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Volumn 9, Issue 17, 2010, Pages 3460-3469

The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

Author keywords

Apoptosis; DNA PK; p53; Transcription

Indexed keywords

ANTINEOPLASTIC AGENT; CARCINOGEN; DNA DEPENDENT PROTEIN KINASE; PROTEIN P53;

EID: 77956401853     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.17.13043     Document Type: Review
Times cited : (84)

References (152)
  • 1
    • 0141757494 scopus 로고    scopus 로고
    • Regulation and mechanisms of mammalian double-strand break repair
    • DOI 10.1038/sj.onc.1206679
    • Valerie K, Povirk LF. Regulation and mechanisms of mammalian double-strand break repair. Oncogene 2003; 22:5792-812. (Pubitemid 37176701)
    • (2003) Oncogene , vol.22 , Issue.37 REV. ISS. 3 , pp. 5792-5812
    • Valerie, K.1    Povirk, L.F.2
  • 2
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 2001; 27:247-54.
    • (2001) Nat Genet , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 3
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • DOI 10.1038/35056049
    • van G, Hoeijmakers JH, Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2001; 2:196-206. (Pubitemid 33674018)
    • (2001) Nature Reviews Genetics , vol.2 , Issue.3 , pp. 196-206
    • Van Gent, D.C.1    Hoeijmakers, J.H.J.2    Kanaar, R.3
  • 4
    • 0032530658 scopus 로고    scopus 로고
    • Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
    • DOI 10.1093/emboj/17.18.5497
    • Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H, et al. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J 1998; 17:5497-508. (Pubitemid 28427063)
    • (1998) EMBO Journal , vol.17 , Issue.18 , pp. 5497-5508
    • Takata, M.1    Sasaki, M.S.2    Sonoda, E.3    Morrison, C.4    Hashimoto, M.5    Utsumi, H.6    Yamaguchi-Iwai, Y.7    Shinohara, A.8    Takeda, S.9
  • 5
    • 0035968210 scopus 로고    scopus 로고
    • Accurate in vitro end joining of a DNA double strand break with partially cohesive 3′-overhangs and 3′-phosphoglycolate termini: Effect of Ku on repair fidelity
    • Chen S, Inamdar KV, Pfeiffer P, Feldmann E, Hannah MF, Yu Y, et al. Accurate in vitro end joining of a DNA double strand break with partially cohesive 3′-overhangs and 3′-phosphoglycolate termini: effect of Ku on repair fidelity. J Biol Chem 2001; 276:24323-30.
    • (2001) J Biol Chem , vol.276 , pp. 24323-24330
    • Chen, S.1    Inamdar, K.V.2    Pfeiffer, P.3    Feldmann, E.4    Hannah, M.F.5    Yu, Y.6
  • 6
    • 0036250811 scopus 로고    scopus 로고
    • Alu repeats and human genomic diversity
    • Batzer MA, Deininger PL. Alu repeats and human genomic diversity. Nat Rev Genet 2002; 3:370-9.
    • (2002) Nat Rev Genet , vol.3 , pp. 370-379
    • Batzer, M.A.1    Deininger, P.L.2
  • 7
    • 0034599981 scopus 로고    scopus 로고
    • Homologous and non-homologous recombination differentially affect DNA damage repair in mice
    • Essers J, van Steeg H, deWit J, Swagemakers SM, Vermeij M, Hoeijmakers JH, et al. Homologous and non-homologous recombination differentially affect DNA damage repair in mice. EMBO J 2000; 19:1703-10.
    • (2000) EMBO J , vol.19 , pp. 1703-1710
    • Essers, J.1    Van Steeg, H.2    DeWit, J.3    Swagemakers, S.M.4    Vermeij, M.5    Hoeijmakers, J.H.6
  • 8
    • 3242880580 scopus 로고    scopus 로고
    • Structure and function of the double-strand break repair machinery
    • DOI 10.1016/j.dnarep.2004.03.022, PII S1568786404000813
    • Shin DS, Chahwan C, Huffman JL, Tainer JA. Structure and function of the double-strand break repair machinery. DNA Repair (Amst) 2004; 3:863-73. (Pubitemid 38997928)
    • (2004) DNA Repair , vol.3 , Issue.8-9 , pp. 863-873
    • Shin, D.S.1    Chahwan, C.2    Huffman, J.L.3    Tainer, J.A.4
  • 10
    • 0033560796 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase
    • Smith GC, Jackson SP. The DNA-dependent protein kinase. Genes Dev 1999; 13:916-34.
    • (1999) Genes Dev , vol.13 , pp. 916-934
    • Smith, G.C.1    Jackson, S.P.2
  • 12
    • 0029156599 scopus 로고
    • DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
    • Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, et al. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 1995; 82:849-56.
    • (1995) Cell , vol.82 , pp. 849-856
    • Hartley, K.O.1    Gell, D.2    Smith, G.C.3    Zhang, H.4    Divecha, N.5    Connelly, M.A.6
  • 15
    • 0033198709 scopus 로고    scopus 로고
    • Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
    • DOI 10.1093/nar/27.17.3494
    • Gell D, Jackson SP. Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res 1999; 27:3494-502. (Pubitemid 29414677)
    • (1999) Nucleic Acids Research , vol.27 , Issue.17 , pp. 3494-3502
    • Gell, D.1    Jackson, S.P.2
  • 17
    • 0033104498 scopus 로고    scopus 로고
    • Structure of DNA-dependent protein kinase: Implications for its regulation by DNA
    • Leuther KK, Hammarsten O, Kornberg RD, Chu G. Structure of DNA-dependent protein kinase: implications for its regulation by DNA. EMBO J 1999; 18:1114-23. (Pubitemid 29110297)
    • (1999) EMBO Journal , vol.18 , Issue.5 , pp. 1114-1123
    • Leuther, K.K.1    Hammarsten, O.2    Kornberg, R.D.3    Chu, G.4
  • 18
    • 0032509097 scopus 로고    scopus 로고
    • Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase
    • Chiu CY, Cary RB, Chen DJ, Peterson SR, Stewart PL. Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase. J Mol Biol 1998; 284:1075-81.
