메뉴 건너뛰기




Volumn 2, Issue 3, 2007, Pages 295-305

Trans-resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways

Author keywords

Apoptosis; Glutathione; MAP kinases; Oxidative stress; Resveratrol; ROS

Indexed keywords

ACTIN; CASPASE 9; CYTOCHROME C; GLUTATHIONE; GLUTATHIONE DISULFIDE; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; RESVERATROL;

EID: 38349010755     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-007-0059-9     Document Type: Article
Times cited : (86)

References (65)
  • 1
    • 30644475948 scopus 로고    scopus 로고
    • Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: A putative mechanism for anticancer properties
    • Azmi AS, Bhat SH, Hanif S, Hadi SM (2006) Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties. FEBS Lett 580:533-538
    • (2006) FEBS Lett , vol.580 , pp. 533-538
    • Azmi, A.S.1    Bhat, S.H.2    Hanif, S.3    Hadi, S.M.4
  • 3
    • 0023226978 scopus 로고
    • Inhibition of mitochondrial NADH oxidase, succinoxidase, and ATPase by naturally occurring flavonoids
    • Bohmont C, Aaronson LM, Mann K, Pardini RS (1987) Inhibition of mitochondrial NADH oxidase, succinoxidase, and ATPase by naturally occurring flavonoids. J Nat Prod 50:427-433
    • (1987) J Nat Prod , vol.50 , pp. 427-433
    • Bohmont, C.1    Aaronson, L.M.2    Mann, K.3    Pardini, R.S.4
  • 4
    • 0036715252 scopus 로고    scopus 로고
    • Red wine polyphenols inhibit the growth of colon carcinoma cells and modulate the activation pattern of mitogen-activated protein kinases
    • Briviba K, Pan L, Rechkemmer G (2002) Red wine polyphenols inhibit the growth of colon carcinoma cells and modulate the activation pattern of mitogen-activated protein kinases. J Nutr 132:2814-2818
    • (2002) J Nutr , vol.132 , pp. 2814-2818
    • Briviba, K.1    Pan, L.2    Rechkemmer, G.3
  • 5
    • 0345566753 scopus 로고    scopus 로고
    • Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells
    • Clement MV, Hirpara JL, Chawdhury SH, Pervaiz S (1998) Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood 92:996-1002
    • (1998) Blood , vol.92 , pp. 996-1002
    • Clement, M.V.1    Hirpara, J.L.2    Chawdhury, S.H.3    Pervaiz, S.4
  • 6
    • 11344289617 scopus 로고    scopus 로고
    • Mechanism of cytotoxicity of catechols and a naphthalenediol in PC12-AC cells: The connection between extracellular autoxidation and molecular electronic structure
    • Chichirau A, Flueraru M, Chepelev LL, Wright JS, Willmore WG, Durst T, Hussain HH, Charron M (2005) Mechanism of cytotoxicity of catechols and a naphthalenediol in PC12-AC cells: the connection between extracellular autoxidation and molecular electronic structure. Free Radic Biol Med 38:344-355
    • (2005) Free Radic Biol Med , vol.38 , pp. 344-355
    • Chichirau, A.1    Flueraru, M.2    Chepelev, L.L.3    Wright, J.S.4    Willmore, W.G.5    Durst, T.6    Hussain, H.H.7    Charron, M.8
  • 8
    • 0035874886 scopus 로고    scopus 로고
    • Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells
    • Dorrie J, Gerauer H, Wachter Y, Zunino SJ (2001) Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res 61:4731-4739
    • (2001) Cancer Res , vol.61 , pp. 4731-4739
    • Dorrie, J.1    Gerauer, H.2    Wachter, Y.3    Zunino, S.J.4
  • 10
    • 21344445674 scopus 로고    scopus 로고
    • Activation of c-Jun-N-terminal kinase is required for apoptosis triggered by glutathione disulfide in neuroblastoma cells
    • Filomeni G, Aquilano K, Civitareale P, Rotilio G, Ciriolo MR (2005) Activation of c-Jun-N-terminal kinase is required for apoptosis triggered by glutathione disulfide in neuroblastoma cells. Free Radic Biol Med 39:345-354
    • (2005) Free Radic Biol Med , vol.39 , pp. 345-354
    • Filomeni, G.1    Aquilano, K.2    Civitareale, P.3    Rotilio, G.4    Ciriolo, M.R.5
