Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis

Anticancer Research

Volumn 23, Issue 2 B, 2003, Pages 1533-1539

  Hsu, Stephen ^a   Lewis, Jill ^a   Singh, Baldev ^a   Schoenlein, Patricia ^a   Osaki, Tokio ^b   Athar, Mohammad ^c   Porter, Alan G ^d   Schuster, George ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b KOCHI MEDICAL SCHOOL   (Japan)

^c Howard Hughes Medical Institute   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Apoptosis; Breast cancer; EGCG; Oral cancer; Polyphenols; Tea

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BROXURIDINE; CASPASE 3; POLYPHENOL;

ANALYSIS; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ASSAY; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; MITOCHONDRION; MOUTH CARCINOMA; NITROBLUE TETRAZOLIUM TEST; NULL ALLELE; PRIORITY JOURNAL; TARGET CELL DESTRUCTION; TEA; TUMOR CELL; WILD TYPE;

ADENOCARCINOMA; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BONE NEOPLASMS; BREAST NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CASPASES; CATECHIN; DNA REPLICATION; FEMALE; FLAVONOIDS; GENE DELETION; GINGIVAL NEOPLASMS; HUMANS; KERATINOCYTES; LYMPHATIC METASTASIS; MITOCHONDRIA; MOUTH NEOPLASMS; NEOPLASM PROTEINS; OSTEOSARCOMA; PHENOLS; PLANT EXTRACTS; POLYMERS; PROTEINS; TEA; TUMOR CELLS, CULTURED;

EID: 0037832409     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Gupta S, Ahmad N, Mohan RR, Husain MM and Mukhtar H: Prostate cancer chemoprevention by green tea: in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase. Cancer Res 59: 2115-20, 1999.
2. Ingredient in green tea kills prostate cancer cells, study finds. Mayo Clin Health Lett 17: 4, 1999.
3. Khafif A, Schantz SP, al-Rawi M, Edelstein D, Sacks PG: Green tea regulates cell cycle progression in oral leukoplakia. Head Neck 20: 528-34, 1998.
4. Otsuka T, Ogo T, Eto T, Asano Y, Suganuma M and Niho Y: Growth inhibition of leukemic cells by (-)-epigallocatechin gallate, the main constituent of green tea. Life Sci 63: 1397-403, 1998.
5. Paschka AG, Butler R and Young CY: Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate. Cancer Lett 130: 1-7, 1998.
6. Chen C, Yu R, Owuor ED and Kong AN: Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. Arch Pharm Res 236: 605-12, 2000.
7. Ahmad N, Feyes DK, Nieminen AL, Agarwal R and Mukhtar H: Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J Natl Cancer Inst 89: 1881-6, 1997.
8. Islam S, Islam N, Kermode T, Johnstone B, Mukhtar H, Moskowitz RW, Goldberg VM, Malemud CJ and Haqqi TM: Involvement of caspase-3 in epigallocatechin-3-gallate-mediated apoptosis of human chondrosarcoma cells. Biochem Biophys Res Commun 270: 793-7, 2000.
9. Hsu S, Singh B, Lewis JE, Borke JL, Dickinson DP, Drake L, Caughman GB and Schuster GS: Chemoprevention of oral cancer by green tea. General Dentistry 50: 140-146, 2001.
10. Hsu S, Lewis JE, Borke JL, Singh B, Dickinson DP, Caughman GB, Athar M, Drake L, Aiken AC, Huynh CT, Das BR, Osaki T and Schuster GS: Chemopreventive effects of green tea polyphenols correlate with reversible induction of p57 expression. Anticancer Res 21: 3743-3748, 2001.
11. Hsu S, Yu FS, Lewis J, Singh B, Borke J, Osaki T, Athar M and Schuster G: Induction of p57 is required for cell survival when exposed to green tea polyphenols. Anticancer Res, in press, 2002.
12. Leist M and Jaattela M: Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2: 589-98, 2001.
13. Bacus SS, Gudkov AV, Lowe M, Lyass L, Yung Y, Komarov AP, Keyomarsi K, Yarden Y and Seger R: Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 20: 147-55, 2001.
14. Cuvillier O, Nava VE, Murthy SK, Edsall LC, Levade T, Milstien S and Spiegel S: Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells. Cell Death Differ 8: 162-71, 2001.
15. Kagawa S, Gu J, Honda T, McDonnell TJ, Swisher SG, Roth JA and Fang B: Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. Clin Cancer Res 7: 1474-80, 2001.
16. Osaki T, Tatemoto Y, Yoneda K and Yamamoto T: Tumorigenicity of cell lines established from oral squamous cell carcinoma and its metastatic lymph nodes, Eur J Cancer B Oral Oncol 30B: 296-301, 1994.
17. Yoneda K, Yokoyama T, Yamamoto T, Hatabe T and Osaki T: p53 gene mutations and p21 protein expression induced independently of p53, by TGF-beta and gamma-rays in squamous cell carcinoma cells. Eur J Cancer 35: 278-83, 1999.
18. Hsu S, Borke JL, Lewis JE, Singh B, Aiken AC, Huynh CT, Schuster G, Caughman GB, Dickinson DP, Smith AK, Osaki T and Wang XF: Transforming growth factor b1 dysregulation in a human oral carcinoma tumor progression cell line model. Cell Proliferation 35: 183-192, 2002.
19. Janicke RU, Sprengart ML, Wati MR and Porter AG: Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273: 9357-60, 1998.
20. Blanc C, Deveraux QL, Krajewski S, Janicke RU, Porter AG, Reed JC, Jaggi R and Marti A: Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells. Cancer Res 60: 4386-90, 2000.
21. Pan MH, Liang YC, Lin-Shiau SY, Zhu NQ, Ho CT and Lin JK: Induction of apoptosis by the oolong tea polyphenol theasinensin A through cytochrome c release and activation of caspase-9 and caspase-3 in human U937 cells. J Agric Food Chem 48: 6337-46, 2000.
22. Kennedy DO, Kojima A, Yano Y, Hasuma T, Otani S and Matsui-Yuasa I: Growth inhibitory effect of green tea extract in Ehrlich ascites tumor cells involves cytochrome c release and caspase activation. Cancer Lett 166: 9-15, 2001.
23. Blagosklonny MV, Schulte TW, Nguyen P, Mimnaugh EG, Trepel J and Neckers L: Taxol induction of p21WAF1 and p53 requires c-raf-1. Cancer Res 55: 4623-6, 1995.
24. van der Burg B, Rutteman GR, Blankenstein MA, de Laat SW and van Zoelen EJ: Mitogenic stimulation of human breast cancer cells in a growth factor-defined medium: synergistic action of insulin and estrogen. J Cell Physiol 134: 101-8, 1988.
25. Arteaga CL, Tandon AK, Von Hoff DD and Osborne CK: Transforming growth factor beta: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells. Cancer Res 48: 3898-904, 1988.