    • (1998) J Mol Biol , vol.284 , pp. 1075-1081
    • Chiu, C.Y.1    Cary, R.B.2    Chen, D.J.3    Peterson, S.R.4    Stewart, P.L.5
  • 19
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to dna and its implications for double-strand break repair
    • DOI 10.1038/35088000
    • Walker JR, Corpina RA, Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 2001; 412:607-14. (Pubitemid 32772267)
    • (2001) Nature , vol.412 , Issue.6847 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3
  • 20
    • 0033572709 scopus 로고    scopus 로고
    • Geometry of a complex formed by double strand break repair proteins at a single DNA end: Recruitment of DNA-PKcs induces inward translocation of Ku protein
    • Yoo S. Dynan WS. Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein. Nucleic Acids Res 1999; 27:4679-86. (Pubitemid 30006656)
    • (1999) Nucleic Acids Research , vol.27 , Issue.24 , pp. 4679-4686
    • Yoo, S.1    Dynan, W.S.2
  • 23
    • 0033198709 scopus 로고    scopus 로고
    • Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
    • DOI 10.1093/nar/27.17.3494
    • Gell D. Jackson SP. Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res 1999; 27:3494-502. (Pubitemid 29414677)
    • (1999) Nucleic Acids Research , vol.27 , Issue.17 , pp. 3494-3502
    • Gell, D.1    Jackson, S.P.2
  • 24
    • 0037124373 scopus 로고    scopus 로고
    • Synapsis of DNA ends by DNA-dependent protein kinase
    • DOI 10.1093/emboj/cdf299
    • DeFazio LG, Stansel RM, Griffith JD, Chu G. Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J 2002; 21:3192-200. (Pubitemid 34670402)
    • (2002) EMBO Journal , vol.21 , Issue.12 , pp. 3192-3200
    • DeFazio, L.G.1    Stansel, R.M.2    Griffith, J.D.3    Chu, G.4
  • 26
    • 0037423743 scopus 로고    scopus 로고
    • Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment
    • DOI 10.1016/S0022-2836(02)01328-1
    • Calsou P, Delteil C, Frit P, Drouet J, Salles B. Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment. J Mol Biol 2003; 326:93-103. (Pubitemid 36279360)
    • (2003) Journal of Molecular Biology , vol.326 , Issue.1 , pp. 93-103
    • Calsou, P.1    Delteil, C.2    Frit, P.3    Drouet, J.4    Salles, B.5
  • 27
    • 0037187199 scopus 로고    scopus 로고
    • Defining interactions between DNA-PK and ligase IV/XRCC4
    • Amst
    • Hsu HL, Yannone SM, Chen DJ. Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair (Amst) 2002; 1:225-35.
    • (2002) DNA Repair , vol.1 , pp. 225-235
    • Hsu, H.L.1    Yannone, S.M.2    Chen, D.J.3
  • 28
    • 0037224429 scopus 로고    scopus 로고
    • Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro
    • Lee JW, Yannone SM, Chen DJ, Povirk LF. Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro. Cancer Res 2003; 63:22-4.
    • (2003) Cancer Res , vol.63 , pp. 22-24
    • Lee, J.W.1    Yannone, S.M.2    Chen, D.J.3    Povirk, L.F.4
  • 29
    • 0033119394 scopus 로고    scopus 로고
    • DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity
    • Modesti M, Hesse JE, Gellert M. DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity. EMBO J 1999; 18:2008-18.
    • (1999) EMBO J , vol.18 , pp. 2008-2018
    • Modesti, M.1    Hesse, J.E.2    Gellert, M.3
  • 31
    • 0036293744 scopus 로고    scopus 로고
    • Association of DNA polymerase mu (pol mu) with Ku and ligase IV: Role for pol mu in end-joining double-strand break repair
    • Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA. Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. Mol Cell Biol 2000; 22:5194-202.
    • (2000) Mol Cell Biol , vol.22 , pp. 5194-5202
    • Mahajan, K.N.1    Nick McElhinny, S.A.2    Mitchell, B.S.3    Ramsden, D.A.4
  • 32
    • 0037187199 scopus 로고    scopus 로고
    • Defining interactions between DNA-PK and ligase IV/XRCC4
    • Amst
    • Hsu HL, Yannone SM, Chen DJ. Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair (Amst) 2002; 1:225-35.
    • (2002) DNA Repair , vol.1 , pp. 225-235
    • Hsu, H.L.1    Yannone, S.M.2    Chen, D.J.3
  • 34
    • 0031939411 scopus 로고    scopus 로고
    • The XRCC4 gene product is a target for and interacts with the DNA- Dependent protein kinase
    • DOI 10.1074/jbc.273.3.1794
    • Leber R, Wise TW, Mizuta R, Meek K. The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase. J Biol Chem 1998; 273:1794-801. (Pubitemid 28133713)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.3 , pp. 1794-1801
    • Leber, R.1    Wise, T.W.2    Mizuta, R.3    Meek, K.4
  • 35
    • 0030743386 scopus 로고    scopus 로고
    • Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
    • DOI 10.1038/41358
    • Grawunder U, Wilm M, Wu X, Kulesza P, Wilson TE, Mann M, et al. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 1997; 388:492-5. (Pubitemid 27328929)
    • (1997) Nature , vol.388 , Issue.6641 , pp. 492-495
    • Grawunder, U.1    Wilm, M.2    Wu, X.3    Kulesza, P.4    Wilson, T.E.5    Mann, M.6    Lieber, M.R.7
  • 36
    • 0035851181 scopus 로고    scopus 로고
    • Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase
    • Yannone SM, Roy S, Chan DW, Murphy MB, Huang S, Campisi JS, et al. Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. J Biol Chem 2001; 276:38242-8.