  • 11
    • 14044273000 scopus 로고    scopus 로고
    • Antiapoptotic response to GSH depletion: Involvement of heat shock proteins and NF-κB activation
    • Filomeni G, Aquilano K, Rotilio G, Ciriolo MR (2005) Antiapoptotic response to GSH depletion: involvement of heat shock proteins and NF-κB activation. Antioxid Redox Signal 7:446-455
    • (2005) Antioxid Redox Signal , vol.7 , pp. 446-455
    • Filomeni, G.1    Aquilano, K.2    Rotilio, G.3    Ciriolo, M.R.4
  • 12
    • 0141842655 scopus 로고    scopus 로고
    • Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide
    • Filomeni G, Aquilano K, Rotilio G, Ciriolo MR (2003) Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide. Cancer Res 63:5940-5949
    • (2003) Cancer Res , vol.63 , pp. 5940-5949
    • Filomeni, G.1    Aquilano, K.2    Rotilio, G.3    Ciriolo, M.R.4
  • 13
    • 29244489231 scopus 로고    scopus 로고
    • Glutathione-related systems and modulation of extracellular signal-regulated kinases are involved in resistance of AGS adenocarcinoma gastric cells to diallyl disulfide-induced apoptosis
    • Filomeni G, Aquilano K, Rotilio G, Ciriolo MR (2005) Glutathione-related systems and modulation of extracellular signal-regulated kinases are involved in resistance of AGS adenocarcinoma gastric cells to diallyl disulfide-induced apoptosis. Cancer Res 65:11735-11742
    • (2005) Cancer Res , vol.65 , pp. 11735-11742
    • Filomeni, G.1    Aquilano, K.2    Rotilio, G.3    Ciriolo, M.R.4
  • 14
    • 0036710563 scopus 로고    scopus 로고
    • Cell signalling and the glutathione redox system
    • Filomeni G, Rotilio G, Ciriolo MR (2002) Cell signalling and the glutathione redox system. Biochem Pharmacol 64:1057-1064
    • (2002) Biochem Pharmacol , vol.64 , pp. 1057-1064
    • Filomeni, G.1    Rotilio, G.2    Ciriolo, M.R.3
  • 15
    • 27944442839 scopus 로고    scopus 로고
    • Disulfide relays and phosphorylative cascades: Partners in redox-mediated signalling pathways
    • Filomeni G, Rotilio G, Ciriolo MR (2005) Disulfide relays and phosphorylative cascades: partners in redox-mediated signalling pathways. Cell Death Differ 12:1555-1563
    • (2005) Cell Death Differ , vol.12 , pp. 1555-1563
    • Filomeni, G.1    Rotilio, G.2    Ciriolo, M.R.3
  • 16
    • 0037271399 scopus 로고    scopus 로고
    • Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP kinase pathway
    • Filomeni G, Rotilio G, Ciriolo MR (2003) Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP kinase pathway. FASEB J 17:64-66
    • (2003) FASEB J , vol.17 , pp. 64-66
    • Filomeni, G.1    Rotilio, G.2    Ciriolo, M.R.3
  • 17
    • 0033052299 scopus 로고    scopus 로고
    • Glutathione-dependent generation of reactive oxygen species by the peroxidase-catalyzed redox cycling of flavonoids
    • Galati G, Chan T, Wu B, O'Brien PJ (1999) Glutathione-dependent generation of reactive oxygen species by the peroxidase-catalyzed redox cycling of flavonoids. Chem Res Toxicol 12:521-525
    • (1999) Chem Res Toxicol , vol.12 , pp. 521-525
    • Galati, G.1    Chan, T.2    Wu, B.3    O'Brien, P.J.4
  • 18
    • 0036679809 scopus 로고    scopus 로고
    • Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics
    • Galati G, Sabzevari O, Wilson JX, O'Brien PJ (2002) Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 177:91-104
    • (2002) Toxicology , vol.177 , pp. 91-104
    • Galati, G.1    Sabzevari, O.2    Wilson, J.X.3    O'Brien, P.J.4
  • 19
    • 3042574709 scopus 로고    scopus 로고
    • Potential toxicity of flavonoids and other dietary phenolics: Significance for their chemopreventive and anticancer properties
    • Galati G, O'Brien PJ (2004) Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 37:287-303
    • (2004) Free Radic Biol Med , vol.37 , pp. 287-303
    • Galati, G.1    O'Brien, P.J.2
  • 20
