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Volumn 35, Issue 12, 2007, Pages 3869-3878

Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CELL EXTRACT; DNA DEPENDENT PROTEIN KINASE; PROTEIN KINASE INHIBITOR; SERINE; THREONINE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; NUCLEAR PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE (ATP); PRKDC PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 34547636294     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkm339     Document Type: Article
Times cited : (33)

References (28)
  • 1
    • 0141757494 scopus 로고    scopus 로고
    • Regulation and mechanisms of mammalian double-strand break repair
    • Valerie,K. and Povirk,L.F. (2003) Regulation and mechanisms of mammalian double-strand break repair. Oncogene, 22, 5792-5812.
    • (2003) Oncogene , vol.22 , pp. 5792-5812
    • Valerie, K.1    Povirk, L.F.2
  • 2
    • 3242875642 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase: The director at the end
    • Meek,K., Gupta,S., Ramsden,D.A. and Lees-Miller,S.P. (2004) The DNA-dependent protein kinase: The director at the end. Immunol. Rev. 200, 132-141.
    • (2004) Immunol. Rev , vol.200 , pp. 132-141
    • Meek, K.1    Gupta, S.2    Ramsden, D.A.3    Lees-Miller, S.P.4
  • 3
    • 22044445683 scopus 로고    scopus 로고
    • DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining
    • Douglas,P., Gupta,S., Morrice,N., Meek,K. and Lees-Miller,S.P. (2005) DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. DNA Repair, 4, 1006-1018.
    • (2005) DNA Repair , vol.4 , pp. 1006-1018
    • Douglas, P.1    Gupta, S.2    Morrice, N.3    Meek, K.4    Lees-Miller, S.P.5
  • 4
    • 0037106180 scopus 로고    scopus 로고
    • Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    • Chan,D.W., Chen,B.P., Prithivirajsingh;S., Kurimasa,A., Story,M.D., Qin,J. and Chen,D.J. (2002) Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev., 16, 2333-2338.
    • (2002) Genes Dev , vol.16 , pp. 2333-2338
    • Chan, D.W.1    Chen, B.P.2    Prithivirajsingh, S.3    Kurimasa, A.4    Story, M.D.5    Qin, J.6    Chen, D.J.7
  • 5
    • 0043133778 scopus 로고    scopus 로고
    • Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair
    • Ding,Q., Reddy,Y.V., Wang,W., Woods,T., Douglas,P., Ramsden,D.A., Lees-Miller,S.P. and Meek,K. (2003) Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol. Cell. Biol., 23, 5836-5848.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 5836-5848
    • Ding, Q.1    Reddy, Y.V.2    Wang, W.3    Woods, T.4    Douglas, P.5    Ramsden, D.A.6    Lees-Miller, S.P.7    Meek, K.8
  • 6
    • 4544295689 scopus 로고    scopus 로고
    • Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends
    • Reddy,Y.V., Ding,Q., Lees-Miller,S.P., Meek,K. and Ramsden,D.A. (2004) Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends. J. Biol. Chem., 279, 39408-39413.
    • (2004) J. Biol. Chem , vol.279 , pp. 39408-39413
    • Reddy, Y.V.1    Ding, Q.2    Lees-Miller, S.P.3    Meek, K.4    Ramsden, D.A.5
  • 7
    • 4043073590 scopus 로고    scopus 로고
    • Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends
    • Block,W.D., Yu,Y., Merkle,D., Gifford,J.L., Ding,Q., Meek,K. and Lees-Miller,S.P. (2004) Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Res., 32, 4351-4357.
    • (2004) Nucleic Acids Res , vol.32 , pp. 4351-4357
    • Block, W.D.1    Yu, Y.2    Merkle, D.3    Gifford, J.L.4    Ding, Q.5    Meek, K.6    Lees-Miller, S.P.7
  • 8
    • 2642543876 scopus 로고    scopus 로고
    • Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells
    • Goodarzi,A.A. and Lees-Miller,S.P. (2004) Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells. DNA Repair, 3, 753-767.