    • (2001) J Biol Chem , vol.276 , pp. 38242-38248
    • Yannone, S.M.1    Roy, S.2    Chan, D.W.3    Murphy, M.B.4    Huang, S.5    Campisi, J.S.6
  • 37
    • 45549099011 scopus 로고    scopus 로고
    • Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase
    • DOI 10.1093/nar/gkn205
    • Yannone SM, Khan IS, Zhou RZ, Zhou T, Valerie K, Povirk LF. Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase. Nucleic Acids Res 2008; 36:3354-65. (Pubitemid 351859004)
    • (2008) Nucleic Acids Research , vol.36 , Issue.10 , pp. 3354-3365
    • Yannone, S.M.1    Khan, I.S.2    Zhou, R.-Z.3    Zhou, T.4    Valerie, K.5    Povirk, L.F.6
  • 38
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • DOI 10.1016/S0092-8674(02)00671-2
    • Ma Y, Pannicke U, Schwarz K, Lieber MR. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 2002; 108:781-94. (Pubitemid 34327530)
    • (2002) Cell , vol.108 , Issue.6 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 39
    • 33750685856 scopus 로고    scopus 로고
    • cs dependence of Artemis endonucleolytic activity, differences between hairpins and 5′ or 3′ overhangs
    • cs dependence of Artemis endonucleolytic activity, differences between hairpins and 5′ or 3′ overhangs. J Biol Chem 2006; 281:33900-9.
    • (2006) J Biol Chem , vol.281 , pp. 33900-33909
    • Niewolik, D.1    Pannicke, U.2    Lu, H.3    Ma, Y.4    Wang, L.C.5    Kulesza, P.6
  • 41
    • 1942453356 scopus 로고    scopus 로고
    • How homologous recombination is initiated: Unexpected evidence for single-strand nicks from v(d)j site-specific recombination
    • Smith GR. How homologous recombination is initiated: unexpected evidence for single-strand nicks from v(d)j site-specific recombination. Cell 2004; 117:146-8.
    • (2004) Cell , vol.117 , pp. 146-148
    • Smith, G.R.1
  • 42
    • 49349116358 scopus 로고    scopus 로고
    • A biochemically defined system for coding joint formation in V(D)J recombination
    • Lu H, Shimazaki N, Raval P, Gu J, Watanabe G, Schwarz K, et al. A biochemically defined system for coding joint formation in V(D)J recombination. Mol. Cell 2008; 31:485-97.
    • (2008) Mol. Cell , vol.31 , pp. 485-497
    • Lu, H.1    Shimazaki, N.2    Raval, P.3    Gu, J.4    Watanabe, G.5    Schwarz, K.6
  • 43
    • 0842303307 scopus 로고    scopus 로고
    • Unraveling V(D)J recombination; insights into gene regulation
    • Jung D, Alt FW. Unraveling V(D)J recombination; insights into gene regulation. Cell 2004; 116:299-311.
    • (2004) Cell , vol.116 , pp. 299-311
    • Jung, D.1    Alt, F.W.2
  • 44
    • 0032438115 scopus 로고    scopus 로고
    • Analysis of variable (diversity) joining recombination in DNA-dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation
    • DOI 10.1073/pnas.95.26.15559
    • Bogue MA, Jhappan C, Roth DB. Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation. Proc Natl Acad Sci USA 1998; 95:15559-64. (Pubitemid 29018738)
    • (1998) Proceedings of the National Academy of Sciences of the United States of America , vol.95 , Issue.26 , pp. 15559-15564
    • Bogue, M.A.1    Jhappan, C.2    Roth, D.B.3
  • 46
    • 0034280093 scopus 로고    scopus 로고
    • Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTA GGG repeats and the G-strand overhang
    • Samper E, Goytisolo FA, Slijepcevic P, van Buul PP, Blasco MA. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTA GGG repeats and the G-strand overhang. EMBO Rep 2000; 1:244-52.
    • (2000) EMBO Rep , vol.1 , pp. 244-252
    • Samper, E.1    Goytisolo, F.A.2    Slijepcevic, P.3    Van Buul, P.P.4    Blasco, M.A.5
  • 47
    • 0035023139 scopus 로고    scopus 로고
    • The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
    • DOI 10.1128/MCB.21.11.3642-3651.2001
    • Goytisolo FA, Samper E, Edmonson S, Taccioli GE, Blasco MA. The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol Cell Biol 2001; 21:3642-51. (Pubitemid 32466978)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.11 , pp. 3642-3651
    • Goytisolo, F.A.1    Samper, E.2    Edmonson, S.3    Taccioli, G.E.4    Blasco, M.A.5
  • 48
    • 0035822641 scopus 로고    scopus 로고
    • Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
    • dda di Fagagna F, Hande MP, Tong WM, Roth D, Lansdorp PM, Wang ZQ, et al. Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol 2001; 11:1192-6.
    • (2001) Curr Biol , vol.11 , pp. 1192-1196
    • Dda Di Fagagna, F.1    Hande, M.P.2    Tong, W.M.3    Roth, D.4    Lansdorp, P.M.5    Wang, Z.Q.6
  • 50
    • 0035023139 scopus 로고    scopus 로고
    • The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
    • DOI 10.1128/MCB.21.11.3642-3651.2001
    • Goytisolo FA, Samper E, Edmonson S, Taccioli GE, Blasco MA. The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol Cell Biol 2001; 21:3642-51. (Pubitemid 32466978)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.11 , pp. 3642-3651
    • Goytisolo, F.A.1    Samper, E.2    Edmonson, S.3    Taccioli, G.E.4    Blasco, M.A.5
  • 51
    • 0032536861 scopus 로고    scopus 로고
    • Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
    • Boulton SJ, Jackson SP. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J 1998; 17:1819-28.
