Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 4, 2007, Pages 1003-1007

  Tang, Pingping ^a   Mamdani, Fatemah ^b   Hu, Xiaoyi ^b   Liu, Jun O ^b   Yu, Biao ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antiproliferative activities; Glycosides; OSW saponins; Synthesis

Indexed keywords

2 O ACETYL ALPHA LEVO ARABINOPYRANOSIDE; DISACCHARIDE; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARBOHYDRATES; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLESTENONES; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; INDICATORS AND REAGENTS; JURKAT CELLS; ORNITHOGALUM; SAPONINS; THYMIDINE;

EID: 33846640843     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.11.032     Document Type: Article

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23. 3): δ 8.05 (d, J = 8.3 Hz, 2H), 7.97 (d, J = 8.8 Hz, 2H), 7.56-7.43 (m, 2H), 6.91 (d, J = 8.8 Hz, 2H), 5.78 (m, 1H), 5.56 (m, 1H), 5.35 (br s, 2H), 5.11 (d, J = 2.0 Hz, 2H), 4.53 (br, 1H), 4.36-4.29 (m, 3H), 4.21 (m, 1H), 4.07-3.89 (m, 3H), 3.86 (s, 3H), 3.81-3.73 (m, 3H), 3.53 (m, 2H), 3.00 (q, J = 7.5 Hz, 1H), 1.01 (s, 3H);