species. Int. J. Biochem. Cell Biol. 2009, 41(5):1002-1005.
122. Patel B.P., Rawal U.M., Dave T.K., Rawal R.M., Shukla S.N., Shah P.M., Patel P.S. Lipid peroxidation, total antioxidant status, and total thiol levels predict overall survival in patients with oral squamous cell carcinoma. Integr. Cancer Ther. 2007, 6(4):365-372.
123. Pathania D., Millard M., Neamati N. Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism. Adv. Drug Deliv. Rev. 2009, 61(14):1250-1275.
124. Pedersen P.L. Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment's roles together with hexokinase-2 in the "Warburg effect" in cancer. J. Bioenerg. Biomembr. 2008, 40(3):123-126.
125. Pelicano H., Feng L., Zhou Y., Carew J.S., Hileman E.O., Plunkett W., Keating M.J., Huang P. Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J. Biol. Chem. 2003, 278(39):37832-37839.
126. Pelicano H., Martin D.S., Xu R.H., Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006, 25(34):4633-4646.
127. Peng W., Tang P., Hu X., Liu J.O., Yu B. Synthesis of the A, B-ring-truncated OSW saponin analogs and their antitumor activities. Bioorg. Med. Chem. Lett. 2007, 17(20):5506-5509.
128. Pervaiz S., Clement M.V. Tumor intracellular redox status and drug resistance-serendipity or a causal relationship?. Curr. Pharm. Des. 2004, 10(16):1969-1977.
129. Pettit G.R., Gaddamidi V., Cragg G.M. Antineoplastic agents, 105. Zephyranthes grandiflora. J. Nat. Prod. 1984, 47(6):1018-1020.
130. Pfeiffer T., Schuster S., Bonhoeffer S. Cooperation and competition in the evolution of ATP-producing pathways. Science 2001, 292(5516):504-507.
131. Pilorget A., Berthet V., Luis J., Moghrabi A., Annabi B., Beliveau R. Medulloblastoma cell invasion is inhibited by green tea (-)epigallocatechin-3-gallate. J. Cell. Biochem. 2003, 90(4):745-755.
132. Pinlaor S., Yongvanit P., Prakobwong S., Kaewsamut B., Khoontawad J., Pinlaor P., Hiraku Y. Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini. Mol. Nutr. Food Res. 2009, 53(10):1316-1328.
133. Prasad K.N., Edwards-Prasad J., Sakamoto A. Vitamin K3 (menadione) inhibits the growth of mammalian tumor cells in culture. Life Sci. 1981, 29(13):1387-1392.
134. Qanungo S., Das M., Haldar S., Basu A. Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. Carcinogenesis 2005, 26(5):958-967.
135. Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., Werb Z., Bissell M.J. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005, 436(7047):123-127.
136. Ralph S.J., Neuzil J. Mitochondria as targets for cancer therapy. Mol. Nutr. Food Res. 2009, 53(1):9-28.
137. Ralph S.J., Rodriguez-Enriquez S., Neuzil J., Moreno-Sanchez R. Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger. Mol. Aspects Med. 2009.
138. Ray S. Synergy of Pancratistatin and Tamoxifen in inducing apoptosis in breast cancer cells. Cancer Biol. Ther. 2008, 7(3):385-386.
139. Reed J.C. Molecular biology of chronic lymphocytic leukemia. Semin. Oncol. 1998, 25(1):11-18.
140. Robey I.F., Lien A.D., Welsh S.J., Baggett B.K., Gillies R.J. Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia 2005, 7(4):324-330.
141. Rose P., Whiteman M., Huang S.H., Halliwell B., Ong C.N. beta-Phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells. Cell. Mol. Life Sci. 2003, 60(7):1489-1503.
142. Roy P., Kalra N., Prasad S., George J., Shukla Y. Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways. Pharm. Res. 2009, 26(1):211-217.
143. Sarin S.K., Kumar M., Garg S., Hissar S., Pandey C., Sharma B.C. High dose vitamin K3 infusion in advanced hepatocellular carcinoma. J. Gastroenterol. Hepatol. 2006, 21(9):1478-1482.
144. Sasaki R., Suzuki Y., Yonezawa Y., Ota Y., Okamoto Y., Demizu Y., Huang P., Yoshida H., Sugimura K., Mizushina Y. DNA polymerase gamma inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells. Cancer Sci. 2008, 99(5):1040-1048.
145. Satyan K.S., Swamy N., Dizon D.S., Singh R., Granai C.O., Brard L. Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation. Gynecol. Oncol. 2006, 103(1):261-270.
146. Schroeder E.K., Kelsey N.A., Doyle J., Breed E., Bouchard R.J., Loucks F.A., Harbison R.A., Linseman D.A. Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons. Antioxid. Redox Signal. 2009, 11(3):469-480.
147. Schumacker P.T. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 2006, 10(3):175-176.
148. Schwartzenberg-Bar-Yoseph F., Armoni M., Karnieli E. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res. 2004, 64(7):2627-2633.