    • (1998) EMBO J , vol.17 , pp. 1819-1828
    • Boulton, S.J.1    Jackson, S.P.2
  • 52
    • 0032076127 scopus 로고    scopus 로고
    • Yeast Ku as a regulator of chromosomal DNA end structure
    • DOI 10.1126/science.280.5364.741
    • Gravel S, Larrivee M, Labrecque P, Wellinger RJ. Yeast Ku as a regulator of chromosomal DNA end structure. Science 1998; 280:741-4. (Pubitemid 28243349)
    • (1998) Science , vol.280 , Issue.5364 , pp. 741-744
    • Gravel, S.1    Larrivee, M.2    Labrecque, P.3    Wellinger, R.J.4
  • 53
    • 0035822641 scopus 로고    scopus 로고
    • Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
    • dda di Fagagna F, Hande MP, Tong WM, Roth D, Lansdorp PM, Wang ZQ, et al. Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol 2001; 11:1192-6.
    • (2001) Curr Biol , vol.11 , pp. 1192-1196
    • Dda Di Fagagna, F.1    Hande, M.P.2    Tong, W.M.3    Roth, D.4    Lansdorp, P.M.5    Wang, Z.Q.6
  • 55
    • 0033597820 scopus 로고    scopus 로고
    • Ku binds telomeric DNA in vitro
    • Bianchi A, de LT. Ku binds telomeric DNA in vitro. J Biol Chem 1999; 274:21223-7.
    • (1999) J Biol Chem , vol.274 , pp. 21223-21227
    • Bianchi, A.1    De, L.T.2
  • 56
    • 0034669104 scopus 로고    scopus 로고
    • Ku acts in a unique way at the mammalian telomere to prevent end joining
    • Hsu HL, Gilley D, Galande SA, Hande MP, Allen B, Kim SH, et al. Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev 2000; 14:2807-12.
    • (2000) Genes Dev , vol.14 , pp. 2807-2812
    • Hsu, H.L.1    Gilley, D.2    Galande, S.A.3    Hande, M.P.4    Allen, B.5    Kim, S.H.6
  • 59
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • DOI 10.1038/35020592
    • Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000; 406:641-5. (Pubitemid 30641052)
    • (2000) Nature , vol.406 , Issue.6796 , pp. 641-645
    • Artandl, S.E.1    Chang, S.2    Lee, S.-L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    DePinho, R.A.7
  • 62
    • 0030009738 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
    • Chan DW, Lees-Miller SP. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. J Biol Chem 1996; 271:8936-41.
    • (1996) J Biol Chem , vol.271 , pp. 8936-8941
    • Chan, D.W.1    Lees-Miller, S.P.2
  • 63
    • 0035374588 scopus 로고    scopus 로고
    • Protein phosphatases regulate DNA-dependent protein kinase activity
    • Douglas P, Moorhead GB, Ye R, Lees-Miller SP. Protein phosphatases regulate DNA-dependent protein kinase activity. J Biol Chem 2001; 276:18992-8.
    • (2001) J Biol Chem , vol.276 , pp. 18992-18998
    • Douglas, P.1    Moorhead, G.B.2    Ye, R.3    Lees-Miller, S.P.4
  • 64
    • 4043073590 scopus 로고    scopus 로고
    • Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends
    • DOI 10.1093/nar/gkh761
    • Block WD, Yu Y, Merkle D, Gifford JL, Ding Q, Meek K, et al. Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Res 2004; 32:4351-7. (Pubitemid 39232307)
    • (2004) Nucleic Acids Research , vol.32 , Issue.14 , pp. 4351-4357
    • Block, W.D.1    Yu, Y.2    Merkle, D.3    Gifford, J.L.4    Ding, Q.5    Meek, K.6    Lees-Miller, S.P.7
  • 65
    • 28544448011 scopus 로고    scopus 로고
    • Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice
    • DOI 10.1128/MCB.25.24.10842-10852.2005
    • Cui X, Yu Y, Gupta S, Cho YM, Lees-Miller SP, Meek K. Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Mol Cell Biol 2005; 25:10842-52. (Pubitemid 41747129)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.24 , pp. 10842-10852
    • Xiaoping, C.1    Yaping, Y.2    Gupta, S.3    Cho, Y.-M.4    Lees-Miller, S.P.5    Meek, K.6
  • 67
    • 0043133778 scopus 로고    scopus 로고
    • Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair
    • DOI 10.1128/MCB.23.16.5836-5848.2003
    • Ding Q, Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, et al. Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol Cell Biol 2003; 23:5836-48. (Pubitemid 36951345)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.16 , pp. 5836-5848
    • Ding, Q.1    Reddy, Y.V.R.2    Wang, W.3    Woods, T.4    Douglas, P.5    Ramsden, D.A.6    Lees-Miller, S.P.7    Meek, K.8
  • 68
    • 34248231265 scopus 로고    scopus 로고
    • Trans autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining
    • DOI 10.1128/MCB.02366-06
    • Meek K, Douglas P, Cui X, Ding Q, Lees-Miller SP. trans- Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining. Mol Cell Biol 2007; 27:3881-90. (Pubitemid 46726193)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.10 , pp. 3881-3890
    • Meek, K.1    Douglas, P.2    Cui, X.3    Ding, Q.4    Lees-Miller, S.P.5
  • 69
    • 4544295689 scopus 로고    scopus 로고
    • Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends
    • DOI 10.1074/jbc.M406432200
    • Reddy YV, Ding Q, Lees-Miller SP, Meek K, Ramsden DA. Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation- dependent rearrangement at DNA ends. J Biol Chem 2004; 279:39408-13. (Pubitemid 39258205)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.38 , pp. 39408-39413
    • Reddy, Y.V.R.1    Ding, Q.2    Lees-Miller, S.P.3    Meek, K.4    Ramsden, D.A.5
  • 71
    • 0037106180 scopus 로고    scopus 로고
    • Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    • DOI 10.1101/gad.1015202
    • Chan DW, Chen BP, Prithivirajsingh S, Kurimasa A, Story MD, Qin J, et al. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev 2002; 16:2333-8. (Pubitemid 35034402)
    • (2002) Genes and Development , vol.16 , Issue.18 , pp. 2333-2338
    • Chan, D.W.1    Chen, B.P.-C.2    Prithivirajsingh, S.3    Kurimasa, A.4    Story, M.D.5    Qin, J.6    Chen, D.J.7
  • 72
    • 0043133778 scopus 로고    scopus 로고
    • Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair
    • DOI 10.1128/MCB.23.16.5836-5848.2003
    • Q' Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, et al. Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol Cell Biol 2003; 23:5836-48. (Pubitemid 36951345)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.16 , pp. 5836-5848
    • Ding, Q.1    Reddy, Y.V.R.2    Wang, W.3    Woods, T.4    Douglas, P.5    Ramsden, D.A.6    Lees-Miller, S.P.7    Meek, K.8
  • 74
    • 34547636294 scopus 로고    scopus 로고
    • Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts
    • DOI 10.1093/nar/gkm339
    • Povirk LF, Zhou RZ, Ramsden DA, Lees-Miller SP, Valerie K. Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts. Nucleic Acids Res 2007; 35:3869-78. (Pubitemid 47244611)
    • (2007) Nucleic Acids Research , vol.35 , Issue.12 , pp. 3869-3878
    • Povirk, L.F.1    Zhou, R.-Z.2    Ramsden, D.A.3    Lees-Miller, S.P.4    Valerie, K.5
  • 75
    • 33644871780 scopus 로고    scopus 로고
    • Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis
    • Jovanovic M, Dynan WS. Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis. Nucleic Acids Res 2006; 34:1112-20.