    • 28844492580 scopus 로고    scopus 로고
    • Chemosensitization and radiosensitization of tumors by plant polyphenols
    • Garg AK, Buchholz TA, Aggarwal BB (2005) Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid Redox Signal 7:1630-1647
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1630-1647
    • Garg, A.K.1    Buchholz, T.A.2    Aggarwal, B.B.3
  • 21
    • 0034515783 scopus 로고    scopus 로고
    • Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds
    • Hadi SM, Asad SF, Singh S, Ahmad A (2000) Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds. IUBMB Life 50:167-171
    • (2000) IUBMB Life , vol.50 , pp. 167-171
    • Hadi, S.M.1    Asad, S.F.2    Singh, S.3    Ahmad, A.4
  • 22
    • 23344431622 scopus 로고    scopus 로고
    • Checkpoint kinase 1 regulates diallyl trisulfide-induced mitotic arrest in human prostate cancer cells
    • Herman-Antosiewicz A, Singh SV (2005) Checkpoint kinase 1 regulates diallyl trisulfide-induced mitotic arrest in human prostate cancer cells. Journal of Biol Chem 280:28519-28528
    • (2005) Journal of Biol Chem , vol.280 , pp. 28519-28528
    • Herman-Antosiewicz, A.1    Singh, S.V.2
  • 23
    • 1442360000 scopus 로고    scopus 로고
    • Intrinsic oxidative stress in cancer cells: A biochemical basis for therapeutic selectivity
    • Hileman EO, Liu J, Albitar M, Keating MJ, Huang P (2003) Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity. Cancer Chemother Pharmacol 53:209-219
    • (2003) Cancer Chemother Pharmacol , vol.53 , pp. 209-219
    • Hileman, E.O.1    Liu, J.2    Albitar, M.3    Keating, M.J.4    Huang, P.5
  • 24
    • 0022517744 scopus 로고
    • Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids: A structure-activity study
    • Hodnick WF, Kung FS, Roettger WJ, Bohmont CW, Pardini RS (1986) Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids: a structure-activity study. Biochem Pharmacol 35:2345-2357
    • (1986) Biochem Pharmacol , vol.35 , pp. 2345-2357
    • Hodnick, W.F.1    Kung, F.S.2    Roettger, W.J.3    Bohmont, C.W.4    Pardini, R.S.5
  • 25
    • 0023901222 scopus 로고
    • Electrochemistry of flavonoids: Relationships between redox potentials, inhibition of mitochondrial respiration, and production of oxygen radicals by flavonoids
    • Hodnick WF, Milosavljevic EB, Nelson JH, Pardini RS (1988) Electrochemistry of flavonoids: relationships between redox potentials, inhibition of mitochondrial respiration, and production of oxygen radicals by flavonoids, Biochem Pharmacol 37:2607-2611
    • (1988) Biochem Pharmacol , vol.37 , pp. 2607-2611
    • Hodnick, W.F.1    Milosavljevic, E.B.2    Nelson, J.H.3    Pardini, R.S.4
  • 26
    • 0031708666 scopus 로고    scopus 로고
    • Induction of oxidative stress by redox active flavonoids
    • Hodnick WF, Ahmad S, Pardini RS (1998) Induction of oxidative stress by redox active flavonoids. Adv Exp Med Biol 439:131-150
    • (1998) Adv Exp Med Biol , vol.439 , pp. 131-150
    • Hodnick, W.F.1    Ahmad, S.2    Pardini, R.S.3
  • 27
    • 0033602719 scopus 로고    scopus 로고
    • Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines
    • Hsieh TC, Wu JM (1999) Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines. Exp Cell Res 249:109-115
    • (1999) Exp Cell Res , vol.249 , pp. 109-115
    • Hsieh, T.C.1    Wu, J.M.2
  • 29
    • 0034896098 scopus 로고    scopus 로고
    • Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death
    • Kagawa S, Gu J, Honda T, McDonnell TJ, Swisher SG, Roth JA, Fang B (2001) Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. Clin Cancer Res 7:1474-1480
    • (2001) Clin Cancer Res , vol.7 , pp. 1474-1480
    • Kagawa, S.1    Gu, J.2    Honda, T.3    McDonnell, T.J.4    Swisher, S.G.5    Roth, J.A.6    Fang, B.7
  • 30
    • 3042606371 scopus 로고    scopus 로고
