A conserved element in Myc that negatively regulates its proapoptotic activity

EMBO Reports

Volumn 6, Issue 2, 2005, Pages 177-183

  Herbst, Andreas ^a,b   Hemann, Michael T ^a   Tworkowski, Kathryn A ^a,c   Salghetti, Simone E ^a   Lowe, Scott W ^a   Tansey, William P ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Apoptosis; Myc; Transcription; Transformation

Indexed keywords

MYC PROTEIN; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CARCINOGENESIS; CELL CULTURE; CELL CYCLE S PHASE; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; GENE EXPRESSION REGULATION; HUMANS; LYMPHOMA; MICE; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MYC; TRANSCRIPTION, GENETIC;

EID: 14644396659     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.7400333     Document Type: Article

References (18)

1. Bhatia K, Spangler G, Gaidano G, Hamdy N, Dalla-Favera R, Magrath I (1994) Mutations in the coding region of c-myc occur frequently in acquired immunodeficiency syndrome-associated lymphomas. Blood 84: 883-888
2. Eilers M, Picard D, Yamamoto KR, Bishop JM (1989) Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature 340: 66-68
3. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119-128
4. Flinn EM, Busch CMC, Wright APH (1998) Myc boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome. Mol Cell Biol 18: 5961-5969
5. Grandori C, Cowley SM, James LP, Eisenman RN (2000) The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu Rev Cell Dev Biol 16: 653-699
6. Herbst A, Salghetti SE, Kim SY, Tansey WP (2004) Multiple cell-type-specific elements regulate Myc protein stability. Oncogene 23: 9448-9456
7. Kim SY, Herbst A, Tworkowski KA, Salghetti SE, Tansey WP (2003) Skp2 regulates Myc protein stability and activity. Mol Cell 11: 1177-1188
8. Mateyak MK, Obaya AJ, Adachi S, Sedivy JM (1997) Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ 8: 1039-1048
9. McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD (1998) The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94: 363-374
10. Pelengaris S, Khan M, Evan G (2002) c-MYC: more than just a matter of life and death. Nat Rev Cancer 2: 764-776
11. Reilly PT, Herr W (2002) Spontaneous reversion of tsBN67 cell proliferation and cytokinesis defects in the absence of HCF-1 function. Exp Cell Res 277: 119-130
12. Sarid J, Halazonetis TD, Murphy W, Leder P (1987) Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity. Proc Natl Acad Sci USA 84: 170-173
13. Schmitt CA, Rosenthal CT, Lowe SW (2000) Genetic analysis of chemoresistance in primary murine lymphomas. Nat Med 6: 1029-1035
14. Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, Lowe SW (2002) A senescence program controlled by p53 and p16(INK4a) contributes to the outcome of cancer therapy. Cell 109: 335-346
15. Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR (2000) Multiple Rasdependent phosphorylation pathways regulate Myc protein stability. Genes Dev 14: 2501-2514
16. Spotts GD, Patel SV, Xiao Q, Hann SR (1997) Identification of downstreaminitiated c-Myc proteins which are dominant-negative inhibitors of transactivation by full-length c-Myc proteins. Mol Cell Biol 17: 1459-1468
17. Stone J, de Lange T, Ramsay G, Jakobovits E, Bishop JM, Varmus H, Lee W (1987) Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol Cell Biol 7: 1697-1709
18. Vaux DL, Cory S, Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440-442