    • (2006) Nucleic Acids Res , vol.34 , pp. 1112-1120
    • Jovanovic, M.1    Dynan, W.S.2
  • 77
    • 9744220428 scopus 로고    scopus 로고
    • A pathway of double-strand break rejoining dependent upon ATM, Artemis and proteins locating to gamma-H2AX foci
    • Riballo E, Kuhne M, Rief N, Doherty A, Smith GC, Recio MJ, et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis and proteins locating to gamma-H2AX foci. Mol Cell 2004; 16:715-24.
    • (2004) Mol Cell , vol.16 , pp. 715-724
    • Riballo, E.1    Kuhne, M.2    Rief, N.3    Doherty, A.4    Smith, G.C.5    Recio, M.J.6
  • 78
    • 1642556817 scopus 로고    scopus 로고
    • A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity
    • DOI 10.1158/0008-5472.CAN-03-2384
    • Kuhne M, Riballo E, Rief N, Rothkamm K, Jeggo PA Lobrich M. A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res 2004; 64:500-8. (Pubitemid 38120888)
    • (2004) Cancer Research , vol.64 , Issue.2 , pp. 500-508
    • Kuhne, M.1    Riballo, E.2    Rief, N.3    Rothkamm, K.4    Jeggo, P.A.5    Lobrich, M.6
  • 79
    • 16444384872 scopus 로고    scopus 로고
    • Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM
    • DOI 10.1158/0008-5472.CAN-04-3451
    • Peng Y, Woods RG, Beamish H, Ye R, Lees-Miller SP, Lavin MF, et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes downregulation of ATM. Cancer Res 2005; 65:1670-7. (Pubitemid 40478591)
    • (2005) Cancer Research , vol.65 , Issue.5 , pp. 1670-1677
    • Peng, Y.1    Woods, R.G.2    Beamish, H.3    Ye, R.4    Lees-Miller, S.P.5    Lavin, M.F.6    Bedford, J.S.7
  • 80
    • 0035125901 scopus 로고    scopus 로고
    • Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis
    • Gurley KE, Kemp CJ. Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis. Curr Biol 2001; 11:191-4.
    • (2001) Curr Biol , vol.11 , pp. 191-194
    • Gurley, K.E.1    Kemp, C.J.2
  • 82
    • 33744827665 scopus 로고    scopus 로고
    • P53-independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc
    • DOI 10.1158/1541-7786.MCR-05-0258
    • Gladdy RA, Nutter LM, Kunath T, Danska JS, Guidos CJ. p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol Cancer Res 2006; 4:311-8. (Pubitemid 43837332)
    • (2006) Molecular Cancer Research , vol.4 , Issue.5 , pp. 311-318
    • Gladdy, R.A.1    Nutter, L.M.J.2    Kunath, T.3    Danska, J.S.4    Guidos, C.J.5
  • 83
    • 72949105139 scopus 로고    scopus 로고
    • Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin
    • Amst
    • Sakasai R, Teraoka H, Tibbetts RS. Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin. DNA Repair (Amst) 2010; 9:76-82.
    • (2010) DNA Repair , vol.9 , pp. 76-82
    • Sakasai, R.1    Teraoka, H.2    Tibbetts, R.S.3
  • 84
    • 77952058117 scopus 로고    scopus 로고
    • Transcription-dependent activation of ataxia telangiectasia- Mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison
    • Sakasai R, Teraoka H, Takagi M, Tibbetts RS. Transcription-dependent activation of ataxia telangiectasia- mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. J Biol Chem 2010; 15201-8.
    • (2010) J Biol Chem , pp. 15201-15208
    • Sakasai, R.1    Teraoka, H.2    Takagi, M.3    Tibbetts, R.S.4
  • 85
    • 0028855064 scopus 로고
    • DNA-dependent protein kinase: A potent inhibitor of transcription by RNA polymerase I
    • Kuhn A, Gottlieb TM, Jackson SP, Grummt I. DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I. Genes Dev 1995; 9:193-203.