    • Involvement of p21WAF1/CIP1, pRB, Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells
    • Kim YA, Lee WH, Choi TH, Rhee SH, Park KY, Choi YH (2003) Involvement of p21WAF1/CIP1, pRB, Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells. Int J Oncol 23:1143-1149
    • (2003) Int J Oncol , vol.23 , pp. 1143-1149
    • Kim, Y.A.1    Lee, W.H.2    Choi, T.H.3    Rhee, S.H.4    Park, K.Y.5    Choi, Y.H.6
  • 31
    • 0035212419 scopus 로고    scopus 로고
    • Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE)
    • Kong AN, Owuor E, Yu R, Hebbar V, Chen C, Hu R, Mandlekar S (2001) Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab Rev 33:255-271
    • (2001) Drug Metab Rev , vol.33 , pp. 255-271
    • Kong, A.N.1    Owuor, E.2    Yu, R.3    Hebbar, V.4    Chen, C.5    Hu, R.6    Mandlekar, S.7
  • 33
    • 24744448676 scopus 로고    scopus 로고
    • Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids
    • Lee ER, Kang YJ, Kim JH, Lee HAT, Cho SG (2005) Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem 280:31498-31507
    • (2005) J Biol Chem , vol.280 , pp. 31498-31507
    • Lee, E.R.1    Kang, Y.J.2    Kim, J.H.3    Lee, H.A.T.4    Cho, S.G.5
  • 34
    • 33847008028 scopus 로고    scopus 로고
    • Li Y, Liu J, Liu X, Xing K, Wang Y, Li F, Yao L (2006) Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9. Appl Biochern Biotechnol 135:181-192
    • Li Y, Liu J, Liu X, Xing K, Wang Y, Li F, Yao L (2006) Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9. Appl Biochern Biotechnol 135:181-192
  • 35
    • 0347721000 scopus 로고    scopus 로고
    • Mitochondrial dysfunction as an early event in the process of apoptosis induced by woodfordin I in human leukemia K562 cells
    • Liu MJ, Wang Z, Li HX, Wu RC, Liu YZ, Wu QY (2004) Mitochondrial dysfunction as an early event in the process of apoptosis induced by woodfordin I in human leukemia K562 cells. Toxicol Appl Pharmacol 194:141-155
    • (2004) Toxicol Appl Pharmacol , vol.194 , pp. 141-155
    • Liu, M.J.1    Wang, Z.2    Li, H.X.3    Wu, R.C.4    Liu, Y.Z.5    Wu, Q.Y.6
  • 37
    • 0034660659 scopus 로고    scopus 로고
    • Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation
    • Manna SK, Mukhopadhyay A, Aggarwal BB (2000) Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol 164:6509-6519
    • (2000) J Immunol , vol.164 , pp. 6509-6519
    • Manna, S.K.1    Mukhopadhyay, A.2    Aggarwal, B.B.3
  • 38
    • 14044265068 scopus 로고    scopus 로고
    • Stress-responsive protein kinases in redox-regulated apoptosis signaling
    • Matsuzawa A, Ichijo H (2005) Stress-responsive protein kinases in redox-regulated apoptosis signaling, Antioxid Redox Signal 7:472-481
    • (2005) Antioxid Redox Signal , vol.7 , pp. 472-481
    • Matsuzawa, A.1    Ichijo, H.2
  • 39
    • 0036019933 scopus 로고    scopus 로고
    • Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: Advanced findings from ASK1 knockout mice
    • Matsuzawa A, Nishitoh H, Tobiume K, Takeda K, Ichijo H (2002) Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice. Antioxid Redox Signal 4:415-425
    • (2002) Antioxid Redox Signal , vol.4 , pp. 415-425
    • Matsuzawa, A.1    Nishitoh, H.2    Tobiume, K.3    Takeda, K.4    Ichijo, H.5
  • 41
    • 0031891466 scopus 로고    scopus 로고
    • Antiproliferative effect of synthetic resveratrol on human breast epithelial cells
    • Mgbonyebi OP, Russo J, Russo IH (1998) Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int J Oncol 12:865-869
    • (1998) Int J Oncol , vol.12 , pp. 865-869
    • Mgbonyebi, O.P.1    Russo, J.2    Russo, I.H.3
  • 43
    • 33745849139 scopus 로고    scopus 로고
    • Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol
    • Mohan J, Gandhi AA, Bhavya BC, Rashmi R, Karunagaran D, Indu R, Santhoshkumar TR (2006) Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol. J Biol Chem 281:17599-17611
