Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2)

Liver International

Volumn 28, Issue 10, 2008, Pages 1458-1464

  Deng, Junfang ^a   Qian, Yigang ^a   Geng, Lei ^a   Chen, Jie ^a   Wang, Xiaohui ^a   Xie, Haiyang ^a   Yan, Sheng ^a   Jiang, Guoping ^a   Zhou, Lin ^a   Zheng, Shusen ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl 2; Bcl XL; Caspase; Cytochromec; hepG2; Honokiol; p38

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; CYTOCHROME C; HONOKIOL; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCASPASE 3; PROCASPASE 9; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DOWN REGULATION; DRUG ANTAGONISM; DRUG DETERMINATION; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; HEPATOMA CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; WESTERN BLOTTING;

APOPTOSIS; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; FLOW CYTOMETRY; HUMANS; IMIDAZOLES; LIGNANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; SIGNAL TRANSDUCTION; TETRAZOLIUM SALTS; THIAZOLES;

EID: 54049113056     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2008.01767.x     Document Type: Article

References (30)

1. Li TSC. Chinese and Related North American Herbs: Phytopharmacology and Therapeutic Values. Boca Raton, FL: CRC Press, 2002.
2. Fujita M, Itokawa H, Sashida Y. Studies on the components of Magnolia obovata Thunb. II. On the components of the methanol extract of the bark. Yakugaku Zasshi 1973; 93: 422-8.
3. Tsai TH, Chen CF. Identification and determination of honokiol and magnolol from Magnolis officinalis by high-performance liquid chromatography with photodiode-array UV detection. J Chromatogr 1992; 598: 143-6.
4. Liou KT, Shen YC, Chen CF, Tsao CM, Tsai SK. The anti-inflammatory effect of honokiol on neutrophils: Mechanisms in the inhibition of reactive oxygen species production. Eur J Pharmacol 2003; 475: 19-27.
5. Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988; 50: 757-65.
6. Lo YC, Teng CM, Chen CF, Chen CC, Hong CY. Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem Pharmacol 1994; 47: 549-53.
7. Hibasami H, Achiwa Y, Katsuzaki H, et al. Honokiol induces apoptosis in human lymphoid leukemia Molt 4B cells. Int J Mol Med 1998; 2: 671-3.
8. Wang T, Chen F, Chen Z, et al. Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO. World J Gastroenterol 2004; 10: 2205-8.
9. Shigemura K, Arbiser JL, Sun SY, et al. Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Cancer 2007; 109: 1279-89.
10. Yang SE, Hsieh MT, Tsai TH, Hsu SL. Down-modulation of Bcl-X L, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells. Biochem Pharmacol 2002; 63: 1641-51.
11. Konoshima T, Kozuka M, Tokuda H, et al. Studies on inhibitors of skin tumor promotion, IX: Neolignans from Magnolia officinalis. J Nat Prod 1991; 54: 816-22.
12. Bai X, Cerimele F, Ushio-Fukai M, et al. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem 2003; 278: 35501-7.
13. Kroemer G, Zamzami N, Susin SA. Mitochondrial control of apoptosis. Immunol Today 1997; 18: 44-51.
14. Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91: 479-89.
15. Thornberry NA, Lazebnik Y. Caspases: Enemies within. Science 1998; 281: 1312-6.
16. Olson JM, Hallahan AR. p38 MAP kinase: A convergence point in cancer therapy. Trends Mol Med 2004; 10: 125-9.
17. Shen Y, Cai M, Xia W, et al. FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells. Cancer Lett 2007; 254: 288-97.
18. Lee B, Kim CH, Moon SK. Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells. FEBS Lett 2006; 580: 5177-84.
19. Syu WJ, Shen CC, Lu JJ, Lee GH, Sun CM. Antimicrobial and cytotoxic activities of neolignans from Magnolia officinalis. Chem Biodivers 2004; 1: 530-7.
20. Lavrik IN, Golks A, Krammer PH. Caspases: Pharmacological manipulation of cell death. J Clin Invest 2005; 115: 2665-72.
21. Wolf I, O'Kelly J, Wakimoto N, et al. Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest. Int J Oncol 2007; 30: 1529-37.
22. Battle TE, Arbiser J, Frank DA. The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. Blood 2005; 106: 690-7.
23. Shimizu T, Nakazato T, Xian MJ, Sagawa M, Ikeda Y, Kizaki M. Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathways. Biochem Pharmacol 2006; 7: 742-50.
24. Jiang DJ, Jia SJ, Dai Z, Li YJ. Asymmetric dimethylarginine induces apoptosis via p38 MAPK/caspase-3-dependent signaling pathway in endothelial cells. J Mol Cell Cardiol 2006; 40: 529-39.
25. Liu Q, Chen T, Chen H, et al. Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation. Biochem Biophys Res Commun 2004; 319: 980-6.
26. 2+] i elevation. Toxicol Sci 2007; 100: 109-17.
27. Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y. Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-X L. Nature 1995; 374: 811-3.
28. Gottschalk AR, Boise LH, Thompson CB, Quintans J. Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by Bcl-X L but not Bcl-2. Proc Natl Acad Sci USA 1994; 91: 7350-4.
29. Kim MH, Kim MO, Heo JS, Kim JS, Han HJ. Acetylcholine inhibits long-term hypoxia-induced apoptosis by suppressing the oxidative stress-mediated MAPKs activation as well as regulation of Bcl-2, c-IAPs, and caspase-3 in mouse embryonic stem cells. Apoptosis 2008; 13: 295-304.
30. Navas TA, Nguyen AN, Hideshima T, et al. Inhibition of p38a MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X L, Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo. Leukemia 2006; 1017-27.