p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice

Carcinogenesis

Volumn 17, Issue 12, 1996, Pages 2537-2542

  Gurley, Kay E ^a   Kemp, Christopher J ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; DOXORUBICIN; PROTEIN KINASE; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; CRYPT CELL; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME DEFICIENCY; FEMALE; FIBROBLAST; IRRADIATION; MALE; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCID MOUSE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; CELL CYCLE; DNA DAMAGE; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FEMALE; MALE; MICE; MICE, INBRED C3H; MICE, SCID; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030446964     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.12.2537     Document Type: Article

References (25)

1. Cox, L.S. and Lane, D.P. (1995) Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. Bioessays, 16, 501-508.
2. Canman, C.E., Gilmer, T.M., Coutts, S.B. and Kastan, M.B. (1995) Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev. 9, 600-611.
3. Fritsche, M., Haessler, C. and Brandner, G. (1993) Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging. Oncogene, 8, 307-318.
4. Reed, M., Woelker, B., Wang, P., Anderson, M.E. and Tegtmeyer, P. (1995) The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation. Proc. Natl Acad. Sci. USA, 92, 9455-9459.
5. Canman, C.E., Wolff, A.C., Chen, C.Y., Fornace, A.J., Jr. and Kastan, M.B. (1994) The p53-dependent G1 cell cycle checkpoint pathway and ataxiatelangiectasia. Cancer Res. 54, 5054-5058.
6. Jackson, S.P. (1995) Ataxia-telangiectasia at the crossroads. Curr. Biol. 5, 1210-1212.
7. Bosma, M.J. and Caroll, A.M. (1991) The scid mouse mutant;definition, characterization, and potential uses. Annu. Rev. Immunol. 9, 323-350.
8. Chang, C., Biedermann, K.A., Mezzina, M. and Brown, J.M. (1993) Characterization of the DNA double strand break repair defect in scid mice. Cancer Res. 53, 1244-1248.
9. Hendrickson, E.A., Qin, X.Q., Bump, E.A., Schatz, D.G., Oettinger, M. and Weaver, D.T. (1991) A link between double-strand break-related repair and V(D)J recombination: the scid mutation. Proc. Natl Acad. Sci. USA, 88, 4061-4065.
10. Disney, J.E., Barth, A.L. and Shultz, L.D. (1992) Detective repair of radiation-induced chromosomal damage in scid/scid mice. Cytogenet. Cell Genet. 59, 39-44.
11. Danska, J.S., Pflumio, F., Williams, C.J., Huner, O., Dick, J.E. and Guidos, C.J. (1994) Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents. Science, 266, 450-455.
12. Weaver, D.T. (1995) What to do at an end: DNA double strand break repair. Trends Genetics, 11, 388-392.
13. Blunt, T., Finnie, N.J., Taccioli, G.E., Smith, G.C.M., Demengeot, J., Gottlieb, T.M., Varghese, A.J., Alt, F.W., Jeggo, P.A. and Jackson, S.P. (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine SCID mutation. Cell, 80, 813-823.
14. Peterson, S.R., Kurimasa, A., Oshimura, M., Dynan, W.S., Bradbury, E.M. and Chen, D.J. (1995) Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA-double strand break repair mutant mammalian cells. Proc. Natl Acad. Sci. USA, 92, 3171-3174.
15. Kirchgessner, C.U., Patil, C.K., Evans, J.W., Cuomo, C.A., Fried, L.M., Carter, T. and Brown, J.M. (1995) DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science, 267, 1178-1183.
16. Miller, R.D., Hogg, J., Ozaki, J.H., Gell, D., Jackson, S.P. and Riblet, R. (1995) Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proc. Natl Acad. Sci. USA. 92, 10792-10795.
17. Anderson, C.W. (1993) DNA damage and the DNA-activated protein kinase. Trends Biochem. Sci. 18, 433-437.
18. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S.A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
19. Merritt, A.J., Potten, C.S., Kemp, C.J., Hickman, J.A., Lane, D.P. and Hall, P.A. (1994) The role of spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53 deficient mice. Cancer Res. 54, 614-617.
20. Midgley, C.A., Owens, B., Briscoe, C.V., Thomas, D.B., Lane, D.P. and Hall, P.A. (1995) Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo. J. Cell Sci. 108, 1843-1848.
21. Potten, C.S. (1992) The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer Metastasis Rev. 11, 179-195.
22. Biedermann, K.A., Sun, J.R., Giaccia, A.J., Tosto, L.M. and Brown, J.M. (1991) scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc. Natl Acad. Sci. USA, 88, 1394-1397.
23. Ziegler, A., Jonason, A.S., Leffell, D.J., Simon, J.A., Sharma, H.W., Kimmelman, J., Jacks, T. and Brash, D.E. (1994) Sunburn and p53 in the onset of skin cancer [see comments]. Nature, 372, 773-776.
24. Donehower, L.A., Harvey, M., Slagle, B.L., McArthur, M.J., Montgomery, C.A., Jr., Butel, J.S. and Bradley, A. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature, 356, 215-221.
25. Boubnov, N.V. and Weaver, D.T. (1995) scid cells are deficient in ku and replication protein A phosphorylation by the DNA-dependent protein kinase. Mol. Cell. Biol. 15, 5700-5706.