    • (2006) J Biol Chem , vol.281 , pp. 17599-17611
    • Mohan, J.1    Gandhi, A.A.2    Bhavya, B.C.3    Rashmi, R.4    Karunagaran, D.5    Indu, R.6    Santhoshkumar, T.R.7
  • 44
    • 23844541335 scopus 로고    scopus 로고
    • Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species
    • Nakazato T, Ito K, Ikeda Y, Kizaki M (2005) Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. Clin Cancer Res 11:6040-6049
    • (2005) Clin Cancer Res , vol.11 , pp. 6040-6049
    • Nakazato, T.1    Ito, K.2    Ikeda, Y.3    Kizaki, M.4
  • 45
    • 0037457308 scopus 로고    scopus 로고
    • Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets
    • Narayanan BA, Narayanan NK, Re GG, Nixon DW (2003) Differential expression of genes induced by resveratrol in LNCaP cells: p53-mediated molecular targets. Int J Cancer 104:204-212
    • (2003) Int J Cancer , vol.104 , pp. 204-212
    • Narayanan, B.A.1    Narayanan, N.K.2    Re, G.G.3    Nixon, D.W.4
  • 46
    • 27244453562 scopus 로고    scopus 로고
    • Quantitative structure-activity relationships in prooxidant cytotoxicity of polyphenols: Role of potential of phenoxyl radical/phenol redox couple
    • Nemeikaite-Ceniene A, Imbrasaite A, Sergediene E, Cenas N (2005) Quantitative structure-activity relationships in prooxidant cytotoxicity of polyphenols: role of potential of phenoxyl radical/phenol redox couple. Arch Biochem Biophys 441:182-190
    • (2005) Arch Biochem Biophys , vol.441 , pp. 182-190
    • Nemeikaite-Ceniene, A.1    Imbrasaite, A.2    Sergediene, E.3    Cenas, N.4
  • 47
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139:271-279
    • (1991) J Immunol Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 48
    • 0029173888 scopus 로고
    • Toxicity of oxygen from naturally occurring redox-active pro-oxidants
    • Pardini RS (1995) Toxicity of oxygen from naturally occurring redox-active pro-oxidants. Arch Insect Biochem Physiol 29:101-118
    • (1995) Arch Insect Biochem Physiol , vol.29 , pp. 101-118
    • Pardini, R.S.1
  • 49
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • Pelicano H, Carney D, Huang P (2004) ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 7:97-110
    • (2004) Drug Resist Updat , vol.7 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 50
    • 2342427030 scopus 로고    scopus 로고
    • Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: New avenues for cancer chemoprevention and chemotherapy
    • Pellecchia M, Reed JC (2004) Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy. Curr Pharm, Des 10:1387-1398
    • (2004) Curr Pharm, Des , vol.10 , pp. 1387-1398
    • Pellecchia, M.1    Reed, J.C.2
  • 52
    • 19844374460 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells
    • Qanungo S, Das M, Haldar S, Basu A (2005) Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. Carcinogenesis 26:958-967
    • (2005) Carcinogenesis , vol.26 , pp. 958-967
    • Qanungo, S.1    Das, M.2    Haldar, S.3    Basu, A.4
  • 53
    • 23944513613 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments
    • Raza H, John A (2005) Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments. Toxicol Appl Pharmacol 207:212-220
    • (2005) Toxicol Appl Pharmacol , vol.207 , pp. 212-220
    • Raza, H.1    John, A.2
  • 54
    • 33845785423 scopus 로고    scopus 로고
    • Putative mechanisms of apoptosis related to redox unbalance
    • Ozben K, Chevion M (eds) Frontiers in neurodegenerative disorders and aging: fundamental aspect, clinical perspectives and new insight. IOS press, The Netherlands, pp
    • Rossi L, Aquilano A, Filomeni G, Lombardo MF, Rotilio G, Ciriolo MR (2004) Putative mechanisms of apoptosis related to redox unbalance. In: Ozben K, Chevion M (eds) Frontiers in neurodegenerative disorders and aging: fundamental aspect, clinical perspectives and new insight. IOS press, NATO Sciences Series, The Netherlands, pp 207-250