    • (2004) DNA Repair , vol.3 , pp. 753-767
    • Goodarzi, A.A.1    Lees-Miller, S.P.2
  • 9
    • 0030480425 scopus 로고    scopus 로고
    • Construction of a vector containing a site-specific DNA double-strand break with 3′-phosphoglycolate termini and analysis of the products of end-joining in CV-1 cells
    • Bennett,R.A.O., Gu,X.-Y. and Povirk,L.F. (1996) Construction of a vector containing a site-specific DNA double-strand break with 3′-phosphoglycolate termini and analysis of the products of end-joining in CV-1 cells. Intl. J. Radiat. Biol., 70, 623-636.
    • (1996) Intl. J. Radiat. Biol , vol.70 , pp. 623-636
    • Bennett, R.A.O.1    Gu, X.-Y.2    Povirk, L.F.3
  • 10
    • 0035968210 scopus 로고    scopus 로고
    • Accurate in vitro end-joining of a DNA double-strand break with partially cohesive 3′-overhangs and 3′-phosphoglycolate termini: Effect of Ku on repair fidelity
    • Chen,S., Inamdar,K.V., Pfeiffer,P., Feldmann,E., Hannah,M.F., Yu,Y., Lee,J.W., Zhou,T., Lees-Miller,S.P. et al. (2001) Accurate in vitro end-joining of a DNA double-strand break with partially cohesive 3′-overhangs and 3′-phosphoglycolate termini: Effect of Ku on repair fidelity. J. Biol. Chem., 276, 24323-24330.
    • (2001) J. Biol. Chem , vol.276 , pp. 24323-24330
    • Chen, S.1    Inamdar, K.V.2    Pfeiffer, P.3    Feldmann, E.4    Hannah, M.F.5    Yu, Y.6    Lee, J.W.7    Zhou, T.8    Lees-Miller, S.P.9
  • 11
    • 0032564469 scopus 로고    scopus 로고
    • DNA end-joining catalyzed by human cell-free extracts
    • Baumann,P. and West,S.C. (1998) DNA end-joining catalyzed by human cell-free extracts. Proc. Natl Acad. Sci. USA, 95, 14066-14070.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 14066-14070
    • Baumann, P.1    West, S.C.2
  • 12
    • 0347683431 scopus 로고    scopus 로고
    • Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts
    • Lee,J.W., Blanco,L., Zhou,T., Bebenek,K., Garcia-Diaz,M., Kunkel,T.A., Wang,Z. and Povirk,L.F. (2004) Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. J. Biol. Chem., 279, 805-811.
    • (2004) J. Biol. Chem , vol.279 , pp. 805-811
    • Lee, J.W.1    Blanco, L.2    Zhou, T.3    Bebenek, K.4    Garcia-Diaz, M.5    Kunkel, T.A.6    Wang, Z.7    Povirk, L.F.8
  • 13
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam,J.D., Lebovitz,R.M. and Roeder,R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res., 11, 1475-1489.
    • (1983) Nucleic Acids Res , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 15
    • 0035870583 scopus 로고    scopus 로고
    • Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells
    • Wang,H., Zeng,Z.C., Perrault,A.R., Cheng,X., Qin,W. and Iliakis,G. (2001) Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells. Nucleic Acids Res., 29, 1653-1660.
    • (2001) Nucleic Acids Res , vol.29 , pp. 1653-1660
    • Wang, H.1    Zeng, Z.C.2    Perrault, A.R.3    Cheng, X.4    Qin, W.5    Iliakis, G.6
  • 17
    • 8844254050 scopus 로고    scopus 로고
    • Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries
    • Leahy,J.J., Golding,B.T., Griffin,R.J., Hardcastle,I.R., Richardson,C., Rigoreau,L. and Smith,G.C. (2004) Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg. Med. Chem. Lett., 14 6083-6087.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 6083-6087
    • Leahy, J.J.1    Golding, B.T.2    Griffin, R.J.3    Hardcastle, I.R.4    Richardson, C.5    Rigoreau, L.6    Smith, G.C.7
  • 19
    • 0036464515 scopus 로고    scopus 로고
    • Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction
    • Huang,J. and Dynan,W.S. (2002) Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction. Nucleic Acids Res., 30 667-674.
