Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl serine followed by rapid apoptosis specifically in human lymphoma cells

Cancer Chemotherapy and Pharmacology

Volumn 56, Issue 1, 2005, Pages 29-38

  Kekre, Natasha ^a   Griffin, Carly ^a   McNulty, James ^b   Pandey, Siyaram ^a  

^a UNIVERSITY OF WINDSOR   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Anticancer drugs; Apoptosis; Caspases; Double strand DNA breaks; Genotoxicity

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; DNA FRAGMENT; ETOPOSIDE; PACLITAXEL; PANCRATISTATIN; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; AMARYLLIDACEAE ALKALOID; CASP3 PROTEIN, HUMAN; CASPASE; ISOQUINOLINE DERIVATIVE;

APOPTOSIS; ARTICLE; BLOOD CELL; CELL MEMBRANE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG EFFECT; DRUG SPECIFICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LYMPHOMA CELL; PRIORITY JOURNAL; CELL CULTURE; LEUKEMIA CELL LINE; LYMPHOMA; PATHOLOGY;

AMARYLLIDACEAE ALKALOIDS; APOPTOSIS; CASPASE 3; CASPASES; DNA DAMAGE; ENZYME ACTIVATION; HUMANS; ISOQUINOLINES; JURKAT CELLS; LYMPHOMA; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 21244439798     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-004-0941-8     Document Type: Article

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