149. Semenza G.L. HIF-1 mediates the Warburg effect in clear cell renal carcinoma. J. Bioenerg. Biomembr. 2007, 39(3):231-234.
150. Sen S., Sharma H., Singh N. Curcumin enhances Vinorelbine mediated apoptosis in NSCLC cells by the mitochondrial pathway. Biochem. Biophys. Res. Commun. 2005, 331(4):1245-1252.
151. Shanafelt T.D., Lee Y.K., Call T.G., Nowakowski G.S., Dingli D., Zent C.S., Kay N.E. Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies. Leuk. Res. 2006, 30(6):707-712.
152. Shanafelt T.D., Call T.G., Zent C.S., LaPlant B., Bowen D.A., Roos M., Secreto C.R., Ghosh A.K., Kabat B.F., Lee M.J., Yang C.S., Jelinek D.F., Erlichman C., Kay N.E. Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia. J. Clin. Oncol. 2009, 27(23):3808-3814.
153. Sharief M.K., Matthews H., Noori M.A. Expression ratios of the Bcl-2 family proteins and disease activity in multiple sclerosis. J. Neuroimmunol. 2003, 134(1-2):158-165.
154. Sheu M.L., Chiang C.K., Tsai K.S., Ho F.M., Weng T.I., Wu H.Y., Liu S.H. Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis. Free Radic. Biol. Med. 2008, 44(12):2043-2050.
155. Shim H., Dolde C., Lewis B.C., Wu C.S., Dang G., Jungmann R.A., Dalla-Favera R., Dang C.V. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl. Acad. Sci. U. S. A. 1997, 94(13):6658-6663.
156. Shnyder S.D., Cooper P.A., Millington N.J., Gill J.H., Bibby M.C. Sodium pancratistatin 3, 4-o-cyclic phosphate, a water-soluble synthetic derivative of pancratistatin, is highly effective in a human colon tumor model. J. Nat. Prod. 2008, 71(3):321-324.
157. Siedlakowski P., McLachlan-Burgess A., Griffin C., Tirumalai S.S., McNulty J., Pandey S. Synergy of Pancratistatin and Tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria. Cancer Biol. Ther. 2008, 7(3):376-384.
158. Singh S., Khar A. Biological effects of curcumin and its role in cancer chemoprevention and therapy. Anticancer Agents Med. Chem. 2006, 6(3):259-270.
159. Stegehuis J.H., de Wilt L.H., de Vries E.G., Groen H.J., de Jong S., Kruyt F.A. TRAIL receptor targeting therapies for non-small cell lung cancer: Current status and perspectives. Drug Resist. Updat. 2009.
160. Subudhi U., Das K., Paital B., Bhanja S., Chainy G.B. Alleviation of enhanced oxidative stress and oxygen consumption of L-thyroxine induced hyperthyroid rat liver mitochondria by vitamin E and curcumin. Chem. Biol. Interact. 2008, 173(2):105-114.
161. Sullivan R., Graham C.H. Chemosensitization of cancer by nitric oxide. Curr. Pharm. Des. 2008, 14(11):1113-1123.
162. Szatrowski T.P., Nathan C.F. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 1991, 51(3):794-798.
163. Takeuchi O., Fisher J., Suh H., Harada H., Malynn B.A., Korsmeyer S.J. Essential role of BAX, BAK in B cell homeostasis and prevention of autoimmune disease. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(32):11272-11277.
164. Tang P., Mamdani F., Hu X., Liu J.O., Yu B. Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities. Bioorg. Med. Chem. Lett. 2007, 17(4):1003-1007.
165. Thayyullathil F., Chathoth S., Hago A., Patel M., Galadari S. Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells. Free Radic. Biol. Med. 2008, 45(10):1403-1412.
166. Tiligada E. Chemotherapy: induction of stress responses. Endocr.-Relat. Cancer 2006, 13(Suppl 1):S115-S124.
167. Trachootham D., Zhou Y., Zhang H., Demizu Y., Chen Z., Pelicano H., Chiao P.J., Achanta G., Arlinghaus R.B., Liu J., Huang P. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 2006, 10(3):241-252.
168. Trachootham D., Lu W., Ogasawara M.A., Nilsa R.D., Huang P. Redox regulation of cell survival. Antioxid. Redox Signal. 2008, 10(8):1343-1374.
169. Trachootham D., Zhang H., Zhang W., Feng L., Du M., Zhou Y., Chen Z., Pelicano H., Plunkett W., Wierda W.G., Keating M.J., Huang P. Effective Elimination of Fludarabine-Resistant CLL Cells by PEITC through a Redox-Mediated Mechanism. Blood 2008, 112(5):1912-1922.
170. Trachootham D., Alexandre J., Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?. Nat. Rev. Drug Discov. 2009, 8(7):579-591.
171. Tsai T.H., Chou C.J., Cheng F.C., Chen C.F. Pharmacokinetics of honokiol after intravenous administration in rats assessed using high-performance liquid chromatography. J. Chromatogr. B Biomed. Appl. 1994, 655(1):41-45.
