OSW-1: A natural compound with potent anticancer activity and a novel mechanism of action

Journal of the National Cancer Institute

Volumn 97, Issue 23, 2005, Pages 1781-1785

  Zhou, Yan ^a   Garcia Prieto, Celia ^a   Carney, Dennis A ^a   Xu, Rui hua ^a   Pelicano, Helene ^a   Kang, Ying ^b   Yu, Wensheng ^b   Lou, Changgang ^a   Kondo, Seiji ^a   Liu, Jinsong ^a   Harris, David M ^a   Estrov, Zeev ^a   Keating, Michael J ^a   Jin, Zhendong ^b   Huang, Peng ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA,16BETA,17ALPHA TRIHYDROXYCHOLEST 5 EN 22 ONE 16 O (2 O 4 METHOXYBENZOYL BETA XYLOPYRANOSYL)(1-3) (2 O ACETYL ALPHA LEVO ARABINOPYRANOSIDE); ANTINEOPLASTIC AGENT; CALCIUM; FLUDARABINE; MITOCHONDRIAL DNA; NATURAL PRODUCT; ORNITHOGALUM SAUDERSIAE EXTRACT; OSW 1; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CLONE; CELL SURVIVAL; CELL VIABILITY; CHEMICAL ANALYSIS; CHRONIC LYMPHATIC LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; LEUKEMIA CELL LINE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; ORNITHOGALUM; ORNITHOGALUM SAUDERSIAE; PANCREAS CANCER; PRIORITY JOURNAL; RESPIRATORY FAILURE; STATISTICAL SIGNIFICANCE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM CHANNELS; CELL LINE, TUMOR; CHOLESTENONES; DRUG RESISTANCE, NEOPLASM; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MICROSCOPY, ELECTRON; MITOCHONDRIAL MEMBRANES; SAPONINS; VIDARABINE;

EID: 28944437750     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/dji404     Document Type: Article

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