    • (1995) Genes Dev , vol.9 , pp. 193-203
    • Kuhn, A.1    Gottlieb, T.M.2    Jackson, S.P.3    Grummt, I.4
  • 86
    • 0036868349 scopus 로고    scopus 로고
    • Mechanism of inhibition of RNA polymerase I transcription by DNA-dependent protein kinase
    • DOI 10.1515/BC.2002.189
    • Michaelidis TM, Grummt I. Mechanism of inhibition of RNA polymerase I transcription by DNA-dependent protein kinase. Biol Chem 2002; 383:1683-90. (Pubitemid 36033082)
    • (2002) Biological Chemistry , vol.383 , Issue.11 , pp. 1683-1690
    • Michaelidis, T.M.1    Grummt, I.2
  • 87
    • 0028088993 scopus 로고
    • Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation
    • Hoff CM, Ghosh AK, Prabhakar BS, Jacob ST. Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation. Proc Natl Acad Sci USA 1994; 91:762-6.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 762-766
    • Hoff, C.M.1    Ghosh, A.K.2    Prabhakar, B.S.3    Jacob, S.T.4
  • 88
    • 0027223736 scopus 로고
    • The nucleolar transcription activator UBF relieves Ku antigen-mediated repression of mouse ribosomal gene transcription
    • Kuhn A, Stefanovsky V, Grummt I. The nucleolar transcription activator UBF relieves Ku antigen-mediated repression of mouse ribosomal gene transcription. Nucleic Acids Res 1993; 21:2057-63. (Pubitemid 23160721)
    • (1993) Nucleic Acids Research , vol.21 , Issue.9 , pp. 2057-2063
    • Kuhn, A.1    Stefanovsky, V.2    Grummt, I.3
  • 89
    • 0033583204 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA
    • Calsou P, Frit P, Humbert O, Muller C, Chen DJ, Salles B. The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA J Biol Chem 1999; 274:7848-56.
    • (1999) J Biol Chem , vol.274 , pp. 7848-7856
    • Calsou, P.1    Frit, P.2    Humbert, O.3    Muller, C.4    Chen, D.J.5    Salles, B.6
  • 90
    • 0029143646 scopus 로고
    • Scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase
    • Boubnov NV, Weaver DT. Scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase. Mol Cell Biol 1995; 15:5700-6.
    • (1995) Mol Cell Biol , vol.15 , pp. 5700-5706
    • Boubnov, N.V.1    Weaver, D.T.2
  • 91
    • 0025224761 scopus 로고
    • Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53 and the human Ku autoantigen
    • Lees-Miller SP, Chen YR, Anderson CW. Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53 and the human Ku autoantigen. Mol Cell Biol 1990; 10:6472-81.
    • (1990) Mol Cell Biol , vol.10 , pp. 6472-6481
    • Lees-Miller, S.P.1    Chen, Y.R.2    Anderson, C.W.3
  • 93
    • 0027230415 scopus 로고
    • C-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif
    • Bannister AJ, Gottlieb TM, Kouzarides T, Jackson SP. c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. Nucleic Acids Res 1993; 21:1289-95. (Pubitemid 23155629)
    • (1993) Nucleic Acids Research , vol.21 , Issue.5 , pp. 1289-1295
    • Bannister, A.J.1    Gottlieb, T.M.2    Kouzarides, T.3    Jackson, S.P.4
  • 94
    • 0026552386 scopus 로고
    • DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats
    • Peterson SR, Dvir A, Anderson CW, Dynan WS. DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats. Genes Dev 1992; 6:426-38.
    • (1992) Genes Dev , vol.6 , pp. 426-438
    • Peterson, S.R.1    Dvir, A.2    Anderson, C.W.3    Dynan, W.S.4
  • 95
    • 0035907345 scopus 로고    scopus 로고
    • The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase
    • Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, et al. The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase. J Biol Chem 2001; 276:16848-56.
    • (2001) J Biol Chem , vol.276 , pp. 16848-16856
    • Schild-Poulter, C.1    Pope, L.2    Giffin, W.3    Kochan, J.C.4    Ngsee, J.K.5    Traykova-Andonova, M.6
  • 98
    • 0033527543 scopus 로고    scopus 로고
    • Involvement of DNA-dependent protein kinase in UV-induced replication arrest
    • Park JS, Park SJ, Peng X, Wang M, Yu MA, Lee SH. Involvement of DNA-dependent protein kinase in UV-induced replication arrest. J Biol Chem 1999; 274:32520-7.
    • (1999) J Biol Chem , vol.274 , pp. 32520-32527
    • Park, J.S.1    Park, S.J.2    Peng, X.3    Wang, M.4    Yu, M.A.5    Lee, S.H.6
  • 99
    • 70449840425 scopus 로고    scopus 로고
    • Cell nonhomologous end joining capacity controls SAF-A phosphorylation by DNA-PK in response to DNA double-strand breaks inducers
    • Britton S, Froment C, Frit P, Monsarrat B, Salles B, Calsou P. Cell nonhomologous end joining capacity controls SAF-A phosphorylation by DNA-PK in response to DNA double-strand breaks inducers. Cell Cycle 2009; 8:3717-22.
    • (2009) Cell Cycle , vol.8 , pp. 3717-3722
    • Britton, S.1    Froment, C.2    Frit, P.3    Monsarrat, B.4    Salles, B.5    Calsou, P.6
  • 100
    • 67650544671 scopus 로고    scopus 로고
    • DNA-PK: Relaying the insulin signal to USF in lipogenesis
    • Wong RH, Sul HS. DNA-PK: relaying the insulin signal to USF in lipogenesis. Cell Cycle 2009; 8:1977-8.
    • (2009) Cell Cycle , vol.8 , pp. 1977-1978
    • Wong, R.H.1    Sul, H.S.2
  • 101
    • 62149105212 scopus 로고    scopus 로고
    • A role of DNA-PK for the metabolic gene regulation in response to insulin
    • Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS. A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell 2009; 136:1056-72.
    • (2009) Cell , vol.136 , pp. 1056-1072
    • Wong, R.H.1    Chang, I.2    Hudak, C.S.3    Hyun, S.4    Kwan, H.Y.5    Sul, H.S.6
  • 102
    • 33745255099 scopus 로고    scopus 로고
    • A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription
    • DOI 10.1126/science.1127196
    • Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, Glass CK, et al. A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science 2006; 312:1798-802. (Pubitemid 43962898)
    • (2006) Science , vol.312 , Issue.5781 , pp. 1798-1802
    • Ju, B.-G.1    Lunyak, V.V.2    Perissi, V.3    Garcia-Bassets, I.4    Rose, D.W.5    Glass, C.K.6    Rosenfeld, M.G.7
  • 103
    • 33751212444 scopus 로고    scopus 로고
    • A breaking strategy for topoisomerase IIbeta/PARP-1-dependent regulated transcription
    • Ju BG. Rosenfeld MG. A breaking strategy for topoisomerase IIbeta/PARP-1-dependent regulated transcription. Cell Cycle 2006; 5:2557-60.
