-
1
-
-
0035370483
-
Regulation and function of the p53 tumor suppressor protein
-
Ryan, K. M., Phillips, A. C. & Vousden, K. H. Regulation and function of the p53 tumor suppressor protein. Curr. Opin. Cell Biol. 13, 332-337 (2001).
-
(2001)
Curr. Opin. Cell Biol
, vol.13
, pp. 332-337
-
-
Ryan, K.M.1
Phillips, A.C.2
Vousden, K.H.3
-
2
-
-
0035156737
-
Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling
-
El-Deiry, W. S. Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling. Cell Death Differ. 8, 1066-1075 (2001).
-
(2001)
Cell Death Differ
, vol.8
, pp. 1066-1075
-
-
El-Deiry, W.S.1
-
3
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
El-Deiry, W. S. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825 (1993).
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
El-Deiry, W.S.1
-
4
-
-
0034654623
-
PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family
-
Attardi, L. D. et al. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev. 14, 704-718 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 704-718
-
-
Attardi, L.D.1
-
5
-
-
0033812557
-
Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis
-
Lin, Y., Ma, W. & Benchimol, S. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nature Genet. 26, 122-127 (2000).
-
(2000)
Nature Genet
, vol.26
, pp. 122-127
-
-
Lin, Y.1
Ma, W.2
Benchimol, S.3
-
6
-
-
0028883179
-
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
-
Miyashita, T. & Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299 (1995).
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
7
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano, K. & Vousden, K. H. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7, 683-694 (2001).
-
(2001)
Mol. Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
8
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda, E. et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288, 1053-1058 (2000).
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
-
9
-
-
0035265823
-
PUMA induces the rapid apoptosis of colorectal cancer cells
-
Yu, J., Zhang, L., Hwang, P. M., Kinzler, K. W. & Vogelstein, B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7, 673-682 (2001).
-
(2001)
Mol. Cell
, vol.7
, pp. 673-682
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Kinzler, K.W.4
Vogelstein, B.5
-
10
-
-
0031253977
-
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
-
Wu, G. S. et al. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nature Genet. 17, 141-143 (1997).
-
(1997)
Nature Genet
, vol.17
, pp. 141-143
-
-
Wu, G.S.1
-
11
-
-
0001203366
-
Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor
-
Wu, G. S., Burns, T. F., Zhan, Y., Alnemri, E. S. & El-Deiry, W. S. Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res. 59, 2770-2775 (1999).
-
(1999)
Cancer Res
, vol.59
, pp. 2770-2775
-
-
Wu, G.S.1
Burns, T.F.2
Zhan, Y.3
Alnemri, E.S.4
El-Deiry, W.S.5
-
12
-
-
0031743648
-
P53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
-
Muller, M. et al. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J. Exp. Med. 188, 2033-2045 (1998).
-
(1998)
J. Exp. Med
, vol.188
, pp. 2033-2045
-
-
Muller, M.1
-
13
-
-
0033215387
-
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
-
Murphy, M. et al. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev. 13, 2490-2501 (1999).
-
(1999)
Genes Dev
, vol.13
, pp. 2490-2501
-
-
Murphy, M.1
-
14
-
-
0036479115
-
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
-
Hoffman, W. H., Biade, S., Zilfou, J. T., Chen, J. & Murphy, M. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J. Biol. Chem. 277, 3247-3257 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 3247-3257
-
-
Hoffman, W.H.1
Biade, S.2
Zilfou, J.T.3
Chen, J.4
Murphy, M.5
-
15
-
-
0032575688
-
The Bcl-2 protein family: Arbiters of cell survival
-
Adams, J. M. & Cory, S. The Bcl-2 protein family: arbiters of cell survival. Science 281, 1322-1326 (1998).
-
(1998)
Science
, vol.281
, pp. 1322-1326
-
-
Adams, J.M.1
Cory, S.2
-
16
-
-
0029807585
-
BID: A novel BH3 domain-only death agonist
-
Wang, K., Yin, X. M., Chao, D. T., Milliman, C. L. & Korsmeyer, S. J. BID: a novel BH3 domain-only death agonist. Genes Dev. 10, 2859-2869 (1996).
-
(1996)
Genes Dev
, vol.10
, pp. 2859-2869
-
-
Wang, K.1
Yin, X.M.2
Chao, D.T.3
Milliman, C.L.4
Korsmeyer, S.J.5
-
17
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li, H., Zhu, H., Xu, C. J. & Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94, 491-501 (1998).
-
(1998)
Cell
, vol.94
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
18
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo, X., Budihardjo, I., Zou, H., Slaughter, C. & Wang, X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94, 481-490 (1998).
-
(1998)
Cell
, vol.94
, pp. 481-490
-
-
Luo, X.1
Budihardjo, I.2
Zou, H.3
Slaughter, C.4
Wang, X.5
-
19
-
-
0034534795
-
Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis
-
Zha, J., Weiler, S., Oh, K. J., Wei, M. C. & Korsmeyer, S. J. Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science 290, 1761-1765 (2000).