    • (2004) NATO Sciences Series , pp. 207-250
    • Rossi, L.1    Aquilano, A.2    Filomeni, G.3    Lombardo, M.F.4    Rotilio, G.5    Ciriolo, M.R.6
  • 56
    • 0034730942 scopus 로고    scopus 로고
    • Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells
    • Schneider Y, Vincent F, Duranton B, Badolo L, Gosse F, Bergmann C, Seiler N, Raul F (2000) Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett 158:85-91
    • (2000) Cancer Lett , vol.158 , pp. 85-91
    • Schneider, Y.1    Vincent, F.2    Duranton, B.3    Badolo, L.4    Gosse, F.5    Bergmann, C.6    Seiler, N.7    Raul, F.8
  • 57
    • 33750839605 scopus 로고    scopus 로고
    • Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells
    • Sexton E, Van Themsche C, LeBlanc K, Parent S, Lemoine P, Asselin E (2006) Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. Mol Cancer 175:45
    • (2006) Mol Cancer , vol.175 , pp. 45
    • Sexton, E.1    Van Themsche, C.2    LeBlanc, K.3    Parent, S.4    Lemoine, P.5    Asselin, E.6
  • 58
    • 0035866404 scopus 로고    scopus 로고
    • Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase
    • She QB, Bode AM, Ma WY, Chen NY, Dong Z (2001) Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res 61:1604-1610
    • (2001) Cancer Res , vol.61 , pp. 1604-1610
    • She, Q.B.1    Bode, A.M.2    Ma, W.Y.3    Chen, N.Y.4    Dong, Z.5
  • 60
    • 0035408191 scopus 로고    scopus 로고
    • Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bc1-2
    • Tinhofer I, Bernhard D, Senfter M, Anether G, Loeffler M, Kroemer G, Kofler R, Csordas A, Greil R (2001) Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bc1-2. FASEB J 15:1613-1615
    • (2001) FASEB J , vol.15 , pp. 1613-1615
    • Tinhofer, I.1    Bernhard, D.2    Senfter, M.3    Anether, G.4    Loeffler, M.5    Kroemer, G.6    Kofler, R.7    Csordas, A.8    Greil, R.9
  • 62
    • 1842482424 scopus 로고    scopus 로고
    • Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction
    • Woo JH, Lim JH, Kim YH, Sub SI, Min DS, Chang JS, Lee YH, Park JW, Kwon TK (2004) Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. Oncogene 23:1845-1853
    • (2004) Oncogene , vol.23 , pp. 1845-1853
    • Woo, J.H.1    Lim, J.H.2    Kim, Y.H.3    Sub, S.I.4    Min, D.S.5    Chang, J.S.6    Lee, Y.H.7    Park, J.W.8    Kwon, T.K.9
  • 63
    • 0142188703 scopus 로고    scopus 로고
    • Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH2-terminal kinase 1 activation
    • Xiao D, Pinto JT, Soh JW, Deguchi A, Gundersen GG, Palazzo AF, Yoon JT, Shirin H, Weinstein IB (2003) Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH2-terminal kinase 1 activation. Cancer Res 63:6825-6837
    • (2003) Cancer Res , vol.63 , pp. 6825-6837
    • Xiao, D.1    Pinto, J.T.2    Soh, J.W.3    Deguchi, A.4    Gundersen, G.G.5    Palazzo, A.F.6    Yoon, J.T.7    Shirin, H.8    Weinstein, I.B.9
  • 64
    • 0034493221 scopus 로고    scopus 로고
    • Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin
    • Yamashita N, Kawanishi S (2000) Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin. Free Radic Res 33:623-633
    • (2000) Free Radic Res , vol.33 , pp. 623-633
    • Yamashita, N.1    Kawanishi, S.2
  • 65
    • 0034948728 scopus 로고    scopus 로고
    • Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways
    • Yu R, Hebbar V, Kim DW, Mandlekar S, Pezzutc, JM, Kong AN (2001) Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways. Mol Pharmacol 60:217-224
    • (2001) Mol Pharmacol , vol.60 , pp. 217-224
    • Yu, R.1    Hebbar, V.2    Kim, D.W.3    Mandlekar, S.4    Pezzutc, J.M.5    Kong, A.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.