    • (2006) Cell Cycle , vol.5 , pp. 2557-2560
    • Ju, B.G.1    Rosenfeld, M.G.2
  • 104
    • 0035078659 scopus 로고    scopus 로고
    • Neurodegenerative disorders and ischemic brain diseases
    • DOI 10.1023/A:1009676112184
    • Mattson MP, DuanW, Pedersen WA, Culmsee C. Neurodegenerative disorders and ischemic brain diseases. Apoptosis 2001; 6:69-81. (Pubitemid 32233956)
    • (2001) Apoptosis , vol.6 , Issue.1-2 , pp. 69-81
    • Mattson, M.P.1    Duan, W.2    Pedersen, W.A.3    Culmsee, C.4
  • 107
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • DOI 10.1016/S1097-2765(01)00214-3
    • Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001; 7:683-94. (Pubitemid 32706359)
    • (2001) Molecular Cell , vol.7 , Issue.3 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 110
    • 0034640281 scopus 로고    scopus 로고
    • Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
    • DOI 10.1126/science.288.5468.1053
    • Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288:1053-8. (Pubitemid 30324238)
    • (2000) Science , vol.288 , Issue.5468 , pp. 1053-1058
    • Oda, E.1    Ohki, R.2    Murasawa, H.3    Nemoto, J.4    Shibue, T.5    Yamashita, T.6    Tokino, T.7    Taniguchi, T.8    Tanaka, N.9
  • 115
    • 0034602188 scopus 로고    scopus 로고
    • Role of BAX in the apoptotic response to anticancer agents
    • Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B. Role of BAX in the apoptotic response to anticancer agents. Science 2000; 290:989-92.
    • (2000) Science , vol.290 , pp. 989-992
    • Zhang, L.1    Yu, J.2    Park, B.H.3    Kinzler, K.W.4    Vogelstein, B.5
  • 117
    • 48149095219 scopus 로고    scopus 로고
    • Chromium-mediated apoptosis: Involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes
    • Amst
    • Hill R, Leidal AM, Madureira PA, Gillis LD, Waisman DM, Chiu A, et al. Chromium-mediated apoptosis: Involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes. DNA Repair (Amst) 2008; 9:1484-99.
    • (2008) DNA Repair , vol.9 , pp. 1484-1499
    • Hill, R.1    Leidal, A.M.2    Madureira, P.A.3    Gillis, L.D.4    Waisman, D.M.5    Chiu, A.6
  • 118
    • 0026687883 scopus 로고
    • Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
    • Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol 1992; 12:5041-9.
    • (1992) Mol Cell Biol , vol.12 , pp. 5041-5049
    • Lees-Miller, S.P.1    Sakaguchi, K.2    Ullrich, S.J.3    Appella, E.4    Anderson, C.W.5
  • 121
    • 0031025079 scopus 로고    scopus 로고
    • DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage
    • Rathmell WK, Kaufmann WK, Hurt JC, Byrd LL, Chu G. DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Cancer Res 1997; 57:68-74. (Pubitemid 27020332)
    • (1997) Cancer Research , vol.57 , Issue.1 , pp. 68-74
    • Rathmell, W.K.1    Kaufmann, W.K.2    Hurt, J.C.3    Byrd, L.L.4    Chu, G.5
  • 122
    • 0029941651 scopus 로고    scopus 로고
    • p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts
    • Huang LC, Clarkin KC, Wahl GM. p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. Cancer Res 1996; 56:2940-4.
    • (1996) Cancer Res , vol.56 , pp. 2940-2944
    • Huang, L.C.1    Clarkin, K.C.2    Wahl, G.M.3
  • 123
    • 0030446964 scopus 로고    scopus 로고
    • p53 induction, cell cycle checkpoints and apoptosis in DNAPK-deficient scid mice
    • Gurley KE, Kemp CJ. p53 induction, cell cycle checkpoints and apoptosis in DNAPK-deficient scid mice. Carcinogenesis 1996; 17:2537-42.
    • (1996) Carcinogenesis , vol.17 , pp. 2537-2542
    • Gurley, K.E.1    Kemp, C.J.2
  • 124
    • 0029858143 scopus 로고    scopus 로고
    • V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
    • Guidos CJ, Williams CJ, Grandal I, Knowles G, Huang MT, Danska JS. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev 1996; 10:2038-54.
    • (1996) Genes Dev , vol.10 , pp. 2038-2054
    • Guidos, C.J.1    Williams, C.J.2    Grandal, I.3    Knowles, G.4    Huang, M.T.5    Danska, J.S.6
  • 125
    • 0033532174 scopus 로고    scopus 로고
    • The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2 and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase
    • Kachnic LA, Wu B, Wunsch H, Mekeel KL, DeFrank JS, Tang W, et al. The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2 and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase. J Biol Chem 1999; 274:13111-7.
    • (1999) J Biol Chem , vol.274 , pp. 13111-13117
    • Kachnic, L.A.1    Wu, B.2    Wunsch, H.3    Mekeel, K.L.4    DeFrank, J.S.5    Tang, W.6
  • 126
    • 0032514485 scopus 로고    scopus 로고
    • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
    • Woo RA, McLure KG, Lees-Miller SP, Rancourt DE, Lee PW. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature 1998; 394:700-4.
    • (1998) Nature , vol.394 , pp. 700-704
    • Woo, R.A.1    McLure, K.G.2    Lees-Miller, S.P.3    Rancourt, D.E.4    Lee, P.W.5
  • 130
    • 0037124322 scopus 로고    scopus 로고
    • DNA damage-induced apoptosis requires the DNA-dependent protein kinase and is mediated by the latent population of p53
    • Woo RA, McLure KG, Lees-Miller SP, Rancourt DE Lee PW. DNA damage-induced apoptosis requires the DNA-dependent protein kinase and is mediated by the latent population of p53. EMBO J 2002; 21:3000-8.