-
(2000)
Science
, vol.290
, pp. 1761-1765
-
-
Zha, J.1
Weiler, S.2
Oh, K.J.3
Wei, M.C.4
Korsmeyer, S.J.5
-
20
-
-
0034663829
-
Tbid, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
-
Wei, M. C. et al. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14, 2060-2071 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 2060-2071
-
-
Wei, M.C.1
-
21
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei, M. C. et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727-730 (2001).
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
-
22
-
-
0033534446
-
L prevents this release but not tumor necrosis factor-R1/Fas death
-
L prevents this release but not tumor necrosis factor-R1/Fas death. J. Biol. Chem. 274, 1156-1163 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 1156-1163
-
-
Gross, A.1
-
23
-
-
0033607006
-
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
-
Yin, X. M. et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400, 886-891 (1999).
-
(1999)
Nature
, vol.400
, pp. 886-891
-
-
Yin, X.M.1
-
24
-
-
0032536771
-
Two CD95 (APO-1/Fas) signaling pathways
-
Scaffidi, C. et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17, 1675-1687 (1998).
-
(1998)
EMBO J
, vol.17
, pp. 1675-1687
-
-
Scaffidi, C.1
-
25
-
-
0036007116
-
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis
-
Scorrano, L. et al. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev. Cell 2, 55-67 (2002).
-
(2002)
Dev. Cell
, vol.2
, pp. 55-67
-
-
Scorrano, L.1
-
26
-
-
0026303190
-
P53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts
-
Harvey, D. M. & Levine, A. J. p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev. 5, 2375-2385 (1991).
-
(1991)
Genes Dev
, vol.5
, pp. 2375-2385
-
-
Harvey, D.M.1
Levine, A.J.2
-
27
-
-
0029913730
-
Mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
-
Chen, J., Wu, X., Lin, J. & Levine, A. J. mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol. 16, 2445-2452 (1996).
-
(1996)
Mol. Cell Biol
, vol.16
, pp. 2445-2452
-
-
Chen, J.1
Wu, X.2
Lin, J.3
Levine, A.J.4
-
28
-
-
0027615656
-
Reconstitution of wild-type p53 expression triggers apoptosis in a p53-negative v-myc retrovirus-induced T-cell lymphoma line
-
Wang, Y. et al. Reconstitution of wild-type p53 expression triggers apoptosis in a p53-negative v-myc retrovirus-induced T-cell lymphoma line. Cell Growth Differ. 4, 467-473 (1993).
-
(1993)
Cell Growth Differ
, vol.4
, pp. 467-473
-
-
Wang, Y.1
-
29
-
-
0033518139
-
Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: Investigations of the mechanistic determinants of epithelial apoptosis in vivo
-
Pritchard, D. M., Potten, C. S., Korsmeyer, S. J., Roberts, S. & Hickman, J. A. Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. Oncogene 18, 7287-7293 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 7287-7293
-
-
Pritchard, D.M.1
Potten, C.S.2
Korsmeyer, S.J.3
Roberts, S.4
Hickman, J.A.5
-
30
-
-
0027319521
-
P53 is required for radiation-induced apoptosis in mouse thymocytes
-
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. & Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849 (1993).
-
(1993)
Nature
, vol.362
, pp. 847-849
-
-
Lowe, S.W.1
Schmitt, E.M.2
Smith, S.W.3
Osborne, B.A.4
Jacks, T.5
-
31
-
-
0029051336
-
Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo
-
Midgley, C. A. et al. Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo. J. Cell Sci. 108, 1843-1848 (1995).
-
(1995)
J. Cell Sci
, vol.108
, pp. 1843-1848
-
-
Midgley, C.A.1
-
32
-
-
0035797473
-
Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo
-
Burns, T. F., Bernhard, E. J. & El-Deiry, W. S. Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene 20, 4601-4612 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 4601-4612
-
-
Burns, T.F.1
Bernhard, E.J.2
El-Deiry, W.S.3
-
33
-
-
0032532148
-
BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11
-
Wang, K. et al. BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11. Genomics 53, 235-238 (1998).
-
(1998)
Genomics
, vol.53
, pp. 235-238
-
-
Wang, K.1
-
34
-
-
0026849821
-
Definition of a consensus binding site for p53
-
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W. & Vogelstein, B. Definition of a consensus binding site for p53. Nature Genet. 1, 45-49 (1992).
-
(1992)
Nature Genet
, vol.1
, pp. 45-49
-
-
El-Deiry, W.S.1
Kern, S.E.2
Pietenpol, J.A.3
Kinzler, K.W.4
Vogelstein, B.5
-
35
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden, K. H. & Lu, X. Live or let die: The cell's response to p53. Nature Rev. Cancer 2, 594-604 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
36
-
-
0037039319
-
From the cover: Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
-
Kaeser, M. D. & Iggo, R. D. From the cover: chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc. Natl Acad. Sci. USA 99, 95-100 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 95-100
-
-
Kaeser, M.D.1
Iggo, R.D.2
-
37
-
-
0034664733
-
P53Aip1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
-
Oda, K. et al. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102, 849-862 (2000).
