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Volumn 9, Issue 3, 1999, Pages 419-424

On the relationship of OSW-1 to the cephalostatins

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE DERIVATIVE; ANTINEOPLASTIC AGENT; CEPHALOSTATIN; NATURAL PRODUCT; SAPONIN; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0033535077     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00743-4     Document Type: Article
Times cited : (72)

References (20)
  • 8
    • 0013618219 scopus 로고    scopus 로고
    • The naming system reflects the origins of the steroidal units: 'Ornitho' from Ornithogalum saundersiae, 'statin' from cephalostatin and 'ritter' or 'zine' from ritterazine, in keeping with the system adopted for the earlier hybrid ritterostatins (ref 6).
    • The naming system reflects the origins of the steroidal units: 'Ornitho' from Ornithogalum saundersiae, 'statin' from cephalostatin and 'ritter' or 'zine' from ritterazine, in keeping with the system adopted for the earlier hybrid ritterostatins (ref 6).
  • 9
    • 0013589767 scopus 로고    scopus 로고
    • note
    • The NMR of 8a showed a single diastereomer and was consistent with that of related 22S compounds. The 22S configuration was also calculated to be 2.2 kcal/mol more stable than the 22R epimer (CAChe v.3.5).
  • 10
    • 0013564172 scopus 로고    scopus 로고
    • note
    • 13C NMR spectra, MS and HRMS.
  • 14
    • 0021061819 scopus 로고
    • Mosmann, T. J. Immuno. Methods 1983, 65, 55-63, and Alley, M. C.; Scudiero, D. A.; Monks, A.; Hursey, M. L.; Czerwinski, M. J.; Fine, D. L.; Abbott, B. J.; Mayo, J. G.; Shoemaker, R. H.; Boyd, M. R. Cancer Res. 1988, 48, 589.
    • (1983) J. Immuno. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 16
    • 0013564114 scopus 로고    scopus 로고
    • note
    • TLC indicated some formation of 8b when a chloroform solution of 8a was allowed to stand for 20h.
  • 17
    • 0013617750 scopus 로고    scopus 로고
    • note
    • Conceivably, protonation of the 16αOH in 11 or 12 and β face attack by ketal or ketone oxygen could lead to a hemiketal and an E-ring oxocarbenium ion. However, we have observed no evidence for such reaction in either 12 nor 20 upon standing in acidic chloroform.
  • 18
    • 0028906759 scopus 로고    scopus 로고
    • (a) Jeong, J. U.; Fuchs, P. L. Tetrahedron Lett. 1995, 36, 2431; (b) Jeong, J. U.; Guo, C.; Fuchs, P. L. J. Am. Chem. Soc. in press.
    • (1995) Tetrahedron Lett. , vol.36 , pp. 2431
    • Jeong, J.U.1    Fuchs, P.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.