    • (2002) EMBO J , vol.21 , pp. 3000-3008
    • Woo, R.A.1    McLure, K.G.2    Lees-Miller, S.P.3    Rancourt, D.E.4    Lee, P.W.5
  • 131
    • 0035893389 scopus 로고    scopus 로고
    • Interaction of p53 and DNA-PK in response to nucleoside analogues: Potential role as a sensor complex for DNA damage
    • Achanta G, Pelicano H, Feng L, Plunkett W, Huang P. Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage. Cancer Res 2001; 61:8723-9.
    • (2001) Cancer Res , vol.61 , pp. 8723-8729
    • Achanta, G.1    Pelicano, H.2    Feng, L.3    Plunkett, W.4    Huang, P.5
  • 132
  • 133
    • 33847365838 scopus 로고    scopus 로고
    • MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis
    • Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, Moretti F, et al. MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell 2007; 25:739-50.
    • (2007) Mol Cell , vol.25 , pp. 739-750
    • Rinaldo, C.1    Prodosmo, A.2    Mancini, F.3    Iacovelli, S.4    Sacchi, A.5    Moretti, F.6
  • 134
    • 33646090171 scopus 로고    scopus 로고
    • DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells
    • Amst
    • Mukherjee B, Kessinger C, Kobayashi J, Chen BP, Chen DJ, Chatterjee A, et al. DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. DNA Repair (Amst) 2006; 5:575-90.
    • (2006) DNA Repair , vol.5 , pp. 575-590
    • Mukherjee, B.1    Kessinger, C.2    Kobayashi, J.3    Chen, B.P.4    Chen, D.J.5    Chatterjee, A.6
  • 135
    • 33745934311 scopus 로고    scopus 로고
    • H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation
    • Sluss HK, Davis RJ. H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation. Mol Cell 2006; 23:152-3.
    • (2006) Mol Cell , vol.23 , pp. 152-153
    • Sluss, H.K.1    Davis, R.J.2
  • 136
    • 67649313760 scopus 로고    scopus 로고
    • The apoptotic ring: A novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases
    • Solier S, Pommier Y. The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases. Cell Cycle 2009; 8:1853-9.
    • (2009) Cell Cycle , vol.8 , pp. 1853-1859
    • Solier, S.1    Pommier, Y.2
  • 139
    • 70349272127 scopus 로고    scopus 로고
    • The DNA-PK Catalytic Subunit Regulates Bax-mediated Excitotoxic Cell Death by Ku70 Phosphorylation
    • Liu J, Naegele JR, Lin SL. The DNA-PK Catalytic Subunit Regulates Bax-mediated Excitotoxic Cell Death by Ku70 Phosphorylation. Brain Res 2009; 1296:164-75.
    • (2009) Brain Res , vol.1296 , pp. 164-175
    • Liu, J.1    Naegele, J.R.2    Lin, S.L.3
  • 141
    • 0036566036 scopus 로고    scopus 로고
    • Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres
    • Espejel S, Franco S, Sgura A, Gae D, Bailey SM, Taccioli GE, et al. Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J 2002; 21:2207-19.
    • (2002) EMBO J , vol.21 , pp. 2207-2219
    • Espejel, S.1    Franco, S.2    Sgura, A.3    Gae, D.4    Bailey, S.M.5    Taccioli, G.E.6
  • 146
    • 0037019830 scopus 로고    scopus 로고
    • ARFand p53 levels and an alteration of the Bax/Bcl-2 ratio
    • ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. J Biol Chem 2002; 277:37949-54.
    • (2002) J Biol Chem , vol.277 , pp. 37949-37954
    • Javelaud, D.1    Besancon, F.2
  • 147
    • 45549097099 scopus 로고    scopus 로고
    • Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival
    • Lu X, Yang C, Hill R, Yin C, Hollander MC, Fornace AJ Jr, et al. Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival. Cancer Res 2008; 68:3579-83.
    • (2008) Cancer Res , vol.68 , pp. 3579-3583
    • Lu, X.1    Yang, C.2    Hill, R.3    Yin, C.4    Hollander, M.C.5    Fornace Jr., A.J.6
  • 148
    • 0242329884 scopus 로고    scopus 로고
    • p53 functions through stress- And promoter-specific recruitment of transcription initiation components before and after DNA damage
    • Espinosa JM, Verdun RE, Emerson BM. p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol Cell 2003; 12:1015-27.
    • (2003) Mol Cell , vol.12 , pp. 1015-1027
    • Espinosa, J.M.1    Verdun, R.E.2    Emerson, B.M.3
  • 149
    • 0034881964 scopus 로고    scopus 로고
    • Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
    • Espinosa JM, Emerson BM. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol Cell 2001; 8:57-69.
    • (2001) Mol Cell , vol.8 , pp. 57-69
    • Espinosa, J.M.1    Emerson, B.M.2
  • 150
    • 33644787084 scopus 로고    scopus 로고
    • Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program
    • DOI 10.1101/gad.1398206
    • Gomes NP, Bjerke G, Llorente B, Szostek SA, Emerson BM, et al. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev 2006; 20:601-12. (Pubitemid 43345325)
    • (2006) Genes and Development , vol.20 , Issue.5 , pp. 601-612
    • Gomes, N.P.1    Bjerke, G.2    Llorente, B.3    Szostek, S.A.4    Emerson, B.M.5    Espinosa, J.M.6
  • 151
    • 33846908937 scopus 로고    scopus 로고
    • p53-dependent p21 mRNA elongation is impaired when DNA replication is stalled
    • Mattia M, Gottifredi V, McKinney K, Prives C. p53-dependent p21 mRNA elongation is impaired when DNA replication is stalled. Mol Cell Biol 2006; 4:1309-20.
    • (2006) Mol Cell Biol , vol.4 , pp. 1309-1320
    • Mattia, M.1    Gottifredi, V.2    McKinney, K.3    Prives, C.4


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