-
(2000)
Cell
, vol.102
, pp. 849-862
-
-
Oda, K.1
-
38
-
-
18244408596
-
DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes
-
Costanzo, A. et al. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol. Cell 9, 175-186 (2002).
-
(2002)
Mol. Cell
, vol.9
, pp. 175-186
-
-
Costanzo, A.1
-
39
-
-
0032701521
-
Disruption of p53 in human cancer cells alters the responses to therapeutic agents
-
Bunz, F. et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J. Clin. Invest. 104, 263-269 (1999).
-
(1999)
J. Clin. Invest
, vol.104
, pp. 263-269
-
-
Bunz, F.1
-
40
-
-
0037047157
-
Apoptotic threshold is lowered by p53 transactivation of caspase-6
-
MacLachlan, T. K. & El-Deiry, W. S. Apoptotic threshold is lowered by p53 transactivation of caspase-6. Proc. Natl Acad. Sci. USA 99, 9492-9497 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 9492-9497
-
-
MacLachlan, T.K.1
El-Deiry, W.S.2
-
41
-
-
0034977277
-
Apaf-1 is a transcriptional target for E2F and p53
-
Moroni, M. C. et al. Apaf-1 is a transcriptional target for E2F and p53. Nature Cell Biol. 3, 552-558 (2001).
-
(2001)
Nature Cell Biol
, vol.3
, pp. 552-558
-
-
Moroni, M.C.1
-
42
-
-
0029670422
-
Regulation of p21WAF1/CIP1 expression by p53- independent pathways
-
Zeng, Y. X. & El-Deiry, W. S. Regulation of p21WAF1/CIP1 expression by p53- independent pathways. Oncogene 12, 1557-1564 (1996).
-
(1996)
Oncogene
, vol.12
, pp. 1557-1564
-
-
Zeng, Y.X.1
El-Deiry, W.S.2
-
43
-
-
0036044835
-
The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21(WAF1/CIP1) expression
-
Sax, J. K., Dash, B. C., Hong, R., Dicker, D. T. & El-Deiry, W. S. The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21(WAF1/CIP1) expression. Cell Cycle 1, 90-96 (2002).
-
(2002)
Cell Cycle
, vol.1
, pp. 90-96
-
-
Sax, J.K.1
Dash, B.C.2
Hong, R.3
Dicker, D.T.4
El-Deiry, W.S.5
-
44
-
-
0011443850
-
-
(ed. El-Deiry, W. S.) (Humana Press, Totowa, NJ)
-
Kadkol, S., Juang, J. & Wu, T. C. in Tumor Suppressor Genes: Regulations, Functions and Medicinal Applications Vol. 2 (ed. El-Deiry, W. S.) (Humana Press, Totowa, NJ, 2003).
-
(2003)
Tumor Suppressor Genes: Regulations, Functions and Medicinal Applications
, vol.2
-
-
Kadkol, S.1
Juang, J.2
Wu, T.C.3
-
45
-
-
0030759895
-
WAF1/CIP1
-
WAF1/CIP1, Nature 389, 187-190 (1997).
-
(1997)
Nature
, vol.389
, pp. 187-190
-
-
Somasundaram, K.1
-
46
-
-
0034723347
-
BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression
-
MacLachlan, T. K. et al. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. J. Biol. Chem. 275, 2777-2785 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 2777-2785
-
-
MacLachlan, T.K.1
-
47
-
-
0028209857
-
Sequence-specific transcriptional activation is essential for growth suppression by p53
-
Pietenpol, J. A. et al. Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc. Natl Acad. Sci. USA 91, 1998-2002 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 1998-2002
-
-
Pietenpol, J.A.1
-
48
-
-
0030805466
-
Detection and analysis of living, growth-inhibited mammalian cells following transfection
-
Zeng, Y. X., Somasundaram, K., Prabhu, N. S., Krishnadasan, R. & El-Deiry, W. S. Detection and analysis of living, growth-inhibited mammalian cells following transfection. Biotechniques 23, 88-94 (1997).
-
(1997)
Biotechniques
, vol.23
, pp. 88-94
-
-
Zeng, Y.X.1
Somasundaram, K.2
Prabhu, N.S.3
Krishnadasan, R.4
El-Deiry, W.S.5
-
49
-
-
0034732258
-
Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site
-
Takimoto, R. & El-Deiry, W. S. Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site. Oncogene 19, 1735-1743 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 1735-1743
-
-
Takimoto, R.1
El-Deiry, W.S.2
-
50
-
-
0035028599
-
Kinetics of p53 binding to promoter sites in vivo
-
Szak, S. T., Mays, D. & Pietenpol, J. A. Kinetics of p53 binding to promoter sites in vivo. Mol. Cell. Biol. 21, 3375-3386 (2001).
-
(2001)
Mol. Cell Biol
, vol.21
, pp. 3375-3386
-
-
Szak, S.T.1
Mays, D.2
Pietenpol, J.A.3
|