    • (2002) Nucleic Acids Res , vol.30 , pp. 667-674
    • Huang, J.1    Dynan, W.S.2
  • 20
    • 34547845825 scopus 로고    scopus 로고
    • The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/ 80, DNA-PKcs and XRCC4-LigIV
    • Kuhfittig-Kulle,S., Feldmann,E., Odersky,A., Kuliczkowska,A., Goedecke,W., Eggert,A. and Pfeiffer,P. (2007) The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/ 80, DNA-PKcs and XRCC4-LigIV. Mutagenesis, 22, 217-233.
    • (2007) Mutagenesis , vol.22 , pp. 217-233
    • Kuhfittig-Kulle, S.1    Feldmann, E.2    Odersky, A.3    Kuliczkowska, A.4    Goedecke, W.5    Eggert, A.6    Pfeiffer, P.7
  • 21
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCCI/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • Audebert,M., Salles,B. and Calsou,P. (2004) Involvement of poly(ADP-ribose) polymerase-1 and XRCCI/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J. Biol. Chem., 279, 55117-55126.
    • (2004) J. Biol. Chem , vol.279 , pp. 55117-55126
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 22
    • 13844321898 scopus 로고    scopus 로고
    • Phosphorylation of linker histones by DNA-dependent protein kinase is required for DNA ligase IV-dependent ligation in the presence of histone H1
    • Kysela,B., Chovanec,M. and Jeggo,P.A. (2005) Phosphorylation of linker histones by DNA-dependent protein kinase is required for DNA ligase IV-dependent ligation in the presence of histone H1. Proc. Natl Acad. Sci. USA, 102, 1877-1882.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1877-1882
    • Kysela, B.1    Chovanec, M.2    Jeggo, P.A.3
  • 23
  • 24
    • 0030750923 scopus 로고    scopus 로고
    • Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks
    • Foray,N., Priestley,A., Alsbeih,G., Badie,C., Capulas,E.P., Arlett, C.F. and Malaise,E.P. (1997) Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks. Int. J. Radiat. Biol., 72, 271-283.
    • (1997) Int. J. Radiat. Biol , vol.72 , pp. 271-283
    • Foray, N.1    Priestley, A.2    Alsbeih, G.3    Badie, C.4    Capulas, E.P.5    Arlett, C.F.6    Malaise, E.P.7
  • 25
    • 1642556817 scopus 로고    scopus 로고
    • A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity
    • Kuhne,M., Riballo,E., Rief,N., Rothkamm,K., Jeggo,P.A. and Lobrich,M. (2004) A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res., 64, 500-508.
    • (2004) Cancer Res , vol.64 , pp. 500-508
    • Kuhne, M.1    Riballo, E.2    Rief, N.3    Rothkamm, K.4    Jeggo, P.A.5    Lobrich, M.6
  • 26
    • 9744220428 scopus 로고    scopus 로고
    • A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
    • Riballo,E., Kuhne,M., Rief,N., Doherty,A., Smith,G.C., Recio,M.J., Reis,C., Dahm,K., Fricke,A. et al. (2004) A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol. Cell, 16, 715-724.
    • (2004) Mol. Cell , vol.16 , pp. 715-724
    • Riballo, E.1    Kuhne, M.2    Rief, N.3    Doherty, A.4    Smith, G.C.5    Recio, M.J.6    Reis, C.7    Dahm, K.8    Fricke, A.9
  • 27
    • 28544448011 scopus 로고    scopus 로고
    • Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice
    • Cui,X., Yu,Y., Gupta,S., Cho,Y.M., Lees-Miller,S.P. and Meek,K. (2005) Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Mol. Cell Biol., 25, 10842-10852.
    • (2005) Mol. Cell Biol , vol.25 , pp. 10842-10852
    • Cui, X.1    Yu, Y.2    Gupta, S.3    Cho, Y.M.4    Lees-Miller, S.P.5    Meek, K.6
  • 28
    • 33847185190 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain
    • Douglas,P., Cui,X., Block,W.D., Yu,Y., Gupta,S., Ding,Q., Ye,R., Morrice,N., Lees-Miller,S.P. et al. (2007) The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain. Mol. Cell Biol., 27, 1581-1591.
    • (2007) Mol. Cell Biol , vol.27 , pp. 1581-1591
    • Douglas, P.1    Cui, X.2    Block, W.D.3    Yu, Y.4    Gupta, S.5    Ding, Q.6    Ye, R.7    Morrice, N.8    Lees-Miller, S.P.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.