172. Tse A.K., Wan C.K., Shen X.L., Yang M., Fong W.F. Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation. Biochem. Pharmacol. 2005, 70(10):1443-1457.
173. Turanek J., Wang X.F., Knotigova P., Koudelka S., Dong L.F., Vrublova E., Mahdavian E., Prochazka L., Sangsura S., Vacek A., Salvatore B.A., Neuzil J. Liposomal formulation of alpha-tocopheryl maleamide: in vitro and in vivo toxicological profile and anticancer effect against spontaneous breast carcinomas in mice. Toxicol. Appl. Pharmacol. 2009, 237(3):249-257.
174. Ushio-Fukai M., Nakamura Y. Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett. 2008, 266(1):37-52.
175. Wallace D.C., Fan W. Energetics, epigenetics, mitochondrial genetics. Mitochondrion 2010, 10(1):12-31.
176. Wang F., Ogasawara M.A., Huang P. Small mitochondria-targeting molecules as anti-cancer agents. Mol. Aspects Med. 2009.
177. Warburg O. On the origin of cancer cells. Science 1956, 123(3191):309-314.
178. Weinberg F., Chandel N.S. Mitochondrial metabolism and cancer. Ann. NY Acad. Sci. 2009, 1177:66-73.
179. Wojtkielewicz A., Dlugosz M., Maj J., Morzycki J.W., Nowakowski M., Renkiewicz J., Strnad M., Swaczynova J., Wilczewska A.Z., Wojcik J. New analogues of the potent cytotoxic saponin OSW-1. J. Med. Chem. 2007, 50(15):3667-3673.
180. Wu W.S. The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev. 2006, 25(4):695-705.
181. Wu S.J., Ng L.T., Lin C.C. Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells. Eur. J. Pharmacol. 2005, 518(2-3):96-106.
182. Xu K., Thornalley P.J. Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro. Biochem. Pharmacol. 2001, 61(2):165-177.
183. Xu R.H., Pelicano H., Zhang H., Giles F.J., Keating M.J., Huang P. Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells. Leukemia 2005, 19(12):2153-2158.
184. Xu C., Yuan X., Pan Z., Shen G., Kim J.H., Yu S., Khor T.O., Li W., Ma J., Kong A.N. Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Mol. Cancer Ther. 2006, 5(8):1918-1926.
185. Xue J., Liu P., Pan Y., Guo Z. A total synthesis of OSW-1. J. Org. Chem. 2008, 73(1):157-161.
186. Yamamoto T., Hsu S., Lewis J., Wataha J., Dickinson D., Singh B., Bollag W.B., Lockwood P., Ueta E., Osaki T., Schuster G. Green tea polyphenol causes differential oxidative environments in tumor versus normal epithelial cells. J. Pharmacol. Exp. Ther. 2003, 307(1):230-236.
187. Yang S.E., Hsieh M.T., Tsai T.H., Hsu S.L. Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells. Biochem. Pharmacol. 2002, 63(9):1641-1651.
188. Zhang Y., Talalay P. Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Cancer Res. 1994, 54(7 Suppl):1976s-1981s.
189. Zhang Y., Tang L., Gonzalez V. Selected isothiocyanates rapidly induce growth inhibition of cancer cells. Mol. Cancer Ther. 2003, 2(10):1045-1052.
190. Zhang Y., Li J., Tang L. Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress. Free Radic. Biol. Med. 2005, 38(1):70-77.
191. Zhang H., Trachootham D., Lu W., Carew J., Giles F.J., Keating M.J., Arlinghaus R.B., Huang P. Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism. Leukemia 2008, 22(6):1191-1199.
192. Zhang X., Zhang H., Tighiouart M., Lee J.E., Shin H.J., Khuri F.R., Yang C.S., Chen Z.G., Shin D.M. Synergistic inhibition of head and neck tumor growth by green tea (-)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor. Int. J. Cancer 2008, 123(5):1005-1014.
193. Zhao Y., Neuzil J., Wu K. Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside?. Mol. Nutr. Food Res. 2009, 53(1):129-139.
194. Zhou P., Kalakonda N., Comenzo R.L. Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br. J. Haematol. 2005, 128(5):636-644.
195. Zhou Y., Garcia-Prieto C., Carney D.A., Xu R.H., Pelicano H., Kang Y., Yu W., Lou C., Kondo S., Liu J., Harris D.M., Estrov Z., Keating M.J., Jin Z., Huang P. OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action. J. Natl Cancer Inst. 2005, 97(23):1781-1785.
196. Zhu J., Xiong L., Yu B., Wu J. Apoptosis induced by a new member of saponin family is mediated through caspase-8-dependent cleavage of Bcl-2. Mol. Pharmacol. 2005, 68(6):1831-1838.
197. Zini R., Morin C., Bertelli A., Bertelli A.A., Tillement J.P. Effects of resveratrol on the rat brain respiratory chain. Drugs Exp. Clin. Res. 1999, 25(2-3):87-97.